PRODUCTS

PIOGLITAZONE

CAS NO:111025-46-8
EC NO:601-029-7

Pioglitazone is a diabetes drug (thiazolidinedione-type, also called "glitazones") used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes.
Pioglitazone works by helping to restore your body's proper response to insulin, thereby lowering your blood sugar.Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems. Proper control of diabetes may also lessen your risk of a heart attack or stroke.
Pioglitazone is used either alone or in combination with other diabetes medications (such as metformin or a sulfonylurea such as glyburide).

Pioglitazone, sold under the brand name Actos among others, is an anti-diabetic medication used to treat type 2 diabetes.
Pioglitazone may be used with metformin, a sulfonylurea, or insulin. Use is recommended together with exercise and diet.
Pioglitazone is not recommended in type 1 diabetes.
Pioglitazone is taken by mouth.

Common side effects include headaches, muscle pains, inflammation of the throat, and swelling. Serious side effects may include bladder cancer, low blood sugar, heart failure, and osteoporosis. Use is not recommended in pregnancy or breastfeeding.
Pioglitazone is in the thiazolidinedione (TZD) class and works by improving sensitivity of tissues to insulin.
Pioglitazone was patented in 1985, and came into medical use in 1999.
Pioglitazone is available as a generic medication. In 2019, it was the 179th most commonly prescribed medication in the United States, with more than 3 million prescriptions.
Pioglitazone was withdrawn in France and Germany in 2011.

Pioglitazone is used to lower blood glucose levels in type 2 diabetes either alone or in combination with a sulfonylurea, metformin, or insulin.While pioglitazone does decrease blood sugar levels, the main study that looked at the medication found no difference in the main cardiovascular outcomes that were looked at. The secondary outcome of death from all causes, myocardial infarction, and stroke were lower.

Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes.
Pioglitazone has been linked to rare instances of acute liver injury.

Pioglitazone is a member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring.
Pioglitazone exhibits hypoglycemic activity.
Pioglitazone has a role as an insulin-sensitizing drug, an EC 2.7.1.33 (pantothenate kinase) inhibitor, a xenobiotic, an EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor, a ferroptosis inhibitor, a cardioprotective agent, a PPARgamma agonist, an antidepressant, a geroprotector and a hypoglycemic agent.
Pioglitazone is a member of thiazolidinediones, an aromatic ether and a member of pyridines.

Pioglitazone is an antihyperglycemic used as an adjunct to diet, exercise, and other antidiabetic medications to manage type 2 diabetes mellitus.
Pioglitazone is administered as a racemic mixture, though there is no pharmacologic difference between the enantiomers and they appear to interconvert in vivo with little consequence. The thiazolidinedione class of medications, which also includes [rosiglitazone] and [troglitazone], exerts its pharmacological effect primarily by promoting insulin sensitivity and the improved uptake of blood glucose via agonism at the peroxisome proliferator-activated receptor-gamma (PPARγ).

Pioglitazone is a solid.
Pioglitazone is used as hypoglycemic agent as an adjunct to diet and exercise for the management of type 2 diabetes mellitus.

Pioglitazone is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Pioglitazone is not for treating type 1 diabetes.

Pioglitazone exerts its antihyperglycemic effect only in the presence of endogenous insulin.
Pioglitazone should not be used to treat type 1 diabetes or diabetic ketoacidosis, as it would not be effective in these settings.

Pioglitazone is a thiazolidinedione used adjunctively with diet and exercise to normalize glycemic levels in adults with type 2 diabetes mellitus.

Pioglitazone is used with proper diet and exercise to treat high blood sugar levels caused by type 2 diabetes.
Pioglitazone may be used alone or with other medicines such as insulin, metformin, or sulfonylurea agents.
Pioglitazone works by helping your body use insulin better. This medicine does not help patients who have insulin-dependent or type 1 diabetes.

Pioglitazone is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Pioglitazone is not for treating type 1 diabetes.

Pioglitazone may also be used for purposes not listed in this medication guide.
Pioglitazone is a PPAR agonist with potential antidiabetic characteristics

Pioglitazone selectively stimulates the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) and to a lesser extent PPAR-α.

Pioglitazone (Cas No : 111025-46-8) is soluble in ,NA dimethylformamide, slightly soluble in anhydrous ethanol, very slightly soluble in acetone and acetonitrile, practically insoluble in water, and insoluble in ether.
Pioglitazone is a prescription drug of the class thiazolidinedione (TZD) with hypoglycemic (antihyperglycemic, antidiabetic) action to treat diabetes. Pioglitazone is an antidiabetic medicines used for the treatment of diabetes mellitus type 2.

Pioglitazone is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes.
Pioglitazone has been linked to rare instances of acute liver injury.

About this substance
Helpful information
Pioglitazone is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, for intermediate use only.

Pioglitazone is used at industrial sites and in manufacturing.

Consumer Uses
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Article service life
ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the types of manufacture using this substance. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Formulation or re-packing
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Uses at industrial sites
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. This substance is used for the manufacture of: chemicals.
ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Manufacture
ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

Pioglitazone is a medicine used to treat type 2 diabetes.

Type 2 diabetes is an illness where the body doesn't make enough insulin, or the insulin that it makes doesn't work properly. This can cause high blood sugar levels (hyperglycaemia).

Pioglitazone helps to control your blood sugar levels by helping your body make better use of the insulin it produces.

Pioglitazone is only available on prescription.
Pioglitazone comes as tablets.

Pioglitazone also comes as tablets containing a mixture of pioglitazone and metformin. Metformin is another medicine used to treat diabetes.

Pioglitazone is an insulin sensitizer of the thiazolidinedione class of peroxisome-proliferator activated receptor γ (PPARγ) agonists.

Pioglitazone works by increasing the sensitivity of your body's cells to insulin - so more glucose is taken into cells for the same amount of insulin in the bloodstream.
Pioglitazone can be used on its own, but it is more commonly taken alongside metformin and/or other antidiabetic medicines.

IUPAC names
5-({4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione
5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione
Pioglitazone

SYNONYMS:
PINEPOLLEN
Pioglitazone
Pioglitazone (Actos)
Pioglitazone free base
Pioglitazone and its intermeidates
5-[4-[2-(5-Ethyl-2-pyridyl)ethoxy]benzyl]thiazolidine-2,4-dione
5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl]thiazolidine-2,4-dione
5-(4-[2-(5-ETHYL-PYRIDIN-2-YL)-ETHOXY]-BENZYL)-THIAZOLIDINE-2,4-DIONE
5-[4-[2-(5-ETHYL-2-PYRIDINYL)ETHOXY]PHENYL]METHYL-2,4-THIAZOLIDINEDIONE
2,4-Thiazolidinedione,5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]Methyl]-
5-[[4-[2-(5-ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
PIOGLITAZONE HCL(5-[[4-[2-(5-ETHYLPYRIDIN-2-YL)ETHOXY]PHENYL]METHYL]THIAZOLIDINE-2,4-DIONE, HCL)
Pioglitazone 5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione
111025-46-8 [RN]
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]- [ACD/Index Name]
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]- (9CI)
2,4-Thiazolidinedione, 5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-, (±)-
5-((4-(2-(5-Ethyl-2-pyridinyl)ethoxy)phenyl)methyl)-2,4-thiazolidinedione
5-(4-(2-(5-Ethylpyridin-2-yl)ethoxy)benzyl)thiazolidine-2,4-dione
5-[[4-[2-(5-ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-Thiazolidinedione
5-[[4-[2-[(5-ethyl-2-pyridyl)]ethoxy]phenyl]methyl]thiazolidine- 2,4-dione
5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl}-1,3-thiazolidin-2,4-dion [German] [ACD/IUPAC Name]
5-{4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione [ACD/IUPAC Name]
5-{4-[2-(5-Éthyl-2-pyridinyl)éthoxy]benzyl}-1,3-thiazolidine-2,4-dione [French] [ACD/IUPAC Name]
5-{4-[2-(5-Ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione
6343
Actos [Trade name]
MFCD00865504 [MDL number]
pioglitazona [Spanish] [INN]
Pioglitazone [BAN] [INN] [Wiki]
Pioglitazone [Ban:Inn]
pioglitazonum [Latin] [INN]
UNII:X4OV71U42S
X4OV71U42S