Quick Search
EC / List no.: 923-111-4 / 608-723-9
CAS no.: 28757-47-3 / 32289-58-0
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic.
In dermatological use, it is spelled polihexanide (INN) and sold under the names Lavasept, Serasept, Prontosan, and Omnicide.
PHMB (Polyhexamethylene biguanide) has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumonia.
Products containing PHMB (Polyhexamethylene biguanide) are used for inter-operative irrigation, pre-and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, first aid, surface disinfection, and linen disinfection.
PHMB (Polyhexamethylene biguanide) eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.
PHMB (Polyhexamethylene biguanide) is sold as a swimming pool and spa disinfectant in place of chlorine or bromine-based products under the name Baquacil.
PHMB (Polyhexamethylene biguanide) is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants, and some veterinary products.
PHMB (Polyhexamethylene biguanide) is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors.
The PHMB (Polyhexamethylene biguanide) hydrochloride salt (solution) is used in the majority of formulations.
PHMB (Polyhexamethylene biguanide) is best known for its broad-spectrum antimicrobial and antifungal activity.
PHMB (Polyhexamethylene biguanide) is the standard of care for the treatment of Acanthamoeba keratitis6 and an ingredient in multipurpose contact lens solutions, such as Renu (Bauch & Lomb, Rochester, NY).
PHMB (Polyhexamethylene biguanide) is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.
This interaction results in the disturbance of the cell membrane structure and leakage of the intracellular contents, leading to cell lysis.
PHMB (Polyhexamethylene biguanide) works in a similar fashion at a minimal concentration of 0.02% to be an effective treatment for Acanthamoeba keratitis by targeting the cystic form of the protozoa.
PHMB (Polyhexamethylene biguanide) is also known to be minimally toxic to the corneal epithelium.
Physico-chemical properties
dried PHMB (Polyhexamethylene biguanide) is a dusty solid/powder, off-white with a strong ammonia smell.
PHMB (Polyhexamethylene biguanide) has a glass transition temperature of 90-91°C (non-crystalline polymer) and decomposes at 205-210°C before boiling.
The TK (PHMB (Polyhexamethylene biguanide) as manufacturing, 20% in water) has a boiling point of 100.2°C.
The relative density of TC is 1.20 at 20°C and the relative density of the TK is 1.04 at 20°C.
As a polymer, PHMB (Polyhexamethylene biguanide) is not considered to be volatile.
Henry’s Law Constant is not applicable as PHMB (Polyhexamethylene biguanide) is not considered to be volatile and is present in the ionic form at neutral pH.
PHMB (Polyhexamethylene biguanide) is assumed that PHMB (Polyhexamethylene biguanide) has the only slight possibility to go from water to air.
PHMB (Polyhexamethylene biguanide) is very soluble in water (426 g/L).
PHMB (Polyhexamethylene biguanide) is also soluble in methanol (41%), in ethanol (0.5%), and sparingly soluble in organic solvents (10-3 g/L). The pKa is calculated as approximately 4.4 at 25°C. Log Pow is 2.3 at pH=7.4 and 25°C.
TC is not highly flammable and does not have oxidizing and explosive properties.
A surface tension study should be performed but PHMB (Polyhexamethylene biguanide) is not expected to be surface-active based on structural considerations.
PHMB (Polyhexamethylene biguanide), also known as Polyhexamethylene biguanide, polyhexanide, or polihexanide, is a highly water-soluble and hydrolytically stable polymeric material.
The presence of multiple hydrogen bonds and chelation sites within PHMB (Polyhexamethylene biguanide) renders it of potential interest in the field of supramolecular chemistry.
PHMB (Polyhexamethylene biguanide) shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.
PHMB (Polyhexamethylene biguanide) is available also as a solid.
Polyhexamethylene biguanide (or PHMB) is a chemical product created at the end of the 1950s and used since the 1970s in the formulation of certain biocides.
PHMB (Polyhexamethylene biguanide) is found in particular to kill microbes such as bacteria and viruses or fungi in water in the form of PHMB (Polyhexamethylene biguanide) salt, a pesticide that can be used as a swimming pool disinfectant.
PHMB (Polyhexamethylene biguanide) is also found in some medicines in the form of PHMB (Polyhexamethylene biguanide) hydrochloride.
Acne, disinfection of surgical wounds, and/or in veterinary treatments can be treated with PHMB (Polyhexamethylene biguanide) salts.
PHMB (Polyhexamethylene biguanide) is also used for cleaning and disinfecting objects, surfaces, or premises, including in hospitals.
PHMB (Polyhexamethylene biguanide) is a stable and therefore persistent product that remains effective in the presence of UV light and at different pH values.
PHMB (Polyhexamethylene biguanide) is non-oxidizing, cationic in solution in water, and can be an alternative to other cationic biocidal treatments based on quaternary ammonium or chlorine.
PHMB (Polyhexamethylene biguanide) is an antimicrobial agent active against both Gram-positive and Gram-negative bacteria. PHMB (Polyhexamethylene biguanide) is used in antiseptics, disinfectants and cosmetics.
PHMB (Polyhexamethylene biguanide) is recognized as the safest and the most efficient broad-spectrum antibacterial agent in the 21st century.
PHMB (Polyhexamethylene biguanide) is colorless and tasteless, low bacterial inhibition concentration, broad-spectrum, and low toxicity.
PHMB (Polyhexamethylene biguanide) can form a layer of cations on the surface of the article, which can inhibit bacteria for a long time. PHMB (Polyhexamethylene biguanide) also has no bacteria drug resistance.
Product name: PHMB (Polyhexamethylene biguanide)
Chemical and Physical Specifications
Chemical name: PHMB (Polyhexamethylene biguanide) hydrochloride (PHMB)
INCI Name: Polyaminopropyl Biguanide
Other chemical names
Poly(hexamethylenebiguanide hydrochloride)
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), hydrochloride
Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene), hydrochloride
Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride
CAS: 32289-58-0 / 27083-27-8 / 28757-47-3 / 133029-32-0
Appearance: White or of- white powder or crystalline power, odorless
Solubility: Very soluble in N, N-Dimethylformamide, Soluble in methanol, Sparingly soluble inglacial acetic acid, Very slightly soluble in chloroform, Practically insoluble in water.
Although PHMB (Polyhexamethylene biguanide) has been used in many cleaning products, it had been found an uncommon allergen due to its low frequency of sensitization, with a prevalence of approximately 0.5% of tested patients in the past.
However, PHMB (Polyhexamethylene biguanide) has been reported as a culprit allergen in cosmetic products and contact lens cleaning solutions in patients with allergic contact dermatitis (ACD).
PHMB (Polyhexamethylene biguanide) has not only caused delayed-type hypersensitivity reactions but cases of contact urticaria and anaphylaxis representing immediate-type hypersensitivity also have been reported.
Due to its bactericidal and fungicidal properties, it has been used in wound dressings.
Due to the impaired skin in connection to the wound area, this may as such be a risk factor for sensitization from PHMB (Polyhexamethylene biguanide).
IUPAC NAMES:
CoPoly(bisiminoimidocarbonyl,hexamethylenehydrochloride),(iminoimidocarbonyl , hexamethylène hydrochloride)
Copoly(5-imino-7-imino-4,6,8-triazaundecamethylene hydrochloride) (5-imino4,6-diazanonamethylenehydrochloride)
poly(hexamethylenebiguanide) hydrochloride
Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene),hydrochloride (8CI)
Poly[iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl] hydrochloride
Polyaminopropyl Biguanide, HCl
polyhexamethylene biguanide hydrochloride; PHMB
SYNONYMS:
Polyhexanide
Polyxedinine
Polyhexidine
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl)
OLIGOHEXAMETHYLENEBIGUANIDE
POLY(IMINOIMIDOCARBONYLIMINOIMIDOCARBONYLIMINOHEXAMETHYLENE)
Epa pesticide chemical code 111801
Polyhexamethylene biguanide, sru
Sanitized T 96-04
Hexyl biguanide HCl
1-(diaminomethylidene)-2-hexylguanidine
POLIHEXANIDE
Polyhexamethylene biguanide,
Polyhexanide
28757-47-3
1-(diaminomethylidene)-2-hexylguanidine
Lavasept
Vantoci
polihexanide hydrochloride
Purista
Microcare mbg
Cosmocil cq
n-hexylbiguanide
1-Hexylbiguanid
SCHEMBL45011
CHEMBL2106939
SCHEMBL20753163
DTXSID40873856
N-Hexylimidodicarbonimidic diamide
ZINC4217340
AKOS017531707
FT-0700841
Q408205
24717-31-5
