PRODUCTS

PHENONIP

Phenonip is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics and toiletries. Phenonip provides activity against gram positive and gram negative bacteria, yeasts and molds, and retains activity in the presence of most cosmetic ingredients. This product has been successfully used to protect most types of personal care products from microbial contamination.

CAS No. : 8066-38-4
EC No. : 204-589-7

Synonyms:
Phenoxyethanol (and) Methylparaben (and) Ethylparaben (and) Propylparaben (and) Butylparaben (and) Isobutylparaben; fenonip; phenonipe; Phenoxyethanol; metil paraben; etil paraben; butil paraben; propil paraben; phenonip; METHYLPARABEN; Methyl paraben; Methyl p-hydroxybenzoate; Nipagin; Methyl parahydroxybenzoate; Maseptol; p-Hydroxybenzoic acid methyl ester; p-Methoxycarbonylphenol; 4-Hydroxybenzoic acid methyl ester; Benzoic acid, 4-hydroxy-, methyl ester; p-Carbomethoxyphenol; Tegosept M; Methaben; Metoxyde; Preserval; wet wipes; Metaben; Moldex; Paridol; Septos; Solbrol; Methyl parasept; Methyl butex; Methyl chemosept; Nipagin M; Aseptoform; Methylben; Abiol; Methyl-p-hydroxybenzoate; Preserval M; Solbrol M; 4-(Methoxycarbonyl)phenol; Methyl p-oxybenzoate; 4-Hydroxybenzoic acid, methyl ester; Methyl ester of p-hydroxybenzoic acid; p-Oxybenzoesauremethylester; FEMA No. 2710; Caswell No. 573PP; Benzoic acid, p-hydroxy-, methyl ester; preservative; FEMA Number 2710; UNII-A2I8C7HI9T; NSC 3827; p-Hydroxybenzoic acid, methyl ester; p-Hydroxybenzoic methyl ester; p-Oxybenzoesauremethylester [German]; phenonips; phenonip; phenonp; penonip; fenonip; fenonıp; fenonips; phenonips; fhenonips; EINECS 202-785-7; Methylester kyseliny p-hydroxybenzoove; PHENONIP; Methylparaben [USAN]; methyl 4- hydroxybenzoate; Methylparaben [USAN:NF]; Metagin; METHYL4-HYDROXYBENZOATE; Lexgard M; Paraben M; Methylparaben, NF; Methylparaben, FCC; 4-carbomethoxyphenol; Methylparaben (NF); Methylparaben (TN); INS number 218; Solparol (Salt/Mix); 4-hydroxymethylbenzoate; methyl 4-hydoxybenzoate; ACMC-20aiv0; methyl 4 hydroxybenzoate; methyl 4-hydroxylbenzoate; methyl 4-hydroxy-benzoate; methyl-4-hydroxy-benzoate; Methylis parahydroxybenzoas; wet wipes; preservative; prezervatif; Preserval MS (Salt/Mix); bmse010009; Methylparaben 99-76-3; PHENONIP; 4-hydroxybenzoate methyl ester; Methyl 4-Hydroxybenzoate,(S); Ethylene glycol monophenyl ether; Ethanol, 2-phenoxy-; Phenyl cellosolve; Phenoxytol; Phenoxethol; Phenoxetol; Ethylene glycol phenyl ether; Phenoxyethyl alcohol; 1-Hydroxy-2-phenoxyethane; Rose ether; Phenylmonoglycol ether; 2-Phenoxyethan-1-Ol; Arosol; Dowanol EP; 2-Phenoxyethyl alcohol; Glycol monophenyl ether; 2-Hydroxyethyl phenyl ether; Phenylglycol; Fenyl-cellosolve; 2-Fenoxyethanol; Dowanol EPH; 2-Phenoxy-ethanol; Emery 6705; Emeressence 1160

Phenonip

INCI Name of Phenonip:
Phenoxyethanol (and) Methylparaben (and) Ethylparaben (and) Propylparaben (and) Butylparaben (and) Isobutylparaben

Phenonip P4 is a preservative blend for personal care products. It is a non isobutylparaben version of Phenonip.

Benefits of Phenonip
Water soluble
Headspace preservation
Heat stable
Easy to handle and to dose

Technical Data of Phenonip
Appearance: Viscous liquid
Active substance (ca.): 100%
INCI-Name: Phenoxyethanol, Methylparaben, Ethylparaben, Propylparaben, Butylparaben
Secret Code of Beauty
Xpert Code
Liquid version of the optimized paraben blend

Trend Code
Option to meet regulatory requirements on branched esters

Applications of Phenonip
Leave-on products
Rinse-off products
Wet wipes

Broad spectrum, liquid preservative system ideal for use in a wide variety of personal care applications. Effective against Gram-positive and Gram-negative bacteria, yeasts and molds and retains activity in the presence of most cosmetic ingredients. Phenonip is oil soluble. It can be used in emulsions and anhydrous formulations.

• Retains activity over the range pH 3.0 - 8.0.

• Non-volatile - there is no loss of preservative due to volatility even on prolonged storage.

• Highly stable - aqueous solutions of Phenonip can withstand autoclave sterilisation with no loss of activity.

• Phenonip has an excellent toxicological profile and is non-irritant to skin, eye and mucous membranes at normal use concentrations.

• The components of Phenonip are biodegradable at the low concentrations found in effluent.

INCI: Phenoxyethanol (and) Methylparaben (and) Ethylparaben (and) Butylparaben (and) Propylparaben (and) Isobutylparaben

California Prop 65 Statement: The following statement is made in order to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. Phenonip may contain trace amounts of 1,4-dioxane (< 0.75 ppm), ethylene oxide (< 1.5 ppm) and methanol (< 500 ppm) which are known to the State of California to cause cancer, birth defects or other reproductive harm.

Ingredients (Common Name): Phenonip

Ingredients (INCI Name): Phenoxyethanol, Methylparaben, Ethylparaben, Butylparaben, Propylparaben

Shelf Life of Phenonip: 3 years

Recommended for Cold Process: no

Recommended for Melt and Pour: no

Recommended for Bath Bombs: no

Eye Safe: no

Lip Safe: no

Usage Instructions of Phenonip: Use at 0.5 to 1 percent of the total weight in products like lotion and scrub. Add the Phenonip when your product is 200 F or below. Higher temperatures can degrade the preservative.

Shipping Restrictions of Phenonip: No Shipping Restrictions

Phenoxyethanol (and) Methylparaben (and) Ethylparaben (and) Propylparaben (and) Butylparaben (and) Isobutylparaben. Phenonip acts as a preservative blend. Phenonip is effective against Gram-negative and Gram-positive bacteria, yeasts and moulds. Phenonip has an excellent toxicological profile and is non-irritant to skin, eye and mucous membranes at normal use concentrations. Phenonip is used in all kinds of personal care products specially in wet wipes.

Experience has shown that Phenonip will preserve many cosmetics and toiletries when incorporated at concentrations from 0.25% to 1.0%. This blend of preservatives is highly effective against gram positive and gram negative bacteria yeasts and moulds and is suitable for Moisturisers Lotions and Creams Sugar Scrubs Conditioners to name but a few.

The higher concentrations are typically only required for formulations which by their nature are particularly difficult to preserve.

>Emulsified systems both o/w and w/o types may be effectively preserved by the addition of this preservative at 0.4 - 0.7%. Whilst emulsions based on non-ionic surfactants may require slightly increased concentrations eg. 0.5 - 1.0%.
Shampoos and foam baths may be preserved with concentrations typically between 0.25 - 0.65%. Products with a high protein content may require levels from 0.5% - 1.0%.
Other surfactant-based products for example liquid dishwashing detergents are generally preserved levels over the range 0.2% - 0.6%.
Phenonip is more suitable than Germaben II for products that are manufactured at higher temperature ranges. Phenonip should only be added below 100 °C degrees when adding to the recipe. Phenonip is not a formaldehyde donor.

Parabens
Parabens are preservatives and widely used in mainstream beauty products and can be added to the oil phase of formulation. Phenonip is a common oil-soluble, broad-spectrum, paraben-based preservative. If you want to preserve an oil-based sugar scrub that might come in contact with water, phenonip is a good choice. You can add this to the oil phase of your lotions.

Preservatives are ingredients you add to your skin care formulas to prevent the growth of bacteria, yeast and fungi. Some preservatives, like Germall Plus, Otiphen, or Phenonip are broad spectrum, which means they protect against all three. Preservatives can also be limited, like potassium sorbate or natural botanicals. These can be used alone or combined with other preservatives to achieve broad spectrum protection.

Phenonip is a synergistic blend of esters of para-hydroxybenzoic acid (parabens) in phenoxyethanol designed for preservation of a wide range of cosmetics and toiletries. INCI: Phenoxyethanol, Methylparaben, Ethylparaben, Butylparaben, Propylparaben, Isobutylparaben

Usage levels of Phenonipmay vary depending on your exact formula. Phenonip will preserve cosmetics and toiletries when incorporated at concentrations from 0.25 % to 1 %. The higher concentrations are generally required only for formulations which are particularly difficult to preserve.

Phenoip is 100% oil-soluble and is not very water Soluble (see info below ) in water, but works well in emulsified systems. Phenonip can be readily dissolved in a liquid phase prior to emulsification. Depending on your formulation, it may be effective to split the amount you will use in to two phases between the water & oil phases during their preparation (ie when making a cream or butter product, add .5% to water phase & .5% to oil phase).

For aqueous formulations, like shampoos that are cold blended you can add Phenonip by adding it to a suitable solvent like propylene glycol or glycerin, and stirring this concentrate into the water.

Usage Levels of Phenonip In Aqueous systems / formulations like shampoos and foam baths may be preserved with Phenonip at concentrations between 0.25 % to 0.65 %. However, products with high protein content may require levels from 0.5 % - 1 %. Other surfactant- based formulations, for example liquid dishwashing detergents, are generally preserved with Phenonip over the range 0.2 %- 0.6 %. Emulsified systems, both O/W and W/O types, may be effectively preserved by Phenonip at 0.4 %- 0.7 %. Phenonip can also be used to preserve emulsions based on nonionic surfactants, but slightly increased concentrations may be required, e.g. increase usage to 0.5 -1 %.

Specifications of Phenonip
Appearance -Clear viscous Liquid
Phenonip is effective in pH range of 3.0 - 8.0.
Formaldehyde Free
Solubility - Water insoluble (0.50), Ethanol -Miscible, Isopropanol miscible, Propylene Glycol miscible, Isopropyl Myristate Miscible,Glycerin 10 %, Triethanolamine- Miscible, Polysorbate- 80 Miscible

Helpful info Phenonip can withstand higher temperatures than many preservatives, up to up to 176 F. Phenonip can be used up to a maximum concentration of 1.33 % in cosmetic product, no further restrictions, according to Annex VI, 76/768/EEC (Europe).
Phenonip is permitted for Japan up to 1.33 %, no further restrictions. Phenonip is considered safe as used (CIR 2006).
Storage instructions
The product must be protected from excessively high and low temperatures during storage.

Although Phenonip provides excellent antimicrobial preservation, testing should be done to assure preservative efficacy, and this applies to all preservative systems.

Phenonip withstands high temperatures up to 176 F and is preferred over Germaben II for high temp applications.
Phenonip can be added to the aqueous phase readily. It is 100% oil-soluble & .5% soluble in water. In emulsified systems, Phenonip is readily dissolved in the liquid phase prior to emulsification, although it is often good practice to divide the Phenonip content between the water & oil phases during their preparation (ie for lotion, add .5% to water phase & .5% to oil phase).

If the water content of the formulation is low, it may not be convenient to add the preservative directly to water during manufacture. Heating the water to 140-176F prior to Phenonip addition will, in most instances, allow the appropriate quantity to be dissolved.
For aqueous systems which cannot be heated, Phenonip can be incorporated by preparing a concentrate in a suitable solvent, e.g. propylene glycol or glycerin, and stirring this concentrate into the water.

Emulsified systems, both o/w and w/o types, may be effectively preserved by the addition of Phenonip.
Although Phenonip provides excellent antimicrobial preservation, individual testing should be done to assure preservative efficacy.

Recommended usage of Phenonip: 0.5 - 1%
Appearance of Phenonip: Clear, viscous liquid
Formaldehyde Free
INCI of Phenonip: Phenoxyethanol, Methylparaben, Ethylparaben, Butylparaben, Propylparaben, Isobutylparaben

Phenonip
Phenonip is a combination of phenoxyethanol, methylparaben, butylparaben, ethylparaben and propylparaben. Have you noticed all the parabens? So basically phenohip is a group of parabens mixed with phenoxyethanol. As mentioned earlier in Part I, phenoxyethanol, also known as ethelyne glycol phenyl ether 11 glycol ether and glycol ethers are solvents used in paints and cleaning agents, 12 as well as preservatives in cosmetics and pharmaceuticals.

As stated previously, Phenoxyethanol is part of a family of chemically related compounds known as ethehelene glycol ethors, as research shows that there is evidence that this chemical is toxic to the liver and kidney, 13 and can lead to anemia. 14

For more information on the dangers of ethylene glycol ethers and their family members, see section 1 of the sequence. The dangers of many paraben species were also discussed in the first part.

Phenonip was designed with cosmetics in mind and is especially effective in preventing bacteria, mold and fungal growth. It is especially effective in oil-based products, but also works well in aqueous solutions. Broad spectrum, liquid preservative ideal in variety of personal care applications, including oil-in-water, water-in-oil & all oil formulations such as lotions, creams, shampoos, conditioners, liquid soaps, scrubs and balms. It can be used in emulsions and anhydrous formulations. Effective in pH range of 3.0 - 8.0. Phenonip withstands high temperatures up to 176 F and is preferred over Germaben II for high temp applications.Phenonip can be added to the aqueous phase readily. It is 100% oil-soluble & .5% soluble in water. In emulsified systems, Phenonip is readily dissolved in the liquid phase prior to emulsification, although it is often good practice to divide the Phenonip content between the water & oil phases during their preparation (ie for lotion, add .5% to water phase & .5% to oil phase). If the water content of the formulation is low, it may not be convenient to add the preservative directly to water during manufacture. Heating the water to 140-176F prior to Phenonip addition will, in most instances, allow the appropriate quantity to be dissolved.For aqueous systems which cannot be heated, Phenonip can be incorporated by preparing a concentrate in a suitable solvent, e.g. propylene glycol or glycerin, and stirring this concentrate into the water. Emulsified systems, both o/w and w/o types, may be effectively preserved by the addition of Phenonip. Although Phenonip provides excellent antimicrobial preservation, individual testing should be done to assure preservative efficacy.

Phenonip and similar mixed preservatives have been successfully used to protect most types of personal care products from microbial contamination. This liquid preservative is used to inhibit microbial growth in your creams lotions and salt/sugar scrubs. As with other preservations the correct use concentration depends upon several factors including the chemical and physical nature of the product its ability to support microbial growth and the likelihood of recontamination during use.Experience has shown that Phenonip will preserve many cosmetics and toiletries when incorporated at concentrations from 0.25% to 1.0%. This blend of preservatives is highly effective against gram positive and gram negative bacteria yeasts and moulds and is suitable for Moisturisers Lotions and Creams Sugar Scrubs Conditioners to name but a few. The higher concentrations are typically only required for formulations which by their nature are particularly difficult to preserve. >Emulsified systems both o/w and w/o types may be effectively preserved by the addition of this preservative at 0.4 - 0.7%. Whilst emulsions based on non-ionic surfactants may require slightly increased concentrations eg. 0.5 - 1.0%. Shampoos and foam baths may be preserved with concentrations typically between 0.25 - 0.65%. Products with a high protein content may require levels from 0.5% - 1.0%. Other surfactant-based products for example liquid dishwashing detergents are generally preserved levels over the range 0.2% - 0.6%.Broad spectrum, liquid preservative system ideal for use in a wide variety of personal care applications. Effective against Gram-positive and Gram-negative bacteria, yeasts and molds and retains activity in the presence of most cosmetic ingredients. Phenonip is oil soluble. It can be used in emulsions and anhydrous formulations.Phenonip - A liquid preservative to inhibit a full range of microbial growth in your cremes, lotions, salt scrubs, dusting powders and liquid soap bases. This preservative is more suitable than Germaben II for products that are manufactured at higher temperature ranges. Temperature should be below 200F degrees when added to recipe. Phenonip is not a formaldehyde donor. Use at a rate of .5 -1.0% of the total weight of your product.While volume vs. weight measurements vary, these measurements may help you if you don't have a scale handy.Cosmetics and toiletries are a popular protective blend in the industry. It is the product of a comprehensive investigation of the combination of Nipa esters, optimized by Nipa in a convenient liquid form. It is an optimal blend of paraben esters in phenoxyethanol. In addition to the most effective ratio of the esters, an antimicrobial solvent option raises the activity spectrum, reducing the use concentration to a minimum.

Benefits:

- Broad spectrum activity; gram positive, gram negative bacteria, efficacy against yeast and seeds.
- Easily incorporated into formulations.
- pH: Does not lose its activity in the range of 3-8.
- Compatible with a wide range of cosmetic raw materials.
- It is not volatile, it does not lose any protection even in long-term storage.
- Old-fashioned stable; aqueous solutions can withstand autoclave sterilization without loss of activity.
- Has an excellent toxicological profile and is not irritating to the skin, eyes, and mucous membranes.
- Their composition is biodegradable.
- Phenonip has not been tested on animals that are longer than 10 years.
- Phenonip's components spontaneously sprout in a variety of plants and animals.

Applications: Many types of personal care products are successfully used to protect microbial contamination. Similar to other preservatives, the correct use concentration depends on the ability to support microbial growth, including the chemical and physical properties of the product, and the likelihood of recoiling during use. Experiments have shown that cosmetics and toiletries are retained when added at concentrations ranging from 0.25 to 1.0%. Higher concentrations are generally necessary for natural formulations that are difficult to maintain. Shampoos and bath foams can typically be stored at concentrations of 0.25-0.65% with Phenonip. High protein content may require 0.5-1.0%. Other surfactant-based products (eg liquid dishwashing detergents) are usually preserved at concentrations of 0.2-0.6% of phenonip.Emulsified systems can be effectively protected by adding both o / w and w / o types of Phenonip between 0.4-0.7%. Phenonip may be used to protect non-ionic surfactant-based emulsions, but slightly increasing concentrations may be required (eg, 0.5-1%).

Note: The effectiveness of Phenonip in the control of gram negative bacteria guided the use of Phenonip in some skin antiseptic products where traditional antiseptic agents have a weakness in their activity spectrum against these organisms.

Usage: Phenonip can easily be added to the limit of the solubility limit. The relatively low aqueous solubility of the phenonip means that if the water content of the formulation is low, it is not feasible to add the preservative directly to the water during production. Heating the water to about 60-70 ° C before the phenonip is added allows the appropriate amount to be dissolved many times.

For non-heatable aqueous systems, a concentrate of Phenonip in a suitable solvent (e.g., in propylene glycol) can be added by mixing it into the water to provide a final concentration below the maximum water solubility of the phenonip in water.

Emulsification systems; Phenonip is readily dissolved in the liquid phase prior to emulsification, although separation of the Phenonip content between the aqueous and lipid phases during the preparation is good practice.In surfactant and detergent-based products, phenonip may be dissolved in the surfactant prior to addition of water and other components.

About the product

All Natural Presevative - Broadspectrum preservative for Shampoo, lotion, cream etc.
Preservative was designed with cosmetics in mind
Can be used as a replacement for Optiphen
Clear solution - mixes well in lotion making. - Great for waterbased sollutions.

Nanosuspensions as aqueous formulations need to be preserved. However, preservatives could vitiate the physical stability of suspensions and to a greater extent nanosuspensions. The impact of six varied preservatives on the physical stability of previously prepared nanosuspensions was studied. The hesperetin nanosuspensions were stabilized using plantacare 2000.30 cycles of high pressure homogenization (HPH) led to a mean photon correlation spectroscopy (PCS) diameter of 335 nm. The preservatives were, caprylyl glycol, Euxyl PE9010, Hydrolite-5, MultiEx naturotics, Phenonip and Rokonsal PB5. On one hand, aggregations were noticed after adding caprylyl glycol, MultiEx naturotics and Phenonip reaching PCS mean diameters of about 500, 1070, 800 nm, respectively. While on the other hand Euxyl PE9010, Hydrolite-5 and Rokonsal PB5 have not significantly affected the physical stability of the nanosuspensions with mean PCS diameters of about 365, 332, 350 nm, respectively. The obtained nanosuspensions were further characterized by measuring zeta potential. From the obtained data it was found that the lipophilicity of the used preservatives demonstrates major influence on the stability of the nanosuspensions, i.e. the higher lipophilicity of the preservative, the stronger the destabilizing effect. Briefly, highly hydrophilic preservatives are recommended to preserve hesperetin nanosuspensions in order to maintain their physical stability during storage.

Phenonip, is an effective broad spectrum preservative that provides activity against gram positive and gram negative bacteria, yeasts and molds, and retains activity in the presence of most cosmetic ingredients. It is an excellent choice for many cosmetic and personal care applications, especially oil-based products. It works across a broad range of formulating spectrums, and is also effective in aqueous solutions, Oil-in-water, water-in-oil & all oil formulations. So whether you are formulating lotions, creams, balms, scrubs, or even shampoos, and body washes Phrnonip may be an excellent choice as a preservative.Phenonip is a synergistic blend of esters of para-hydroxybenzoic acid (parabens) in phenoxyethanol designed for preservation of a wide range of cosmetics and toiletries.
INCI: Phenoxyethanol, Methylparaben, Ethylparaben, Butylparaben, Propylparaben, Isobutylparaben Usage levels may vary depending on your exact formula. Phenonip will preserve cosmetics and toiletries when incorporated at concentrations from 0.25 % to 1 %. The higher concentrations are generally required only for formulations which are particularly difficult to preserve.Phenoip is 100% oil-soluble and is not very water Soluble (see info below ) in water, but works well in emulsified systems. Phenonip can be readily dissolved in a liquid phase prior to emulsification. Depending on your formulation, it may be effective to split the amount you will use in to two phases between the water & oil phases during their preparation (ie when making a cream or butter product, add .5% to water phase & .5% to oil phase).For aqueous formulations, like shampoos that are cold blended you can add Phenonip by adding it to a suitable solvent like propylene glycol or glycerin, and stirring this concentrate into the water.Usage Levels In Aqueous systems / formulations like shampoos and foam baths may be preserved with Phenonip at concentrations between 0.25 % to 0.65 %. However, products with high protein content may require levels from 0.5 % - 1 %. Other surfactant- based formulations, for example liquid dishwashing detergents, are generally preserved with Phenonip over the range 0.2 %- 0.6 %. Emulsified systems, both O/W and W/O types, may be effectively preserved by Phenonip at 0.4 %- 0.7 %. Phenonip can also be used to preserve emulsions based on nonionic surfactants, but slightly increased concentrations may be required, e.g. increase usage to 0.5 -1 %.