Quick Search
POE (20) SORBITAN MONOOLEATE = TWEEN 20
CAS Number: 9005-65-6
EC Number: 500-019-9
MDL number: MFCD00082107
Chemical formula: C58H114O26
Kotilen-20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan monolaurate.
As the name implies the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.
Appearance: Yellow to amber oily liquid to cream
POE (20) sorbitan monooleate is a sorbitan fatty acid ester ethoxylate and is a well-known highly effective adjuvant.
POE (20) sorbitan monooleate has been the workhorse nonionic surfactant adjuvant for several decades and consistently demonstrates both high levels of activity across broad varieties of pesticidal active ingredients as well as providing superior plant safety.
POE (20) sorbitan monooleate has a long and robust history as an "activator adjuvant" performing across such varied herbicide classes as glyphosate and triketones.
POE (20) sorbitan monooleate has a substantial positive track record with many global agricultural companies and often appears as a screening tool when assessing the bioavailability of new active ingredients and formulations.
Like many liquid polysorbate surfactants POE (20) sorbitan monooleate displays mammalian and ecological safety, biodegradability, excellent physical properties, ease of formulation, superior dilution performance and virtually no phytotoxicity.
TPOE (20) sorbitan monooleate also offers ready availability and safety with demonstrated biological performance in combination with many pesticides.
A lot of POE (20) sorbitan monooleate detergents are available in a variety of structures and under trade names.
Most are industrial products containing a mixture of related structures.
The composition often varies with batches.
Furthermore, POE (20) sorbitan monooleate detergents tend to alter, mostly by oxidation, and this aging process is increased by light and temperature.
Oxidation generates peroxides, carboxyls and free radicals that may reach up to 0.2%.
Even at far lower concentration, these oxidizing agents may be very critical in your application : such contaminants are often responsible for inactivation, denaturation, fragmentation of the desired biomolecule, especially during the extraction from cell lysates.
Sulfhydryls are readily oxidized by peroxides that induce receptors aggregation or transition of conformation state.
Contaminants may also interfere in biochemical analysis (i.e. for estrogen), or even protein with Coomassie.
POE (20) sorbitan monooleate is derived from a superior quality food grade raw materials.
POE (20) sorbitan monooleate consists of sorbitol, ethylene oxide and oleic acid.
POE (20) sorbitan monooleate has a molecular formula of C64H124O26.
At room temperature POE (20) sorbitan monooleate is in the form of pale-yellow to amber oily liquid.
POE (20) sorbitan monooleate is an O/W emulsifier with an HLB value of 15.0.
POE (20) sorbitan monooleate is soluble in water, ethanol, ethyl acetate and toluene.
POE (20) sorbitan monooleate is derived from polyethoxylated sorbitan and oleic acid.
The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid.
POE (20) sorbitan monooleate is a polyoxyethylene derivative of sorbitan monolaurate, and is distinguished from the other members in the polysorbate range by the length of the polyoxyethylene chain and the fatty acid ester moiety.
POE (20) sorbitan monooleate is derived from coconut oil.
POE (20) sorbitan monooleate is a non-toxic, nonionic surfactant/emulsifier and a water-soluble yellowish liquid used as a dispersing agent which allows oil and water to mix without the use of alcohol.
POE (20) sorbitan monooleate a fragrance solubilizer and stabilizer; it lubricates and has a soothing effect on the skin.
The polysorbates are amphipathic, nonionic surfactants composed of fatty acid esters of polyoxyethylene sorbitan being polyoxyethylene sorbitan monolaurate for POE (20) sorbitan monooleate and polyoxyethylene sorbitan monooleate for polysorbate 80.
POE (20) sorbitan monooleate is a polysorbate surfactant which helps in stabilizing proteins and in protein membrane studies.
POE (20) sorbitan monooleate, dioxane free (sorbitan esters).
POE (20) sorbitan monooleate is in form of liquid.
Lemon to amber colored liquid; Yellow liquid
POE (20) sorbitan monooleate are oily liquids derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids.
Surfactants that are esters of plain (non-PEG-ylated) sorbitan with fatty acids are usually referred to by the name Span.
POE (20) sorbitan monooleate exist in form of oligomers.
All oligomers are separated on Primesep D HPLC column.
One of the oligomers can be used in quantitating polysorbate in various drug and food formulations.
POE (20) sorbitan monooleate is a viscous, water-soluble yellow liquid.
Dispersible in water, in anhydrous ethanol, in ethyl acetate and in methanol, practically insoluble in fatty oils, and in liquid paraffin
POE (20) sorbitan monooleate is a mixture of sorbitol, stearic acid (C18) and ethylene oxide, also known as polyoxyethylene (20) sorbitan monostearate.
A polysorbate is a substance that is derived from sorbitan esterified with fatty acids.
Among their uses are cosmetics to solubilize essential oils in water, pharmaceuticals, detergents, paints, and plastic applications.
POE (20) sorbitan monooleate is soluble in water and insoluble in vegetable oils and mineral oils.
USES and APPLICATIONS of POE (20) SORBITAN MONOOLEATE:
-POE (20) sorbitan monooleate is a high HLB surfactant suggested for use in, cosmetic applications, household products, textile chemicals and plastics.
-Used alone or combination with sorbitan fatty acid esters and glycerol fatty acid esters:whipped topping, coffee whitener, shortening for bread, semi sweet chocolate, salad dressing.
-POE (20) sorbitan monooleate is often used as a very effective stabilzer and emulsifier in a wide range of food products and industrial applications and is especially effective at forming stable emulsions, especially when combined with sorbitan esters.
-Oil in Water Emulsification, Adhesives & Cements, Boiler treatment additives, Dispersing agent in foam control products, Textile lubricants, Wax emulsions, Animal feed applications, Inks
-Polyoxyethylene (20) sorbitan monooleate, or POE 20S, is one of palm-based surfactants commonly used as adjuvant in pesticide formulation.
-As a reagent of the molecular biology grade, POE (20) sorbitan monooleate has been confirmed for DNase and RNase activities.
-In food, POE (20) sorbitan monooleate is more commonly used than polysorbate 80, although both are used.
-As an emulsifier for salad dressings and chocolates, POE (20) sorbitan monooleate is a non-ionic surfactant.
-When used in personal care formulations, POE (20) sorbitan monooleate is used as an emulsifier and thickener.
-POE (20) sorbitan monooleate can also be used as an oral care dispersant.
-POE (20) sorbitan monooleate has been widely used in the preparations of drugs, cosmetics, skin care products and food as a solubilizer, emulsifier and stabilizer.
-POE (20) sorbitan monooleate is a non-ionic, hydrophilic surfactant used to make oil-in-water emulsions.
-POE (20) sorbitan monooleate are mostly used in food among the category of Polysorbates.
-POE (20) sorbitan monooleate are the most commonly used in bakery food production.
-POE (20) sorbitan monooleate is a non-toxic, nonionic surfactant/emulsifier and a water-soluble yellowish liquid used as a dispersing agent which allows oil and water to mix without the use of alcohol.
-POE (20) sorbitan monooleate is a fragrance solubilizer and stabilizer, POE (20) sorbitan monooleate lubricates and has a soothing effect on the skin.
-POE (20) sorbitan monooleate is used extensively in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.) and also for body mists and linen sprays.
-A non-ionic detergent useful for the extraction of membrane-bound proteins as well as isolation of nuclei from mammalian cell lines.
-POE (20) sorbitan monooleate is a water dispersible nonionic surfactant used in a variety of agricultural formulations.
-POE (20) sorbitan monooleate is an ethoxylated sorbitan monooleate (POE 20) and used as an emulsifier and wetter.
-POE (20) sorbitan monooleate is a hydrophilic emulsifier and co-emulsifier for petroleum oils, fats, solvents and waxes.
-POE (20) sorbitan monooleate is used for the following applications: emulsifier concentrates, emulsion (oil and water), microemulsions, oil dispersions, suspo-emulsions, and soluble liquids.
-POE (20) sorbitan monooleate is a nonionic surfactant and emulsifier often used in foods and cosmetics.
-POE (20) sorbitan monooleate is a surfactant with numerous applications in food, pharmaceutical and cosmetics.
-POE (20) sorbitan monooleate can also use as an emulsifier for culture medium to reduce surface tension of the medium, which enhances the growth of cells.
-POE (20) sorbitan monooleate is also widely used in industrial productions such as, use as a wetting agent and dispersant for photographic film making; as a stabilizer and foaming agent for polyurethane foaming plastic.
-POE (20) sorbitan monooleate liquid, (a viscous, water-soluble yellow liquid), is used as an emulsifier in food manufacture including ice cream.
-POE (20) sorbitan monooleate makes the ice cream smoother and increases the resistance to melting.
By adding POE (20) sorbitan monooleate, POE (20) sorbitan monooleate prevents milk proteins from completely coating the fat droplets in ice cream.
By doing this POE (20) sorbitan monooleate allows them to join together and capture air in the mixture.
This provides a firmer texture.
-POE (20) sorbitan monooleate can also used in the manufacture of lotions, skin creams and hair care products.
When used, POE (20) sorbitan monooleate delivers a medium, fine textured result.
-POE (20) sorbitan monooleate can also be used as a spreading aid for bath oils, adding water dispersibility to anhydrous systems and a stabiliser for oils and fragrances.
-POE (20) sorbitan monooleate are a class of emulsifiers used in some pharmaceuticals and food preparation.
-POE (20) sorbitan monooleate are often used in cosmetics to solubilize essential oils into water-based products.
-Used as emulsifiers and dispersing agents in medicinal products, defoamers and emulsifiers in foods, and surfactants for pharmaceuticals
-POE (20) sorbitan monooleate is regularly used for the extraction of membrane proteins and isolation of nuclei from cells.
-POE (20) sorbitan monooleate is used extensively in oil-in-water emulsions (lotions, conditioners, cream rinses, shampoos, liquid soaps, body polishes or scrubs, etc.) and also for body mists and linen sprays.
-POE (20) sorbitan monooleate will be found as an ingredient in the majority of body toiletries, cosmetics and wipes now in the market.
-POE (20) sorbitan monooleate are generally used in combination with other emulsifiers such as mono- and diglycerides or sorbitan monostearates for various purposes such as to disperse flavors and colors, to make essential oils and vitamins soluble and to improve volume and texture in baked goods.
-Use: Hydrophilic emulsifier; solubilizer; dispersant; water soluble
-POE (20) sorbitan monooleate ensures effective delivery of actives by minimising drug interaction with the excipient. Recommended topical usage levels of 0.5-5%.
-POE (20) sorbitan monooleate is a highly hydrophilic surfactant and approved as a food additives.
POE (20) sorbitan monooleate is a useful emulsifier, dispersant and solubilizer for aroma chemiclas and oils.
Combination of EMASOL L-120V and highly lipophlic one of EMASOL-series lead to a giving an excellent emulsifier.
-Emulsifier and conditioning agent (low substantive effect).
-Detoxifying agent in shampoos (low irritation), Fragrances solubilizer.
-Emulsifier for pharmaceuticals and cosmetics, Stabilizer for color materials, Stabilizer for emulsion polymerizations, Emulsifier for adjuvant of agrochemicals, Emulsifier for water based metal process cutting oils, Surface coating type antistatic agents.
-POE (20) sorbitan monooleate is an oil-in-water emulsifier.
The pair of emulsifiers produces medium, fine-textured lotions and creams in skin and hair care products.
-POE (20) sorbitan monooleate also acts as a spreading aid for bath oils, adds water dispersibility to anhydrous systems and is a solubilizer for oils and fragrances.
-POE (20) sorbitan monooleate is a nonionic, solubilizer, o/w emulsifier, antistat and fiber lubricant used in textile industry, wetting agent, viscosity modifier, suspending agent used in food, cosmetics, drugs, textile and metal working industries, solubilizer for perfumes and flavours, insecticides, herbicides, paints and inks, pharmaceuticals.
-POE (20) sorbitan monooleate are used in the formulation of biotherapeutic products for both preventing surface adsorption and as stabilizers against protein aggregation.
-Emulsifier, stabiliser, flavouring agent, dispersant POE (20) sorbitan monooleate is a polysorbate surfactant whose stability and relative non-toxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
-A non-ionic detergent useful for the extraction of membrane-bound proteins as well as isolation of nuclei from mammalian cell lines.
-Emulsifier and dispersing agent; cosmetics, surfactant; foaming and defoaming agent; pharmaceuticals, shortenings and baked goods.
-Emulsifier and dispersing agent for medicinal products for internal use.
-POE (20) sorbitan monooleate used as emulsifier.
-Used as emulsifier, foaming agent, lubricant, solubilizing agent, antistatic agent, washing agent, penetrating agent, dispersing agent, degreasing agent and chemical intermediate in the industry.
-POE (20) sorbitan monooleate is a polysorbate surfactant which helps in stabilizing proteins and in protein membrane studies.
-POE (20) sorbitan monooleate is regularly used for the extraction of membrane proteins and isolation of nuclei from cells.
-POE (20) sorbitan monooleate has a broad range of application in biotechs:
*as a washing agent in immunoassays, such as Western blots and ELISAs.
POE (20) sorbitan monooleate helps to prevent non-specific antibody binding.
These buffers are used for washes between each immunoreactions, to remove unbound immunologicals, and eventually for incubation solutions of immunoreagents (labeled antibodies) to reduce unspecific background.
*as a solubilizing agent of membrane proteins.
Combined generally to other detergents, it is used at a concentration of 0.05% to 0.5% v/v for lysing mammalian cells.
However is not well dialysable.
*To stabilize proteins (i.e.PPD solution used in skin testing for tuberculosis exposure) or to saturate binding sites on
surfaces (i.e. to coat polystyrene microplates, generally combined to proteins such a s BSA).
-POE (20) sorbitan monooleate is also used in medicine as an emulsifier in the manufacture of medications and as part of an adjuvant of vaccines, in some eye drops, in food industry as an emulsifier in foods (particularly in ice cream).
-POE (20) sorbitan monooleate is used to stabilize immunoreagents.
-POE (20) sorbitan monooleate is also used in food industry as a wetting agent, and in pharma industry as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.
-Emulsifying, dispersing and solubilising agent for preparations for both internal and external use.
-Preparation of o/w type emulsions
-Preparation of w/o type emulsifiers.
-Emulsifier of mineral oils and fats in o/w emulsions.
-Solubiliser for water insoluble substances: vitamins, essential oils, fragrances, tannins, medicines, etc.
-Wetting agent. Preparation of o/w viscous milks and non-irritant gels and shampoos.
-Solubilisation of essential oils.
-Preparation of water-free pomades.
-Used as emulsifier, foaming agent, lubricant, solubilizing agent, antistatic agent, washing agent, penetrating agent, dispersing agent, degreasing agent and chemical intermediate in the industry.
-Effective emulsifier for industrial and textile lubricants
-Surfactants - Esters - Ethoxylates, Surfactants
-The function(s) performed by the food additive when used in cooking.
-Emulsifier - An agent that forms or preserves a mixture of substances normally incapable of being mixed eg. oil and water
-POE (20) sorbitan monooleate is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.
-POE (20) sorbitan monooleate In biological techniques and sciences, POE (20) sorbitan monooleate has a broad range of applications.
-POE (20) sorbitan monooleate is used as a washing agent in immunoassays, such as Western blots and ELISAs.
POE (20) sorbitan monooleate helps to prevent non-specific antibody binding.
In this major application, POE (20) sorbitan monooleate is dissolved in Tris-buffered saline or phosphate buffered saline at dilutions of 0.05% to 0.5% v/v.
These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.
-To saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).
-To stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosis exposure
-As a solubilizing agent of membrane proteins
-For lysing mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.
-POE (20) sorbitan monooleate is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.
-POE (20) sorbitan monooleate is used in many brands of baby wipes.
-POE (20) sorbitan monooleate is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.
-POE (20) sorbitan monooleate is also used as wetting agent in rubber balers in the elastomer industry.
-POE (20) sorbitan monooleate has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies.
-POE (20) sorbitan monooleate's stability and relative nontoxicity allows POE (20) sorbitan monooleate to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
FUNCTIONS of POE (20) SORBITAN MONOOLEATE:
-Adjuvant - Glyphosate adjuvant
-Adjuvant - Humectant
-Adjuvant - Leaf penetration aid
-O/W emulsifier
ALTERNATIVE PARENTS of POE (20) SORBITAN MONOOLEATE:
*Tetrahydrofurans
*Carboxylic acid esters
*Oxacyclic compounds
*Monocarboxylic acids and derivatives
*Dialkyl ethers
*Primary alcohols
*Organic oxides
*Hydrocarbon derivatives
*Carbonyl compounds
SUBSTITUENTS of POE (20) SORBITAN MONOOLEATE:
*Fatty acid ester
*Tetrahydrofuran
*Carboxylic acid ester
*Carboxylic acid derivative
*Dialkyl ether
*Ether
*Monocarboxylic acid or derivatives
*Organoheterocyclic compound
*Oxacycle
*Organic oxide
*Carbonyl group
*Alcohol
*Organooxygen compound
*Primary alcohol
*Hydrocarbon derivative
*Organic oxygen compound
*Aliphatic heteromonocyclic compound
PHYSICAL and CHEMICAL PROPERTIES of POE (20) SORBITAN MONOOLEATE:
Molecular Weight: 604.8
XLogP3-AA: 5.3
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 10
Rotatable Bond Count: 31
Exact Mass: 604.41864811
Monoisotopic Mass: 604.41864811
Topological Polar Surface Area: 133 Ų
Heavy Atom Count: 42
Formal Charge: 0
Complexity: 632
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 4
Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Appearance Form: liquid
Color: yellow
Odor: No data available
Odor Threshold: No data available
pH: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flash point: > 113 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: < 1,33 hPa at 20 °C
Vapor density: No data available
Relative density: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Autoignition temperature: No data available
Water Solubility: 0.018 g/L
logP: 2.75
logP: 2.39
logS: -4.5
pKa (Strongest Acidic): 14.64
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 9
Hydrogen Donor Count: 3
Polar Surface Area: 133.14 Ų
Rotatable Bond Count: 26
Refractivity: 134.25 m³·mol⁻¹
Polarizability: 60.33 ų
Number of Rings: 1
Bioavailability: No
Rule of Five: No
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule: No
FIRST AID MEASURES of POE (20) SORBITAN MONOOLEATE:
-Description of first-aid measures:
*After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*After swallowing:
Make victim drink water (two glasses at most).
ACCIDENTAL RELEASE MEASURES of POE (20) SORBITAN MONOOLEATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of POE (20) SORBITAN MONOOLEATE:
-Extinguishing media:
*Suitable extinguishing media:
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of POE (20) SORBITAN MONOOLEATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses.
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 30 min
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of POE (20) SORBITAN MONOOLEATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Store at room temperature.
-Specific end use(s):
No other specific uses are stipulated
STABILITY and REACTIVITY of POE (20) SORBITAN MONOOLEATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
SYNONYMS:
Kolliphor PS 20
Montanox 20
Polysorbate 20
PEG(20)sorbitan monolaurate
Alkest TW 20
Tween 20
Kotilen-20
Inhibited ethylene glycol, antifreeze
Polysorbate 80 (glycol)
sorbate80
EG Coolant 1
EG Coolant 2
EG Coolant 3
Tween™ 80
Polyoxyethylene 20 sorbitan monooleate
Polyoxyethylene (20)
Inhibited ethylene glycol
DSSTox_CID_1175
DSSTox_RID_75992
DSSTox_GSID_21175
SCHEMBL15879
Tox21_303472
NCGC00257261-01
2-hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-{2-[(9E)-octadec-9-enoyloxy]ethyl}hexofuranoside
CAS-9005-65-6
alkamuls PSML-20
cremophor PS 20
emasol L-120V
glycosperse L-20 KFG
hetsorb L-20
kaopan TW-L-120
liposorb L-20
lonzest SML-20
monebatt - 20
mulsifan SML-20
nikkol TL-10
norfox sorbo T-20
peg-20 sorbitan laurate
peg-20 sorbitan monolaurate
polyethylene glycol (20) sorbitan laurate
polyethylene glycol (20) sorbitan monolaurate
polyoxyethylene (20) sorbitan laurate
polyoxyethylene (20) sorbitan monolaurate
rheodol TW-L120
super refined polysorbate 20
T-maz 20K
tween 20
