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PHENONIP
Phenonip acts as a preservative blend. It is effective against Gram-negative and Gram-positive bacteria, yeasts and moulds. It has an excellent toxicological profile and is non-irritant to skin, eye and mucous membranes at normal use concentrations. Phenonip is used in all kinds of personal care products specially in wet wipes.
Popular Products That Use This Ingredient: Shampoos, Washes, Foaming Bath Products, Lotions, Washes, Lotion Bars. Oil Based Scrubs. Approved for Lips.
Formula pH: 3.0-8.0
Effective Against: Bacteria, Mold, Yeast
Very Mild. Biodegradable.
Physical Form: Clear Liquid
Solubility: Insoluble in Water
CAS No.: 8066-38-4
EC No.: 617-140-9
SYNONYMS:
Phenoxyethanol (and) Methylparaben (and) Ethylparaben (and) Propylparaben (and) Butylparaben (and) Isobutylparaben; fenonip; phenonipe; Phenoxyethanol; metil paraben; etil paraben; butil paraben; propil paraben; phenonip; METHYLPARABEN; Methyl paraben; Methyl p-hydroxybenzoate; Nipagin; Methyl parahydroxybenzoate; Maseptol; p-Hydroxybenzoic acid methyl ester; p-Methoxycarbonylphenol; 4-Hydroxybenzoic acid methyl ester; Benzoic acid, 4-hydroxy-, methyl ester; p-Carbomethoxyphenol; Tegosept M; Methaben; Metoxyde; Preserval; wet wipes; Metaben; Moldex; Paridol; Septos; Solbrol; Methyl parasept; Methyl butex; Methyl chemosept; Nipagin M; Aseptoform; Methylben; Abiol; Methyl-p-hydroxybenzoate; Preserval M; Solbrol M; 4-(Methoxycarbonyl)phenol; Methyl p-oxybenzoate; 4-Hydroxybenzoic acid, methyl ester; Methyl ester of p-hydroxybenzoic acid; p-Oxybenzoesauremethylester; FEMA No. 2710; Caswell No. 573PP; Benzoic acid, p-hydroxy-, methyl ester; preservative; FEMA Number 2710; UNII-A2I8C7HI9T; NSC 3827; p-Hydroxybenzoic acid, methyl ester; p-Hydroxybenzoic methyl ester; p-Oxybenzoesauremethylester [German]; phenonips; phenonip; phenonp; penonip; fenonip; fenonıp; fenonips; phenonips; fhenonips; EINECS 202-785-7; Methylester kyseliny p-hydroxybenzoove; PHENONIP; Methylparaben [USAN]; methyl 4- hydroxybenzoate; Methylparaben [USAN:NF]; Metagin; METHYL4-HYDROXYBENZOATE; Lexgard M; Paraben M; Methylparaben, NF; Methylparaben, FCC; 4-carbomethoxyphenol; Methylparaben (NF); Methylparaben (TN); INS number 218; Solparol (Salt/Mix); 4-hydroxymethylbenzoate; methyl 4-hydoxybenzoate; ACMC-20aiv0; methyl 4 hydroxybenzoate; methyl 4-hydroxylbenzoate; methyl 4-hydroxy-benzoate; methyl-4-hydroxy-benzoate; Methylis parahydroxybenzoas; wet wipes; preservative; prezervatif; Preserval MS (Salt/Mix); bmse010009; Methylparaben 99-76-3; PHENONIP; 4-hydroxybenzoate methyl ester; Methyl 4-Hydroxybenzoate,(S); Ethylene glycol monophenyl ether; Ethanol, 2-phenoxy-; Phenyl cellosolve; Phenoxytol; Phenoxethol; Phenoxetol; Ethylene glycol phenyl ether; Phenoxyethyl alcohol; 1-Hydroxy-2-phenoxyethane; Rose ether; Phenylmonoglycol ether; 2-Phenoxyethan-1-Ol; Arosol; Dowanol EP; 2-Phenoxyethyl alcohol; Glycol monophenyl ether; 2-Hydroxyethyl phenyl ether; Phenylglycol; Fenyl-cellosolve; 2-Fenoxyethanol; Dowanol EPH; 2-Phenoxy-ethanol; Emery 6705; Emeressence 1160
INCI Names:
Phenoxyethanol, Methylparaben ,Ethylparaben, Propylparaben, Butylparaben, Isobutylparaben
PHENONIP:
Phenonip is a preservative that is intended to prevent bacteria, mold and fungal growth in your handmade products. Insoluble in water and most commonly used in salt and sugar scrubs as well as lotion bars. Phenonip is a broad spectrum, liquid preservative system ideal for use in a wide variety of personal care applications.
Phenonip is an optimised blend of paraben esters in phenoxyethanol. Phenoxyethanol helps to further boost the performance and solubilizes Parabens, easier handling and dosing antiperspirant & deodorant decorative cosmetic. Phenonip and similar mixed preservatives have been successfully used to protect most types of personal care products from microbial contamination. This liquid preservative is used to inhibit microbial growth in your creams lotions and salt/sugar scrubs. As with other preservations the correct use concentration depends upon several factors including the chemical and physical nature of the product its ability to support microbial growth and the likelihood of recontamination during use.
Experience has shown that Phenonip will preserve many cosmetics and toiletries when incorporated at concentrations from 0.25% to 1.0%. This blend of preservatives is highly effective against gram positive and gram negative bacteria yeasts and moulds and is suitable for Moisturisers Lotions and Creams Sugar Scrubs Conditioners to name but a few.
The higher concentrations are typically only required for formulations which by their nature are particularly difficult to preserve.
Emulsified systems both o/w and w/o types may be effectively preserved by the addition of this preservative at 0.4 - 0.7%. Whilst emulsions based on non-ionic surfactants may require slightly increased concentrations eg. 0.5 - 1.0%.
Shampoos and foam baths may be preserved with concentrations typically between 0.25 - 0.65%. Products with a high protein content may require levels from 0.5% - 1.0%.
Other surfactant-based products for example liquid dishwashing detergents are generally preserved levels over the range 0.2% - 0.6%.
This preservative is more suitable than Germaben II for products that are manufactured at higher temperature ranges. The product should only be added below 100 °C degrees when adding to the recipe. Phenonip is not a formaldehyde donor.
Phenonip is used as preservative for lotion, cream, lip balm or body butter etc.
Appearance: colourless liquid (colorless to yellow), viscous liquid
Odour: slight
Specific gravity - 1.124
Solubility in water: approximately 0.5%
Solubility in organic solvents:
• Ethanol - miscible
• ethanol/water (50/50) - >95.0%
• isopropanol - miscible
• acetone - miscible
• propylene glycol - miscible
• isopropyl myristate - miscible
• peanut oil - 25.0%
• liquid paraffin - <0.1%
• glycerol - 10.0%
• triethanolamine - miscible
• polysorbate 80 - miscible
• triethanolamine lauryl sulphate (40%) - 35.0%
Description:
• Phenonip preservative is especially effective when used with oil based products..
• Great preservative for making natural soap, lotion, cream, shampoo, etc..
• Recommended usage 0.3% to 1%. This 8 oz bottle should provide enough preservative for about 48 lbs of solution..
• Phenonip tolerates higher temperature then other common preservatives..
• Best if used within one year from opening.
• Imported from USA.
Phenonip Phenonip is a preservative that works in a multitude of applications. It is a clear liquid and the application rates vary from 0.3% to 1% by weight depending on the circumstances. Most applications are in the .3% to .5% range. To preserve 200g of salt scrub at .5% application rate would mean using approximately 1g of Phenonip. This preservative was designed with cosmetics in mind and is especially effective when used in conjunction with oil based products but also works extremely well in aqueous solutions up to a .5% application rate. Phenonip can also tolerate higher temperatures than many other preservatives and still maintain its effectiveness.
Applications & Uses:
Markets: Home & Personal Care
Applications: Home & Personal Care — Beauty & Care, AP/Deo, Bath & Shower, Color Cosmetics, Hair Care, Other Beauty & Care, Skin Care, Sun Care, Home & Personal Care — Personal Hygiene, Wipes, Tissue & Towel
Application Format: Bar, Creams, Gel, Lotions, Powder, Rinse Off, Roll On, Serum, Spray, Stick, Wipes
AP/Deo Applications: Antiperspirants & Deodorants, Fragrance (Men)
Bath & Shower Applications: Bar Soaps, Body Creams & Lotions, Body Wash & Cleanser, Bubble Bath, Hand Soap
Color Cosmetic Applications: Eye Liner, Foundation, Mascara
Fragrances & Perfume Applications: Fragrances & Perfumes
Hair Care Applications: Hair Conditioner, Hair Styling Products, Shampoos & Rinses, Other Beauty & Care Applications, Liquid Hand Soap, Skin Care Applications, Body Creams & Lotions, Face Creams & Lotions, Hand Cream
Phenonip is a broad spectrum antimicrobial agent comprisinga synergistic blend of esters of para-hydroxybenzoic acid (parabens) in phenoxyethanol designed for preservation of a wide range of cosmetics and toiletries.
Phenonip provides activity against gram positive and gram negative bacteria, yeasts and molds.
It retains activity in the presence of most cosmetic ingredients.
Phenonip has been successfully used to protect most types of personal care products from microbial contamination. As withother preservatives,the correct use concentration depends upon several factors, including the chemical and physical nature of the product, its ability to support microbial growth and the likelihood of recontamination during use.
Experience has shown that Phenonip will preserve cosmetics and toiletries when incorporated at concentrations from0.25 % to 1 %. The higher concentrations are generally required only for formulations which,by nature, are particularly difficult to preserve.
Shampoos and foam baths may be preserved with Phenonip® at concentrations between 0.25 % to 0.65 %. Products with high proteincontent may require levels from 0.5 % - 1 %. Other surfactant- based products, for example liquid dishwashing detergents, are generally preserved with Phenonip over the range 0.2 %- 0.6 %. Emulsified systems, both O/W and W/O types, may be effectively preserved by the addition of Phenonip at 0.4 %- 0.7 %. Phenonip can also be used topreserve emulsions based on nonionic surfactants, but slightly increased concentrations may be required, e.g. 0.5 -1 %.
About Phenonip:
• A broad spectrum preservative for making shampoo, lotion, cream, bath balm, body scrub etc.
• Preservative was designed with cosmetics in mind
• Can be used as a replacement for Optiphen
• Clear solution - mixes well in lotion making. - Great for waterbased sollutions. - Best if used within one year from opening
Phenonip is oil soluble. It can be used in emulsions and anhydrous formulations.
• Retains activity over the range pH 3.0 - 8.0.
• Non-volatile - there is no loss of preservative due to volatility even on prolonged storage.
• Highly stable - aqueous solutions of Phenonip can withstand autoclave sterilisation with no loss of activity.
• Phenonip has an excellent toxicological profile and is non-irritant to skin, eye and mucous membranes at normal use concentrations.
• The components of Phenonip are biodegradable at the low concentrations found in effluent.
Phenonip was designed with cosmetics in mind and is especially effective in preventing bacteria, mold and fungal growth. It is especially effective in oil-based products, but also works well in aqueous solutions. Broad spectrum, liquid preservative ideal in variety of personal care applications, including oil-in-water, water-in-oil & all oil formulations such as lotions, creams, shampoos, conditioners, liquid soaps, scrubs and balms. It can be used in emulsions and anhydrous formulations. Effective in pH range of 3.0 - 8.0.
Benefits:
- Broad spectrum activity; gram positive, gram negative bacteria, efficacy against yeast and seeds.
- Easily incorporated into formulations.
- pH: Does not lose its activity in the range of 3-8.
- Compatible with a wide range of cosmetic raw materials.
- It is not volatile, it does not lose any protection even in long-term storage.
- Old-fashioned stable; aqueous solutions can withstand autoclave sterilization without loss of activity.
- Has an excellent toxicological profile and is not irritating to the skin, eyes, and mucous membranes.
- Their composition is biodegradable.
- Phenonip has not been tested on animals that are longer than 10 years.
- Phenonip's components spontaneously sprout in a variety of plants and animals.
Applications: Many types of personal care products are successfully used to protect microbial contamination. Similar to other preservatives, the correct use concentration depends on the ability to support microbial growth, including the chemical and physical properties of the product, and the likelihood of recoiling during use. Experiments have shown that cosmetics and toiletries are retained when added at concentrations ranging from 0.25 to 1.0%. Higher concentrations are generally necessary for natural formulations that are difficult to maintain. Shampoos and bath foams can typically be stored at concentrations of 0.25-0.65% with Phenonip. High protein content may require 0.5-1.0%. Other surfactant-based products (eg liquid dishwashing detergents) are usually preserved at concentrations of 0.2-0.6% of phenonip.Emulsified systems can be effectively protected by adding both o / w and w / o types of Phenonip between 0.4-0.7%. Phenonip may be used to protect non-ionic surfactant-based emulsions, but slightly increasing concentrations may be required (eg, 0.5-1%).
Note: The effectiveness of Phenonip in the control of gram negative bacteria guided the use of Phenonip in some skin antiseptic products where traditional antiseptic agents have a weakness in their activity spectrum against these organisms.
Usage: Phenonip can easily be added to the limit of the solubility limit. The relatively low aqueous solubility of the phenonip means that if the water content of the formulation is low, it is not feasible to add the preservative directly to the water during production. Heating the water to about 60-70 ° C before the phenonip is added allows the appropriate amount to be dissolved many times.
For non-heatable aqueous systems, a concentrate of Phenonip in a suitable solvent (e.g., in propylene glycol) can be added by mixing it into the water to provide a final concentration below the maximum water solubility of the phenonip in water.
Emulsification systems; Phenonip is readily dissolved in the liquid phase prior to emulsification, although separation of the Phenonip content between the aqueous and lipid phases during the preparation is good practice.In surfactant and detergent-based products, phenonip may be dissolved in the surfactant prior to addition of water and other components.
About the product
• All Natural Presevative - Broadspectrum preservative for Shampoo, lotion, cream etc.
• Preservative was designed with cosmetics in mind
• Can be used as a replacement for Optiphen
• Clear solution - mixes well in lotion making. - Great for waterbased sollutions.
Nanosuspensions as aqueous formulations need to be preserved. However, preservatives could vitiate the physical stability of suspensions and to a greater extent nanosuspensions. The impact of six varied preservatives on the physical stability of previously prepared nanosuspensions was studied. The hesperetin nanosuspensions were stabilized using plantacare 2000.30 cycles of high pressure homogenization (HPH) led to a mean photon correlation spectroscopy (PCS) diameter of 335 nm. The preservatives were, caprylyl glycol, Euxyl PE9010, Hydrolite-5, MultiEx naturotics, Phenonip and Rokonsal PB5. On one hand, aggregations were noticed after adding caprylyl glycol, MultiEx naturotics and Phenonip reaching PCS mean diameters of about 500, 1070, 800 nm, respectively. While on the other hand Euxyl PE9010, Hydrolite-5 and Rokonsal PB5 have not significantly affected the physical stability of the nanosuspensions with mean PCS diameters of about 365, 332, 350 nm, respectively. The obtained nanosuspensions were further characterized by measuring zeta potential. From the obtained data it was found that the lipophilicity of the used preservatives demonstrates major influence on the stability of the nanosuspensions, i.e. the higher lipophilicity of the preservative, the stronger the destabilizing effect. Briefly, highly hydrophilic preservatives are recommended to preserve hesperetin nanosuspensions in order to maintain their physical stability during storage.
Phenonip withstands high temperatures up to 176 F and is preferred over Germaben II for high temp applications.
Phenonip can be added to the aqueous phase readily. It is 100% oil-soluble & .5% soluble in water. In emulsified systems, Phenonip is readily dissolved in the liquid phase prior to emulsification, although it is often good practice to divide the Phenonip content between the water & oil phases during their preparation (ie for lotion, add .5% to water phase & .5% to oil phase).
If the water content of the formulation is low, it may not be convenient to add the preservative directly to water during manufacture. Heating the water to 140-176F prior to Phenonip addition will, in most instances, allow the appropriate quantity to be dissolved.
For aqueous systems which cannot be heated, Phenonip can be incorporated by preparing a concentrate in a suitable solvent, e.g. propylene glycol or glycerin, and stirring this concentrate into the water.
Emulsified systems, both o/w and w/o types, may be effectively preserved by the addition of Phenonip.
Although Phenonip provides excellent antimicrobial preservation, individual testing should be done to assure preservative efficacy.
Formulation Guidelines:
Phenonip can be added to the aqueous phase readily up to its limit of solubility.The relatively low aqueous solubility of Phenonip means that if the water content of the formulation is low, it may not be convenient to add the preservative directly to water during manufacture.Heating the water to 60 –70 °C prior to Phenonip addition will, in most instances, allow the appropriatequantity to be dissolved. For aqueous systems whichcannot be heated,Phenonip can be incorporated by preparing a concentrate in a suitable solvent,e.g. Propylene Glycol, and stirring this concentrate into the water to give a final Phenonip concentration below its maximum water solubility.
In emulsified systems, Phenonip is readily dissolved in the lipid phase prior to emulsification although it is often good practice to divide the Phenonip content between the aqueous and the lipid phases during their preparation. To add Phenonip into the final emulsion during the cooling stage isalso possible for a lot of emulsions.In surfactant and detergent based products Phenonip can be dissolved in the surfactant prior to the addition of water and otheringredients.
Directions:
The correct use concentration depends upon several factors including the chemical and physical nature of the product, its ability to support microbial growth and the likelihood of recontamination during use. Experience has shown that Phenonip will preserve cosmetics and toiletries when incorporated at concentrations from 0.25% to 1.0%.
The higher concentrations are generally required only for formulations which, by their nature, are particularly difficult to preserve.
Shampoos and foam baths may be preserved with Phenonip at concentrations typically between 0.25 - 0.65%.
Products with a high protein content may require levels from 0.5% - 1.0%.
Other surfactant-based products, for example liquid dishwashing detergents, are generally preserved with Phenonip over the range 0.2% - 0.6%.
Emulsified systems, both o/w and w/o types, may be effectively preserved by the addition of Phenonip at 0.4 - 0.7%.
Phenonip can also be used to preserve emulsions based on nonionic surfactants, but slightly increased concentrations may be required, eg. 0.5 - 1.0%.
Use Phenonip at 1% in the presence of 5% polysorbate 80.
TIPS: Performs best when formulation pH is 3.0-8.0. Inactivated by Polysorbate 20, Polysorbate 80, and ceteareth-20. The recommended usage rates are provided only as a guideline to provide proper preservation. All new formulations should be tested to ensure preservative efficacy. Protect clothing and work area when mixing.
STORAGE: Store in an airtight, cool, dark location. When stored properly, best used within 1 year from date of purchase.
The first widespread use of Phenoxyethanol(PE) was in a preservative blend called Phenonip (EU) (Nipa Labs, now Clariant (EU)) which was formulated in combination with parabens (EU). PE became extremely popular after Denmark banned parabens in cosmetic products for children under 3 on December 10, 2010. On May 3, 2011 the French National Assembly voted to pass a bill of law that would immediately ban the use of phthalates (EU), alkylphenols (EU) and parabens in consumer and professional products. The trend towards formulating with globally-approved, non-formaldehyde-releasing preservatives also accelerated its use.
The general media and the internet has been extensively used to self promote many products and we are sure you may be aware of the so called ""negatives"" of parabens. We amongst a number of other technically minded formulators think it's important that you have some more of the facts before deciding whether parabens are ""good"" or ""bad"" for your products.
Why are preservatives used?
Preservatives are used in home care and cosmetics to protect them against microbial growth (from gram positive and gram negative bacteria yeasts and moulds) both to protect the users and to maintain product integrity.
Interesting medical articles: overview of parabens and contact dermatitis as well as The Health Controversies of Parabens
Are there health risks associated with the use of parabens in cosmetics?
The Cosmetic Ingredient Review (CIR) reviewed the safety of methylparaben propylparaben and butylparaben in 1984 and concluded they were safe for use in cosmetic products at levels up to 25%. Note that typically parabens are used at levels ranging from 0.01 to 0.3%.
On November 14 2003 the CIR began the process to reopen the safety assessments of methylparaben ethylparaben propylparaben and butylparaben in order to offer interested parties an opportunity to submit new data for consideration. In September 2005 the CIR decided to re-open the safety assessment for parabens to request exposure estimates and a risk assessment for cosmetic uses. In December 2005 after considering the margins of safety for exposure to women and infants the Panel determined that there was no need to change its original conclusion that parabens are safe as used in cosmetics. Parabens are an effective antimicrobial against yeast and mould & the FDA has stated that at the present time there is no reason for consumers to be concerned about the use of parabens in products. Parabens have been safely used in cosmetics since the 1920's & historical data indicates that parabens are safe.
WASHINGTON March 7 2012 /PRNewswire/ -- The Cosmetic Ingredient Review (CIR) an independent panel of scientific and medical experts reaffirmed this week at their public meeting that parabens a family of preservatives used in cosmetics and personal care products are safe.
""The cosmetic industry formally requested that CIR re-examine the safety of parabens as they are used in cosmetics and we are gratified that the panel has done so and confirmed the safety of these ingredients said Halyna Breslawec chief scientist for the Personal Care Products Council (the Council). ""The Council also appreciates that the Consumer Federation of America (CFA) and the U.S. Food and Drug Administration (FDA) supported the CIR decision she said.
In December 2011 the Council requested that CIR reexamine its review of parabens in light of two recent opinions by the European Commission's Scientific Committee on Consumer Safety (SCCS). SCCS concluded among other things that some parabens are safe at current use levels but recommended that levels of others used be reduced.
At its March 5-6 2012 meeting CIR carefully reviewed the SCCS opinions and concluded that there were little additional new data concerning parabens. The panel voted to reaffirm its earlier conclusions that parabens are safe for use as cosmetic ingredients. CIR initially reviewed the safety of parabens in 1984 and since then has continually examined newly available data related to the safety of these ingredients. Its last comprehensive report was published in 2008.
Phenonip P4 is a preservative blend for personal care products. It is a non isobutylparaben version of Phenonip.
Benefits:
• Water soluble
• Headspace preservation
• Heat stable
• Easy to handle and to dose
