POLOXAMER 184

POLOXAMER 184

POLOXAMER 184= POLYOXYETHYLENE POLYOXYPROPYLENE GLYCOL=Polyethylene-polypropylene glycol=Pluronic L64

CAS NUMBER:9003-11-6
EC NUMBER:618-355-0
Molecular Weight: 102.132
Molecular Formula:C5H10O2

⯈ DEFINITION OF POLOXAMER 184:
Poloxamer 184 is a polyoxyethylene, polyoxypropylene block polymer. 
Poloxamer 184 is a surfactant functioning both as cleansing and solubilizing agent
Poloxamer 184 is an interesting molecule with an oil-loving part in the middle surrounded by two water-loving parts. 
The numbers in the molecule refer to the overall molecular size and the water-loving part in it (40%).
Poloxamer 184, Surfactant is a nonionic triblock copolymer. 
Poloxamer 184 is made up of a main hydrophobic chain of polyoxypropylene bordered on each side by two hydrophilic chains of polyoxyethylene. 
Poloxamer 184 is in the form of a colorless or almost colorless liquid
Poloxamer 184 is a synthetic substance
Poloxamer 184 is a nonionic surfactant 
Poloxamer 184 has an amphiphilic structure (has both hydrophilic and lipophilic properties)
Poloxamer 184 is very gentle on the skin and mucous membranes.
Poloxamer 184 may contain impurities.
when Poloxamer 184 is applied to the skin, only a small amount should be absorbed and this absorption should take place slowly.
Poloxamer 184 is considered safe (if impurities are removed by appropriate steps or kept at permitted levels), non-irritating and non-sensitizing.
Poloxamer 184 -is the polymer of polyoxyethylene and polyoxypropylene.

Poloxamers are nonionic triblock copolymers composed of a central hydrophobic chain of polyoxypropylene (poly(propylene oxide)) flanked by two hydrophilic chains of polyoxyethylene (poly(ethylene oxide)). 
The word poloxamer was coined by BASF inventor, Irving Schmolka, who received the patent for these materials in 1973.
Poloxamers are also known by the trade names Pluronic, Kolliphor (pharma grade),and Synperonic.

⯈ USES/BENEFITS OF POLOXAMER 184: 
POLOXAMER 184 is classified as emulsifying and surfactant.
A synthetic polymer (a big molecule made of repeated units) that's used as a mild cleansing agent. 
Poloxamer 184 is also used in contact lens solutions and a regular on the ingredient lists of micellar cleansing waters.
Poloxamer 184 is almost half-half oil and water-soluble, likes to form micelles (molecules gathered into a ball form with oil-loving parts inside and water-loving parts outside)  and is claimed to be an effective cleansing agent.
Synperonic PE poloxamers find application as solubilizers, emulsifiers, surfactants, thermo-reversible gelling agents, wetting agents, foaming agents and defoaming agents, depending on different PEO/PPO indexes and molecular weights. 
Synperonic PE/L 64 (poloxamer 184) is a solubilizer with cleaning, wetting and dispersing properties.
Due to its non-ionic nature, Poloxamer 184 is miscible and compatible with almost all anionic and cationic surfactants. 
Poloxamer 184 do not react with calcium and magnesium cations present in hard water.

•Anti-foaming Agent / Defoamer 
Poloxamer 184 reduces or hinders the formation of foam.
•Drug / Medicine 
Poloxamer 184 is Used to treat, alleviate, cure or prevent sickness. 
As officially declared by a governmental drug/medicine regulatory body
•Surfactant 
Poloxamer 184 reduces the surface tension to allow mixtures to be formed evenly. 
Emulsifier is a specific type of surfactant which allows two liquids to mix together evenly

shortly,
•surfactant 
•cleansing agent
•solubilizing agent
•Emulsifier

Poloxamers have surfactant properties that make them useful in industrial applications because of their amphiphilic structures.
Among other things, poloxamers can be used to increase the water solubility of hydrophobic, oily substances or otherwise increase the miscibility of two substances with different hydrophobicities. 
For this reason, tpoloxamers are commonly used in industrial applications, cosmetics, and pharmaceuticals. 
Poloxamers have also been evaluated for various drug delivery applications and were shown to sensitize drug-resistant cancers to chemotherapy.

⯈ APPLICATIONS OF POLOXAMER 184:
Poloxamer 184 can be used in hair care products and cleansers.
Poloxamer 184 enhances the appearance and feel of hair.
Poloxamer 184 leaves the hair easy to comb, supple, soft and shiny and/or imparting volume, lightness, gloss, texture, etc. 
Poloxamer 184 maintains the skin in good condition.
Poloxamer 184 is used as a solvent and surfactant, mainly in a variety of cleaners, detergents and detergents.
Poloxamer 184 is a member of the family of poloxamers, polymers used as a cleaning agent, mild surfactant. 
Among this family, Poloxamer 184 is the softest and most non-irritating, but also has the strongest cleansing properties.
Poloxamer 184 is widely used in pharmaceuticals, because even suitable for lens solutions and oral products.
In cosmetics, Poloxamer 184 is used for mild cleansers and is an indispensable component for micellar waters.
In emulsions, Poloxamer 184 helps create a well-dispersed structure by helping to loosen surface tension.

In bioprocess applications, poloxamers are used in cell culture media for their cell cushioning effects because their addition leads to less stressful shear conditions for cells in reactors.
In materials science, the poloxamer P123 has recently been used in the synthesis of mesoporous materials, including SBA-15.
When poloxamers  are mixed with water, concentrated solutions of poloxamers can form hydrogels. 
These gels can be extruded easily, acting as a carrier for other particles, and used for robocasting.

Poloxamer 184 Market Size by Applications:
• Dermatology
Cleansing water, leather conditioner,lotions and creams,make-up removers,cleansers,wet wipes.
• Human Pharmaceutical
• Veterinary Health
• Others

Production Methods
Poloxamer polymers are prepared by reacting propylene oxide with propylene glycol to form polyoxypropylene glycol. 
Ethylene oxide is then added to form the block copolymer.

⯈ SAFETY MEASURES:
•First aid measures:
-Skin Contact 
Wash off immediately with soap and plenty of water removing all contaminated clothing and shoes. 
Get medical attention if irritation develops. 
Consult a physician if necessary
-Eye Contact: 
Flush eyes with water for 15 minutes.
Get medical attention if irritation occurs. 
If symptoms persist, call a physician.
-Ingestion
Do not induce vomiting without medical advice. 
Never give anything by mouth to an unconscious person

•Firefighting Measures:
Suitable Extinguishing Media: Carbon dioxide (CO2). Dry chemical. Water spray mist or foam.

•Handling and storage:
Provide sufficient air exchange and/or exhaust in work rooms. 
Remove all sources of ignition. Keep away from incompatible materials.

⯈ PHYSICAL PROPERTIES OF POLOXAMER 184:
Physical state: :Liquid
Odor:Polyol
Specific gravity:1.05
Melting point:57-61 °C
Boiling point:>200 °C(lit.)
Solubility: Soluble in Water
Solubility in Water at 25 deg. C: >10%
Flashpoint (°C/°F): >204 °C/>399 °F
PH Range: 5.0 - 7.5

⯈ SYNONYMS OF POLOXAMER 184:
PluronicL64
Polyoxyethylene-Polyoxypropylene Block Copolymer
Poly(Ethyleneoxide-co-Polypropylene oxide), Block 
Block Copolymer of Ethylene Oxide, 
Propylene Oxide and Propylene Glycol

⯈ ADDITIONAL INFORMATION ON POLOXAMER 184:
• Why is it used in cosmetics and personal care products?
Poloxamers help to form emulsions by reducing the surface tension of the substances to be emulsified and help other ingredients to dissolve in a solvent in which they would not normally dissolve. 
They also clean the skin and hair by helping water to mix with oil and dirt so that they can be rinsed away. 
Poloxamer 188 kills microorganisms, or prevents or inhibits their growth and reproduction. 
Poloxamer 182 Dibenzoate acts as a lubricant on the skin’s surface, which gives the skin a soft and smooth appearance.

•Poloxamer 184 Market Size by Types:
- Liquid
- Liquid Gel