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Pluriol A 520 PE is a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.
The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups.
The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups.
CAS: 25322-68-3
MF: (C2H4O)nH2O
MW: 0
EINECS: 500-038-2
Synonyms
1,2-ethanediol,homopolymer;2-ethanediyl),.alpha.-hydro-.omega.-hydroxy-Poly(oxy-1;Alcox E 160;Alcox E 30;alcoxe30;Poly(ethylene oxide),approx. M.W. 600,000;Poly(ethylene oxide),approx. M.W. 200,000;Poly(ethylene oxide),approx. M.W. 900,000
The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides.
The average molecular weight of any specific Pluriol A 520 PE product falls within quite narrow limits (°5%).
The number of ethylene oxide units or their approximate molecular weight (e.g., PEG-4 or PEG-200) commonly designates the nomenclature of specific polyethylene glycols.
Pluriol A 520 PE with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.
These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Pluriol A 520 PE Chemical Properties
Melting point: 64-66 °C
Boiling point: >250°C
Tg: -67
Density: 1.27 g/mL at 25 °C
Vapor density: >1 (vs air)
Vapor pressure: <0.01 mm Hg ( 20 °C)
Refractive index: n20/D 1.469
Fp: 270 °C
Storage temp.: 2-8°C
Solubility: H2O: 50 mg/mL, clear, colorless
Form: waxy solid
Color: White to very pale yellow
Specific Gravity: 1.128
PH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
λmax λ: 260 nm Amax: 0.6
λ: 280 nm Amax: 0.3
Merck: 14,7568
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -0.698 at 25℃
NIST Chemistry Reference: Pluriol A 520 PE (25322-68-3)
EPA Substance Registry System: Pluriol A 520 PE (25322-68-3)
Pluriol A 520 PE is a polymer which is hydrolyzed by ethylene oxide.
Pluriol A 520 PE has no toxicity and irritation.
Pluriol A 520 PE is widely used in various pharmaceutical preparations.
The toxicity of low molecular weight Pluriol A 520 PE is relatively large.
In general, the toxicity of diols is very low.
Topical application of Pluriol A 520 PE, especially mucosal drug, can cause irritant pain.
In topical lotion, Pluriol A 520 PE can increase the flexibility of the skin, and has a similar moisturizing effect with glycerin.
Pluriol A 520 PE can occur in large doses of oral administration.
In injection, the maximum Pluriol A 520 PE 300 concentration is about 30% (V/V). Hemolysis could occur when the concentration is more than 40% (V/V).
The USP32–NF27 describes Pluriol A 520 PE as being an addition polymer of ethylene oxide and water.
Pluriol A 520 PE grades 200–600 are liquids; grades 1000 and above are solids at ambient temperatures.
Liquid grades (PEG 200–600) occur as clear, colorless or slightly yellow-colored, viscous liquids.
They have a slight but characteristic odor and a bitter, slightly burning taste.
Pluriol A 520 PE can occur as a solid at ambient temperatures.
Pluriol A 520 PE are white or off-white in color, and range in consistency from pastes to waxy flakes.
They have a faint, sweet odor.
Grades of Pluriol A 520 PE and above are available as freeflowing milled powders.
Application in biomedicine
Pluriol A 520 PE is also known as polyoxirane (PEO).
Pluriol A 520 PE is a linear polyether obtained by ring opening polymerization of ethylene oxide.
The main uses in the field of biomedicine are as follows:
Contact lens liquid.
The viscosity of Pluriol A 520 PE is sensitive to the shear rate and it is not easy for bacteria to grow on polyethylene glycol.
Synthetic lubricants.
The condensation polymer of ethylene oxide and water.
Pluriol A 520 PE is a cream matrix for preparing water-soluble drugs.
Pluriol A 520 PE can also be used as a solvent for acetylsalicylic acid and caffeine, which is difficult to dissolve in water.
Drug sustained-release and immobilized enzyme carrier.
The Pluriol A 520 PE is applied to the outer layer of the pill to control the diffusion of drugs in the pill so as to improve the efficacy.
Surface modification of medical polymer materials.
The biocompatibility of medical polymer materials in contact with blood can be improved by adsorption, interception and grafting of two amphiphilic copolymers containing Pluriol A 520 PE on the surface of medical polymers.
Pluriol A 520 PE can make the membrane of the alkanol contraceptive pill.
Pluriol A 520 PE can make hydrophilic anticoagulant polyurethane.
Pluriol A 520 PE is an osmotic laxative.
Pluriol A 520 PEcan increase osmotic pressure and absorb moisture in the intestinal cavity, which makes the stool soften and increase in volume, resulting in bowel movement and defecation.
Denture fixing agent.
Pluriol A 520 PE nontoxic and gelatinous nature can be used as a component of denture fixer.
Pluriol A 520 PE is commonly used to promote cell fusion or protoplast fusion and help organisms (such as yeasts) to take DNA in transformation.
PEG absorbs water from the solution, so it is also used to concentrate the solution.
Pluriol A 520 PE molecules of approximately 2000 monomers.
Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry.
Recent research has shown PEG m aintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals.
In rats, Pluriol A 520 PE has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery.
Pluriol A 520 PE is industrially produced as a lubricating substance for various surfaces to reduce friction.
Pluriol A 520 PE is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
Manufacturing Process
Pluriol A 520 PE was obtained by polymerization of ethylene oxide in an autoclave at 80-100°C using as a catalyst dipotassium alcogolate of polyethylene glycol 400.
Dipotassium alcogolate of Pluriol A 520 PE was synthesized by a heating of the dry mixture of polyethylene glycol 400 and potassium hydroxide.
The molecular weight of polymer was regulated by the ratio of monomer:catalyst.
Production Methods
Pluriol A 520 PE polymers are formed by the reaction of ethylene oxide and water under pressure in the presence of a catalyst.
