PIROCTONE ETHANOLAMINE

Piroctone ethanolamine is a preservative that is also used in anti-dandruff shampoos for anti-fungal functions.
Piroctone ethanolamine works to treat dandruff at the root cause by functioning as a fungicide with specific efficacy against Malassezia.
Piroctone ethanolamine has anti-fungal properties and appears as a crystalline powder in raw form that is white or slightly yellow in color.

CAS Number: 68890-66-4
EC Number: 272-574-2
Molecular Formula: C14H23NO2·C2H7NO
Molecular Weight: 298.42

Synonyms: PIROCTONE OLAMINE, 68890-66-4, Octopirox, Piroctone ethanolamine, Kopirox, Piroctoneolamine, Octopyrox, Piroctone ethanolamine salt, Piroctone olamine [USAN], C14H23NO2.C2H7NO, 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, EINECS 272-574-2, UNII-A4V5C6R9FB, A4V5C6R9FB, NSC-759894, PIROCTONE ETHANOLAMINE SALT (1:1), Piroctone olamine (USAN), EC 272-574-2, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1), Octopirox (TN), SCHEMBL2843, CHEMBL2107154, PIROCTONE OLAMINE [INCI], PIROCTONE OLAMINE [MART.], PIROCTONE OLAMINE [USP-RS], AMY40819, BCP29912, HY-B1345, MFCD01690792, s5213, Piroctone olamine, analytical standard, AKOS025149526, CCG-267454, CS-7659, NSC 759894, PIROCTONE ETHANOLAMINE [WHO-DD], AS-15254, C14-H23-N-O2.C2-H7-N-O, LS-133057, FT-0653357, P2178, D05505, Piroctone ethanolamine salt; Octopirox; Kopirox, PIROCTONE ETHANOLAMINE SALT (1:1) [MI], A836281, Q412572, W-104652, 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine, Piroctone olamine, United States Pharmacopeia (USP) Reference Standard, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2 pyridon and its monoethanolamine salt, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt, 1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE MONOETHANOLAMINE, (+/-)-, 1- hydroxy- 4- methyl- 6- (2, 4, 4- trimethylpentyl)pyridin- 2(1H)- one, compound with 2- aminoethanol (1:1), Ethanol, 2-amino-, compd. with 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1) (9CI); 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt; Octopirox; Octopyrox; Piroctone ethanolamine salt; Piroctone olamine, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon --2-aminoethanol (1:1) [German] [ACD/IUPAC Name], 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinon--2-aminoethanol(1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone - 2-aminoethanol (1:1) [ACD/IUPAC Name], 1-Hydroxy-4-méthyl-6-(2,4,4-triméthylpentyl)-2(1H)-pyridinone - 2-aminoéthanol (1:1) [French] [ACD/IUPAC Name], 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone 2-Aminoethanol Salt, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1) [ACD/Index Name], 272-574-2 [EINECS], 68890-66-4 [RN], A4V5C6R9FB, MFCD01690792, octopirox [Trade name], Piroctone ethanolamine, Piroctone ethanolamine salt, Piroctone olamine [Wiki], UNII:A4V5C6R9FB, [68890-66-4] [RN], 1-Aminoethane, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanol ammonium salt, 1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1), 2-aminoethanol and 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, 2-hydroxyethylammonium; 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone, Octopirox| Piroctone ethanolamine, Piroctone, Piroctone olamin, PIROCTONE OLEAMINE, QA-6124

Piroctone ethanolamine is a compound sometimes used in the treatment of fungal infections.
Piroctone ethanolamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.

Piroctone ethanolamine is often used in anti-dandruff shampoo as a replacement for the commonly used compound Piroctone ethanolamine.
Piroctone ethanolamine is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis.

Piroctone ethanolamine is a preservative that is also used in anti-dandruff shampoos for Piroctone ethanolamine anti-fungal functions.

Piroctone ethanolamine, also known as Piroctone olamine, was developed as a solution to the problem of seborrheic dermatitis, that is, dandruff, and has antibacterial, antimicrobial and antifungal properties that can help treat scalp psoriasis and acne.
The mentioned properties can destroy fungi, bacteria and microorganisms that can cause itchy complaints in the hair and scalp and cause the scalp to become flaky.

Piroctone ethanolamine has the potential to have antifungal effects to prevent or treat fungal infections.
Piroctone ethanolamine helps reduce inflammation in the skin.

Piroctone ethanolamine provides antioxidant effect by protecting the skin from the harmful effects of free radicals.
Piroctone ethanolamine shows cleansing potential to remove dirt, oil and debris.
Piroctone ethanolamine can help eliminate bad odors.

Piroctone ethanolamine is a wide spectrum antibacterial and antifungal agent used in the treatment of dandruff,fungal infections.
Piroctone ethanolamine works to treat dandruff at the root cause by functioning as a fungicide with specific efficacy against Malassezia.

Piroctone ethanolamine is a synthetic ingredient that is used mainly as a preservative in personal care and cosmetic products.
Shampoos with Piroctone ethanolamine are very effective in curing dandruff and preventing hair loss.

Piroctone ethanolamine (or Piroctone olamine) is a coordination complex of zinc.
Piroctone ethanolamine has fungistatic (inhibiting the division of fungal cells) and bacteriostatic (inhibiting bacterial cell division) properties and is used in the treatment of seborrhoeic dermatitis[2] and dandruff.

Piroctone ethanolamine has anti-fungal properties and appears as a crystalline powder in Piroctone ethanolamine raw form that is white or slightly yellow in color.
Further, Piroctone ethanolamine is slightly soluble in oil and water.
The chemical formula of Piroctone ethanolamine is C14H23NO2.C2H7NO.

Piroctone ethanolamine has a petrochemical origin.
Piroctone ethanolamine is an ethanolamine salt extracted from hydroxamic acid derivative piroctone.
Typically, Piroctone ethanolamine is an alternative to the commonly used compound Piroctone ethanolamine.

Almost everyone faces hair related issues like dandruff, hair loss, slow hair growth, and split ends.
Shampoos containing Piroctone ethanolamine are effective in treating various kinds of hair problems.

Piroctone ethanolamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and at the same time, provided hair conditioning advantages.
Recently was shown, that Piroctone ethanolamine could induce apoptosis and possessed a significant in vivo effect against myeloma.

Piroctone ethanolamine is a pyridone derivative, which is known to have bactericidal effects on gram-positive and gram-negative bacteria and fungicidal effects and hence is a component of many cosmetic products such as anti-dandruff shampoo.

Piroctone ethanolamine, also called Octopirox, is an antifungal of the hydroxy-pyridone family unrelated to other antiseptics used in veterinary medicine.
Members of the “pirox” family are currently used in the human field as topicals to cure onychomycosis and Malassezia-related skin disorders.

Piroctone ethanolamine has broad in vitro activity against major dermal veterinary pathogens, including dermatophytes and yeasts as well as some Gram positive (Staphylococcus) and Gram negative (Pseudomonas) bacteria.
As opposed to azole derivatives, PO remains fully active on resting fungal cells; Piroctone ethanolamine antiseptic activity proceeds from inhibition of the respiratory chain in yeast mitochondria.

No resistance to PO has been documented to date.
In addition, this antiseptic acts at low concentrations, has high affinity for keratin and is completely safe.
Incorporation of PO in Allermyl therefore aims at controlling microbial proliferation associated with allergic disease.

Piroctone ethanolamine is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Piroctone ethanolamine is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Piroctone ethanolamine is known for many years as a successor to Ketoconazole as an excellent anti-dandruff agent.
More recently Piroctone ethanolamine has been discovered that Piroctone ethanolamine has a much broader protection range against all kinds of microbiological species.

Is also being used in many preservative formulations at neutral pH, which is important for sunscreen formulations.

Piroctone ethanolamine is slightly soluble in both water and oil.
Freely soluble in 10% ethanol in water.

Soluble in solutions containing surfactants in water or in 1-10% ethanol.
The solubility of Piroctone ethanolamine in water varies by pH value.
This is a little larger in neutral or weak basic solutions than in acid solutions.

Typical use level is only 0.05 – 0.2%.

Piroctone ethanolamine is a hydroxamic acid that inhibits ergosterol synthesis, the main component of the cell wall of most fungi.
Piroctone ethanolamine is used as a cream or shampoo at a 0.5–1% concentration.

Piroctone ethanolamine alone or in combination with other agents has been demonstrated to reduce erythema, scaling, burning/stinging sensation, and pruritus in patients with FSD, with excellent cosmetic results.
Piroctone ethanolamine is an antidandruff agent used in antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Designed specifically to treat seborrheic dermatitis and dry scalp, Piroctone ethanolamine offers additional benefits: Piroctone ethanolamine is environmentally friendly, multifunctional (doubles as preserving agent), and flexible for various cosmetic formats.
Piroctone ethanolamine is compatible with most surfactants, additives and active ingredients used in cosmetic formulations.

Piroctone ethanolamine is an effective, practically nontoxic antidandruff active ingredient.
Piroctone ethanolamine is particularly suitable for the manufacture of antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Piroctone ethanolamine is a highly effective antidandruff agent and an anti-acne active agent.
Piroctone ethanolamine is antimicrobial, soluble in surfactant systems.
Piroctone ethanolamine is used shampoos, shower products, liquid soaps, hair conditioners, hair styling products, antiperspirant & deodorants.

Piroctone ethanolamine, despite the recent upsurge in usage, has historically not been a hugely popular ingredient.
So very few independent clinical studies have been performed.
Piroctone ethanolamine main advantage is that it’s well tolerated, and so can be used frequently to control mild dandruff, but this hasn’t been properly evaluated.

Piroctone ethanolamine is one of the more recent active ingredients found in dandruff shampoos.
Designed to treat seborrheic dermatitis and dry scalp Piroctone ethanolamine is one of the most innovative areas of dandruff treatment on the market today.

Dandruff and seborrheic dermatitis can cause hair loss and thinning hair.
Piroctone ethanolamine is assumed that dandruff and seborrheic dermatitis (dandruff is a form of seborrheic dermatitis) are caused by a yeast (single cell fungus) on the skin, the Malassezia globose.
This is a fungus that occurs only on the scalp.

Often times, the problem will not go away on Piroctone ethanolamine own and requires continues treatment.
A well-known agent for this is shampoo with Ketoconazole in high concentration.
Multiple studies about the effectiveness of Piroctone ethanolamine have shown that Piroctone ethanolamine stimulates hair growth and helps against hereditary hair loss.

Ketoconazole is most well-known, but Piroctone ethanolamine is not the only proven anti-dandruff ingredient in shampoos which stimulates hair growth.
Piroctone ethanolamine has a similar effect as Ketoconazole.

Piroctone ethanolamine is also listed under the brand name 'Octopirox'.
In a study with 150 men who suffer from hereditary hair loss and dandruff, Ketoconazole and Piroctone ethanolamine were compared.

Excessive secretion of sebum, dandruff and seborrheic dermatitis are often linked with hair loss and hereditary hair loss.
The 150 men received a shampoo with 1% Ketoconazole or 1% Piroctone ethanolamine.
They had to use this shampoo 2 to 3 times per week for a duration of six months.

All treatments showed a reduction in itching and dandruff after 2 to 6 weeks.

If we take a look at the effect of the treatments on various hair growth parameters, we see the following figures (in percentages):
The severity of hair loss decreases (Ketoconazole: -17.3%, Piroctone ethanolamine: -16.5%)

The percentage of hairs in the growth phase increases (Ketoconazole 4.9%, Piroctone ethanolamine: 7.9%)
The effect on the hair diameter is increased by 5.4% with Ketoconazole and by 7.7% with Piroctone ethanolamine.

Thus, the study shows that Piroctone ethanolamine scores better in a number of areas in comparison to Ketoconazole.

Compared to Ketoconazole, Piroctone ethanolamine ensures an increase in the number of hairs in the growth phase (anagen phase) by more than 10% in 33% of people.
Piroctone ethanolamine gives 88% of the people thicker hair, despite hereditary hair loss, whereby this is 78% with Ketoconazole.
If we take a look at how many people experience a significant increase (more than 10%) of the hair diameter, this is 28% with Ketoconazole and as much as 34% with Piroctone ethanolamine (10% larger diameter means that the hair became 20% heavier).

The above results show that both Ketoconazole and Piroctone ethanolamine have a positive effect on multiple aspects of hair growth.
They have a similar effect on itch and dandruff.
Piroctone ethanolamine generally scores better when Piroctone ethanolamine comes to hair growth.

Piroctone ethanolamine is a preservative also used for Piroctone ethanolamine antifungal functions in anti-dandruff shampoos.
Piroctone ethanolamine is forbidden in organic.

Restriction in Europe:
Maximum concentration in ready-to-use preparation

Maximum content of secondary amine: 0.5%

Other restrictions:
Do not use with nitrosating systems
Minimum purity: 99%
Maximum content of secondary amine: 0.5% (applies to raw materials)
Maximum nitrosamine content: 50 micrograms / kg
Keep in containers without nitrite

If used as a conservator:

The maximum concentration allowed in ready-to-use cosmetic preparations is:
1.0% in Piroctone ethanolamines to be rinsed
0,5% in other products

Applications of Piroctone ethanolamine:
Piroctone ethanolamine is quite beneficial in maintaining cosmetic and personal care products.
Piroctone ethanolamine can commonly be found in products like shampoos, cleansers, and hair masks.

Skin care:
Piroctone ethanolamine can be used to eliminate the bad odor from the surface of the skin.
Piroctone ethanolamine is a great preservative that helps in keeping skin care products free from bacterial growth.

Hair care:
Piroctone ethanolamine is one of the most common 'anti-dandruff' ingredients that is added to hair care products.
Piroctone ethanolamine is also good for preventing hair loss and split ends.

Cosmetic products:
In cosmetic products, Piroctone ethanolamine makes use of Piroctone ethanolamine antifungal properties to keep Piroctone ethanolamines free from unwanted bacterial growth for a longer time.
The addition of Piroctone ethanolamine improves the quality of Piroctone ethanolamines and makes them last longer.

Uses of Piroctone ethanolamine:
Piroctone ethanolamine is a broad-spectrum microbiocide/microbiostat, may be used in formulating antidandruff shampoo, hair keep and hair care, soap, etc.

Piroctone ethanolamine is used in shampoo, hair care, bath liquid, cosmetics, skin care products and washing products.
Piroctone ethanolamine has a unique effect in relieving skin itching, with excellent anti-itch effect, can effectively kill fungi on the skin, and has a special effect in eliminating body odor.
Piroctone ethanolamine is a safe, non-toxic, non-stimulating, ideally effective fungicide.

Piroctone ethanolamine anti-dandruff and anti-itch effect is superior to similar products.
Excellent solubility and compound performance, no precipitation or stratification when mixed with cosmetic raw materials.
Unique anti-dandruff mechanism, very low irritation, no hair loss, no hair breakage, safety is better than similar anti-dandruff anti-itch products.

Medicine:
Piroctone ethanolamine can be used to treat dandruff and seborrhoeic dermatitis.
Piroctone ethanolamine also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera.
Its other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, atopic dermatitis, tinea versicolor and vitiligo.

Paint:
Because of its low solubility in water (8 ppm at neutral pH), Piroctone ethanolamine is suitable for use in outdoor paints and other products that protect against mildew and algae.
Piroctone ethanolamine is an algaecide.

Piroctone ethanolamine is chemically incompatible with paints relying on metal carboxylate curing agents.
When Piroctone ethanolamine is used in latex paints with water containing much iron, a sequestering agent that preferentially binds the iron ions is needed.
Piroctone ethanolamine is decomposed by ultraviolet light slowly, providing years of protection in direct sunlight.

Sponges:
Piroctone ethanolamine is an antibacterial treatment for household sponges, as used by the 3M Corporation.

Clothing:
A process to apply Piroctone ethanolamine to cotton with washable results was patented in the United States in 1984.
Piroctone ethanolamine is used to prevent microbe growth in polyester.

Textiles with applied Piroctone ethanolamine protect against odor-causing microorganisms.
Export of antimicrobial textiles reached US$497.4 million in 2015.

Suggested use:
One in every three persons suffers from a problem related to their hair.
Whether Piroctone ethanolamine is dandruff, loss of hair, slow growth of hair or split ends, the masses are struggling to find a solution to their hair problems.

And in this search for the solution, they often find themselves looking at different shampoos and conditioners to solve the problem.
The issue is that most people end up selecting famous shampoos and conditioners, which may not necessarily be the most effective ones.

The most effective are not usually the ones which are famous (as anything can become famous if Piroctone ethanolamine is marketed and advertised well), they are the ones that have the appropriate ingredients.
Piroctone ethanolamine is the answer to that question.

Rate of Application:
Antidandruff hair keep: 0.1-0.8% active ingredient.
Antidandruff fixing agent: 0.05-0.2% active ingredient.
Antidandruff hair emulsion: 0.1-0.3% active ingredient.
Antidandruff hair supporting: 0.05-0.1% active ingredient.
Preservative: 0.2-0.5% active ingredient
Smell-eliminating agent: 0.2-0.5% active ingredient
Smell-eliminating scented soap: 0.2-0.5% active ingredient.

Consumer Uses:
Piroctone ethanolamine is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Other release to the environment of Piroctone ethanolamine is likely to occur from: indoor use as processing aid.

Widespread uses by professional workers:
Piroctone ethanolamine is used in the following products: cosmetics and personal care products.
Piroctone ethanolamine is used for the manufacture of: chemicals.
Other release to the environment of Piroctone ethanolamine is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners).

Uses at industrial sites:
Piroctone ethanolamine is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Piroctone ethanolamine is used for the manufacture of: chemicals.
Release to the environment of Piroctone ethanolamine can occur from industrial use: in processing aids at industrial sites and in the production of articles.

Benefits of Piroctone ethanolamine:
Piroctone ethanolamine has been specially developed to solve dandruff problems.
Piroctone ethanolamine prevents the scalp from flaking.

Piroctone ethanolamine contributes to the purification of hair roots from bacteria and fungi.
Piroctone ethanolamine is effective in eliminating the factors that cause itching at the roots of the hair.
Piroctone ethanolamine helps purify and cleanse the hair and scalp.

Shampoos, which have Piroctone ethanolamine as one of their ingredients, are known to eliminate dandruff.
However, before we learn how they cure dandruff, we must know what causes dandruff in the first place.

Dandruff is caused due to fungal growth, excess sebum secretion and local inflammations.
Often all these together cause dandruff.

Moreover, when the scalp’s skin renewal process is impaired, the excess dead cells form clumps on the head and seem like visible flakes to the eye, which are termed as dandruff.
Excess sebum also acts as an ingredient for the growth of fungus on the scalp, which increases the acids on the scalp that cause irritation and itching.

This leads to local inflammation, which enhances the growth of cells leading to the formation of flakes that seem like dandruff on the scalp.
The reason why shampoos with Piroctone ethanolamine can reduce and eliminate dandruff is that Piroctone ethanolamine is known to kill the fungus or the fungal infections that irritate the scalp.

Moreover, Piroctone ethanolamine is also well known for reducing hair loss and promoting the growth of hair.
Due to these many benefits, Piroctone ethanolamine is considered a great ingredient in shampoos.

Cures Dandruff:
Malassezia Globosa is not a friendly fungus found in your scalp.
Piroctone ethanolamine is the main reason behind scalp issues like dandruff and seborrheic dermatitis.

Your scalp becomes irritated and starts shedding tiny flakes.
In severe cases, you will notice inflammation, redness, and extremely itchy patches.
If you want to prevent your scalp from worsening, it’s essential to control the situation promptly.

Piroctone ethanolamine has antifungal properties, which will help you control the spread of Malassezia globosa.
Use an anti-dandruff shampoo containing Piroctone ethanolamine to fight dandruff.

Prevents Hair Loss:
Regardless of your gender and age, you may face hair fall, mostly caused due to dirt, dust, pollution, dandruff, excessive use of hair styling tools, etc.
Dandruff makes your scalp itchy, which leads to constant scratching, redness, and hair follicle damage.

Even though hair fall due to dandruff is not a significant concern but in people with androgenic alopecia (a condition that leads to baldness), Piroctone ethanolamine is a proven cure for reducing hair fall.
As Piroctone ethanolamine effectively works on dandruff and fungal infections, naturally, your hair loss decreases over time.

Boosts Hair Growth:
Piroctone ethanolamine encourages hair growth in many ways.
Piroctone ethanolamine reduces hair fall and increases the hair diameter.
Piroctone ethanolamine is often compared to Ketoconazole, which is a widely used ingredient for dandruff, but Piroctone ethanolamine provides better results for dandruff and fungal infections.

Ketoconazole + Piroctone ethanolamine is a combination of two antifungal medicines:
Ketoconazole and Piroctone ethanolamine which treat dandruff.

Ketoconazole kills fungi by destroying the fungal cell membrane.
Piroctone ethanolamine works by penetrating the cell membrane of the fungi to interfere with their energy metabolism and oxygen uptake.
This kills the fungi and clears up the infection.

Functions of Piroctone ethanolamine:

Preservative:
Inhibits the development of microorganisms in cosmetic products.

Anti dandruff:
Helps fight against dandruff.
Piroctone ethanolamine is an active, dandruff-fighting ingredient used in some of our shampoos.

Characteristics of Piroctone ethanolamine:
Piroctone ethanolamine is known for its bacteriostatic and fungistatic properties specifically working against Pityrosporum ovale, which lives on the skin and is associated with dandruff and other manifestations of flaking on the face and scalp.
Piroctone ethanolamine also reduced sebum production.

Appearance of Piroctone ethanolamine:
Piroctone ethanolamine has a white crystalline powder structure.

Resolution of Piroctone ethanolamine:
Piroctone ethanolamine has low solubility in water.
Piroctone ethanolamine dissolves better in some organic compounds.

Structure of Piroctone ethanolamine:
The pyrithione ligands, which are formally monoanions, are chelated to Zn2+ via oxygen and sulfur centers.
In the crystalline state, Piroctone ethanolamine exists as a centrosymmetric dimer, where each zinc is bonded to two sulfur and three oxygen centers.
In solution, however, the dimers dissociate via scission of one Zn-O bond.

This compound was first described in the 1930s.
Pyrithione is the conjugate base derived from 2-mercaptopyridine-N-oxide (CAS# 1121-31-9), a derivative of pyridine-N-oxide.

Solubility of Piroctone ethanolamine:
The solubility of Piroctone ethanolamine is greatly dependent on the pH.
Generally speaking, Piroctone ethanolamine solubility in aqueous formulations is greater in the neutral and weakly alkaline ranges than in the acid range (formation of free acid).
Piroctone ethanolamine does however have adequate solubility in the usual pH range (pH5 - 8) in commercial surfactant solutions and alcohol-water mixtures.

Extraction method of Piroctone ethanolamine:
Piroctone ethanolamine is a particular salt that is also known as Octopirox and Zinc pyrithione.
Piroctone ethanolamine is a compound, which is often used to cure fungal infections.
Piroctone ethanolamine is a hydroxamic acid derivative Piroctone.

Action Mechanism of Piroctone ethanolamine:
Piroctone ethanolamine antifungal effect is thought to derive from Piroctone ethanolamine ability to disrupt membrane transport by blocking the proton pump that energizes the transport mechanism.

Origin of Piroctone ethanolamine:
Piroctone ethanolamine is of petrochemical origin and helps treat dandruff.
There is no natural alternative that comes close to being as effective as this.

History of Piroctone ethanolamine:
Piroctone ethanolamine has been used for around 40 years, first developed by Schwarzkopf-Henkel for use in anti-dandruff shampoo in the late 1970s.
All the initial clinical and safety studies were conducted by Hoechst AG, but this changed in the mid-1990s when other cosmetics companies began using the ingredient.

Piroctone ethanolamine was first submitted for approval to the European Union and United States FDA in the 1980s.
The ingredient was first approved for addition to the United States Pharmacopeia (USP) in 2008, after the FDA sought additional safety and effectiveness data in 2004.

Health effects of Piroctone ethanolamine:
Piroctone ethanolamine is approved for over-the-counter topical use in the United States as a treatment for dandruff and is the active ingredient in several anti-dandruff shampoos and body wash gels.
In Piroctone ethanolamine industrial forms and strengths, Piroctone ethanolamine may be harmful by contact or ingestion.
Piroctone ethanolamine can in the laboratory setting trigger a variety of responses, such as DNA damage in skin cells.

Legal status of Piroctone ethanolamine:
Use of Piroctone ethanolamine is prohibited in the European Union since December 2021.
Piroctone ethanolamine was considered safe for use in rinse-off and leave-in products of different tested concentrations, but due to environmental toxicity standard regulation was considered against potential alternatives – and as no submission was made for its use Piroctone ethanolamine was automatically prohibited.

Environmental concerns of Piroctone ethanolamine:
A large Swedish study shows that Piroctone ethanolamine is broken down in wastewater plants and does not release into waterways.
A Danish study shows that Piroctone ethanolamine biodegrades quickly, but that a risk of continuous leaching from boat paint may cause environmental toxicity.

Handling and storage of Piroctone ethanolamine:

Advice on safe handling:
Avoid contact with skin and eyes.
Avoid formation of dust and aerosols.

Advice on protection against fire and explosion:
Provide appropriate exhaust ventilation at places where dust is formed.

Hygiene measures:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.

Conditions for safe storage, including any incompatibilities:

Storage conditions:
Keep container tightly closed in a dry and well-ventilated place.
Store in cool place.

Storage stability:

Recommended storage temperature: 2 - 8 °C

Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids

Stability and reactivity of Piroctone ethanolamine:

Reactivity:
No data available

Chemical stability:
Stable under recommended storage conditions.

Possibility of hazardous reactions:
No data available

Conditions to avoid:
No data available

Incompatible materials:
Strong acids and oxidizing agents, Strong oxidizing agents

Health Effect of Piroctone ethanolamine:
If used as a preservative, Piroctone ethanolamine should be used at a maximum rate of 1.0% in rinsed products and at a maximum rate of 0.5% in other products.
Piroctone ethanolamine should not be used together with nitrosamine-forming agents.

Nitrosamines are carcinogenic substances.
The impurity rate should be 99%.

The maximum amount of secondary amine should be 0.5%.
The maximum amount of nitrosamine cannot exceed 50 micrograms/kg. The raw material should be stored in nitrite-free packaging.

Piroctone ethanolamine is a synthetic component.
They are raw materials produced using various processes under laboratory conditions.

These are raw materials obtained without using animal sources (propolis, honey, beeswax, lanolin, collagen, snail extract, milk, etc.).
Piroctone ethanolamine is a criterion that should be taken into consideration for those who want to use vegan products.

Studies have concluded that different effects can be seen on each skin type.
For this reason, the allergy/irritation effect may vary from person to person.
However, Piroctone ethanolamine causes stinging, tingling, itching, redness and irritation, especially in people with sensitive skin types.

Precaution of Piroctone ethanolamine:
However, just like excess of anything is bad, too much of Piroctone ethanolamine can be bad for the scalp too.
This is precisely why shampoos with Piroctone ethanolamine have a very minor amount of Piroctone ethanolamine so that its side effects do not affect the scalp in any way.

Piroctone ethanolamine should be kept in mind that shampoos with Piroctone ethanolamine should not be used more than twice a week, unlike other daily use shampoos that don’t have this ingredient.
One of the biggest side effects of Piroctone ethanolamine is that Piroctone ethanolamine can cause irritation and itchiness on the head.

First aid measures of Piroctone ethanolamine:

General advice:
Consult a physician.

If inhaled:
If breathed in, move person into fresh air.
If not breathing, give artificial respiration.
Consult a physician.

In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.

In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.

If swallowed:
Never give anything by mouth to an unconscious person.
Rinse mouth with water.
Consult a physician.

Firefighting measures of Piroctone ethanolamine:

Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.

Special hazards arising from Piroctone ethanolamine:
Carbon oxides
Nitrogen oxides (NOx)

Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.

Further information:
No data available

Accidental release measures of Piroctone ethanolamine:

Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
Avoid dust formation.

Avoid breathing vapors, mist orgas.
Ensure adequate ventilation.

Evacuate personnel to safe areas.
Avoid breathing dust.

Environmental precautions of Piroctone ethanolamine:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up:
Pick up and arrange disposal without creating dust.
Sweep up and shovel.
Keep in suitable, closed containers for disposal.

Identifiers of Piroctone ethanolamine:
CAS Number: 68890-66-4
ChemSpider: 45574
ECHA InfoCard: 100.065.957
MeSH: Piroctone+olamine
PubChem CID: 50258
UNII: A4V5C6R9FB
CompTox Dashboard (EPA): DTXSID4046735
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
Key: BTSZTGGZJQFALU-UHFFFAOYSA-N
InChI=1/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
Key: BTSZTGGZJQFALU-UHFFFAOYAP
SMILES: CC1=CC(=O)N(C(=C1)CC(C)CC(C)(C)C)O.C(CO)N

CAS NO: 68890-66-4
EC NO: 272-574-2

Synonym(s): 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt
Empirical Formula (Hill Notation): C14H23NO2 · C2H7NO
CAS Number: 68890-66-4
Molecular Weight: 298.42
EC Number: 272-574-2
MDL number: MFCD01690792
PubChem Substance ID: 329757760
NACRES: NA.24

Product Number: P2178
Purity / Analysis Method: >97.0%(T)(HPLC)
Molecular Formula / Molecular Weight: C14H23NO2·C2H7NO = 298.43
Physical State (20 deg.C): Solid
Storage Temperature: 0-10°C
Condition to Avoid: Heat Sensitive
CAS No: 68890-66-4
Related CAS No: 50650-76-5
Reaxys Registry Number: 7503297
PubChem Substance ID: 253662076
Merck Index (14): 7502
MDL Number: MFCD01690792

Properties of Piroctone ethanolamine:
Chemical formula: C16H30N2O3
Molar mass: 298.421

Molecular weight: 298.43
Formula: C14H23NO2·C2H7NO
Purity: >97.0%(T)(HPLC)
Color/Form: White to Almost white powder to crystal
MDL: MFCD01690792
Melting point: 136 °C
Flash point: 136 °C
HS code: 2933790090

grade: analytical standard
Quality Level: 100
Assay: ≥99.0% (HPLC)
shelf life: limited shelf life, expiry date on the label

technique(s)
HPLC: suitable
gas chromatography (GC): suitable

application(s):
agriculture
environmental

format: neat
storage temp.: 2-8°C
SMILES string: NCCO.CC(CC1=CC(C)=CC(=O)N1O)CC(C)(C)C
InChI: 1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChI key: BTSZTGGZJQFALU-UHFFFAOYSA-N

Molecular Weight: 298.42 g/mol
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Exact Mass: 298.22564282 g/mol
Monoisotopic Mass: 298.22564282 g/mol
Topological Polar Surface Area: 86.8Ų
Heavy Atom Count: 21
Complexity: 371
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Is Canonicalized: Yes

Specification of Piroctone ethanolamine:
Appearance: White or slightly yellow crystalline powder
Odor: Characteristic

Solubility:
Water (0.10g +10ml):non-soluble
Methanol (1.00g + 10ml): soluble

Purity(HPLC) %: ≥99.0
PH value(1% aqueous suspension,20℃): 8.5-10.0
Melting Point ℃: 130-135
Drying loss %: ≤0.3
Ash(SO4) %: ≤0.2
Particle size distribution: D(0.5): 30-50um Provide a profile representative of the raw material
E1% (1cm) at 317 nm expressed an dried substance: 214-236
Ethanolamine %: 20.0-21.0
Nitrosamine content PPB: ≤50
Heavy metals(Pb,As,Cd,Co,Cr,Hg,Ni,Sb) PPM: ≤10
Hexane(GC) PPM: ≤300
Ethyl acetate(GC) PPM: ≤5000

Names of Piroctone ethanolamine:

Regulatory process names:
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl) 2-pyridon, monoethanolamine salt
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd. with 2-aminoethanol (1:1)
Kopirox
Octopirox
Piroctone ethanolamine salt
Piroctone olamine
Bio Boost 2300EX
Blo Boost 2300EX
Pyrithione zinc
Pyrithione zinc
pyrithione zinc
Pyrithione zinc (Piroctone ethanolamine)
pyrithione zinc; (T-4)-bis[1-(hydroxy-κO)pyridine-2(1H)-thionato-κS]zinc
Piroctone ethanolamine
Zinc Pyrithlone
Zink Pyrithione (zinc omadine)

IUPAC names:
(RS)-1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2(1H)-PYRIDINONE ETHANOLAMINE (1:1)
1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpently)pyridin-2-(1H)-one compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one - 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one,compound with 2-aminoethanol (1:1)
1-hydroxy-4methyl-6-(2,4,4-trimethylphenyl)pyridine-2(1H)-one, compound with 2-aminoethanol(1:1)
2-aminoethanol; 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
2-amminoetanolo; 1-idrossi-4-metil-6-(2,4,4-trimethylpentyl) pyridin-2-one
Octopirox
Piroctone Olamine
Piroctone Olamine
Piroctone olamine
1-oxidopyridine-6-thiolate, zinc (II) cation
2-Mercaptopyridine N-Oxide Zinc Salt
Bis [1-hydroxy-2(1H)-pyridinethionato-O,S](T-4)-zinc
bis(1-hydroxy-2(1h)-pyridinethionato)zinc
bis(1-hydroxy-2(1H)-pyridinethionato-O,S)-(T-4) zinc
Bis(1-hydroxy-2(1H)-pyridinthionato-O,S) zinc
bis(2-pyridylthio)zinc 1,1'-dioxide
bis[1-hydroxy-2-(1H)-pyridine-thionato]zinc
Kopthione Zn
Mercaptopyridine N-oxide zinc salt, Pyrithione
Mercaptopyridine N-oxidezinc salt
Pyrithione zinc
pyrithione zinc
pyrithione zinc`
Zinc 1-oxidopyridin-1-ium-2-thiolate
zinc 1-oxidopyridin-1-ium-2-thiolate
Zinc 2-pyridinethiol-1-oxide
zinc bis(2-thioxopyridin-1(2H) -olate)
zinc bis(2-thioxopyridin-1(2H)-olate)
Zinc pyridinethione
Zinc pyrithion
Piroctone ethanolamine
Piroctone ethanolamine
zinc(2+) bis(2-sulfanylidene-1,2-dihydropyridin-1-olate)
ZINC, BIS(1-HYDROXY-2(1H)-PYRIDINETHIONATO)- (6CI,7CI,8CI)
zinc;1-oxidopyridin-1-ium-2-thiolate

Translated names:
Cinko piritionas (lt)
Piirition taż-żingu (Piirition taż-żingu) (mt)
Pirition cink (cinkov pirition) (hr)
Pirition cink (cinkov pirition) (sl)
Pirition-cink (Cink-pirition) (hu)
Piritiona de cinc (es)
Piritiona-zinco (piritiona de zinco) (pt)
Piritioncinks (cinka piritions) (lv)
Piritionă de zinc (ro)
Pirytionian cynku (pl)
Pyrithion-Zink (Zink-Pyrithion) (de)
Pyrithione zinc (Piroctone ethanolamine) (no)
Pyrithione zincique (pyrithione de zinc) (fr)
pyrithionzink (da)
Pyrithionzink (zinkpyrithion) (nl)
Pyritionisinkki (sinkkipyritioni) (fi)
Tsinkpüritioon (et)
Zinco piritione (piritione zincica) (it)
zink-1-oxo-1λ5-pyridin-2-thiolát (cs)
zinkium-pyritión (sk)
Zinkpyrition (Pyritionzink) (sv)
Άλας πυριθειόνης με ψευδάργυρο (Piroctone ethanolamine) (el)
Цинков пиритион (bg)
Picroctone Olamine
Piroctone olamine

Other identifiers:
1021487-49-9
109702-19-4
118480-78-7
1192-70-7
1199553-62-2
1320-68-9
1323439-04-8
13463-41-7
14376-32-0
15686-64-3
162400-43-3
16782-00-6
17652-47-0
186322-74-7
192458-89-2
208398-70-3
226883-65-4
244778-79-8
266692-38-0
31089-48-2
3138-01-0
318995-78-7
35430-20-7
3590-23-6
3865-77-8
39412-61-8
51148-10-8
51406-57-6
55172-61-7
613-333-00-7
74261-71-5
943428-71-5
68890-66-4