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CAS NUMBER: 12001-79-5
EC NUMBER: 279-833-9
MOLECULAR FORMULA: C31H46O2
MOLECULAR WEIGHT: 450.7
IUPAC NAME: 2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
Phytol Naphthoquinone plays a key role in helping the blood clot, preventing excessive bleeding.
Unlike many other vitamins, Phytol Naphthoquinone is not typically used as a dietary supplement.
Phytol Naphthoquinone is actually a group of compounds.
The most important of these compounds appears to be Phytol Naphthoquinone1 and Phytol Naphthoquinone2.
Phytol Naphthoquinone is obtained from leafy greens and some other vegetables.
Phytol Naphthoquinone is a group of compounds largely obtained from meats, cheeses, and eggs, and synthesized by bacteria.
Phytol Naphthoquinone is one of the fat-soluble vitamins.
Phytol Naphthoquinone helps with blood clotting.
The major source of Phytol Naphthoquinone is found in green plants.
This form is called phylloquinone.
Another form of Phytol Naphthoquinone is made by bacteria living in the intestine.
This form is called menaquinone.
The synthetic form of Phytol Naphthoquinone is called menadione.
This form is the most potent.
Phytol Naphthoquinone is a fat-soluble vitamin, so your body stores it in fat tissue and the liver.
Phytol Naphthoquinone is best known for its role in helping blood clot
Phytol Naphthoquinone has 2 times the activity of phylloquinone.
But some experts say that humans may not absorb as much of this form of Phytol Naphthoquinone as they had thought.
Phytol Naphthoquinone is needed for the normal clotting (coagulation) of blood.
Phytol Naphthoquinone is the main form of Phytol Naphthoquinone supplement available in the U.S.
Recently, some people have looked to Phytol Naphthoquinone2 to treat osteoporosis and steroid-induced bone loss, but the research is conflicting.
At this point there is not enough data to recommend using Phytol Naphthoquinone2 for osteoporosis
Phytol Naphthoquinone is a lipid cofactor that is required for normal blood clotting.
Several forms of Phytol Naphthoquinone have been identified:
Phytol Naphthoquinone is a natural product found in Secale cereale, Cannabis sativa, and other organisms with data available.
Phytol Naphthoquinone is found in:
-green leafy vegetables – such as broccoli and spinach
-vegetable oils
-cereal grains
Small amounts can also be found in meat and dairy foods.
Phytol Naphthoquinone is a fat-soluble vitamin that comes in two forms.
The main type is called phylloquinone, found in green leafy vegetables like collard greens, kale, and spinach.
The other type, menaquinones, are found in some animal foods and fermented foods.
Menaquinones can also be produced by bacteria in the human body.
Phytol Naphthoquinone helps to make various proteins that are needed for blood clotting and the building of bones.
Prothrombin is a Phytol Naphthoquinone-dependent protein directly involved with blood clotting. Osteocalcin is another protein that requires Phytol Naphthoquinone to produce healthy bone tissue.
Phytol Naphthoquinone is found throughout the body including the liver, brain, heart, pancreas, and bone.
Phytol Naphthoquinone is broken down very quickly and excreted in urine or stool.
Phytol Naphthoquinone deficiency in adults is rare, but may occur in people taking medications that block Phytol Naphthoquinone metabolism such as antibiotics, or in those with conditions that cause malabsorption of food and nutrients.
A deficiency is also possible in newborn infants because Phytol Naphthoquinone does not cross the placenta, and breast milk contains a low amount.
The limited amount of blood clotting proteins at birth increases the risk of bleeding in infants if they are not given Phytol Naphthoquinone supplements.
The following are the most common signs of a deficiency.
-A longer time for blood to clot or a prolonged prothrombin time (as measured in a physician’s office)
-Bleeding
-Hemorrhaging
-Osteopenia or osteoporosis
Phytol Naphthoquinone refers to a group of fat-soluble vitamins that play a role in blood clotting, bone metabolism, and regulating blood calcium levels.
USES:
Phylloquinone, also known as Phytol Naphthoquinone1, is found in plants.
When people eat it, bacteria in the large intestine convert it to its storage form, Phytol Naphthoquinone2.
Phytol Naphthoquinone is absorbed in the small intestine and stored in fatty tissue and the liver.
Without Phytol Naphthoquinone, the body cannot produce prothrombin, a clotting factor that is necessary for blood clotting and bone metabolism.
Medically valid uses:
Phytol Naphthoquinone is used to prevent and treat certain blood clotting (coagulation) issues.
Phytol Naphthoquinone’s also used to prevent severe bleeding (hemorrhagic disease) in newborns.
Phytol Naphthoquinone may be used in cases of ongoing IV feeding.
Phytol Naphthoquinone may also be used when antibiotics have killed bacteria in the intestines that make Phytol Naphthoquinone.
BENEFITS:
*Bone Health:
There appears to be a correlation between low intake of Phytol Naphthoquinone and osteoporosis.
Several studies have suggested that Phytol Naphthoquinone supports the maintenance of strong bones, improves bone density and decreases the risk of fractures.
However, research has not confirmed this.
*Cognitive Health:
Increased blood levels of Phytol Naphthoquinone have been linked with improved episodic memory in older adults.
In one study, healthy individuals over the age of 70 years with the highest blood levels of Phytol Naphthoquinone1 had the highest verbal episodic memory performance.
*Heart Health:
Phytol Naphthoquinone may help keep blood pressure lower by preventing mineralization, where minerals build up in the arteries.
This enables the heart to pump blood freely through the body.
Mineralization naturally occurs with age, and it is a major risk factor for heart disease. Adequate intake of Phytol Naphthoquinone has also been shown to lower the risk of stroke.
Phytol Naphthoquinone is a nutrient that the body needs to stay healthy.
Phytol Naphthoquinone’s important for blood clotting and healthy bones and also has other functions in the body
What foods provide Phytol Naphthoquinone?
Phytol Naphthoquinone is found naturally in many foods.
You can get recommended amounts of Phytol Naphthoquinone by eating a variety of foods, including the following:
-Green leafy vegetables, such as spinach, kale, broccoli, and lettuce
-Vegetable oils
-Some fruits, such as blueberries and figs
-Meat, cheese, eggs, and soybeans
Phytol Naphthoquinone refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements.
The human body requires Phytol Naphthoquinone for post-synthesis modification of certain proteins that are required for blood coagulation (K from koagulation, Danish for "coagulation") or for controlling binding of calcium in bones and other tissues.
The complete synthesis involves final modification of these so-called "Gla proteins" by the enzyme gamma-glutamyl carboxylase that uses Phytol Naphthoquinone as a cofactor.
Phytol Naphthoquinone is used in the liver as the intermediate VKH2 to deprotonate a glutamate residue and then is reprocessed into Phytol Naphthoquinone through a Phytol Naphthoquinone oxide intermediate.
The presence of uncarboxylated proteins indicates a Phytol Naphthoquinone deficiency. Carboxylation allows them to bind (chelate) calcium ions, which they cannot do otherwise.
Without Phytol Naphthoquinone, blood coagulation is seriously impaired, and uncontrolled bleeding occurs.
Research suggests that deficiency of Phytol Naphthoquinone may also weaken bones, potentially contributing to osteoporosis, and may promote calcification of arteries and other soft tissues.
Phytol Naphthoquinone is made by plants, and is found in highest amounts in green leafy vegetables, because it is directly involved in photosynthesis.
Phytol Naphthoquinone is active as a vitamin in animals and performs the classic functions of Phytol Naphthoquinone, including its activity in the production of blood-clotting proteins.
Animals may also convert it to Phytol Naphthoquinone2, variant MK-4.
Bacteria in the gut flora can also convert Vitamin K1 into MK-4.
All forms of Phytol Naphthoquinone other than MK-4 can only be produced by bacteria, which use these during anaerobic respiration.
Phytol Naphthoquinone3 is a synthetic form of Phytol Naphthoquinone, was used to treat Phytol Naphthoquinone deficiency, but because it interferes with the function of glutathione, it is no longer used this way in human nutrition
Phytol Naphthoquinone refers to structurally similar, fat-soluble vitamers found in foods and marketed as dietary supplements.
"Phytol Naphthoquinone" include several chemical compounds.
These are similar in structure in that they share a quinone ring, but differ in the length and degree of saturation of the carbon tail and the number of repeating isoprene units in the side chain (see figures in Chemistry section).
Plant-sourced forms are primarily Phytol Naphthoquinone1.
Animal-sourced foods are primarily Phytol Naphthoquinone2.
Phytol Naphthoquinone has several roles: an essential nutrient absorbed from food, a product synthesized and marketed as part of a multi-vitamin or as a single-vitamin dietary supplement, and a prescription medication for specific purposes
PHYSICAL PROPERTIES:
-Molecular Weight: 450.7
-XLogP3-AA: 10.9
-Exact Mass: 450.349780706
-Monoisotopic Mass: 450.349780706
-Topological Polar Surface Area: 34.1 Ų
Phytol Naphthoquinone plays a key role in helping the blood clot, preventing excessive bleeding.
Unlike many other vitamins, Phytol Naphthoquinone is not typically used as a dietary supplement.
Phytol Naphthoquinone is actually a group of compounds.
The most important of these compounds appears to be Phytol Naphthoquinone1 and Phytol Naphthoquinone2.
Phytol Naphthoquinone is obtained from leafy greens and some other vegetables.
Phytol Naphthoquinone is a group of compounds largely obtained from meats, cheeses, and eggs, and synthesized by bacteria.
CHEMICAL PROPERTIES:
-Hydrogen Bond Donor Count: 0
-Hydrogen Bond Acceptor Count: 2
-Rotatable Bond Count: 14
-Heavy Atom Count: 33
-Formal Charge: 0
-Complexity: 696
-Isotope Atom Count: 0
-Defined Atom Stereocenter Count: 0
-Undefined Atom Stereocenter Count: 2
-Defined Bond Stereocenter Count: 1
-Undefined Bond Stereocenter Count: 0
-Covalently-Bonded Unit Count: 1
-Compound Is Canonicalized: Yes
Phytol Naphthoquinone helps to make various proteins that are needed for blood clotting and the building of bones.
Phytol Naphthoquinone is dependent protein directly involved with blood clotting. Osteocalcin is another protein that requires Phytol Naphthoquinone to produce healthy bone tissue.
Phytol Naphthoquinone is found throughout the body including the liver, brain, heart, pancreas, and bone.
Phytol Naphthoquinone is broken down very quickly and excreted in urine or stool.
Phytol Naphthoquinone is a nutrient that the body needs to stay healthy.
Phytol Naphthoquinone’s important for blood clotting and healthy bones and also has other functions in the body
Phytol Naphthoquinone is found throughout the body including the liver, brain, heart, pancreas, and bone.
Phytol Naphthoquinone is broken down very quickly and excreted in urine or stool.
Phytol Naphthoquinone is made by plants, and is found in highest amounts in green leafy vegetables, because it is directly involved in photosynthesis.
Phytol Naphthoquinone is active as a vitamin in animals and performs the classic functions of Phytol Naphthoquinone, including its activity in the production of blood-clotting proteins.
SYNONYMS:
PHYTOL NAPHTHOQUINONE
VITAMIN K
Kephton
Phytol Naphthoquinone1(20)
.alpha.-Phylloquinone
2-methyl-3-[(E)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
Phythyl-menadion
2-methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)naphthalene-1,4-dione
2-methyl-3-[(2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl]-1,4-dihydronaphthalene-1,4-dione
Phytol Naphthoquinone semiquinone radical
2-Methyl-3-phythyl-1,4-naphthochinon
2-methyl-3-[(2E)-3,7,11,15-tetramethylhexadec-2-en-1-yl]naphthalene-1,4-dione
Phytol Naphthoquinone (generic)
Phytomenadione (INN)
Phytol Naphthoquinone1 (TN)
2-methyl-3-(3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione
Phytol Naphthoquinone1 (Phytonadione)
Phytonadione (JP17/USP)
2-Methyl-3-[(2E)-3,7,11,15-tetramethyl-2-hexadecenyl]naphthoquinone #
[r-[r*,R*-(E)]]-2-Methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-1,4-napthalenedione
[r-[r*,R*-(E)]]-2-Methyl-3-(3-7,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-enyl)-1,4-naphthoquinone
3-((2E)-3,7,11,15-tetramethylhexadec-2-enyl)-2-methylnaphthalene-1,4-dione
1, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-
2-(3,7,11,15-Tetramethyl-2-hexadecenyl)-3-methyl-1,4-naphthoquinone
2-(3,7,11,15-Tetramethylhexadec-2-enyl)-3-methylnaphthalene-1,4-dione
2-Methyl-3-(3,11,15-tetramethyl-2-hexadecenyl)-1,4-naphthalenedione
(E)-2-Methyl-3-(3,7,11,15-tetramethylhexadec-2-en-1-yl)naphthalene-1,4-dione1
1, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, [R-[R*,R*-(E)]]-
2-Methyl-3-[(2Z)-3,7,11,15-tetramethyl-2-hexadecenyl]-1,4-naphthoquinone
1,4-Naphthalenedione, 2-methyl-3-((2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl)-, radical ion(1-)
1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, radical ion(1-), (R-(R*,R*-(E)))-
