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PHENYLBENZIMIDAZOLE SULFONIC ACID

Phenylbenzimidazole sulfonic acid can be used in medicated skin care and protective skin tone preparations, and in water resistant formulations.
Phenylbenzimidazole sulfonic acid has been reported as a UV filter and its removal from aerobically treated gray water by ozonation and adsorption onto activated carbon has been reported. 
Phenylbenzimidazole sulfonic acid is a xenobiotic compound detected in gray water from houses and effluents of the biological treatment systems (aerobic, anaerobic, and combined anaerobic+aerobic).

CAS Number: 27503-81-7
Molecular Formula: C13H10N2O3S
Molecular Weight: 274.3
EINECS Number: 248-502-0

Synonyms: Ensulizole, 27503-81-7, 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID, Phenylbenzimidazole sulfonic acid, 2-Phenyl-1H-benzo[d]imidazole-5-sulfonic acid, 2-Phenyl-5-benzimidazolesulfonic acid, 1H-Benzimidazole-5-sulfonic acid, 2-phenyl-, 2-phenyl-3H-benzimidazole-5-sulfonic acid, ensulizol, PARSOL HS, 1H-Benzimidazole-6-sulfonic acid, 2-phenyl-, 2-phenyl-1H-benzimidazole-5-sulfonic acid, 9YQ9DI1W42, DTXSID3038852, 2-Phenyl-1H-benzimidazole-5-sulphonic acid, DTXCID1018852, NCGC00166262-01, 1H-Benzimidazole-5-sulfonic acid-2-phenyl-, 2-phenyl-1H-1,3-benzodiazole-6-sulfonic acid, ENSULIZOLE (MART.), ENSULIZOLE [MART.], ENSULIZOLE (USP-RS), ENSULIZOLE [USP-RS], 2-Phenyl-1H-benzo[d]imidazole-6-sulfonic acid, ENSULIZOLE (USP MONOGRAPH), ENSULIZOLE [USP MONOGRAPH], Ensulizole [INN], CAS-27503-81-7, phenylbenzimidazolesulfonic acid, MFCD00053007, ensulizolum, novantisol, UNII-9YQ9DI1W42, Ensulizole [USAN:USP:INN], EINECS 248-502-0, 2-Phenylbenzimidazole-5-sulfonicacid, PBSA, Ensulizole (Standard), ENSULIZOLE [MI], Ensulizole (USP/INN), ENSULIZOLE [USAN], EC 248-502-0, ENSULIZOLE [WHO-DD], SCHEMBL16277, phenylbenzimidazole-sulfonic-acid, CHEMBL1987518, CHEBI:135132, BDBM181124, BCP17614, Tox21_112381, Tox21_200995, BBL028055, s4419, STK034479, 2-phenylbenzimidazole-5-sulphonic acid, AKOS005381771, AKOS006029164, Tox21_112381_1, US9138393, 2-Phenyl benzimidazole, US9144538, 2-Phenyl benzimidazole, 1ST3421, AT10303, CCG-245160, DB11115, HY-109654R, 2-phenylbenz-imidazole-5-sulphonic acid, NCGC00166262-02, NCGC00166262-03, NCGC00258548-01, AC-11988, AS-12559, DB-021496, HY-109654, 2-phenyl-3H-benzimidazol-1-ium-5-sulfonate, 2-Phenyl-5-benzimidazolesulfonic acid, 96%, CS-0033783, NS00010386, P1670, EN300-24969, D10005, H11816, SBI-0653899.0001, AB00090049-01, Covergirl Outlast Stay Fabulous 3in1 Foundation, AG-690/08752050, AN-512/13208053, SR-01000883690, Q7181424, SR-01000883690-1, 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID [VANDF], BRD-K02729857-001-01-9, US9138393, 2-Phenyl-5- benzimidazole sulfonic acid, FULL SPECTRUM MATTE AMBITION SKIN PRIMER SPF 20, Z203045352, Covergirl Queen Collection All Day Flawless 3in1 Foundation, Ensulizole, United States Pharmacopeia (USP) Reference Standard, 2-Phenyl-5-benzimidazolesulfonic acid, analytical reference material, 2-PHENYLBENZIMIDAZOLE-5-SULFONIC ACID, SECONDARY STANDARD, Covergirl TruBlend Base Business Everyday Defense Primer SPF 20, Prada Reveal Skin Optimizing Foundation Broad Spectrum SPF 17 Sunscreen, Covergirl Outlast Stay Fabulous 3in1 FoundationBroad spectrum SPF 20-805 Ivory, Covergirl Outlast Stay Fabulous 3in1 FoundationBroad spectrum SPF 20-810 Classic Ivory, Covergirl Outlast Stay Fabulous 3in1 FoundationBroad spectrum SPF 20-820 Creamy Natural, Covergirl Outlast Stay Fabulous 3in1 FoundationBroad spectrum SPF 20-825 Buff Beige, Covergirl Outlast Stay Fabulous 3in1 FoundationBroad spectrum SPF 20-832 Nude Beige, Covergirl Outlast Stay Fabulous 3in1 FoundationBroad spectrum SPF 20-840 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Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q810 Classic Bronze, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q815 Brulee, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q820 Toffee, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q825 Golden Honey, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q830 Soft Copper, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q835 Mocha, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q840 Almond Glow, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q845 Warm Caramel, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q850 Sheer Espresso, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q855 Spicy Brown, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q860 Rich Mink, Covergirl Queen Collection All Day Flawless 3in1 FoundationBroad Spectrum SPF 20-Q865 True Ebony, Covergirl Vitalist Healthy Foundation with Vitamins plus Ensulizole Sunscreen Broad Spectrum SPF 20 (All shades), Ensulizole(2-Phenylbenzimidazole 5-sulfonic acid), Pharmaceutical Secondary Standard; Certified Reference Material, Lancome Paris Teint Idole Ultra Care and Glow Skincare Foundation Broad Spectrum SPF 27 Sunscreen, Ensulizole/Phenyl Benzimidazole Sulphonic Acid;2-Phenyl-1H-benimidazole,sulfonicacid;2-phenyl-1h-benzimidazole-5-sulfonicaci;Novantisol;Ultraviolet absorbent UV-T;2-phenyl-1H-benzimidazole-5-sulphonic acid;2-Phenylbenzimidazole-5-Sulfonic Acid(UV-T);2-Phenyl-1H-benzo[d]imidazole-5-sulphonic acid

Phenylbenzimidazole sulfonic acid is better known as Phenylbenzimidazole Sulfonic Acid. 
It is a water-soluble sun filter that offers protection against UV-B and short range UV-A radiation. 
Phenylbenzimidazole sulfonic acid also known as phenylbenzimidazole sulfonic acid) is a common sunscreen agent. 

In 1999, the United States Food and Drug Administration regulated that the name ensulizole be used on sunscreen labels in the United States. 
Ensulizole is primarily a UVB protecting agent providing only minimal UVA protection. 
The scope of UVB is 290 to 340 nanometers whereas the UVA range is 320 to 400 nanometers.

For better UVA protection, it must be paired with avobenzone, titanium dioxide, or zinc oxide; outside of the United States it can also be paired with a UV absorber of the Tinosorb or Mexoryl types. 
Because ensulizole is water-soluble, it has the characteristic of feeling lighter on skin. 
As such, Phenylbenzimidazole sulfonic acid is often used in sunscreen lotions or moisturizers whose aesthetic goal is a non-greasy finish.

The free acid is poorly soluble in water, so it is only used as its soluble salts.
Phenylbenzimidazole sulfonic acid is a UV-B absorber, and has good synergy with recognized UV-A absorbers. 
It is used in preparations of cosmetics like creams and lotions and sunscreens. 

The free acid is poorly soluble in water, so it is only used as it’s soluble salts. 
When combined with oil-soluble UV filters such as AakoSun AVB, AakoSun TiO2 or AakoSun ZnO it offers much better protection against UV-A rays, which is a significant cause of skin cancer.
Phenylbenzimidazole sulfonic acid offered by COSROMA® is called Cosroma FSJ022. 

Phenylbenzimidazole sulfonic acid is a type of UVB sunscreen that also absorbs a small fraction of UVA wavelengths. 
Phenylbenzimidazole sulfonic acid is a water-soluble chemical sunscreen. 
It is often used in combination with other ingredients, such as avobenzone, titanium dioxide, zinc oxide, or celadin.

Phenylbenzimidazole sulfonic acid is often used as a common active ingredient in all sunscreen products. 
Back in the year 1999, the Food and Drug Administration, in the United States, made it mandatory for all manufacturers of cosmetic products to use the name Phenylbenzimidazole Sulfonic Acid on their product labels, if used as an active ingredients. 
Phenylbenzimidazole sulfonic acid is also known as Ensulizole.

Phenylbenzimidazole sulfonic acid is very effective when it comes to protecting the skin from the harmful effects of the sun’s UVB rays. 
In case of UVA protection, it should be kept in mind that the compound does not function efficiently as a shield.
To make sure that Phenylbenzimidazole sulfonic acid has the capability to protect an individual from both the UVA and UVB rays of the sun, it needs to be paired with titanium dioxide, avobenzone or a similar compound like zinc oxide.

If one takes a closer look, outside of the United States, manufacturers often pair Phenylbenzimidazole Sulfonic Acid with compounds like Mexoryl or Tinosorb for better results.
Ensulizole is soluble in water which means that cosmetic products that have the compound as an active ingredient feel light on the skin, post application. 
When used in the manufacturing of lotions, sunscreens and moisturizers, it is often seen that patrons prefer products containing Phenylbenzimidazole sulfonic acid due to its non-greasy and light finish.

It should be kept in mind that there are limited studies in the area of Research & Development that shed some light on the overall efficacy of Phenylbenzimidazole Sulfonic Acid as an active ingredient for cosmetics. 
Selective, independent studies carried out by researchers have revealed time and again that when exposed to direct sunlight, Phenylbenzimidazole Sulfonic acid does not degrade readily. 
In short, it is one of the best protective compounds for human skin against UV radiation.

Phenylbenzimidazole sulfonic acid is a high purity, organic sunscreen agent and UVB absorber. 
It has a non-greasy and lightweight feel. 
It exhibits excellent photostability, ensuring consistent protection over time when exposed to sunlight. 

Due to its low skin sensitization potential, it is ideal for sensitive skin formulations.
Phenylbenzimidazole sulfonic acid can be combined with other UV filters to enhance the overall sun protection factor (SPF) and achieve broad-spectrum protection.
Phenylbenzimidazole sulfonic acid is water-soluble, making it suitable for water-based formulations such as gels, lotions and sprays.

Phenylbenzimidazole sulfonic acid is used in sunscreens, daily moisturizers and skincare products.
It is approved by the FDA (US) and the European Commission (EU).
Phenylbenzimidazole sulfonic acid is a solid water-soluble UVB filter, that absorbs dangerous UV light between 280-320 mm to protect the skin from sunburn and cancer. 

It is a White to pale beige crystalline powder with none to faint odor. 
It may cause synergistic effects on SPF in combination with oil-soluble sunscreens.
UV-B radiation affects especially the epidermal layer of the skin, where it causes the well-known sunburn (erythema). 

Further on it induces damage on the DNA and suppresses the immune response of the skin. 
Frequent and intense exposure to UV-B rays enhances the risk of fatal mutations eventually leading to skin cancer.
Phenylbenzimidazole sulfonic acid is a synthetic organic compound that functions as a chemical UV filter, primarily used in sunscreens and other personal care products to provide protection against harmful ultraviolet (UV) radiation. 

Phenylbenzimidazole sulfonic acidis particularly effective at absorbing UVB rays, which are responsible for causing sunburn, skin damage, and an increased risk of skin cancer.
Unlike some other sunscreen agents, it is highly water-soluble, making it an excellent choice for lightweight, non-greasy, and transparent sunscreen formulations.
Due to its strong UV absorption properties, phenylbenzimidazole sulfonic acid is commonly found in a wide range of skincare and cosmetic products, including facial moisturizers, foundations, lip balms, and body lotions, to enhance their sun-protective capabilities. 

Phenylbenzimidazole sulfonic acid is often combined with other sunscreen agents, such as avobenzone or titanium dioxide, to achieve broad-spectrum UV protection that covers both UVA and UVB rays.
Phenylbenzimidazole sulfonic acid is known for its photostability, meaning that it does not degrade quickly when exposed to sunlight. 

This stability allows it to provide longer-lasting sun protection compared to some other sunscreen agents that may break down over time. 
However, as with all sunscreens, it is recommended to reapply products containing this ingredient every two hours or after swimming or sweating to maintain optimal sun protection.

Melting point: >300 °C (lit.)
Density: 1.3592 (rough estimate)
refractive index: 1.6360 (estimate)
storage temp.: 2-8°C
solubility: ethanol and water: soluble ((as sodium salt))
form: Fine Crystalline Powder
pka: -0.87±0.40(Predicted)
color: White
Water Solubility: soluble
Merck: 14,3593
BRN: 922664
Stability: Hygroscopic
InChIKey: UVCJGUGAGLDPAA-UHFFFAOYSA-N
LogP: -1.42 at 25℃

Phenylbenzimidazole sulfonic acid, also called Ensulizole, is a white to pale beige powder. 
Phenylbenzimidazole sulfonic acid, Sodium Phenylbenzimidazole Sulfonate and TEA-Phenylbenzimidazole Sulfonate are salts of Phenylbenzimidazole Sulfonate. 
In the United States, Phenylbenzimidazole sulfonic acid is used in sun protection products. 

When it is used in these products it is called Ensulizole. 
In addition to the acid, the European Union also permits the Potassium, Sodium and Triethanolamine (TEA) salts of Phenylbenzimidazole sulfonic acid to be used in sun protection products.
A chemical sunscreen agent that gives strong protection in the UVB (280-320nm) range with its peak protection at 306 nm. 

Its special property is that unlike most sunscreen agents, it is not oil but water soluble, so it is ideal to create light, oily skin compatible formulas.  
Phenylbenzimidazole sulfonic acid is also fairly photostable and can be used to protect other less stable UV filters (like famous UVA blocker, avobenzone) in the formula. 
It is approved worldwide and can be used up to 4% in the US and up to 8% in the EU.

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
One of the key advantages of phenylbenzimidazole sulfonic acid is its photostability, meaning it does not degrade quickly when exposed to sunlight, allowing for longer-lasting sun protection. 
Additionally, it has a lightweight and non-greasy feel on the skin, making it a preferred ingredient in daily wear sunscreens and cosmetic formulations. 

Despite its effectiveness, some individuals may experience mild skin irritation or sensitivity, particularly those with very sensitive skin. 
However, Phenylbenzimidazole sulfonic acid is generally considered safe for use in skincare products when formulated within regulatory concentration limits.
Phenylbenzimidazole sulfonic acid, also known as ensulizole, is a water-soluble organic compound that is widely used as an active ingredient in sunscreens and other personal care products designed to protect the skin from the harmful effects of ultraviolet (UV) radiation. 

Phenylbenzimidazole sulfonic acid primarily functions as a UVB filter, effectively absorbing UVB rays, which are known to cause sunburn, premature skin aging, and an increased risk of skin cancer. 
Unlike some other sunscreen agents, which may leave a white cast on the skin, phenylbenzimidazole sulfonic acid is a transparent and lightweight ingredient, making it an ideal choice for use in cosmetic formulations such as facial moisturizers, tinted foundations, and makeup products with sun protection.

One of the notable characteristics of phenylbenzimidazole sulfonic acid is its high water solubility, which allows for the development of non-greasy and easily spreadable sunscreen products. 
This property makes it particularly beneficial for individuals who prefer lightweight sun protection without a heavy or sticky feeling on the skin. 
Because of its ability to dissolve in water, it is often included in formulations for water-based or gel-based sunscreens, which are especially popular among people with oily or acne-prone skin.

Phenylbenzimidazole sulfonic acid is often combined with other sunscreen agents, such as avobenzone, octocrylene, or titanium dioxide, to provide broader-spectrum protection against both UVA and UVB rays. 
Since UVA rays penetrate deeper into the skin and contribute to premature aging and long-term skin damage, pairing phenylbenzimidazole sulfonic acid with complementary ingredients helps to enhance overall sun protection efficacy.
Despite its many advantages, phenylbenzimidazole sulfonic acid has some limitations. 

Phenylbenzimidazole sulfonic acid is not highly effective at blocking UVA rays on its own, which is why it must be used in conjunction with other sunscreen ingredients for comprehensive protection. 
Additionally, while it is generally considered safe for use in cosmetic products, some individuals may experience mild skin irritation or sensitivity, particularly those with very sensitive or reactive skin. 
Regulatory agencies, including the U.S. Food and Drug Administration (FDA) and the European Chemicals Agency (ECHA), have approved its use in sunscreens within specific concentration limits to ensure safety and efficacy.

Phenylbenzimidazole sulfonic acid is a valuable component in modern sunscreen formulations, offering strong UVB protection while maintaining a lightweight, non-greasy, and transparent feel. 
Its versatility in different types of skincare and cosmetic products makes it a popular choice for those seeking effective sun protection without the drawbacks of heavier, opaque sunscreen formulations.

Uses Of Phenylbenzimidazole sulfonic acid:
phenylbenzimidazole sulfonic acid (2-phenyl-5-benzimidazolesulfonic acid; 2-phenylbenzimidazole-5-sulfonic acid, ensulizole) is one of 21 FDA-approved sunscreen chemicals for uVB absorption. 
It has an approved usage level of up to 4 percent in the united States and up to 8 percent in the european union. 
When combined with a proper base, it becomes a water-soluble sunscreen. 

It exhibits a very effective use level versus SPF relationship when compared to other sunscreen chemicals. 
In addition, when combined with other uVB absorbers, it seems to significantly boost SPF. 
Phenylbenzimidazole sulfonic acid can also help protect a product from deterioration when exposed to uV light. 

Also considered excellent for use in clear sunscreen gels.
Phenylbenzimidazole sulfonic acid or ensulizole is a water-soluble UVB absorber that can be utilized in the water phase of emulsion systems, in contrast to most oil-soluble sunscreen ingredients, allowing for a less greasy, more aesthetically pleasing formulation such as a daily use moisturizer containing sunscreen. 
Phenylbenzimidazole sulfonic acid boosts the SPF of organic and inorganic sunscreens. 

Phenylbenzimidazole sulfonic acid can also be used in clear gels owing to its water solubility.
ensulizole is one of the chemical names for phenylbenzimidazole sulfonic acid. 
Used as a sunscreen ingredient and also to protect a product from deterioration caused by uV light.

Ensulizole(2-Phenylbenzimidazole 5-sulfonic acid) may be used as a pharmaceutical reference standard for the determination of the analyte in sunscreen formulations by high performance liquid chromatography (HPLC) technique.
These Secondary Standards are qualified as Certified Reference Materials. 
These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Phenylbenzimidazole sulfonic acid, commonly known as ensulizole, is primarily used as an active ingredient in sunscreen formulations, where it functions as an ultraviolet (UV) light absorber to protect the skin from the damaging effects of UVB radiation. 
UVB rays are responsible for causing sunburn, DNA damage, and an increased risk of skin cancer, making the inclusion of phenylbenzimidazole sulfonic acid in sunscreens essential for reducing these harmful effects. 
Phenylbenzimidazole sulfonic acid is commonly found in various types of sun protection products, including facial sunscreens, body sunscreens, and daily moisturizers that contain SPF, as it helps prevent immediate and long-term sun damage when applied consistently.

Due to its water solubility and lightweight, non-greasy texture, phenylbenzimidazole sulfonic acid is widely used in cosmetic and skincare formulations that require a more aesthetically pleasing finish compared to traditional, oil-based sunscreens. 
Phenylbenzimidazole sulfonic acid is frequently incorporated into gel-based sunscreens, water-based sunscreens, and facial sunblocks that cater to individuals with oily or acne-prone skin, as these formulations allow for a comfortable and breathable feel without clogging pores or leaving behind a heavy, greasy residue. 
In addition to its use in standalone sunscreen products, it is often included in makeup items such as tinted moisturizers, foundations, BB creams, and primers with sun protection, allowing for the seamless integration of UV defense into everyday beauty routines.

Another significant use of phenylbenzimidazole sulfonic acid is in combination with other sunscreen agents to enhance broad-spectrum protection against both UVA and UVB radiation. 
Since it primarily absorbs UVB rays, it is often paired with UVA-blocking ingredients such as avobenzone, bemotrizinol, or titanium dioxide in order to provide more comprehensive sun protection. 
This synergistic approach ensures that skincare and sun care products effectively shield the skin from the full range of harmful UV rays, reducing the risk of premature aging, sunburn, hyperpigmentation, and photoaging-related conditions such as wrinkles, fine lines, and dark spots.

Additionally, phenylbenzimidazole sulfonic acid is used in various daily skincare products that provide sun protection benefits alongside other skin-enhancing properties. 
Many anti-aging creams, brightening serums, and hydrating lotions incorporate this ingredient to offer both skincare benefits and sun defense in a single application. 
By including it in these multifunctional products, cosmetic manufacturers cater to consumers who seek convenience and efficiency in their skincare routines, eliminating the need for separate sunscreen application while still maintaining effective UV protection.

Beyond personal skincare and cosmetics, phenylbenzimidazole sulfonic acid is sometimes used in specialized dermatological formulations designed for individuals with heightened sun sensitivity. 
People with conditions such as melasma, rosacea, or post-inflammatory hyperpigmentation may benefit from sunscreens containing this ingredient, as it helps prevent the worsening of these conditions by minimizing exposure to UV radiation. 
Dermatologists may also recommend it for individuals undergoing treatments such as chemical peels, laser therapy, or retinoid use, as these procedures can increase photosensitivity, making sun protection a crucial part of post-treatment skincare.

In summary, phenylbenzimidazole sulfonic acid is an important ingredient used in a wide range of sunscreen and skincare formulations, providing effective UVB protection while allowing for lightweight and cosmetically elegant applications. 
Phenylbenzimidazole sulfonic acid is utilized in daily wear sunscreens, facial moisturizers, makeup products, and dermatological treatments to ensure optimal sun defense while maintaining a non-greasy and transparent appearance on the skin. 
By combining it with other UVA-blocking agents, manufacturers create well-rounded sun protection products that help reduce the risk of sunburn, premature aging, and long-term skin damage.

Safety Profile Of Phenylbenzimidazole sulfonic acid:
Phenylbenzimidazole sulfonic acid is generally considered to be safe for use in cosmetic and sunscreen formulations when used at recommended concentrations. 
However, like any chemical compound, there are some potential hazards and side effects that users should be aware of, particularly in cases of misuse or excessive exposure.
In some individuals, Phenylbenzimidazole sulfonic acid may cause skin irritation, especially in those with sensitive skin. 

Symptoms of irritation may include redness, itching, rash, or a burning sensation upon application. 
While rare, allergic reactions to this ingredient have been reported, which could lead to more severe reactions such as swelling, hives, or dermatitis.

Direct contact with the eyes should be avoided, as phenylbenzimidazole sulfonic acid may cause irritation if it enters the eyes. 
This could result in symptoms like redness, watering, or discomfort. 
If the product does come into contact with the eyes, it is recommended to rinse thoroughly with water to alleviate any discomfort.


 

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