PLURONIC PE 10400

Pluronic PE 10400 is a non-ionic, low-foaming surfactant and block copolymer, featuring a molecular weight of roughly 5,900 and 40% ethylene oxide content. 
Pluronic PE 10400 comes in a paste form and works well as a wetting agent or cleaner ingredient.

CAS Number: 9003-11-6
Molar Mass (Average): Approx. 5,900 g/mol

Synonyms: alpha.-Hydro-.omega.-hydroxypoly(oxyethylene)poly(oxypropylene)poly(oxyethylene) block copolymer, 75H90000, 9003-11-6, BSP 5000, Berol TVM 370, Bloat guard, Eban 710, Emkalyx EP 64, Emkalyx L 101, Emkalyx L101, Epan 485, Epan 710, Epan 750, Epan 785, Epon 420, Ethylene glycol-propylene glycol polymer, Ethylene oxide-propylene oxide block polymer, NSC63908, Newpol PE-88, Niax 16-46, Niax LG 56, Nissan Pronon 201, Nixolen SL 19, Oligoether L-1502-2-30, Oxirane, polymer with methyloxirane, Pluronic C 121, Pluronic L 61, Pluronic L 62, Pluronic L 64, Pluronic L 68, Pluronic L 92, Pluronic L-101, Pluronic L-81, Pluronic P, Pluronic P 104, Pluronic P 75, Pluronic P 85, Pluronic P-65, Pluronic P-75, Pluronic l44, Pluronicl62(mw 2500), Pluronic l64(mw 2900), Pluronic-68, Poloxalene, Poloxalene L64, Poloxalkol, Poloxamer, Poloxamer 108, Poloxamer 182LF, Poloxamer 188, Poloxamer 331, Poloxamer 407, Poly(mixed ethylene, propylene)glycol, Poly(oxyethylene)-poly(oxypropylene) glycol, Poly(oxyethylene)-poly(oxypropylene) polymer, Poly(propylene oxideethylene oxide), Polyethylene glycol, propoxylated, Polyethylene oxide-polypropylene oxide, Polyethylene oxide-polypropylene oxide copolymer, Polyethylene-Pluronic L-62LF, Polyethylene-polypropylene glycol, Polykol, 
Polylon 13-5, Polyoxyethylenated poly(oxypropylene), Polyoxyethylene polyoxypropylene, Polyoxyethylene-polyoxypropylene, Polyoxyethylene-polyoxypropylene polymer, Polypropylene glycol, ethoxylated, Polypropylene glycol-ethylene oxide copolymer, Proksanol, Pronon, Pronon 102, Pronon 104, Pronon 201, Pronon 204, Pronon 208, Propylen M 12, Propylene oxide-ethylene oxide copolymer, Propylene oxide-ethylene oxide polymer, Proxanol, Proxanol 158, Proxanol 228, RC 102, Regulaid, Rokopol 16P, Rokopol 30P, Rokopol 30P9, SK & F 18,667, SK&F 18,667,  Slovanik, Slovanik 630, Slovanik 660, Supronic B 75, Supronic E 400, Synperonic PE 30/40, TVM 370, Tergitol XH, Tergitol XH (nonionic), Tergitol monionic XH,Teric PE 61, Teric PE 62, Teric PE40, Teric PE60, Teric PE70, Therabloat, TsL 431, Unilube 50MB168X, Unilube 50MB26X, Velvetol OE 2NT1, Voranol P 2001, WS 661, Wyandotte 7135, component of Casakol, component of Epitrate

Pluronic PE 10400, also known as Poloxamer 407, is a chemical feedstock that can be used in various applications. 
Pluronic PE 10400 is a nonionic surfactant consisting of a combination of ethylene oxide and propylene oxide.

Pluronic PE 10400 is widely used in the pharmaceutical industry, particularly in the manufacture of drugs and medical devices. 
Pluronic PE 10400 serves as an emulsifier, stabilizer, and solubilizer for various active ingredients. 
Due to its amphiphilic properties, Pluronic PE 10400 can help improve the solubility of lipophilic substances in aqueous media.

Furthermore, Pluronic PE 10400 is used in biotechnology and cell culture. 
Pluronic PE 10400 can be used as a component of cell culture media to improve cell adhesion and reduce aggregate formation.

Physical properties such as density and flash point are not specifically specified for Pluronic PE 10400. 
Pluronic PE 10400 is a viscous, clear liquid at room temperature.

The chemical name for Pluronic PE 10400 is Poloxamer 407. 
Pluronic PE 10400 has the CAS number 9003-11-6 and the EC number 500-038-2. 
Further information on this substance is available upon request.

Pluronic PE 10400 is an EO/PO block copolymer, primarily valued for its low-foaming, non-ionic surfactant properties. 
In global naming structures, it is also equivalent to Pluronic P104.

Key Physical and Chemical Properties
Form: Paste (solid at room temperature, melting point around 50 °C)
Molecular Weight: Approx. 5,900
Ethylene Oxide (EO) Content: Approx. 40%
Active Content: 100%

Common Uses
Cleaners: Used in household and industrial cleaning productsWetting and Dispersing: Helps spread liquids evenly on hard surfaces.
Industrial Formulations: Acts as a functional ingredient or additive in various chemical processes.

CAS Number: 9003-11-6
Physical Form (23°C): White, waxy paste / solid
Molar Mass (Average): Approx. 5,900 g/mol
Cloud Point (1% in water): Approx. 81°C
HLB Value: Intermediate (~12-14 range)
Ionic Charge: Non-ionic (compatible with anionic/cationic mixes)

Behavioral Characteristics
Solubility Shift: Pluronic PE 10400 dissolves easily in cold water. 
When heated above its cloud point (81°C), Pluronic PE 10400 phase-separates and becomes insoluble.
Foam Suppression: Pluronic PE 10400 functions efficiently as a defoamer or low-foaming agent because its large hydrophobic core prevents stable film formation.
Hard Water Stability: Pluronic PE 10400 displays high dispersing capacity against calcium and magnesium salts, preventing mineral scale buildup in cleaner formulas.

Industrial Applications
Household & Industrial Cleaners: Formulated into heavy-duty detergents, machine dishwashing liquids, and dairy cleaners to cut grease without excessive foaming.
Coatings & Adhesives: Pluronic PE 10400 acts as a stabilizing emulsifier during emulsion polymerization, preventing the settling or coalescence of resins.
Agrochemical Formulations: Serves as a dispersing agent and humectant to keep sparingly water-soluble active ingredients suspended in aqueous pesticide or herbicide mixtures.

Solution Viscosity Dynamics
The physical thickness (viscosity) of Pluronic PE 10400 varies intensely depending on temperature and water dilution.
Pure Melt State: At elevated temperature, its dynamic viscosity sits around 500 mPa·s at 60 °C.
Aqueous Blends (The Viscosity Peak): When mixed with water at room temperature, it does not dissolve linearly. 
Instead, it forms a "viscosity peak" at certain concentrations, transitioning into a rigid, transparent gel network. 
This property allows formulators to use it as a standalone thickener without needing auxiliary gums.

Thermodynamics of Micellization: Because it is an amphiphilic block copolymer, its polymer chains (unimers) self-assemble into complex core-shell structures (micelles) once threshold levels are met:
Critical Micelle Concentration (CMC): Pluronic PE 10400's CMC is highly dependent on temperature. 
At 25°C, the CMC is relatively high, but as the solution warms toward body temperature (37°C), the hydrophobic PPO block rapidly sheds its hydrogen bonds with water, forcing the CMC down significantly.
Solubilization Power: Once these micelles form, the inner hydrophobic core acts as a micro-reservoir. 
Pluronic PE 10400 is highly capable of trapping and stabilizing oil-soluble ingredients, hydrophobic dyes, or poorly soluble chemical entities in an aqueous environment.

Chemical Resistance & Stability Limits
Acid/Base Resistance: Pluronic PE 10400 is fully stable and resistant to acids at typical application concentrations. 
However, because it relies on ether linkages, it is not fully resistant to strong alkalis over prolonged periods or at high heat.

Hard Water & Salt Compatibility: Unlike standard anionic surfactants, the non-ionic structure does not react with calcium or magnesium ions (Ca²⁺ or Mg²⁺). 
Pluronic PE 10400 performs identically in distilled water, hard tap water, and heavy brine solutions without precipitating out.

The Naming Code
The code "10400" reveals its exact molecular architecture: 
The first two digits (10): Indicate the molar mass of the central hydrophobic polypropylene glycol (PPG) block on a scale of 1–10 (approx. 3,250 g/mol).
The third digit (4): Represents the percentage of hydrophilic polyethylene glycol (PEG) in the molecule, multiplied by 10 (40% PEG).
The final two digits (00): Confirm that the product is 100% active substance with no added water.

Safe Handling, Storage, and Processing

Solidification Behavior: Pluronic PE 10400 has a setting/melting point of approximately 50 °C. 
If stored in standard warehouse conditions, Pluronic PE 10400 will arrive as a firm, waxy paste/solid.
Reconstitution: To draw or pump the product out of storage drums, the container must be slowly heated using a drum blanket or hot room to roughly 60 °C until it melts into a clear, easily pourable liquid.
Regulatory Status: Pluronic PE 10400 is relatively non-toxic and used globally as an inert co-formulant ingredient in industrial formulations and registered plant protection products.