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Poly(hexamethylene biguanide) hydrochloride (PHMB) is a highly water soluble and hydrolytically stable polymeric material.
Poly(hexamethylene biguanide) hydrochloride (PHMB) shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.
The presence of multiple hydrogen bond and chelation sites within Poly(hexamethylene biguanide) hydrochloride (PHMB) renders it of potential interest to those studying supramolecular chemical effects.
CAS: 32289-58-0
MF: (C8H17N5)n.xClH
MW: 213.32312
EINECS: 1308068-626-2
Synonyms
PHMB(20%);Polyhexamethyl;PHMB;Biguanide PHMB;Polyhexamethylene biguanidine hydrochloride,~20% in water;PHMB 98%, 20% solution (Polyhexamethylene biguanide hydrochloride);20% solution;98% powder
Poly(hexamethylene biguanide) hydrochloride (PHMB) is available also as 20% aqueous solution.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is best known for its broad-spectrum antimicrobial and antifungal activity.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions, such as Renu (Bauch & Lomb, Rochester, NY).
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a disinfectant and antiseptic.
In dermatological use, Poly(hexamethylene biguanide) hydrochloride (PHMB) is spelled polihexanide (INN) and sold under various brand names.
Poly(hexamethylene biguanide) hydrochloride (PHMB) has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumoniae.
Polihexanide, sold under the brand name Akantior is a medication used for the treatment of Acanthamoeba keratitis.
Products containing Poly(hexamethylene biguanide) hydrochloride (PHMB) are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, first aid, surface disinfection, and linen disinfection.
PHMB eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is sold as a swimming pool and spa disinfectant in place of chlorine or bromine based products under the name Baquacil.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors.
The Poly(hexamethylene biguanide) hydrochloride (PHMB) hydrochloride salt (solution) is used in the majority of formulations.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a colorless or light yellow transparent liquid, in which the guanidine group has high activity, which can make the polymer into a positive charge, and it is easily attacked by various negatively charged bacteria and bacteria.
The virus is adsorbed, thereby inhibiting the division ability of bacteria and viruses, making them lose their reproductive ability, and the film formed by the polymer blocks the respiratory channels of the microorganisms, causing the microorganisms to die quickly.
Guanidine group in this product has strong activity, making the polymer positive, so Poly(hexamethylene biguanide) hydrochloride (PHMB) is easy to be adsorbed by various bacteria and viruses that are usually negative, thus resisting the division function of bacteria and viruses, making the bacteria and viruses lose the reproductive ability.
In addition, the thin film formed by using Poly(hexamethylene biguanide) hydrochloride (PHMB) blocks the breathing channel of microorganisms, making microorganisms suffocate and die quickly.
Poly(hexamethylene biguanide) hydrochloride (PHMB) Chemical Properties
Storage temp.: Inert atmosphere,Room Temperature
Solubility: Water
Form: Solid
Color: White to off-white
InChI: InChI=1S/C10H23N5/c1-9(11)14-7-5-3-4-6-8-15-10(12)13-2/h3-8H2,1-2H3,(H2,11,14)(H3,12,13,15)
InChIKey: SAGIGHPRUJPLKX-UHFFFAOYSA-N
CAS DataBase Reference: 32289-58-0(CAS DataBase Reference)
EPA Substance Registry System: Poly(hexamethylene biguanide) hydrochloride (PHMB) (32289-58-0)
Poly(hexamethylene biguanide) hydrochloride (PHMB) is also used as a surface disinfectant and is alleged to be suitable for skin disinfection.
Poly(hexamethylene biguanide) hydrochloride (PHMB) has a slow effectand does not meet the practical requirementsfor prophylactic antiseptics in this respect.
Although Poly(hexamethylene biguanide) hydrochloride (PHMB) is somewhat less effective than benzalkonium chloride, it is sometimes used instead of benzalkonium because it is less foamproducing under use conditions.
Polyhexamethylene biguanide hydrochloride (PHMB) is a new environment-friendly cationic water-soluble polymer.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a water solution that can be used as a broad spectrum and high efficient disinfectant.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic.
Because of its special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.
Application
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a polymer used as a disinfectant and antiseptic.
In dermatological use, Poly(hexamethylene biguanide) hydrochloride (PHMB) is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide.
Poly(hexamethylene biguanide) hydrochloride (PHMB) has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).
Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in oil field chemicals, water treatment chemicals, daily chemicals, textile printing and dyeing, swimming pool disinfection, flower antiseptic treatment, animal husbandry, aquaculture, agriculture, pet antibacterial, soil improvement, environmental disinfection, disinfection products, etc.
In aquaculture, Poly(hexamethylene biguanide) hydrochloride (PHMB) can rapidly inhibit Gram-negative bacteria, floating Vibrio, Vibrio parahaemolyticus, Vibrio algolyticus and other harmful bacteria in seawater, and has good preventive and therapeutic effects on various diseases caused by bacteria in South American white shrimp and other aquatic products.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a kind of broad-spectrum antibacterial agent recognized as the safest and most efficient in the 21st century.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is colorless and odorless, has low bacteriostatic concentration, broad-spectrum and low toxicity, fast action, low foam volume, and can After forming a layer of cations on the surface of the article for a long time, it will not cause bacteriostasis, and it will not cause antibacterial bacteria.
Poly(hexamethylene biguanide) hydrochloride (PHMB) is currently widely used in medical devices, public environments, home, fabrics, food, milk, and care products. .
Poly(hexamethylene biguanide) hydrochloride (PHMB) is widely used in medical and health, daily chemicals, textiles, paper, wet wipes, animal husbandry, breeding, aquatic products, plastics, agriculture, water treatment and other fields.
As a medicinal product, Poly(hexamethylene biguanide) hydrochloride (PHMB) is used for disinfection of contact lenses, eye drops, and surgical procedures.
Due to the strong tolerance of the eyes to PHMB.
Poly(hexamethylene biguanide) hydrochloride (PHMB) can be used as a drug for the treatment of Acanthopanaxa Miba keratitis and the prevention and treatment of other eye diseases.
At the same time, Poly(hexamethylene biguanide) hydrochloride (PHMB) is also widely used in cosmetics, personal care products, textiles, food industries, etc.
Medical uses
Poly(hexamethylene biguanide) hydrochloride (PHMB) is indicated for the treatment of Acanthamoeba keratitis in people aged 12 years of age and older.
Preparation
The preparation method of Poly(hexamethylene biguanide) hydrochloride (PHMB):By a certain proportion of 1; the own bisguanides of 6-and catalyst join in reaction vessel; under nitrogen protection, said mixture is heated to 80-200 DEGC and reacts, react 2-24 hour; reaction terminates; cooling blowing, obtains poly hexamethylene biguanide, poly hexamethylene biguanide aqueous acid is neutralized to pH value 5-9; and performing filtering so as to obtain a polyhexamethylene biguanidine salt.
Biological Activity
Poly(hexamethylene biguanide) hydrochloride (PHMB) is a cationic polymer with antimicrobial and antiviral properties.
Poly(hexamethylene biguanide) hydrochloride (PHMB) has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.
