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EC / List no.: 225-856-4
CAS no.: 5117-19-1 / 25322-68-3
Mol. formula: C16H34O9
A smallish polymer molecule (created from repeated units of Polyethylene glycol, aka PEG) that's used as a solubilizer and viscosity control agent.
PEG-8 is a clear, colorless liquid that is water-soluble and water-binding (aka humectant) and can help to solubilize sparingly-water soluble things (e.g. vanilla, perfumes) into water-based formulas.
Thanks to its water-binding ability, it also prevents the drying out of formulas, especially when combined with the fellow hygroscopic agent, sorbitol.
PEG 8 are polymers of ethylene glycol. 8 represents the average number of ethylene glycol units. PEG-8 is used as an emollient in the formulation of cosmetic products.
PEG-8 is classified as :
Humectant
Solvent
CAS Number: 5117-19-1 / 25322-68-3 (generic)
EINECS/ELINCS No: 225-856-4
PEG 8 is the polyethylene glycol ester of Lauric Acid and is used in cosmetics and beauty products as a surfactant and emulsifying agent. PEG 8 's low molecular weight means that it is minimally absorbed by the skin (Source).
The inclusion of Lauric Acid, or coconut oil, makes this PEG more irritating than other PEGs, which are generally considered non-irritants.
Although coconut oil is touted for its moisturizing and anti-microbial properties, it is considered an allergen.
PEG-8 is primarily used as a fragrance ingredient and surfactant in cosmetics and beauty products.
PEG 8 is FDA and CIR approved for use, but not on broken skin.
Despite the many fears regarding PEGs, they are seen as an ingredient in a large number of products because of their diverse properties.
In a study published in the Toxicology journal in 2005, entitled "Safety assessment on polyethylene glycols (PEGs) and their derivatives as used in cosmetic products," it was concluded that:
"Taking into consideration all available information from related compounds, as well as the mode and mechanism of action, no safety concern with regard to these endpoints could be identified.
Based on the available data it is therefore concluded that PEGs of a wide molecular weight range (200 to over 10,000), their ethers (laureths, ceteths, ceteareths, steareths, and oleths), and fatty acid esters (laurates, dilaurates, stearates, distearates) are safe for use in cosmetics."
PEG-8 Description
PEG-8 is a synthetic polymer that works to bind moisture to skin and as a solvent for other cosmetic ingredients, helping them penetrate more efficiently.
PEGs are a very broad group of cosmetic ingredients.
They are all derivatives of ethylene glycol.
One of these derivatives is a compound called whose INCI name is PEG-8.
The characteristic properties of PEG-8 include its ability to form emulsions, retain moisture and solubilise.
Thanks to its properties, it is used in the cosmetic industry, construction, and in the production of fertilisers.
PEG-8 properties
The group of synthetic ethylene oxide polymers is generally referred to as PEGs.
These include derivatives of ethylene glycol that are formed by the condensation polymerisation reaction.
The polymer chain structure for polyethylene glycols is varied. Depending on the number of ethylene glycol units in the molecule, “different” PEGs are distinguished.
PEG-8 is therefore a lauric acid monoglyceride ethoxylated with 8 moles of ethylene oxide.
The CAS number of the compound is 25322-68-3.
PEG-8 is a colourless liquid that dissolves well in water.
Its characteristic feature are strong hygroscopic properties, which indirectly result in very good solubility of active substances.
PEG-8 is an ethylene glycol derivative with the highest molecular mass and keeps liquid form at room temperature.
Applications in cosmetic products
What is the purpose of PEG-8 in cosmetic products?
Emulsifier
The application of PEG-8 in cosmetics, personal care products or products used in various industries relies heavily on the emulsifying properties of the compound.
Emulsifiers are substances that are responsible for stabilising formulations.
Many cosmetics and industrial products require two naturally unmixable ingredients to be combined.
These are usually oil-in-water or water-in-oil emulsions. Such combination necessitates the use of an emulsifier such as PEG-8 since it gives the right structure and texture to the product.
Humectant
As a humectant, PEG-8 is responsible for retaining a constant level of moisture.
PEG-8 can absorb moisture and bind with water. Proper hydration is important, for example, for ensuring proper skin function.
PEG-8 prevents the cosmetic formulation from drying (or crystallisation). PEG-8 also serves as a solvent for other ingredients contained in cosmetics.
Solubiliser
The production of cosmetics involves mixing together ingredients of differing chemical nature in order to obtain a uniform texture of the formulation.
The use of PEG-8 in the production process allows to accelerate the distribution of ingredients in the liquid base and to significantly improve the quality of the process.
As a solubiliser,PEG-8 mediates the dissolution process.
PEG-8 is characterised by its ability to form a dispersion, which greatly facilitates the final application of the cosmetic formulation.
Non-cosmetic applications of PEG-8
A number of advantages of PEG-8 make this surfactant readily used in industries other than the cosmetic industry.
Industrial cleaning is an important field of industry that needs effective and efficient surfactants.
PEG-8, with its good anti-electrostatic emulsifying properties, is a popular ingredient in products aimed for industrial cleaning.
As an anti-electrostatic agent, it is also used in metalworking processes or in dye baths as a levelling agent.
Other applications of PEG-8:
fertiliser production,
raw material for ester production,
an agent for curing concrete and cement mortars,
raw material used in self-curing concretes,
indirect food additive,
packaging additives.
Origin(s): Synthetic
INCI name: PEG-8
EINECS/ELINCS number: 225-856-4
Classification: PEG / PPG, Ethoxylated compound, Glycol, Synthetic polymer
Its functions (INCI)
Humectant : Maintains water content of a cosmetic both in its packaging and on the skin
Solvent : Dissolves other substances
Molecular Formula: C16H34O9
Molar Mass: 370.436
Density: 1.115g/cm3
Melting Point: 22 °C
Boling Point: 471.5°C at 760 mmHg
Flash Point: 239°C
Vapor Presure: 7.16E-11mmHg at 25°C
pKa: 14.06±0.10(Predicted)
Storage Condition: -20°C
Refractive Index: 1.462
Physical and Chemical Properties: EPA Chemical Information Octaethylene glycol (5117-19-1)
Use: Uses eight ethylene glycol as alcohol organic matter, can be used as pharmaceutical intermediates.
Application in biomedicine
PEG-8 is also known as polyoxirane (PEO).
PEG-8 is a linear polyether obtained by ring opening polymerization of ethylene oxide.
The main uses in the field of biomedicine are as follows:
Contact lens liquid.
The viscosity of polyethylene glycol solution is sensitive to the shear rate and it is not easy for bacteria to grow on polyethylene glycol.
Synthetic lubricants.
The condensation polymer of ethylene oxide and water.
PEG-8 is a cream matrix for preparing water-soluble drugs.
PEG-8 can also be used as a solvent for acetylsalicylic acid and caffeine, which is difficult to dissolve in water.
Drug sustained-release and immobilized enzyme carrier.
The polyethylene glycol solution is applied to the outer layer of the pill to control the diffusion of drugs in the pill so as to improve the efficacy.
Surface modification of medical polymer materials.
The biocompatibility of medical polymer materials in contact with blood can be improved by adsorption, interception and grafting of two amphiphilic copolymers containing polyethylene glycol on the surface of medical polymers.
PEG-8 can make the membrane of the alkanol contraceptive pill.
PEG-8 can make hydrophilic anticoagulant polyurethane.
PEG-8 is an osmotic laxative.
PEG-8 can increase osmotic pressure and absorb moisture in the intestinal cavity, which makes the stool soften and increase in volume, resulting in bowel movement and defecation.
Denture fixing agent. Peg nontoxic and gelatinous nature can be used as a component of denture fixer.
PEG 8 and PEG 8 are commonly used to promote cell fusion or protoplast fusion and help organisms (such as yeasts) to take DNA in transformation. PEG absorbs water from the solution, so it is also used to concentrate the solution.
Description
PEG-8s are a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.
The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups.
The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups.
The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides.
The average molecular weight of any specific polyethylene glycol product falls within quite narrow limits (°5%).
The number of ethylene oxide units or their approximate molecular weight commonly designates the nomenclature of specific polyethylene glycols.
PEG-8 with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.
These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Uses:
PEG-8 is a binder, coating agent, dispersing agent, flavoring adjuvant, and plasticizing agent that is a clear, colorless, viscous, hygroscopic liquid resembling paraffin (white, waxy, or flakes), with a ph of 4.0–7.5 in 1:20 concentration.
PEG-8 is soluble in water (mw 1,000) and many organic solvents.
polyethylene glycol (PEG) is a binder, solvent, plasticizing agent, and softener widely used for cosmetic cream bases and pharmaceutical ointments. Pegs are quite humectant up to a molecular weight of 500. Beyond this weight, their water uptake diminishes.
Used in conjunction with carbon black to form a conductive composite.
Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.
PEG-8 molecules of approximately 2000 monomers.
PEG-8 is used in various applications from industrial chemistry to biological chemistry.
Pharmaceutical Applications
Polyethylene glycols (PEGs) are widely used in a variety of pharmaceutical formulations, including parenteral, topical, ophthalmic, oral, and rectal preparations.
Polyethylene glycol has been used experimentally in biodegradable polymeric matrices used in controlled-release systems.
Polyethylene glycols are stable, hydrophilic substances that are essentially nonirritant to the skin.
They do not readily penetrate the skin, although the polyethylene glycols are water-soluble and are easily removed from the skin by washing, making them useful as ointment bases.
Solid grades are generally employed in topical ointments, with the consistency of the base being adjusted by the addition of liquid grades of polyethylene glycol.
Mixtures of polyethylene glycols can be used as suppository bases,for which they have many advantages over fats.
For example, the melting point of the suppository can be made higher to withstand exposure to warmer climates, release of the drug is not dependent upon melting point, the physical stability on storage is better, and suppositories are readily miscible with rectal fluids.
Polyethylene glycols have the following disadvantages: they are chemically more reactive than fats, greater care is needed in processing to avoid inelegant contraction holes in the suppositories; the rate of release of water-soluble medications decreases with the increasing molecular weight of the polyethylene glycol, and polyethylene glycols tend to be more irritating to mucous membranes than fats.
Aqueous polyethylene glycol solutions can be used either as suspending agents or to adjust the viscosity and consistency of other suspending vehicles.
When used in conjunction with other emulsifiers, polyethylene glycols can act as emulsion stabilizers.
Liquid polyethylene glycols are used as water-miscible solvents for the contents of soft gelatin capsules.
However, they may cause hardening of the capsule shell by preferential absorption of moisture from gelatin in the shell.
In concentrations up to approximately 30% v/v, PEG 300 and PEG 400 have been used as the vehicle for parenteral dosage forms.
In solid-dosage formulations, higher-molecular-weight polyethylene glycols can enhance the effectiveness of tablet binders and impart plasticity to granules.
However, they have only limited binding action when used alone, and can prolong disintegration if present in concentrations greater than 5% w/w.
When used for thermoplastic granulations,a mixture of the powdered constituents with 10–15% w/w PEG 6000 is heated to 70–75°C.
The mass becomes pastelike and forms granules if stirred while cooling.
This technique is useful for the preparation of dosage forms such as lozenges when prolonged disintegration is required.
Polyethylene glycols can also be used to enhance the aqueous solubility or dissolution characteristics of poorly soluble compounds by making solid dispersions with an appropriate polyethylene glycol.
In film coatings, solid grades of polyethylene glycol can be used alone for the film-coating of tablets or can be useful as hydrophilic polishing materials.
Solid grades are also widely used as plasticizers in conjunction with film-forming polymers.
The presence of polyethylene glycols in film coats, especially of liquid grades, tends to increase their water permeability and may reduce protection against low pH in enteric-coating films.
Polyethylene glycols are useful as plasticizers in microencapsulated products to avoid rupture of the coating film when the microcapsules are compressed into tablets.
Polyethylene glycol grades with molecular weights of 6000 and above can be used as lubricants, particularly for soluble tablets.
The lubricant action is not as good as that of magnesium stearate, and stickiness may develop if the material becomes too warm during compression.
An antiadherent effect is also exerted, again subject to the avoidance of overheating.
Polyethylene glycols have been used in the preparation of urethane hydrogels, which are used as controlled-release agents. Polyethylene glycol has also been used in insulin-loaded microparticles for the oral delivery of insulin.
PEG-8 has been used in inhalation preparations to improve aerosolization;polyethylene glycol nanoparticles have been used to improve the oral bioavailability of cyclosporine.
PEG-8 has been used in self-assembled polymeric nanoparticles as a drug carrier, and copolymer networks of polyethylene glycol grafted with poly(methacrylic acid) have been used as bioadhesive controlled drug delivery formulations.
About PEG-8
Helpful information
PEG-8 is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
PEG-8 is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.
Consumer Uses
PEG-8 is used in the following products: cosmetics and personal care products, pharmaceuticals, polymers, air care products, finger paints and washing & cleaning products.
Other release to the environment of PEG-8 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Article service life
Other release to the environment of PEG-8 is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials). PEG-8 can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines).
PEG-8 can be found in products with material based on, plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys) and paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper).
Widespread uses by professional workers
PEG-8 is used in the following products, polymers, pharmaceuticals, laboratory chemicals and washing & cleaning products.
PEG-8 is used in the following areas: health services, printing and recorded media reproduction and scientific research and development.
PEG-8 is used for the manufacture of, food products and rubber products.
Other release to the environment of PEG-8 is likely to occur from, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Formulation or re-packing
PEG-8 is used in the following products: inks and toners, polymers, cosmetics and personal care products, textile treatment products and dyes and washing & cleaning products.
Release to the environment of PEG-8 can occur from industrial use, formulation of mixtures and formulation in materials.
Uses at industrial sites
PEG-8 is used in the following products: polymers, washing & cleaning products, lubricants and greases, inks and toners and textile treatment products and dyes.
PEG-8 is used in the following areas, printing and recorded media reproduction.
PEG-8 is used for the manufacture of, rubber products, plastic products, machinery and vehicles and textile, leather or fur.
Release to the environment of PEG-8 can occur from industrial use, as processing aid, in the production of articles, in processing aids at industrial sites and of substances in closed systems with minimal release.
Manufacture
ECHA has no public registered data on the routes by which PEG-8 is most likely to be released to the environment.
IUPAC NAMES:
2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol
3,6,9,12,15,18,21-heptaoxatricosane-1,23-diol
3,6,9,12,15,18,21,24,27,30,33,36,39-tridecaoxahentetracontane-1,41-diol
a,w-Hydroxypoly(ethylene oxide)
alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl)
ethane-1,2-diol
Ethane-1,2-diol, ethoxylated
Not available
PEG 200
Polietilenoglicol
Poly(ethylene glycol)
Poly(ethylene glycol), flake, 600
Poly(oxy-1,2-ethanediyl) , .alpha.-hydro-.omega.-hydroxy-
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy- (90,000 mol EO average molar ratio)
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-
Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-
Poly(oxy-1,2-ethanediyl), α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),-hydro-hydroxy- Ethane-1,2-diol,
Poly(oxy-1,2-ethanediyl),.alpha.-hydro-.omega.-hydroxy
Poly(oxy-1,2-ethanediyl),.alpha.-hydro-.omega.-hydroxy;
Poly(oxy-1,2-ethanediyl),?-hydro-?-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),??-hydro-??-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),a-hydro-?-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylate
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy-Ethane-1,2-diol, ethoxylated
Poly(oxyethylene)
poly(oxyethylene)
poly(oxyethylene) {structure-based}
poly(oxyethylene) {structure-based}, poly(ethylene oxide) {source-based}
POLYETHYLENE GLYCOL
Polyethylene Glycol
Polyethylene glycol
polyethylene glycol
Polyethylene glycol
Polyethylene Glycol 1000
Polyethylene glycol 3,350
Polyethylene glycol 400
Polyethylene Glycol 400
Polyethyleneglycol
polyethyleneglycol
polyethylenglycol
Polyethylenglykol
Polyethylenglykole (PEG)
Polymer aus Ethy
SYNONYMS:
Octaethylene glycol
5117-19-1
3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diol
Octanethyl glycol
HO-PEG8-OH
2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
MFCD00698694
12034-81-0
PE8
C16H34O9
EINECS 225-856-4
Octa-ethylene glycol
4gs9
SCHEMBL45160
DTXSID3058618
CHEBI:44794
AMY19030
BCP33115
ZINC5178830
AKOS015839805
HY-W050087
MCULE-3002372725
SB67136
s1068
AS-19695
BP-21369
SY024582
DB-051916
CS-0031650
FT-0635546
O0295
Y4953
Octaethylene glycol, >=95% (oligomer purity)
117O191
A829142
A871353
J-511381
Q27120582
3,6,9,12,15,18,21-Heptaoxatricosane-21,23-diol
2-[2-[2-[2-[2-[2-[2-(2-hydroxyethyloxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
HO-PEG(8)-OH
OCTAETHYLENE GLYCOL
PED-DIOL (N=8)
3,6,9,12,15,18,21-Heptaoxatricosane-21,23-diol
Octoethyleneglycol
3,6,9,12,15,18,21-heptaoxatricosane-1,23-diol
POLYETHYLENEGLYCOL8
HO-8-OH
2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
HO-dPEG8-OH
Octaethylene glycol >=95% (oligoMer purity)
Octanethyl glycol
ctaethylene glycol
OH-PEG8-OH
OctaethyleneGlycol>
Octaethylene glycol, PEG8
1,2-ethanediol,homopolymer
2-ethanediyl),.alpha.-hydro-.omega.-hydroxy-Poly(oxy-1
Alcox E 160
Alcox E 30
alcoxe30
Poly(ethylene oxide),approx. M.W. 600,000
Poly(ethylene oxide),approx. M.W. 200,000
Poly(ethylene oxide),approx. M.W. 900,000
Poly(ethylene oxide),approx. M.W. 100,000
Poly(ethylene oxide),approx. M.W. 300,000
POLYETHYLENE GLYCOL 1550PRACT.
Poly(ethylene glycol),Macrogol 6,000, PEG
Poly(ethylene glycol),Macrogol 1000, PEG
Poly(ethylene glycol),Macrogol 35,000, PEG
Poly(ethylene glycol),Macrogol 3,000, PEG
Poly(ethylene oxide),PEG, Poly(ethylene glycol)
Poly(ethylene glycol),Macrogol 300, PEG
Poly(ethylene glycol),Macrogol 400, PEG
Poly(ethylene glycol),Macrogol 1,500, PEG
Poly(ethylene glycol),Macrogol 4,000, PEG
Poly(ethylene glycol),Macrogol 20,000, PEG
Polyethylene glycol solution,PEG solution
Polyethylene glycol 200, synthesis grade
Polyethylene glycol 300, synthesis grade
Polyethylene glycol 400, synthesis grade
Polyethylene glycol 550, synthesis grade
Polyethylene glycol 600, synthesis grade
Polyethylene glycol 1500, synthesis grade
Polyethylene glycol 4000, synthesis grade
Polyethylene glycol 6000, synthesis grade
Polyethylene glycol 8000, synthesis grade
Poly(ethylene oxide) 1g [25322-68-3]
PEG 400 5g [25322-68-3]
PEG 600 5g [25322-68-3]
PEG 1000 1g [25322-68-3]
500 G POLYETHYLENE GLYCOL 1550PRACT.
Poly(ethylene oxide),PEO
Polyethylene Oxide (100 mg)
Polyethylene glycol, MW ≈ 6,000
Polyethylene glycol, MW ≈ 4,000
alkapolpeg-8000
alpha,omega-Hydroxypoly(ethylene oxide)
alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl)
alpha-hydro-omega-hydroxy-poly(oxy-2-ethanediyl)
alpha-Hydro-omega-hydroxypoly(oxyethylene)
Aquaffin
Bradsyn PEG
bradsynpeg
Carbowax 100
Carbowax 1500
Carbowax 1540
Carbowax 20
Carbowax 200
Carbowax 2OM
Carbowax 300
Carbowax 5000
Carbowax 550
Carbowax 600
