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Phylloquinone, also known as vitamin K1, is a fat-soluble vitamin primarily found in green leafy vegetables.
It plays a critical role in blood coagulation by acting as a cofactor in the synthesis of clotting factors.
Phylloquinone also contributes to bone health and calcium metabolism, making it an essential nutrient for overall well-being.
CAS Number: 84-80-0
EC Number: 201-564-2
Molecular Formula: C31H46O2
Molecular Weight: 450.71 g/mol
Synonyms: Phylloquinone, Vitamin K1, Phytonadione, K1-Vitamin, Phytomenadione, AquaMEPHYTON, Konakion, Phylloquinone Supplement, Vitamin K1 Phylloquinone, Blood Clotting Vitamin, Fat-Soluble Vitamin K1, Vitamin K1 for Bone Health, Coagulation Vitamin K1, Phylloquinone for Pharmaceuticals, Nutritional Phylloquinone, Dietary Phylloquinone, Green Leaf Vitamin K1, Vitamin K1 Phytonadione
APPLICATIONS
Phylloquinone is widely used in dietary supplements to support blood clotting and promote bone health.
Phylloquinone is included in fortified foods, such as dairy products and cereals, to prevent vitamin K deficiency.
Phylloquinone is employed in pharmaceutical formulations, such as tablets and injections, for the treatment of bleeding disorders.
Phylloquinone is used in newborn care to prevent hemorrhagic disease of the newborn through prophylactic administration.
Phylloquinone is incorporated into topical formulations for its potential in wound healing and skin rejuvenation.
Phylloquinone is applied in clinical nutrition programs to address deficiencies in at-risk populations, such as the elderly.
Phylloquinone is utilized in bone health supplements to support calcium regulation and reduce the risk of osteoporosis.
Phylloquinone is added to veterinary formulations for the prevention and treatment of bleeding disorders in animals.
Phylloquinone is included in multivitamin complexes to ensure balanced nutrient intake and prevent deficiencies.
Phylloquinone is used in functional beverages, such as fortified juices and smoothies, to deliver health benefits conveniently.
Phylloquinone is incorporated into personalized nutrition products targeting cardiovascular and skeletal health.
Phylloquinone is employed in medical research to study its role in coagulation and bone mineralization.
Phylloquinone is found in anti-aging skincare products for its antioxidant and skin-firming properties.
Phylloquinone is utilized in infant formulas to provide essential nutrients during early development.
Phylloquinone is included in weight management products to support overall health during calorie-restricted diets.
Phylloquinone is applied in food fortification programs to combat widespread vitamin K deficiencies in certain populations.
Phylloquinone is used in therapeutic formulations for individuals on anticoagulant therapy requiring careful vitamin K balance.
Phylloquinone is incorporated into wound care products for its role in enhancing the healing process.
Phylloquinone (Vitamin K1) is widely used in dietary supplements to support bone health by aiding calcium absorption and bone mineralization.
Phylloquinone is included in multivitamin formulations to ensure adequate vitamin K intake, particularly for individuals who have limited dietary sources.
Phylloquinone is used in clinical treatments for individuals with vitamin K deficiency to prevent bleeding disorders, as it plays a critical role in blood clotting.
Phylloquinone is employed in newborn care to prevent vitamin K deficiency bleeding, which can occur in infants, particularly those born prematurely or with inadequate vitamin K intake.
Phylloquinone is used in cosmetics and skincare products for its antioxidant properties, helping to protect the skin from oxidative stress and maintain a healthy complexion.
Phylloquinone is included in nutritional formulas for the elderly, as vitamin K is important for preventing fractures and maintaining bone strength.
Phylloquinone is applied in the treatment of osteoporosis, as it supports bone mineral density and reduces the risk of fractures.
Phylloquinone is used in the formulation of anti-aging products due to its ability to improve skin elasticity and prevent wrinkles through its role in collagen synthesis.
Phylloquinone is used in combination with other vitamins and minerals in bone health supplements to enhance calcium metabolism and support skeletal function.
Phylloquinone is employed in anticoagulant therapy to help regulate blood clotting factors and manage conditions like warfarin therapy.
Phylloquinone is used in the food industry to fortify products such as dairy, juices, and cereals, ensuring adequate vitamin K intake, especially in populations at risk for deficiency.
Phylloquinone is used in wound healing products, as vitamin K plays a key role in the formation of blood clots, aiding in the healing of cuts and abrasions.
Phylloquinone is included in plant-based dietary supplements for individuals who avoid animal products, as plant-based sources of vitamin K1 are essential for overall health.
Phylloquinone is used in cardiovascular health supplements to promote proper blood circulation and prevent excessive bleeding.
Phylloquinone is used in intravenous vitamin K therapy for patients with severe deficiencies, particularly those undergoing surgeries or treatment for bleeding disorders.
Phylloquinone is applied in certain eye care products due to its potential benefits for eye health, particularly in supporting blood vessel health in the eyes.
Phylloquinone is used in weight loss supplements to aid in fat metabolism, as vitamin K is involved in regulating fat storage and utilization.
Phylloquinone is incorporated into anti-inflammatory treatments, as it may help modulate inflammation, particularly in conditions like arthritis.
Phylloquinone is used in pregnancy supplements to support maternal and fetal health, particularly to ensure proper blood clotting during labor and delivery.
Phylloquinone is used in cancer prevention products for its potential role in inhibiting cancer cell growth through its involvement in gene expression regulation.
Phylloquinone is employed in fertility supplements to support healthy reproductive function in both men and women.
Phylloquinone is used in topical formulations for skin healing and improving wound recovery, especially in individuals with poor vitamin K absorption.
Phylloquinone is incorporated in liver health products due to its role in liver function and regulation of blood clotting factors.
Phylloquinone is used in joint health supplements for its potential to reduce inflammation and support cartilage health.
Phylloquinone is employed in digestion and gut health products to promote proper enzyme function and regulate nutrient absorption.
DESCRIPTION
Phylloquinone is a yellow to amber viscous liquid that is soluble in fats and oils but insoluble in water.
This compound is synthesized by plants during photosynthesis and is abundant in green leafy vegetables such as spinach and kale.
Phylloquinone functions as a coenzyme for the carboxylation of glutamic acid residues in clotting factors, enabling effective blood coagulation.
Phylloquinone is essential for the activation of osteocalcin, a protein required for calcium binding in bones and teeth.
This vitamin is stable under normal storage conditions but sensitive to light and oxidation, necessitating protective packaging.
Phylloquinone has low toxicity and is safe for use in dietary and pharmaceutical applications within recommended dosages.
Phylloquinone is highly bioavailable when consumed with dietary fats, ensuring effective absorption and utilization.
This compound supports cardiovascular health by preventing excessive calcification of blood vessels.
Phylloquinone is recognized for its role in maintaining healthy skin by contributing to cellular repair and rejuvenation.
Phylloquinone (Vitamin K1) is a fat-soluble vitamin primarily found in green leafy vegetables, such as spinach, kale, and broccoli, as well as in certain plant oils.
Phylloquinone is essential for blood clotting, as it plays a crucial role in synthesizing proteins that regulate the clotting process in the body.
Phylloquinone is involved in the metabolism of calcium and the maintenance of bone health, as it aids in the incorporation of calcium into the bone matrix.
Phylloquinone has antioxidant properties that help to protect cells from oxidative damage, contributing to skin and overall health.
Phylloquinone is a vital component in the synthesis of osteocalcin, a protein that is crucial for bone mineralization and strength.
Phylloquinone is primarily absorbed in the small intestine and transported via the lymphatic system to tissues throughout the body.
Phylloquinone is synthesized by photosynthetic organisms, including plants and certain bacteria, making it a key nutrient in a plant-based diet.
Phylloquinone deficiency can lead to increased bleeding, weakened bones, and a higher risk of fractures, particularly in individuals with poor dietary intake or absorption.
Phylloquinone has been studied for its potential benefits in cardiovascular health, as it may help regulate vascular calcification and reduce the risk of arterial stiffness.
Phylloquinone is stored in the liver and used as needed by the body for various physiological processes, including blood clotting, bone health, and metabolic regulation.
PROPERTIES
Chemical Formula: C31H46O2
Molecular Weight: 450.71 g/mol
Common Name: Phylloquinone
Appearance: Yellow to amber viscous liquid
Odor: Odorless
Solubility: Soluble in fats and oils; insoluble in water
Melting Point: Not applicable (viscous liquid)
Reactivity: Stable under normal conditions; sensitive to light and oxidation
Chemical Stability: Stable when stored in dark, airtight containers
Storage Temperature: Store at 2–8°C in a cool, dark place
FIRST AID
Inhalation:
If vapors or aerosols of Phylloquinone are inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.
Skin Contact:
Wash the affected area thoroughly with soap and water.
If skin irritation or rash develops, seek medical attention.
Remove contaminated clothing and wash before reuse.
Eye Contact:
Flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.
Ingestion:
If Phylloquinone is ingested in large amounts, rinse the mouth thoroughly with water.
Do not induce vomiting unless instructed by medical personnel.
Seek medical attention if discomfort or symptoms persist.
If the person is conscious, give small sips of water to drink.
Note to Physicians:
Treat symptomatically.
No specific antidote is required.
Provide supportive care as needed.
HANDLING AND STORAGE
Handling:
Personal Protection:
Wear appropriate personal protective equipment (PPE), such as gloves, safety goggles, and protective clothing, when handling Phylloquinone.
Avoid generating aerosols during handling.
Ventilation:
Ensure proper ventilation during handling to minimize exposure to vapors.
Use local exhaust systems if necessary.
Avoidance:
Avoid direct contact with eyes, skin, and clothing.
Do not eat, drink, or smoke while handling.
Wash hands thoroughly after handling.
Spill and Leak Procedures:
Contain spills to prevent further release.
Use absorbent materials (e.g., paper towels, cloth) to clean up spills.
Dispose of waste according to local regulations.
Storage:
Store in a cool, dry, well-ventilated area away from moisture, light, and incompatible materials.
Keep containers tightly closed and properly labeled.
Protect from direct sunlight to preserve stability.
Handling Cautions:
Avoid exposure to high temperatures or oxidizing agents to prevent degradation.
Ensure containers are clean and sealed properly.
