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CAS NO:32289-58-0
EC NO:608-723-9
Poly(hexamethylene) biguanide hydrochloride is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under the names Lavasept, Serasept, Prontosan, and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumoniae.
Products containing Poly(hexamethylene) biguanide hydrochloride are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, first aid, surface disinfection, and linen disinfection.
Poly(hexamethylene) biguanide hydrochloride eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.
Poly(hexamethylene) biguanide hydrochloride is sold as a swimming pool and spa disinfectant in place of chlorine or bromine based products under the name Baquacil.
Poly(hexamethylene) biguanide hydrochloride is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products.
Poly(hexamethylene) biguanide hydrochloride is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors.
The Poly(hexamethylene) biguanide hydrochloride hydrochloride salt (solution) is used in the majority of formulations.
Poly(hexamethylene) biguanide hydrochloride is a highly water soluble and hydrolytically stable polymeric material. The presence of multiple hydrogen bond and chelation sites within PHMB renders it of potential interest in the field of supramolecular chemistry.
Poly(hexamethylene) biguanide hydrochloride shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.
Poly(hexamethylene) biguanide hydrochloride is available also as a solid.
A hydrochloride salt of polyhexamethylene biguanide.
Poly(hexamethylene) biguanide hydrochloride is a broad spectrum and fast acting bactericide which is used for the formulation of disinfectants and sanitisers.
Properties:
Melting:
0 °C (32 °F)
Boiling:
100 °C (212 °F)
Flash Pt.:
Noncombustible
Polyhexamethylene biguanide hydrochloride (PHMB) is a chemical biocide which is a polymer utilized in a wide variety of antimicrobial applications.
Polyhexamethylene biguanide hydrochloride (PHMB-HCl) is widely used as a disinfectant in personal care products such as cosmetics and toiletries and as a sanitizer in swimming pools.
Poly(hexamethylene) biguanide hydrochloride is used in the stabilization of fabric linings in shoes. Biguanide solution used in cleaning contact lenses.
Poly(hexamethylene) biguanide hydrochloride is a polymer used as a sanitizer or preservative to kill bacteria.
Poly(hexamethylene) biguanide hydrochloride is used as an antimicrobial hand wash and sanitization and in air filtration treatment as an alternative to ozone.
Poly(hexamethylene) biguanide hydrochloride is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms. As a preservative, PHMB is used in cosmetics, personal care products, fabric softeners, contact lens solutions and more.
Poly(hexamethylene) biguanide hydrochloride is widely used in environmental disinfection including hospitals, schools, hotels, and public places.
Molecular Formula: C18H41ClN10
Molar Mass: 433.038
Poly(hexamethylene) biguanide hydrochloride is best known for its broad-spectrum antimicrobial and antifungal activity.
Poly(hexamethylene) biguanide hydrochloride is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions, such as Renu (Bauch & Lomb, Rochester, NY).
Poly(hexamethylene) biguanide hydrochloride is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.
Poly(hexamethylene) biguanide hydrochloride is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).
Poly(hexamethylene) biguanide hydrochloride is an antimicrobial agent active against both Gram-positive and Gram-negative bacteria.
Poly(hexamethylene) biguanide hydrochloride is used in antiseptic, disinfectant and cosmetics.
Poly(hexamethylene) biguanide hydrochloride can be used as a disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant, etc.
Widely used in health care, chemicals, textiles, paper, wipes, livestock, aquaculture, fisheries, plastics, agriculture, water treatment and other fields.
Poly(hexamethylene) biguanide hydrochloride can be used directly after dilution with purified water or with other additive agent compounds.
Poly(hexamethylenebiguanide) hydrochloride is an antimicrobial agent, which can be used in medical, apparel, and household textile sectors.
IUPAC names:
poly(hexamethylenebiguanide) hydrochloride
Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene),hydrochloride (8CI)
Poly[iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl] hydrochloride
Polyaminopropyl Biguanide, HCl
polyhexamethylene biguanide hydrochloride; PHMB
SYNONYMS:
PHMB
Polihexanide
Polihexanido
Polihexanido [INN-Spanish]
Polihexanidum
Polihexanidum [INN-Latin]
Poly(hexamethylenebiguanide hydrochloride)
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl), hydrochloride
Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) hydrochloride
Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride
Polyhexanide
poly(hexamethylenebiguanide) hydrochloride
Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride
Polihexanide
POLY(HEXAMETHYLENEBIGUANIDE) HCL
Polyhexamethylene biguanidine
Acticide SR 1296
Arlagard E
BG 1
BG-IR
Cosmocil
Lavasept
Lonzabac BG 1
Polyhexanide Discontinued
Poly-(hexamethylenbiguanid)hydrochlorid
polihexanidum
Poly(hexamethylene diguanide) hydrochloride
