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Piroctone olamine (Piroctone Ethanolamine) is a compound sometimes used in the treatment of fungal infections.
Piroctone olamine (Piroctone Ethanolamine) is the ethanolamine salt of the hydroxamic acid derivative piroctone.
White or slightly yellow crystalline powder.
CAS: 68890-66-4
MF: C16H30N2O3
MW: 298.43
EINECS: 272-574-2
Synonyms
2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1);4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon;octopiroxolamine;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1);Hydroxyl pyrazole ketones;1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine;1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl);-one compound with 2-aminoethanol (1:1)
An organoammonium salt that is the ethanolamine salt of piroctone.
Piroctone olamine (Piroctone Ethanolamine) is a compound sometimes used in the treatment of fungal infections.
Piroctone olamine (Piroctone Ethanolamine) is the ethanolamine salt of the hydroxamic acid derivative piroctone.
Piroctone olamine (Piroctone Ethanolamine) was first synthesized in 1979 by Schwarzkopf-Henkel (Germany).
Piroctone olamine (Piroctone Ethanolamine) is often used in anti-dandruff shampoo as a replacement for the commonly used compound zinc pyrithione which was banned in the EU in 2021 because of concerns for environmental toxicity.
Piroctone olamine (Piroctone Ethanolamine) is structurally similar to ciclopirox and pyrithione, containing a substituted pyridine (pyridinone) group which inhibits ergosterol synthesis.
Piroctone olamine (Piroctone Ethanolamine) is a synthetic ingredient that is used mainly as a preservative in personal care and cosmetic products.
Shampoos with Piroctone olamine (Piroctone Ethanolamine) are very effective in curing dandruff and preventing hair loss.
Piroctone olamine (Piroctone Ethanolamine) has anti-fungal properties and appears as a crystalline powder in its raw form that is white or slightly yellow in color.
Further, Piroctone olamine (Piroctone Ethanolamine) is slightly soluble in oil and water.
The chemical formula of Piroctone olamine (Piroctone Ethanolamine) is C14H23NO2.C2H7NO.
Piroctone olamine (Piroctone Ethanolamine) offered is called Cosroma® OCT.
Piroctone olamine (Piroctone Ethanolamine) which is an ethanolamine salt of pyrrolidone hydroxamic acid derivative.
Piroctone olamine (Piroctone Ethanolamine) is famous for its bacteriostatic effect, especially for inhibiting Plasmodium ovale parasitic in dandruff, face and other dandruff.
Piroctone olamine (Piroctone Ethanolamine) is usually used in shampoo instead of ZPT.
Piroctone olamine (Piroctone Ethanolamine) is the ethanolamine salt of pyroctone hydroxamic acid.
Piroctone olamine (Piroctone Ethanolamine) effectively controls the exaggerated production of cells in the skin and scalp, decreasing desquamation and normalizing the natural renewal cycle.
At the same time Piroctone olamine (Piroctone Ethanolamine) exerts an antibacterial and antifungal activity on germs that cause common skin and scalp disorders.
Specifically, Piroctone olamine (Piroctone Ethanolamine) has a specific action against Pityrosporum Ovale, the agent responsible for the production of dandruff.
The combination of both mechanisms of action (reduction of the fungal population and reduction of the formation of new dandruff) makes Piroctone Olamine an effective and safe alternative to the use of Zinc Pyrithione, with the added advantage that it has also been shown.
On the other hand, this active ingredient also has deodorant properties, reduces the amount of sebum on the skin and, finally, also increases the average thickness of the hair shaft.
Piroctone olamine (Piroctone Ethanolamine) makes the only anti-dandruff and anti-itch agent that can be used in leave-on hair products so far.
Piroctone olamine (Piroctone Ethanolamine) has a broad-spectrum killing effect on fungi and molds, and has good therapeutic effect on ringworm of feet and hands.
Piroctone olamine (Piroctone Ethanolamine) can be used as a preservative in cosmetics and a fungicide in soap, and has thickening properties.
Therefore, Piroctone olamine (Piroctone Ethanolamine) is a multifunctional anti-dandruff and anti-itch antiseptic, which is widely used in shampoo, bath, cosmetics and detergents.
Piroctone olamine (Piroctone Ethanolamine) Chemical Properties
Melting point: 134.0 to 138.0 °C
Boiling point: 135-235℃[at 101 325 Pa]
Density: 1.1[at 20℃]
Vapor pressure: 0-0Pa at 20-25℃
Storage temp.: Inert atmosphere,2-8°C
Solubility: Chloroform (Slightly, Sonicated), Methanol (Slightly)
pka: 5.9-7.4[at 20 ℃]
Form: Solid
Color: White to Off-White
Water Solubility: 400-50000mg/L at 20-25℃
Merck: 14,7502
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChIKey: BTSZTGGZJQFALU-UHFFFAOYSA-N
LogP: 1.05-3.86 at 20-25℃
CAS DataBase Reference: 68890-66-4(CAS DataBase Reference)
Uses
Piroctone olamine (Piroctone Ethanolamine) is an anti-dandruff agent used in shampoo formulations.
Piroctone olamine (Piroctone Ethanolamine) is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages.
Recently was shown, that Piroctone olamine (Piroctone Ethanolamine) could induce apoptosis and possessed a significant in vivo effect against myeloma.
Piroctone olamine (Piroctone Ethanolamine) is quite beneficial in maintaining cosmetic and personal care products.
Piroctone olamine (Piroctone Ethanolamine) can commonly be found in products like shampoos, cleansers, and hair masks.
Skin care: Piroctone olamine (Piroctone Ethanolamine) can be used to eliminate the bad odor from the surface of the skin.
Piroctone olamine (Piroctone Ethanolamine) is a great preservative that helps in keeping skin care products free from bacterial growth
Hair care: Piroctone olamine (Piroctone Ethanolamine) is one of the most common 'anti-dandruff' ingredients that is added to hair care products.
Piroctone olamine (Piroctone Ethanolamine) is also good for preventing hair loss and split ends
Cosmetic products: In cosmetic products, Piroctone olamine (Piroctone Ethanolamine) makes use of its antifungal properties to keep the products free from unwanted bacterial growth for a longer time.
The addition of Piroctone olamine (Piroctone Ethanolamine) improves the quality of the products and makes them last longer
One in every three persons suffers from a problem related to their hair.
Whether Piroctone olamine (Piroctone Ethanolamine) is dandruff, loss of hair, slow growth of hair or split ends, the masses are struggling to find a solution to their hair problems.
And in this search for the solution, they often find themselves looking at different shampoos and conditioners to solve the problem.
The issue is that most people end up selecting famous shampoos and conditioners, which may not necessarily be the most effective ones.
The most effective are not usually the ones which are famous (as anything can become famous if Piroctone olamine (Piroctone Ethanolamine) is marketed and advertised well), they are the ones that have the appropriate ingredients.
Benefits
Piroctone olamine (Piroctone Ethanolamine) is a popular ingredient in hair care products that treat dandruff and other scalp conditions.
Controls dandruff: Piroctone olamine (Piroctone Ethanolamine) is effective at controlling the growth of Malassezia, a yeast that can contribute to dandruff and other scalp issues.
By controlling the growth of this yeast, Piroctone olamine (Piroctone Ethanolamine) can help to reduce or eliminate dandruff.
Soothes the scalp: Piroctone olamine (Piroctone Ethanolamine) has moisturizing properties that can help to soothe and hydrate the scalp.
This can help prevent dryness, flakiness, and itching, common symptoms of dandruff and other scalp conditions.
Safe for coloured hair: Piroctone olamine (Piroctone Ethanolamine) is safe for use on coloured hair and will not cause fading or strip colour.
Prevents fungal growth: Piroctone olamine (Piroctone Ethanolamine) not only controls the growth of Malassezia, but it also prevents the growth of other fungi that can cause scalp problems.
Long-lasting effect: Piroctone olamine (Piroctone Ethanolamine) has been shown to have a longer-lasting effect than some other dandruff-fighting ingredients, meaning you may be able to go longer between washes.
Gentle on the scalp: Piroctone olamine (Piroctone Ethanolamine) is gentle on the scalp, making it suitable for sensitive skin.
Shampoos, which have Piroctone olamine (Piroctone Ethanolamine) as one of their ingredients, are known to eliminate dandruff.
Dandruff is caused due to fungal growth, excess sebum secretion and local inflammations. Often all these together cause dandruff.
Moreover, when the scalp’s skin renewal process is impaired, the excess dead cells form clumps on the head and seem like visible flakes to the eye, which are termed as dandruff.
Excess sebum also acts as an ingredient for the growth of fungus on the scalp, which increases the acids on the scalp that cause irritation and itching.
This leads to local inflammation, which enhances the growth of cells leading to the formation of flakes that seem like dandruff on the scalp.
The reason why shampoos with Piroctone olamine (Piroctone Ethanolamine) can reduce and eliminate dandruff is that Piroctone Olamine is known to kill the fungus or the fungal infections that irritate the scalp.
Moreover, Piroctone olamine (Piroctone Ethanolamine) is also well known for reducing hair loss and promoting the growth of hair.
Due to these many benefits, Piroctone olamine (Piroctone Ethanolamine) is considered a great ingredient in shampoos.
EXTRACTION METHOD
Piroctone olamine (Piroctone Ethanolamine) is a particular salt that is also known as Octopirox and Piroctone ethanolamine.
Piroctone olamine (Piroctone Ethanolamine) is a compound, which is often used to cure fungal infections.
Piroctone olamine (Piroctone Ethanolamine) is a hydroxamic acid derivative Piroctone.
