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Phenoxy Ethanol is produced in the industry by the hydroxyethylation of phenol (Williamson synthesis), for example, in the presence of alkali-metal hydroxides or alkali-metal borohydrides.
Phenoxy Ethanol is effective against gram-negative and gram-positive bacteria, and the yeast Candida albicans.
Phenoxy Ethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen.
CAS Number: 122-99-6
Molecular Formula: C8H10O2
Molecular Weight: 138.16
EINECS Number: 204-589-7
Synonyms: 2-PHENOXYETHANOL, Phenoxyethanol, 122-99-6, Phenoxy Ethanol, Phenyl cellosolve, Phenoxethol, Ethanol, 2-phenoxy-, Phenoxytol, 2-Phenoxyethan-1-Ol, Ethylene glycol phenyl ether, 1-Hydroxy-2-phenoxyethane, Phenoxetol, Phenoxyethyl alcohol, Rose ether, Phenylmonoglycol ether, Arosol, Fenyl-cellosolve, 2-Fenoxyethanol, Dowanol EP, 2-Phenoxyethyl alcohol, Glycol monophenyl ether, 2-Hydroxyethyl phenyl ether, Fenylcelosolv, Phenylglycol, Dowanol EPH, 2-Phenoxy-ethanol, Emery 6705, Emeressence 1160, EGMPE, beta-Hydroxyethyl phenyl ether, MFCD00002857, Plastiazan-41, NSC 1864, PHE-G, .beta.-Hydroxyethyl phenyl ether, HSDB 5595, UNII-HIE492ZZ3T, NSC-1864, 9004-78-8, EINECS 204-589-7, HIE492ZZ3T, BRN 1364011, CCRIS 9481, Phenoxyethanol [NF], Ethylene glycol-monophenyl ether, AI3-00752()C, DTXSID9021976, CHEBI:64275, PHE-S, .beta.-Phenoxyethyl alcohol, DTXCID401976, 2-Phenoxyethyl--d4 Alcohol, FEMA NO. 4620, EC 204-589-7, 4-06-00-00571 (Beilstein Handbook Reference), Phenoxyethanol (NF), NCGC00090731-01, NCGC00090731-05, PHENOXYETHANOL (II), PHENOXYETHANOL [II], PHG, PHENOXYETHANOL (MART.), PHENOXYETHANOL [MART.], PHENOXYETHANOL (USP-RS), PHENOXYETHANOL [USP-RS], Fenylcelosolv [Czech], 2-Fenoxyethanol [Czech], Fenyl-cellosolve [Czech], PHENOXYETHANOL (EP MONOGRAPH), PHENOXYETHANOL [EP MONOGRAPH], Plastiazan-41 [Russian], beta-Phenoxyethanol, CAS-122-99-6, .beta.-Phenoxyethanol, phenylcellosolve, Phenoxyethanolum, Dalpad A, 2-phenyloxyethanol, Newpol EFP, 2-phenoxy ethanol, 2-(phenoxy)ethanol, 2-phenoxy-1-ethanol, CPAP WIPES, VAXOL PURI, beta-phenoxyethylalcohol, starbld0047047, 2-Phenoxyethanol, 9CI, 2-Phenoxyethanol, 99%, Phenoxyethanol (Standard), WLN: Q2OR, 2-Phenoxyethanol-1,1-d2, SCHEMBL15708, 2-Phenoxyethanol, >=99%, PHENOXYETHANOL [HSDB], MLS002174254, ethyleneglycol monophenyl ether, Euxyl K 400 (Salt/Mix), ProClin? 8020 preservatives, 2-PHENOXYETHANOL [MI], Fungal Terminator (veterinary), PHENOXYETHANOL [WHO-DD], CHEMBL1229846, HY-B1729R, MSK2538, NSC1864, HMS2268A20, HY-B1729, STR04582, WAA27338, Tox21_111002, Tox21_113532, Tox21_202111, Tox21_300842, BBL027410, STK802556, 2-Phenoxyethanol, analytical standard, Fungal Terminator [veterinary] (TN), AKOS000118741, Tox21_111002_1, DB11304, FP31791, NCGC00090731-02, NCGC00090731-03, NCGC00090731-04, NCGC00090731-06, NCGC00090731-07, NCGC00090731-08, NCGC00254745-01, NCGC00259660-01, 56257-90-0, DA-76810, Phenoxy Ethanol, >=90%, SMR000112131, ETHANOL,2-PHENOXY MFC8 H10 O2, CS-0013737, NS00002984, P0115, P1953, EN300-19339, 2-Phenoxyethanol, tested according to Ph.Eur., D08359, G74506, SBI-0653920.0001, Q418038, SR-01000838345, SR-01000838345-2, F1905-6997, Z104473570, Phenoxy Ethanol, SAJ first grade, >=95.0%, Phenoxyethanol, European Pharmacopoeia (EP) Reference Standard, Phenoxyethanol, United States Pharmacopeia (USP) Reference Standard, InChI=1/C8H10O2/c9-6-7-10-8-4-2-1-3-5-8/h1-5,9H,6-7H, 2-Phenoxyethanol, Pharmaceutical Secondary Standard, Certified Reference Material, Phenoxy Ethanol Phenyl Cellosolve Phenyl Glycol, Phenoxy Ethanol FOR SYN, (2-Hydroxyethoxy)benzene, PhG, Protectol PE, ACETONITRILE ACS GRADE, beta-Phenoxyethanol, beta-phenoxyethanol[qr]
Phenoxy Ethanol is found in cosmetics, fragrances, moisturizers, sunscreens, cosmetics, hair conditioners and shampoos, nail polish, body wash, lotions and creams, haircare products, lip balm, baby lotions, soaps, shaving cream, deodorant, toothpaste, hand sanitizer, ultrasound gel, cleaning products, dish detergents, and laundry detergents.
Phenoxy Ethanol is a colorless liquid with a pleasant odor.
Phenoxy Ethanol is a glycol ether used as a perfume xative, insect repellent, antiseptic, solvent, preservative, and also as an anesthetic in sh aquaculture.
Phenoxy Ethanol is an ether alcohol with aromatic properties.
Phenoxy Ethanol is both naturally found and manufactured synthetically.
Demonstrating antimicrobial ability, phenoxyethanol acts as an eective preservative in pharmaceuticals, cosmetics and lubricants.
Phenoxy Ethanol, or PE, is the most commonly used globally-approved preservative in personal care formulations.
Phenoxy Ethanol may be used as a starting material to synthesize diorganodiselenides derivatives.
Phenoxy Ethanol can undergo aromatic alkylation with uoren-9-one to form 9,9-bis[4-(2- hydroxyethoxy)phenyl]uorene in the presence of Ti4+ cation-exchanged montmorillonite catalyst.
Preservation of cosmetics, toiletry and household products and their raw materials.
Phenoxy Ethanol is often used in combination with other active substances.
In some cases positive synergetic eects can be obtained.
Phenoxy Ethanol is a colorless oily liquid.
Phenoxy Ethanol is a bactericide (usually used in conjunction with quaternary ammonium compounds).
Phenoxy Ethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.
Phenoxy Ethanol is used in acne treatment.
Due to its low evaporation, Phenoxy Ethanol is used as a xative in perfumes and fragrance.
Phenoxy Ethanol is compatible with the vast majority of raw materials used in cosmetic and personal care products (highly ethoxylated compounds may reduce ecacy).
Phenoxy Ethanol is a clear, thin, colorless to light straw-colored solution of ve parabens in phenoxyethanol.
The Phenoxy Ethanol imparts a slight “rose essence” aroma to the product.
As a mobile liquid, Phenoxy Ethanol can be easily incorporated without high temperature processing.
Nonetheless, it is essentially nonvolatile and is not adversely aected by typical hot processing (up to 85°C) conditions.
Due to the limited water solubility of its ingredients, addition to the oil phase (or to a water phase after addition of surfactants) will promote solution.
Addition to the water phase optimizes initial antimicrobial activity, as parabens will tend to migrate into an oil phase with time.
Phenoxy Ethanol is optimally eective at acidic to neutral pH, and is recommended for use over the pH range of 3 to 8.
Phenoxy Ethanol, also known as phenoxyethanol, is an organic chemical compound that consists of an ethylene glycol (2-hydroxyethyl) group attached to a phenyl (benzene) ring via an ether bond.
Phenoxy Ethanol is a colorless, slightly viscous liquid with a faint pleasant odor and burning taste.
Phenoxy Ethanol is a bactericide (usually used in conjunction with quaternary ammonium compounds).
Phenoxy Ethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.
Phenoxy Ethanol can be used over a wide pH range.
This means that other preservatives can lose their effectiveness if the product is not within the right pH range.
It does not smell unpleasant or change the color of the product, which can be the case when using natural antimicrobial substances.
Phenoxy Ethanolis a tried-and-tested preservative, which is welltolerated by the skin and has a low allergy risk.
Phenoxy Ethanol is the organic compound with the formula C6H5OC2H4OH.
It is a colorless oily liquid.
It can be classified as a glycol ether and a phenol ether.
Phenoxy Ethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen.
Phenoxy Ethanol is a colorless oily liquid.
Phenoxy Ethanol is commonly found in skincare products, lotions, and makeup formulations to prevent bacterial contamination and extend shelf life.
Phenoxy Ethanol has a faint rose-like aroma.
Additionally, Phenoxy Ethanol is used as a solvent for dyes, inks, resins, and cellulose esters, making it valuable in paint, coating, and printing industries.
In medical and pharmaceutical applications, Phenoxy Ethanol is frequently incorporated into vaccines and topical antiseptics due to its ability to inhibit microbial growth.
Phenoxy Ethanol also functions as a stabilizer in perfume formulations, ensuring that fragrances retain their intended scent over time.
Despite its widespread use, Phenoxy Ethanol can pose certain health risks if misused or exposed to in excessive amounts.
Prolonged skin contact or inhalation may cause irritation, while ingestion in large quantities can lead to toxic effects, including central nervous system depression and organ damage.
As a result, regulatory bodies have established concentration limits for its use in consumer products to ensure safety.
Phenoxy Ethanol is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.
Phenoxy Ethanol was first prepared by W. H. Perkin Jr. and his graduate student Edward Haworth in 1896.
They reacted sodium, phenol and 2-chloroethanol in anhydrous ethanol.
Starting from the 1920s, it has been commercially available as a cellulose acetate solvent under the trademark of "Phenyl cellosolve".
Phenoxy Ethanol is a common preservative in vaccine formulations.
Phenoxy Ethanol appears as a colorless, oily liquid with a faint floral odor and is only slightly soluble in water while being highly soluble in alcohol and other organic solvents.
Phenoxy Ethanol is widely used in cosmetics, pharmaceuticals, and industrial applications due to its antimicrobial and preservative properties.
Melting point: 11-13 °C (lit.)
Boiling point: 247 °C (lit.)
Density: 1.102 g/mL at 25 °C (lit.)
Vapor density: 4.8 (vs air)
Vapor pressure: 0.01 mm Hg (20 °C)
Refractive index: n20/D 1.539
FEMA: 4620 | 2-PHENOXYETHANOL
Flash point: >230 °F
Storage temp.: Store below +30°C.
Solubility: Soluble, clear, colorless to very faintly yellow
pKa: 14.36±0.10 (Predicted)
Form: Liquid
Color: Clear colorless
Specific gravity: 1.109 (20/4℃)
Odor: Faint aromatic odor
pH range: 7 at 10 g/L at 23 °C
pH: 7 (10 g/L, H₂O, 23℃)
Explosive limit: 1.4-9.0% (V)
Odor type: Floral
Viscosity: 29 mm²/s (20°C)
Water solubility: 30 g/L (20 ºC)
Merck: 14,7257
BRN: 1364011
InChIKey: QCDWFXQBSFUVSP-UHFFFAOYSA-N
LogP: 1.2 at 23℃
Phenoxy Ethanol is a colorless, clear, oily liquid with a faint aromatic odor at room temperature and a low water solubility and evaporation rate.
Phenoxy Ethanol is produced by reacting phenol (EU) and ethylene oxide (EU) at a high temperature and pressure.
Phenoxy Ethanol occurs naturally in green tea (EU).
According to the European Union Cosmetics Regulation (EC) n.1223/2009, Phenoxy Ethanol is authorized as a preservative in cosmetic formulations at a maximum concentration of 1.0%.
Phenoxy Ethanol has been classied as an antimicrobial and preservative by Health Canada.
Phenoxy Ethanol has also been used in vaccines and shown to inactivate bacteria, and several types of yeast.
Phenoxy Ethanol is being reviewed for use as a biocide in the EEA and/or Switzerland, for: human hygiene, disinfection, food and animals feeds.
In view of phenoxyethanol's widespread use, its biodegradation has been examined.
One pathway entails initial conversion to phenol and acetaldehyde.
Aqueous phenoxyethanol solutions are stable and may be sterilized by autoclaving.
The bulk material is also stable and should be stored in a well-closed container in a cool, dry place.
The antimicrobial activity of phenoxyethanol may be reduced by interaction with nonionic surfactants and possibly by absorption by polyvinyl chloride.
The antimicrobial activity of phenoxyethanol against Pseudomonas aeruginosa may be reduced in the presence of cellulose derivatives (methylcellulose, sodium carboxymethylcellulose, and hypromellose (hydroxypropylmethylcellulose)).
In cases of ingestion or significant exposure, Phenoxy Ethanol can act as a central nervous system depressant, causing nausea, vomiting, confusion, and, in severe cases, organ toxicity.
Studies have shown that large doses can negatively affect the liver and kidneys, making it important to use the compound in controlled amounts.
Due to these potential hazards, various regulatory agencies, including the European Union (EU), the U.S. Food and Drug Administration (FDA), and the Cosmetic Ingredient Review (CIR) panel, have set maximum allowable concentrations for Phenoxy Ethanol in consumer products.
In the EU, for example, cosmetic formulations cannot contain more than 1% phenoxyethanol to minimize health risks while ensuring product effectiveness.
Phenoxy Ethanol, commonly referred to as phenoxyethanol, is a glycol ether that consists of an ethylene glycol molecule bound to a phenyl group through an oxygen (ether) linkage.
This structural arrangement gives the compound both hydrophilic (water-attracting) and lipophilic (fat-attracting) properties, making it a versatile solvent and emulsifier in various industries.
Phenoxy Ethanol appears as a colorless, slightly viscous liquid with a mild floral odor and has a moderate boiling point, allowing it to function effectively in different formulations.
Phenoxy Ethanol is prepared by treating phenol with ethylene oxide in an alkaline medium.
Phenoxy Ethanol is an aromatic ether that is phenol substituted on oxygen by a 2-hydroxyethyl group.
It has a role as an antiinfective agent and a central nervous system depressant.
Phenoxy Ethanol is a primary alcohol, a glycol ether and an aromatic ether.
It is functionally related to a phenol.
Phenoxy Ethanol is an antimicrobial preservative used in cosmetics and topical pharmaceutical formulations at a concentration of 0.5–1.0%, it may also be used as a preservative and antimicrobial agent for vaccines.
Therapeutically, a 2.2% solution or 2.0% cream has been used as a disinfectant for superficial wounds, burns, and minor infections of the skin and mucous membranes.
Phenoxy Ethanol has a narrow spectrum of activity and is thus frequently used in combination with other preservatives,
Phenoxy Ethanol is a colorless or straw-colored oily liquid with slight solubility in water but soluble in ethanol and is used as an immersion anesthetic.
This agent has bactericidal and fungicidal properties and has been used as a topical anesthetic.
This agent can provide deep stages of anesthesia and is relatively inexpensive.
Nevertheless, Phenoxy Ethanol has no other significant advantages over other drugs.
Using Phenoxy Ethanol can elicit several side effects, such as decreased respiratory and heart rate, reduced blood pressure and blood oxygenation, alterations of blood parameters, and elevated plasma levels of adrenaline, glucose, and cortisol, as shown in bighead carp.
In addition, sustained and prolonged exposure to Phenoxy Ethanol can cause neuropsychological syndrome in handlers.
Phenoxy Ethanol is an aromatic ether that is phenol substituted on oxygen by a 2-hydroxyethyl group.
Phenoxy Ethanol has a role as an antiinfective agent and a central nervous system depressant.
Phenoxy Ethanol is a hydroxyether, a primary alcohol and an aromatic ether.
Phenoxy Ethanol derives from a phenol.
Phenoxy Ethanol is a colorless liquid with a pleasant odor.
Phenoxy Ethanol is a glycol ether used as a perfume xative, insect repellent, antiseptic, solvent, preservative, and also as an anesthetic in sh aquaculture.
Phenoxy Ethanol is an ether alcohol with aromatic properties.
Phenoxy Ethanol is both naturally found and manufactured synthetically.
Demonstrating antimicrobial ability, Phenoxy Ethanol acts as an eective preservative in pharmaceuticals, cosmetics and lubricants.
Phenoxy Ethanol (EU), or PE, is the most commonly used globally-approved preservative in personal care formulations.
Phenoxy Ethanol is very easy to use in various types of formulations and is chemically stable.
Uses Of Phenoxy Ethanol:
Phenoxy Ethanol is used as a perfume fixative, an insect repellent, an antiseptic, a solvent for cellulose acetate, dyes, inks, and resins, a preservative for pharmaceuticals, cosmetics and lubricants, an anesthetic in fish aquaculture, and in organic synthesis.
One of the primary applications of Phenoxy Ethanol is as a preservative in cosmetics and personal care products.
Due to its antimicrobial properties, it helps prevent bacterial and fungal contamination in lotions, creams, shampoos, deodorants, and baby wipes.
Phenoxy Ethanol is often used as an alternative to parabens, which have raised concerns regarding their potential hormonal effects.
In many skincare formulations, Phenoxy Ethanol is combined with other preservatives, such as caprylyl glycol, to create broad-spectrum antimicrobial protection.
In the pharmaceutical and medical fields, Phenoxy Ethanol plays a crucial role as a preservative in vaccines and topical antiseptics.
Phenoxy Ethanol is also used as a solvent in intravenous medications and ophthalmic solutions, ensuring the stability and sterility of these formulations.
Additionally, it is included in antiseptic creams, wound care products, and disinfectant wipes due to its ability to inhibit the growth of harmful microorganisms.
Beyond healthcare and personal care, this compound is widely used in industrial applications, particularly in paints, inks, dyes, and coatings.
Phenoxy Ethanol acts as a solvent that helps dissolve resins and pigments, improving the flow and application properties of various formulations.
In printing and textile industries, Phenoxy Ethanol serves as a dispersing agent, ensuring that colors and dyes spread evenly on fabrics and paper.
Phenoxy Ethanol also finds use in cleaning products and household disinfectants, where it contributes to the effectiveness of formulations by enhancing the solubility of active ingredients.
Due to its mild fragrance and non-volatile nature, it is included in perfumes, air fresheners, and scented products, where it stabilizes fragrances and prevents premature evaporation.
Phenoxy Ethanol is an alternative to formaldehyde-releasing preservatives.
In Japan and the European Union, its concentration in cosmetics is restricted to 1%.
Phenoxy Ethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties.
Phenoxy Ethanol has a relatively low sensitizing factor in leave-on cosmetics.
Phenoxy Ethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens.
In addition, it is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types.
Phenoxy Ethanol can be obtained from phenol.
Ethylene glycol phenyl ether at a 1.0% level acts as a preservative in personal care products.
Phenoxy Ethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments.
The preservative Euxyl-K 400 also contains Phenoxy Ethanol, in combination with methyldibromoglutaronitrile.
Phenoxy Ethanol is commonly used in cosmetics for its antibacterial and antifungal properties.
Phenoxy Ethanol is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to Phenoxy Ethanol have rarely been reported.
Three cases of CoU induced by Phenoxy Ethanol in cosmetics have been reported.
Phenoxy Ethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4- dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.
The possibility of immunological IgE-mediated reaction could not be conrmed because specic IgE against Phenoxy Ethanol was negative.
Antimicrobial preservative, also used topically in treatment of bacterial infections.
Phenoxy Ethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties.
It has a relatively low sensitizing factor in leave-on cosmetics.
Phenoxy Ethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens.
In addition, Phenoxy Ethanol is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types.
It can be obtained from phenol.
Phenoxy Ethanol at a 1.0% level acts as a preservative in personal care products.
Phenoxy Ethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments.
The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxy Ethanol is commonly used in cosmetics for its antibacterial and antifungal properties.
Phenoxy Ethanol is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.
Reactions to phenoxyethanol have rarely been reported.
Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.
Phenoxy Ethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.
The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.
Release to the environment of Phenoxy Ethanol can occur from industrial use: in processing aids at industrial sites, of substances in closed systems with minimal release and as an intermediate step in further manufacturing of another substance (use of intermediates).
Release to the environment of Phenoxy Ethanol can occur from industrial use: manufacturing of the substance, in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).
Phenoxy Ethanol is a preservative added to cosmetics and pharmaceuticals such as antibiotic ointments and solutions, ear-drops, and vaccines.
Phenoxy Ethanol has antibacterial properties and is eective against strains of Pseudomonas aeruginosa even in the presence of 20% serum.
Phenoxy Ethanol is less eective against Proteus vulgaris, other Gram-negative organisms, and Gram-positive organisms.
Phenoxy Ethanol has been used as a preservative at a concentration of 1%.
A wider spectrum of antimicrobial activity is obtained with preservative mixtures of Phenoxy Ethanol and hydroxybenzoates.
Antimicrobial preservative, also used topically in treatment of bacterial infections.
Phenoxy Ethanol is used as a preservative in cosmetic formulations at a maximum concentration of 1.0%.
Phenoxy Ethanol is a broad spectrum preservative which has excellent activity against a wide range of Gram negative and Gram positive bacteria, yeast and mould.
Phenoxy Ethanol is also used as a solvent and, because of its properties as a solvent, it is used in many blends and mixtures with other preservatives.
Phenoxy Ethanol is not registered as a food additive in the EU.
An ester of 2-Phenoxyethanol, Phenoxy Ethanol and 2-Phenoxyacetic acid, the main metabolite of 2-Phenoxyethanol, were mentioned in a WHO publication where 43 flavouring agents in food were evaluated (WHO 2003, AR4), however at intakes assessed to be very low in Europe (around 1 µg/kg bw/day).
Phenoxy Ethanol has germicidal and germistatic properties.
Phenoxy Ethanol is often used together with quaternary ammonium compounds.
Safety Profile Of Phenoxy Ethanol:
Phenoxy Ethanol is used as a solvent for ester-type resins.
Phenoxy Ethanol is a vaccine preservative and potential allergen, which may result in a nodular reaction at the site of injection.
Possible symptoms include rashes, eczema, and possible death.
Phenoxy Ethanol reversibly inhibits NMDAR-mediated ion currents.
Phenoxy Ethanol produces a local anesthetic effect on the lips, tongue, and other mucous membranes.
The pure material is a moderate irritant to the skin and eyes.
In animal studies, a 10% v/v solution was not irritant to rabbit skin and a 2% v/v solution was not irritant to the rabbit eye.Long-term exposure to phenoxyethanol may result in CNS toxic effects similar to other organic solvents.
Safety issues related to preservatives used in vaccines, including 2-phenoxyethanol have been reviewed.
Contact urticaria has been reported upon exposure to 2-phenoxyethanol-containing cosmetics.
While Phenoxy Ethanol is generally regarded as safe when used within regulatory limits, excessive exposure can pose health risks.
Prolonged skin contact may cause irritation, redness, or allergic reactions, especially in individuals with sensitive skin.
Inhalation of high concentrations, particularly in occupational settings, may lead to respiratory discomfort, dizziness, or headaches.
Moderately toxic by ingestion and skin contact.
A skin and severe eye irritant.
Mutation data reported.
Some glycol ethers have dangerous human reproductive effects.
Combustible when exposed to heat or flame, can react vigorously with oxidizing materials.
When heated to decomposition it emits acrid smoke and irritating fumes.
To fight fEe, use CO2, dry chemical.
