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Phthaldialdehyde is an aromatic dialdehyde compound widely used as a chemical reagent, analytical indicator, sterilizing agent precursor, and intermediate in specialty synthesis.
Phthaldialdehyde reacts readily with primary amines to form fluorescent isoindole derivatives, making it valuable in chromatographic and biochemical detection.
Phthaldialdehyde is valued for its high reactivity, strong chromophoric behavior, and versatility in laboratory and industrial chemical processes.
CAS Number: 643-79-8
EC Number: 211-402-2
Molecular Formula: C₈H₆O₂
Molecular Weight: 134.13 g/mol
Synonyms: Phthaldialdehyde, o-Phthalaldehyde, OPA, Orthophthalaldehyde, 1,2-Benzenedicarboxaldehyde, Phthaldialdehyde, OPA, o-Phthaldialdehyde, o-Phthalaldehyde, Ortho-Phthalaldehyde, Ortho-Phthaldialdehyde, o-Phthalic Dialdehyde, Phthalic Dialdehyde, 1,2-Phthalic Dialdehyde, 1,2-Benzenedicarboxaldehyde, 1,2-Diformylbenzene, Benzene-1,2-dicarbaldehyde, Benzene-1,2-dialdehyde, Benzene-o-dialdehyde, Aromatic Dialdehyde, Aromatic Dialdehyde OPA, Aromatic Phthalaldehyde, o-Benzene Dialdehyde, Orthobenzenedialdehyde, Orthobenzenedial, Dialdehyde OPA, High-level Disinfectant OPA, Instrument Disinfectant OPA, Medical Instrument Disinfectant OPA, Endoscope Disinfectant OPA, Clinical Disinfectant OPA, Hospital Disinfectant OPA, High-level Medical Disinfectant OPA, Healthcare Disinfectant OPA, Cold Sterilant OPA, Liquid Sterilant OPA, Biocidal Agent OPA, Microbicidal Agent OPA, Antimicrobial Solution OPA, Instrument Processing Solution OPA, Reprocessing Disinfectant OPA, Sterilizing Reagent OPA, Sterilizing Chemical OPA, Antiseptic Dialdehyde (context), Dialdehyde Sterilant, Dialdehyde Disinfectant, Phthalaldehyde Sterilant, Phthalaldehyde Disinfectant, Phthaldialdehyde Reagent Grade, Phthaldialdehyde Analytical Grade, Phthaldialdehyde Laboratory Grade, Phthaldialdehyde Industrial Grade, Phthaldialdehyde Technical Grade, Phthaldialdehyde Fine Chemical, Phthaldialdehyde Specialty Chemical, Phthaldialdehyde Organic Intermediate, Phthaldialdehyde Chemical Intermediate, Phthaldialdehyde Production Intermediate, Phthaldialdehyde Synthetic Intermediate, OPA Chromogenic Reagent, OPA Fluorescent Reagent, OPA Derivatization Reagent, OPA Amino Acid Reagent, OPA HPLC Reagent, OPA Chromatography Reagent
APPLICATIONS
Phthaldialdehyde is used as a chemical reagent in analytical chemistry.
Phthaldialdehyde forms fluorescent derivatives with primary amines.
Phthaldialdehyde is employed in HPLC and fluorimetric detection methods.
Phthaldialdehyde is utilized in biochemical research.
Phthaldialdehyde enables amino acid and peptide quantification.
Phthaldialdehyde supports ultra-sensitive assay protocols.
Phthaldialdehyde is used in industrial sterilant systems.
Phthaldialdehyde functions as a precursor for high-level disinfectants.
Phthaldialdehyde assists in disinfection of medical instruments.
Phthaldialdehyde is applied in organic synthesis.
Phthaldialdehyde serves as an intermediate in aromatic modifications.
Phthaldialdehyde facilitates ring functionalization strategies.
Phthaldialdehyde is used in specialty polymer and resin chemistry.
Phthaldialdehyde contributes to crosslinking reactions.
Phthaldialdehyde enhances mechanical and chemical properties of materials.
Phthaldialdehyde is used as a high-level disinfectant in medical device sterilization.
Phthaldialdehyde is used to disinfect endoscopes and reusable medical instruments.
Phthaldialdehyde is used in hospital reprocessing centers.
Phthaldialdehyde provides effective disinfection at low processing temperatures.
Phthaldialdehyde is used as an alternative to glutaraldehyde.
Phthaldialdehyde reduces odor and vapor irritation in disinfection environments.
Phthaldialdehyde is used in automated endoscope reprocessors.
Phthaldialdehyde shortens processing cycles for high-level disinfection.
Phthaldialdehyde is used in equipment reprocessing for dental clinics.
Phthaldialdehyde helps ensure infection control in dental care instruments.
Phthaldialdehyde is used in outpatient surgical centers.
Phthaldialdehyde supports instrument turnaround for high patient volumes.
Phthaldialdehyde is used in laboratory decontamination protocols.
Phthaldialdehyde disinfects reusable analytical and optical components.
Phthaldialdehyde is used in protein detection assays.
Phthaldialdehyde reacts with primary amines to form fluorescent adducts.
Phthaldialdehyde is used in HPLC fluorescence derivatization.
Phthaldialdehyde enables sensitive detection of amino acid compounds.
Phthaldialdehyde is used in biochemical quantification methods.
Phthaldialdehyde facilitates detection of peptides and amines in research samples.
Phthaldialdehyde is used in clinical diagnostics.
Phthaldialdehyde enhances analytical sensitivity for biological assays.
Phthaldialdehyde is used in neuroscience research.
Phthaldialdehyde labels neurotransmitter-associated amines for fluorescence analysis.
Phthaldialdehyde is used in pharmaceuticals research.
Phthaldialdehyde assists in API purity testing and amine profiling.
Phthaldialdehyde is used in analytical chemistry workflows.
Phthaldialdehyde increases detection thresholds in trace amine analysis.
Phthaldialdehyde is used in amino acid derivatization kits.
Phthaldialdehyde improves peak resolution in chromatographic separation.
Phthaldialdehyde is used in food testing laboratories.
Phthaldialdehyde aids in quality control of amino acid profiles.
Phthaldialdehyde is used in environmental monitoring laboratories.
Phthaldialdehyde assists in detecting trace amines in water and air samples.
Phthaldialdehyde is used in industrial hygiene sampling.
Phthaldialdehyde enhances detection of airborne amines in occupational settings.
Phthaldialdehyde is widely used as both a disinfectant and analytical reagent.
Phthaldialdehyde provides high-level disinfection for heat-sensitive medical devices.
Phthaldialdehyde is recognized for superior odor and exposure profile compared to glutaraldehyde.
DESCRIPTION
Phthaldialdehyde appears as pale yellow to off-white crystalline solid.
Phthaldialdehyde may darken gradually upon storage due to oxidation or polymerization.
Phthaldialdehyde has a characteristic aromatic odor.
Phthaldialdehyde is slightly soluble in water.
Phthaldialdehyde is readily soluble in polar organic solvents such as alcohols and acetone.
Phthaldialdehyde displays strong reactivity toward amines and nucleophiles.
Phthaldialdehyde contains two aldehyde groups in ortho-orientation on a benzene ring.
Phthaldialdehyde undergoes condensation, reduction, and addition reactions.
Phthaldialdehyde forms fluorescent isoindole products upon reaction with amines.
Phthaldialdehyde is sensitive to oxygen, heat, and alkaline environments.
Phthaldialdehyde gradually polymerizes or decomposes under improper storage.
Phthaldialdehyde typically requires protection from light and moisture.
Phthaldialdehyde is an aromatic dialdehyde composed of a benzene ring bearing two formyl groups.
Phthaldialdehyde is also known as o-Phthalaldehyde or OPA.
Phthaldialdehyde typically appears as a white to pale yellow crystalline solid.
Phthaldialdehyde dissolves in organic solvents and forms reactive solutions in water.
Phthaldialdehyde exhibits strong reactivity toward primary amines.
Phthaldialdehyde forms fluorescent isoindole products upon derivatization.
Phthaldialdehyde is incompatible with strong oxidizers and bases.
Phthaldialdehyde requires proper handling and controlled ventilation when used in disinfection.
Phthaldialdehyde must be stored in sealed light-protected containers.
Phthaldialdehyde is sensitive to oxidation and polymerization.
Phthaldialdehyde is regulated in healthcare use due to occupational exposure considerations.
Phthaldialdehyde is valued for its analytical versatility and its disinfection efficiency for medical instrumentation.
PROPERTIES
Chemical Formula: C₈H₆O₂
Molecular Weight: 134.13 g/mol
Appearance: Pale yellow to off-white crystalline solid
Odor: Mild aromatic odor
Density: ~1.26 g/cm³ (solid)
Melting Point: ~54–56 °C
Boiling Point: ~315–320 °C (decomposes)
Solubility in Water: Slight (~1–2 g/L at ambient)
Solubility in Alcohols: Freely soluble
Solubility in Acetone: Soluble
Vapor Pressure: Low at ambient temperature
Flash Point: >160 °C (closed cup)
Stability: Sensitive to oxidation and polymerization
Reactivity: Highly reactive with primary amines
Fluorescence Behavior: Forms fluorescent isoindole derivatives
pKa: Non-ionizing under neutral conditions (aldehyde functional)
Thermal Stability: Decomposes at elevated temperatures
Hygroscopicity: Low
Storage Stability: Good when protected from air, heat, and light
FIRST AID
Inhalation:
Move to fresh air immediately.
Seek medical attention if respiratory irritation occurs.
Skin Contact:
Wash thoroughly with soap and water.
Remove contaminated clothing.
Seek medical attention if irritation develops.
Eye Contact:
Rinse with plenty of water for at least 15 minutes.
Seek immediate medical attention.
Ingestion:
Rinse mouth with water.
Do not induce vomiting.
Seek immediate medical care.
Note to Physicians:
Treat symptomatically; manage irritation or sensitization responses.
HANDLING AND STORAGE
Handling:
Use gloves, goggles, and local exhaust ventilation.
Avoid dust generation and prolonged handling.
Avoidance:
Avoid exposure to strong bases, heat, and oxidizing agents.
Avoid skin and eye contact.
Spill Procedures:
Collect solid carefully and avoid dust formation.
Clean area with suitable solvent-compatible materials.
Dispose of in accordance with regulations.
Storage:
Store in tightly sealed containers.
Keep in a cool, dry, well-ventilated area.
Protect from light, heat, and moisture.
Minimize air exposure to reduce degradation.
