PRODUCTS

PEG-7 GLYCERYL COCOATE

CAS NUMBER: 68201-46-7
EC/LİST NUMBER: 614-376-4

PEG-7 Glyceryl Cocoate, PEG-30 Glyceryl Cocoate, PEG-40 Glyceryl Cocoate, PEG-78 Glyceryl Cocoate and PEG-80 Glyceryl Cocoate are polyethylene glycol ethers of Glyceryl Cocoate.
In cosmetics and personal care products, PEG Glyceryl Cocoate ingredients are used in the formulation of hair dyes and colors, shampoos, cleaning products, and skin care and bath products.

PEG-7 Glyceryl Cocoate acts as a lubricant on the skin's surface, which gives the skin a soft and smooth appearance.
PEG-7 Glyceryl Cocoate also helps to form emulsions by reducing the surface tension of the substances to be emulsified.
PEG-30, -40, -78 and -80 Glyceryl Cocoate clean the skin and hair by helping water to mix with oil and dirt so that these substances can be rinsed away.

PEG-7 Glyceryl Cocoate coconut oil ester is a kind of hydrophilic moisturizer prepared by natural oil and ethylene oxide.
PEG-7 Glyceryl Cocoate can be used in surfactant system to supplement oil, fat rich additive, small influence on foam, can replace water-soluble wool.
As oil soluble in transparent products, it can maintain oil balance of skin and hair, reduce dryness and increase lubrication of skin and hair.
Suitable for all kinds of bath and water agent products.

universal, effective emollient and conditioning agent in washable cosmetics,
smoothes the skin and hair,
compatibility and synergism with anionic and amphoteric surfactants,
foam stabilizer,
is a co-emulsifier supporting the formation of emulsions,
stabilizes oil-in-water emulsions (o / w),
is biodegradable and well tolerated by the skin and mucous membranes,
based on renewable vegetable raw materials.

PEG-7 glyceryl cocoate is a synthetic polymer that functions as an emollient, surfactant, and emulsifier in cosmetics and skincare products.

PEG-7 glyceryl cocoate is a polyethylene glycol (PEG) ether of glyceryl cocoate.
PEG-7 Glyceryl Cocoate is a monoester of glycerin and coconut fatty acids, which are both very beneficial to the skin.
Glycerin, also referred to as glycerol, is a natural alcohol and humectant that helps the skin to retain moisture.
Coconut fatty acids restore the skin’s lipid barrier, which also helps to improve the skin’s moisture retention.

PEG-7 glyceryl cocoate is produced by the ethoxylation of glyceryl cocoate.
Ethoxylation is a chemical reaction in which ethylene oxide is added to a substrate.
In this case, 7 units of ethylene oxide are added to glyceryl cocoate

In cosmetics and skincare products, PEG-7 glyceryl cocoate functions as an emollient, surfactant, and emulsifier.
PEG-7 glyceryl cocoate also helps to protect the skin’s natural barrier and retain the skin’s moisture levels.

Emollient
As an emollient, PEG-7 glyceryl cocoate provides a lightweight and non-greasy barrier that helps to increase moisture retention at the skin’s surface.
This property makes PEG-7 glyceryl cocoate very useful for products such as lotions, creams, and facial moisturizers.
While all skin types can benefit from emollients like PEG-7 glyceryl cocoate, emollients are especially helpful for those who have dry, rough, and/or flaky skin.
Emollients may help to alleviate these symptoms, leaving the skin looking and feeling soft and smooth.
In addition, emollients may benefit those that suffer from conditions such as eczema, psoriasis, or other inflammatory skin conditions.

Surfactant
PEG-7 glyceryl cocoate also functions as a surfactant because it contains one end that is hydrophilic or attracted to water and one end that is lipophilic or attracted to oil.
Surfactants work by lowering the surface tension between two substances, such as two liquids or a liquid and a solid.
This allows surfactants to attract and suspends oils, dirt, and other impurities that have accumulated on the skin and wash them away.
Due to these properties, PEG-7 glyceryl cocoate can be found in many different cleansers, shampoos, and body washes.

Emulsifier
As an emulsifier, PEG-7 glyceryl cocoate is often used in formulations that contain both water and oil components.
Mixing water and oil can be difficult as they tend to separate and split.
To address this problem, an emulsifier like PEG-7 glyceryl cocoate can be added to improve the consistency of a product, which enables an even distribution of topical skin care benefits.

PEG-7 Glyceryl Cocoate is a hydrophilic oil with a light yellow color and a characteristic odor.
Chemically it consists of polyethylene glycol and coconut fatty acids.
In cosmetics it is used as a degreaser in shampoos and body cleansers, thanks to its lubricating, emollient and conditioned properties for the skin and hair.

Furthermore PEG-7 Glyceryl Cocoate improves the foam quality of the detergents in which it is inserted.
PEG-7 Glyceryl Cocoate is also used for its solubilizing properties against fat-soluble substances in aqueous systems, such as some active ingredients (menthol, camphor, salicylic acid) and essential oils and having an HLB of about 11 can also be used as a coemulsifier.

PEG-7 Glyceryl Cocoate can be inserted into any type of cleansing product, for skin and hair.
PEG-7 Glyceryl Cocoate is often used used as a solubilizer and emollient in hair sprays without rinsing and in micellar cleansing waters.

PEGs Glyceryl Cocoate polymers are the polyethylene glycol ethers of glyceryl cocoate.
They function as skin conditioning agents, emollients, surfactants, nonionic emulsifying agents, and solubilizing agents in cosmetic formulations.
Only limited data on the safety of PEG-7 Glyceryl Cocoate were found, and no data were available on the higher molecular weight polymers in this group.
Data from previous safety assessments of Polyethylene Glycol (PEG), and several fatty acids (Stearic Acid, Oleic Acid, Lauric Acid, Palmitic Acid, and Myristic Acid) were considered relevant and added to the review.
PEG-7 Glyceryl Cocoate has low oral and dermal toxicity.
The fatty acids have slight oral toxicity, but little or no dermal toxicity.
Dermal application of PEG-7 Glyceryl Cocoate at a concentration of SO% did not produce irritation in mice and guinea pigs, but did produce slight irritation in rabbits.
Intracutaneous injection of PEG-7 Glyceryl Cocoate at a concentration of 10% did not produce sensitization.
This same concentration was not an ocular irritant in animal tests.

PEG-7 Glyceryl Cocoate was not phototoxic at a concentration of SO%.
Although monoalkyl ethers of ethylene glycol are reproductive and developmental toxins, given the methods of manufacture of PEG-7 Glyceryl Cocoate, there is no likelihood of such compounds being present as impurities.
The structure of the PEGs Glyceryl Cocoate polymers is such that it is unlikely that they would cause reproductive or developmental effects.
PEG-7 Glyceryl Cocoate did not produce reproductive toxicity in oral toxicity studies.
Oleic Acid in feed at a concentration of 15% did impair reproductive capacity in female rats, but growth and general health were not affected. No data were available on genotoxicity or carcinogenicity of PEGs Glyceryl Cocoate.
PEG was not genotoxic.

The fatty acids were generally not genotoxic, but positive results were seen for Oleic Acid in one assay.
Neither PEG-7 Glyceryl Cocoate nor the fatty acids were carcinogenic in animals tests.
Of concern was the possible presence of 1,4-dioxane and ethylene oxide impurities.
The importance of using the necessary purification procedures to remove these impurities was stressed.
In clinical studies PEG-7 Glyceryl Cocoate was neither a dermal irritant nor a photosensitizer.
The principal clinical finding related to PEGs is based on data in burn patients—PEGs were mild irritant/sensitizers and there was evidence of nephrotoxicity.
No such effects were seen in animal studies on intact skin.
Cosmetic manufacturers should adjust product formulations containing Polyethylene Glycol to minimize any untoward effects when products are used on damaged skin.
In recognition that PEG-7 Glyceryl Cocoate can enhance the skin penetration of other chemicals, care should also be exercised in using these ingredients in products where the penetration of other ingredients is aconcern.
Based on the limited data on PEGs Glyceryl Cocoate and on safety assessments of other related ingredients, it was concluded that PEG-7, -30, -40, -70, and -80 Glyceryl Cocoate are safe as used in rinse-off products and safe at concentrations up to 10% in leave-on products.

PEG-7 Glyceryl Cocoate was not phototoxic at a concentration of SO%.
Although monoalkyl ethers of ethylene glycol are reproductive and developmental toxins, given the methods of manufacture of PEG-7 Glyceryl Cocoate, there is no likelihood of such compounds being present as impurities.
The structure of the PEGs Glyceryl Cocoate polymers is such that it is unlikely that they would cause reproductive or developmental effects.
PEG-7 Glyceryl Cocoate did not produce reproductive toxicity in oral toxicity studies.
Oleic Acid in feed at a concentration of 15% did impair reproductive capacity in female rats, but growth and general health were not affected.
No data were available on genotoxicity or carcinogenicity of PEGs Glyceryl Cocoate.

PEG was not genotoxic.
The fatty acids were generally not genotoxic, but positive results were seen for Oleic Acid in one assay.
Neither PEG-7 Glyceryl Cocoate nor the fatty acids were carcinogenic in animals tests.
Of concern was the possible presence of 1,4-dioxane and ethylene oxide impurities.
The importance of using the necessary purification procedures to remove these impurities was stressed.
In clinical studies PEG-7 Glyceryl Cocoate was neither a dermal irritant nor a photosensitizer.
The principal clinical finding related to PEGs is based on data in burn patients—PEGs were mild irritant/sensitizers and there was evidence of nephrotoxicity.
No such effects were seen in animal studies on intact skin.
Cosmetic manufacturers should adjust product formulations containing Polyethylene Glycol to minimize any untoward effects when products are used on damaged skin.
In recognition that PEG-7 Glyceryl Cocoate can enhance the skin penetration of other chemicals, care should also be exercised in using these ingredients in products where the penetration of other ingredients is aconcern.
Based on the limited data on PEGs Glyceryl Cocoate and on safety assessments of other related ingredients, it was concluded that PEG-7, -30, -40, -70, and -80 Glyceryl Cocoate are safe as used in rinse-off products and safe at concentrations up to 10% in leave-on products.

PEG 7 glyceryl cocoate is a polyethylene glycol ether of glyceryl cocoate.
PEG 7 glyceryl cocoate is a monoester of glycerin and Coconut fatty acids, both of which are very beneficial for the skin.
PEG 7 glyceryl cocoate improves skin's moisture retention.
PEG 7 glyceryl cocoate is produced by ethoxylation of glyceryl cocoate.
Ethoxylation is a chemical reaction in which a substrate ethylene oxide is added.
In this case, glyceryl cocoate is equipped with unit ethylene oxide and the product is PEG 7 glyceryl cocoate product.

PEG 7 glyceryl cocoate form : room liquid
Demo of PEG 7 glyceryl cocoate: Light yellow solid
Smell of PEG 7 glyceryl cocoate : light
PEG 7 water soluble: water soluble
Color alpha : 100 max.
Active ingredient,%: approx. 100%
Water %: 0.5% max.

In cosmetic and personal use, PEG 7 glyceryl cocoate acts as an emollient, surfactant and emulsifier for oil-in-water emulsions.
The emollient PEG 7 glyceryl cocoate is a light non-oily lubricant that helps increase skin moisture retention.
Such properties make PEG 7 glyceryl cocoate very useful for lotions, creams and face moisturizers.
While all regions can recover from emollients like PEG 7 glyceryl cocoate, softeners are especially for the dry ones.
Emollients such as PEG 7 glycerin provide these additive tissue and body symptoms.

PEG 7 glycerin allows the oils accumulated in the skin to attract dirt and other aggregates and remove and wash them away.
Therefore, PEG 7 glyceryl cocoate multiplies in different cleansers, shampoos and body washes.
As an emulsifier, PEG 7 glyceryl cocoate is used in both water and oil assembly arrangements.
PEG 7 water droplets form an oil droplet glycerine in water.
But this is two-stage for sitting.
To solve this problem, an emulator such as PEG 7 glyceryl cocoate can be added to the system to assist your assistant with the droplets dispersed.
It provides equilibration of tropical skin wounds while improving a production of emulsifiers.

PEG 7 glyceryl cocoate is used to form oil-in-water emulsions.
PEG 7 is a water-soluble polyol fatty acids.
PEG 7 glyceryl cocoate is a non-ideological surfactant and PEG 7 glyceryl cocoate also has super lubrication.
PEG 7 glyceryl cocoate is found in a variety of industries.

PEG 7 glyceryl cocoate is used for a wide variety of applications.
PEG 7 is used as a conditioner and conditioner in shampoos and personal cleansers.
PEG 7 glyceryl is used in cosmetic products, bathroom cleaners, bathroom cleaners.

PEG 7 glyceryl cocoate is a nonionic, ethoxylated polyethylene glycol ester made from glycerin and coconut oil.
PEG 7 glyceryl cocoate is a synthetic polymer that functions as an emollient surfactant and emulsifier in cosmetics and personal care products.
PEG 7 glyceryl cocoate is a polyethylene glycol ether of glyceryl cocoate.
PEG 7 glyceryl cocoater is a monoester of glyceryl and coconut fatty acids, both of which are very beneficial for the skin.
Glycerin, also called glycerol, is a natural alcohol and humectant that helps the skin retain moisture.
Coconut fatty acids are an alcohol and humectant that helps the skin retain moisture.
Coconut fatty acids restore the skin's lipid barrier, which also increases the skin's moisture retention.

Just as oils and other PEG 7 glyceryl cocoate are mixtures, the PEGylated alkyl glycerides are mixtures.
PEGylation of glycerides occurs not only as an etherification of the free alcohol groups of the glycerides with ethylene oxide groups, but also as a transesterification which results in net insertion of PEG groups between the glyceryl and fatty acid components of the glyceride.

For example, the glycerin core of PEG-6 caprylic/capric glycerides is ethoxylated , wherein the sum of alln is equal to the number of ethylene oxide repeat units and need not be the same at all places of the molecule.
PEG 7 glyceryl cocoate should be stated that n is not equal to X.
In other words, wherein the value of X in PEG-X is equal to 6 is not equal to 6.
Instead, X represents the number of stoichiometric equivalents of ethylene
oxide that were added to one stoichiometric equivalent of caprylic/capric glycerides.
Therefore, the sum of all of the different n values in the mixture may be no more than X.
Indeed, when one mole of ethylene oxide is reacted with one mole of fatty alcohol, adducts having no added ethylene oxide are the predominate material in the mixture.

Furthermore, wherein ethylene oxide reacts with mono- or diglyceride, PEG 7 glyceryl cocoate is approximately twice as likely that it will react at an ester site versus an alcohol site.
Moreover, a percentage (13% in one specific case) of the ethylene oxide simply reacts with other molecules of ethylene oxide, resulting in some polyethylene glycols, unattached to glycerides.
Most of the ingredients in this report share in common a specific nomenclature, generically PEG-X “source”/alkyl-chaincommon-name glycerides .
The PEG 7 glyceryl cocoate have a slightly different order of nomenclature, but they are not structurally distinct from the other ingredients in this report.

Most of the PEG 7 glyceryl cocoate glycerides are reported to function as a skin conditioning agent – emollient and as a surfactant –emulsifying agent1
Emollients function by their ability to remain on the skin surface or in the stratum corneum to act as lubricants, to reduce flaking, and to improve the skin's appearance.
For the surfactant – emulsifying agent function, the efficacy of an emulsifying agent depends on its ability to reduce surface tension, to form complex films on the surface of emulsified droplets, and to create a repulsive barrier on emulsified droplets to prevent their coalescence.
A few of the PEGylated alkyl glycerides also are reported to act as surfactant - solubilizing agents or surfactant – cleansing agents.
The FDA collects information from manufacturers on the use of individual ingredients in cosmetics as a function of cosmetic product category in its Voluntary Cosmetic Registration Program (VCRP).
In 2014, VCRP data obtained from the FDA, and data received in response to surveys of the maximum reported use concentration by category that were conducted by the Personal Care Products Council (Council),29-31 indicate that 21 of the 60 ingredients included in this safety assessment are used in cosmetic formulations .
According to 2014 VCRP data, PEG-7 glyceryl cocoate has the most reported uses, i.e., ; the majority of these uses are in rinse-off formulations.

PEG-6 caprylic/capric glycerides is reported to be used in 548 formulations, the majority of
which are rinse-off formulations, and PEG-60 almond glycerides is reported to be used in cosmetic formulations.
All other in-use PEG 7 glyceryl cocoate are reported to be used in less than 45 formulations.
The PEG 7 glyceryl cocoate have increased in use.
In 1996, PEG 7 glyceryl cocoate was reported to be used in formulations, and it is now reported to be used in 858 formulations; however, both then and now, PEG-7 glyceryl cocoate is used mostly in rinse-off formulations.
The frequency of use also has increased for PEG-30 glyceryl cocoate , PEG-40 glyceryl cocoate, and PEG-80 glyceryl cocoate .
The results of the concentration of use survey conducted by the Council indicate the highest leave-on concentrations reported are 11.3% and 6% for PEG-7 glyceryl cocoate in tonics, dressings, and other hair grooming aids and “other” fragrance preparations.

PEG 7 glyceryl cocoate also has the highest rinse-off concentration of use reported, i.e., 10% in skin cleansing products.
At the time of the original safety assessment, concentration of use data were not available from the FDA.
However, based on ocular and sensitization data, a concentration limit of 10% was placed on leave-on products containing PEG glyceryl cocoates.
The current reported concentration of use in leave-on products is slightly higher, i.e., 11.3% in tonics, dressings, and other hair grooming aids.

One ingredient is used in products that could be incidentally ingested and a few of the ingredients are used near the eye or mucous membranes (PEG-7 glyceryl cocoate is used at up to 6.9% in other personal cleanliness products).
Five PEG 7 glyceryl cocoate were reported to the VCRP as used in baby products, but concentration of use data were not submitted by industry for these uses.
Additionally, according to the VCRP, several ingredients are used in products that can be incidentally inhaled, and results of the Council survey reported concentrations of up to 6% PEG-7 glyceryl cocoate in “other” fragrance preparations, 2% PEG-7 glyceryl cocoate in a pump spray deodorant, and up to 1.9% PEG45 palm kernel glyceride in a pump spray suntan product.
In practice, 95 to 99% of the droplets/particles released from cosmetic sprays have aerodynamic equivalent diameters >10 µm.

Therefore, most droplets/particles incidentally inhaled from cosmetic sprays would be deposited in the nasopharyngeal and bronchial regions and would not be respirable to any appreciable amount.
The PEGylated alkyl glycerides named in this safety assessment are listed in the European Union inventory of cosmetic ingredients.

Surfactants can enhance penetration of some compounds through the skin.
The ability of PEG-8 caprylic/capric glycerides to be a dermal penetration enhancer has been investigated in a number of studies; a few examples of those studies are provided.
In one study in which transdermal delivery of lidocaine (lipophilic) and prilocaine hydrochloride (hydrophilic) was measured in vitro in Franz-type diffusion cells, several microemulsion systems that contained 11.5-53% PEG-8 caprylic/capric glycerides, 3-70% isostearyl isostearate, 8-35% polyglyceryl-6 isostearate, and 7-65% water increased delivery of lidocaine up to four times compared to an oil/water emulsion vehicle, and increased the delivery of prilocaine hydrochloride almost ten times compared to a hydrogel.
The increase in delivery was attributed to increased solubility of the drug, and appeared to be dependent on drug mobility in the vehicle.
Another example is the effect of PEG-8 caprylic/capric glycerides on the transdermal flux of carvedilol, a non-selective βadrenergic antagonist, through porcine skin.
The flux of carvedilol from a PEG-8 caprylic/capric glycerides vehicle was 8.6 times greater than that obtained with the control vehicle composed of phosphate buffered saline containing 40% v/v PEG 400.39
However, when placed in the donor compartment, flux was only 4.7 times greater with 5% PEG-8 caprylic/capric glycerides compared to controls.
In another study, when used as a vehicle, PEG-8 caprylic/capric glycerides was only a weak penetration enhancer of cyclosporin A, a non-polar cyclic oligopeptide, through excised rat skin.
A formulation containing 40% PEG-8 caprylic/capric glycerides, 39.75% ethoxydiglycol, 10% ethanol, 5% ethyl oleate, and 5% sorbitan oleate improved the skin delivery of kahalalide F, a lipophilic cyclic molecule with a large molecular weight; however, the amount of kahalalide F that penetrated and permeated through the skin was much greater with dimethyl sulfoxide.
Additionally, a formulation containing 39.75% PEG-8 caprylic/capric glycerides, 35% propylene glycol, 10% ethanol, 10% n-methyl-2-pyrrolidone, and 5% isopropyl myristate did not improve skin delivery of kahalalide F.

PEG 7 glyceryl cocoate is a nonionic ethoxylated surfactant with extreme lubricating and dissolving properties.

PEG 7 glyceryl cocoate is a light yellow hydrophilic oil with a characteristic odour.
Chemically, PEG 7 consists of glyceryl cocoate polyethylene glycol and coconut fatty acids.
In cosmetics, PEG 7 glyceryl cocoate is used as a degreaser in shampoos and body cleansers thanks to its lubricating, emollient and softening properties for skin and hair.

In addition, PEG 7 glyceryl cocoate improves the foam quality of detergents in which it is introduced.
PEG 7 glyceryl cocoate is also used for its solubilizing properties against oil-soluble substances in aqueous systems such as some active ingredients and essential oils, and can also be used as a co-emulsifier, having an HLB of about 11.

PEG 7 glyceryl cocoate can be added to any cleansing product for skin and hair.
PEG 7 glyceryl cocoate is often used as a solvent and softener in hair sprays and micellar cleaners.
PEG 7 glyceryl cocoate is soluble in water and aqueous solutions of tensiottivi are stable in the pH range of 5 to 8.

Nonionic ethoxylated polyethylene glycol ester made from glycerin and coconut oil.
Clear oily liquid with characteristic odour.
PEG 7 glyceryl cocoate is soluble in water and alcohols, insoluble in oils.

PEG 7 glyceryl cocoate compounds are harmless as the manufacturing process may contain contaminants.

The product is used in;
A facial cleansing micellar liquid
facial cleansing gel for sensitive skin eco
Body wash emulsion with chamomile extract
Nourishing and moisturizing body gel with silk and red poppy extract
Hydrophilic cleansing oil for mixed skin
Hydrophilic cleansing oil for dry skin
Hydraphilic cleansing oil for mature skin
For acne and oily skin

PEG 7 glyceryl cocoate is classified as follows;
Plasticizer
emulsifier

This synthetic polymer is based on PEG and fatty acids derived from coconut oil.
Due to the presence of PEG, this component may contain potentially toxic manufacturing impurities such as 1,4 dioxidant.
PEG 7 glyceryl cocoate acts as a lubricant on the surface of the skin, giving the skin a soft and smooth appearance.
PEG 7 glyceryl cocoate also helps to form emulsions by reducing the surface tension of the substances to be emulsified.

Multifunctional agent with excellent emulsifying, softening, refilling and thickening properties
PEG 7 glyceryl cocoate is very useful as a surfactant and foam booster.
PEG 7 glyceryl cocoate has a softening effect for a soft and smooth skin.
PEG 7 glyceryl cocoate can be added to formulas as is, with a normal concentration of 1-10%.
For external use only.
PEG 7 glyceryl cocoate

PEG 7 glyceryl cocoate is a nonionic ethoxylated surfactant with extreme lubricating and dissolving properties.

PEG 7 glyceryl cocoate compounds are harmless as the manufacturing process may contain contaminants.

This report addresses the safety of 60 PEGylated alkyl glycerides as used in cosmetics.
PEG 7 glyceryl cocoate are mono-, di-, and/or tri-glycerides that have been modified with ethylene glycol repeat units .
Most of the PEG 7 glyceryl cocoate are reported to function as skin conditioning agents or surfactants.
VCRP data obtained from the FDA, and data received in response to surveys of the maximum reported use concentration by category that were conducted by the Council, indicate that 21 of the 60 ingredients included in this safety assessment are used in cosmetic formulations.
PEG-7 glyceryl cocoate has the most reported uses, i.e., 858, followed by PEG-6 caprylic/capric glycerides with 548 reported uses; the majority of uses for both of these ingredients are in rinse-off formulations.
The highest concentrations of use reported for products resulting in leave-on dermal exposure are 11.3% and 6% PEG-7 glyceryl cocoate in tonics, dressings, and other hair grooming aids and other fragrance preparations.
PEG-7 glyceryl cocoate also has the highest rinse-off concentration of use reported, i.e., 10% in skin cleansing products.
Since the original safety assessment was published, the frequency of use of PEG-7 glyceryl cocoate increased from 173 reported uses in 1996 to 858 reported uses in 2014.
At the time of the original safety assessment, concentration of use data were not available from the FDA

Five of the ingredients included in this review, i.e. PEG-7 glyceryl cocoate, PEG-30 glyceryl cocoate, PEG-40 glyceryl cocoate, PEG-78 glyceryl cocoate, and PEG-80 glyceryl cocoate, were reviewed previously;
in 1999, the Panel concluded these five ingredients are safe as used in rinse-off products and safe at up to 10% in leave-on products.
The safety assessment of these ingredients was scheduled for re-review in 2014; however, the Panel found it appropriate to include the PEG glyceryl cocoates in this report, rather than conduct a separate re-review.
The Panel used the 1999 PEG glyceryl cocoates report, as well as the 2012 safety assessment of the PEGylated oils and the findings on skin irritation and sensitization included in this current report, in this assessment of the safety of the PEGylated alkyl glycerides.
There are no data on skin penetration by the PEGylated alkyl glycerides, but many of the PEGylated alkyl glycerides are approved for use in dietary supplements and as indirect food additives, and PEG-8 caprylic/capric glycerides is reported to be used as a pharmaceutical excipient.
Data on carcinogenicity were not found, and these ingredients were not mutagenic and lack structural features of concern.
Thus, the Panel focused its review on the safety of topical application.
Some ingredients demonstrated irritation, but at concentrations above those used in cosmetic formulations; however because the potential exists for dermal irritation with the use of products containing PEGylated alky glycerides, the Panel specified that products containing these ingredients must be formulated to be non-irritating.
PEG 7 glyceryl cocoate should be noted that although the conclusion of the 1999 report of PEG glyceryl cocoates limited their use to 10% in leave-on products, negative HRIPT data at and above the reported concentration of use, and the inclusion of the specification that these ingredients be used in products when formulated to be non-irritating, alleviated the need for that concentration limit.

IUPAC NAME:
Glycerides, coco mono- and di-, ethoxylated

Glycerides, coco mono- and di-, ethoxylated (CTS)

Glycerides,coco mono-and di-,ethoxylated

PEG-7 Glyceryl Cocoate

PEG-7 Glyceryl cocoate

Synonyms:

emanon HE
emanon HE-81
glycerox HE
liponate GMC-7
nikkol TMGCO-7
polasperse QBE
poly(oxy-1,2-ethanediyl), .alpha.,.alpha.',.alpha.''-1,2,3-propanetriyltris-.omega.-hydroxy-, monococonut acid ester (7 mol EO average molar ratio)
polyethylene glycol (7) glyceryl cocoate
polyethylene glycol (7) glyceryl monococoate
polyoxyethylene (7) glyceryl cocoate
polyoxyethylene (7) glyceryl monococoate
surfest G-C7