POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE

Poly(hexamethylene) biguanide hydrochloride is used as an antimicrobial hand wash and sanitization and in air filtration treatment as an alternative to ozone.
Poly(hexamethylene) biguanide hydrochloride is also used as an active ingredient for recreational water treatment.
Poly(hexamethylene) biguanide hydrochloride is also used as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms.

CAS Number: 32289-58-0; 27083-27-8
EC Number: 1308068-626-2
Chemical Name:Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride
Chemical Formula: (C8H17N5)n•(HCl)x
Molecular Weight: ≥1,600～2,600

SYNONYMS:
biguanide phmb, polyhexamethylene biguanidine, polihexanide, polyhexanide hydrochloride, Poly(hexamethylenebiguanide) hydrochloride, Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride, PHMB (Poly Hexa Methylene Biguanide), Polyhexamethylene biguanidine Hydrochloride, Pure Polyhexamethylene biguanide Hydrochloride (PHMB) CAS 32289-58-0, Poly(hexamethylenebiguanide) Hcl, Poly(hexamethylenebiguanide)hydrochloride, Polyhexamethylene biguanide, Polyhexamethylene guanide, Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride, Poly(hexamethylenebiguanide), Polihexanide, Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride, biguanide phmb, polyhexamethylene biguanidine, polihexanide, polyhexanide hydrochloride, Poly(hexamethylenebiguanide) hydrochloride, Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride, PHMB(Poly Hexa Methylene Biguanide), Polyhexanide hydrochloride, Polyhexamethylene biguanide hydrochloride, 1-(diaminomethylidene)-2-hexylguanidine hydrochloride, PHMB, Polyhexamethylene biguanide, Poly(hexamethylene) biguanide hydrochloride, Polyhexamethylene biguanide hydrochloride, Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride, N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hydrochloride, biguanide phmb, polyhexamethylene biguanidine, polihexanide, polyhexanide hydrochloride, Poly(hexamethylenebiguanide) hydrochloride, Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride, PHMB (Poly Hexa Methylene Biguanide), Polyhexamethylene biguanidine Hydrochloride, Pure Polyhexamethylene biguanide Hydrochloride (PHMB) CAS 32289-58-0, Poly(hexamethylenebiguanide) Hcl, Poly(hexamethylenebiguanide)hydrochloride, Polyhexamethylene biguanide, Polyhexamethylene guanide, Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride, Poly(hexamethylenebiguanide), Polihexanide, Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride, biguanide phmb, polyhexamethylene biguanidine, polihexanide, polyhexanide hydrochloride, Poly(hexamethylenebiguanide) hydrochloride, Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride, PHMB(Poly Hexa Methylene Biguanide), Polyhexanide hydrochloride, Polyhexamethylene biguanide hydrochloride, 1-(diaminomethylidene)-2-hexylguanidine hydrochloride, PHMB, Polyhexamethylene biguanide, Poly(hexamethylene) biguanide hydrochloride, Polyhexamethylene biguanide hydrochloride, Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride, N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hydrochloride, Poly(hexamethylenebiguanide) hydrochloride, Poly(hexamethylenebicyanoguanide-hexamethylenediamine) hydrochloride, PHMB(Poly Hexa Methylene Biguanide), Polyhexamethylene biguanidine Hydrochloride, Polyhexamethylene biguanide, Polyhexamethylene guanide, Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride, Poly(hexamethylenebiguanide), Polihexanide, Akantior, Lavasept, Tebasept, Prontosan, PHMB, Polihexanide, PHMB(20%), Polihexanide HCl, Polyhexamethylene Biguanidine HCl, BG 1, BG-IR, 99%PHMB, PHMB 98, PHMB HCl

Poly(hexamethylene) biguanide hydrochloride, often abbreviated as PHMB, is a polymer that has gained significant attention in various fields, particularly in healthcare and consumer products.
Known for its broad-spectrum antimicrobial properties and biocompatibility, Poly(hexamethylene) biguanide hydrochloride has found applications ranging from medical disinfection to personal care products.

Poly(hexamethylene) biguanide hydrochloride is a versatile polymer with potent antimicrobial properties, making it invaluable in healthcare, consumer products, and industrial applications.
Its ability to disrupt microbial membranes and biofilms while maintaining biocompatibility has established Poly(hexamethylene) biguanide hydrochloride as a key ingredient in wound care, personal care products, and beyond.

As research continues to explore its efficacy, safety profile, and environmental impact, Poly(hexamethylene) biguanide hydrochloride remains a potential drug for addressing current and future challenges in antimicrobial control and public health.
Poly(hexamethylene) biguanide hydrochloride may also be called polihexanide.

Poly(hexamethylene) biguanide hydrochloride does not occur naturally in the environment.
Disinfection and sanitization: Poly(hexamethylene) biguanide hydrochloride is used in the formulation of disinfectants and sanitizers for various purposes, including cleaning medical equipment, surfaces, and textiles in healthcare settings.

Personal care products: Poly(hexamethylene) biguanide hydrochloride is found in a variety of personal care products, such as wound care products, contact lens solutions, and hand sanitizers, where its antimicrobial properties help prevent infections.
Water treatment: Poly(hexamethylene) biguanide hydrochloride is used in swimming pools, spas, and other water systems to control microbial growth and maintain water quality.

Agriculture: Poly(hexamethylene) biguanide hydrochloride can be used to protect crops from fungal and bacterial diseases, as well as in seed treatments to prevent contamination.
Industrial applications: Poly(hexamethylene) biguanide hydrochloride is also used in industrial settings for microbial control in cooling towers, oilfield operations, and other processes where microbial contamination can be a concern.

Overall, the antimicrobial properties of Poly(hexamethylene) biguanide hydrochloride make it a versatile compound with a wide range of applications in various industries.
Poly(hexamethylene) biguanide hydrochloride is an antimicrobial and antiviral agent.

Poly(hexamethylene) biguanide hydrochloride is active against both Gram-positive and Gram-negative bacteria.
Poly(hexamethylene) biguanide hydrochloride works by adsorbing to the surface of cellulose, which can damage microbial cell membranes and interfere with metabolism.

Poly(hexamethylene) biguanide hydrochloride is best known for its broad-spectrum antimicrobial and antifungal activity.
Poly(hexamethylene) biguanide hydrochloride is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions, such as Renu (Bauch & Lomb, Rochester, NY).

Poly(hexamethylene) biguanide hydrochloride is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.
Poly(hexamethylene) biguanide hydrochloride, also known as PHMB-HCl, is a disinfectant and antiseptic agent commonly used in healthcare settings and consumer products.

Poly(hexamethylene) biguanide hydrochloride is effective against a wide range of bacteria, viruses, and fungi, making it a versatile ingredient for various applications such as wound care, surgical preparation, and surface disinfection.
Poly(hexamethylene) biguanide hydrochloride is known for its high efficacy and low toxicity, making it a popular choice for use in hospitals, clinics, and household cleaning products.

USES and APPLICATIONS of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
Wound care: Poly(hexamethylene) biguanide hydrochloride is used in wound dressings and solutions for its antimicrobial properties and ability to promote wound healing.
Medical equipment: Disinfection and sterilization of medical instruments and devices to prevent healthcare-associated infections.

Contact lenses: Incorporated into contact lens solutions for Poly(hexamethylene) biguanide hydrochloride's antimicrobial effects against pathogens that can cause eye infections.
Poly(hexamethylene) biguanide hydrochloride is widely used in personal care and household products.

Poly(hexamethylene) biguanide hydrochloride is used as an antimicrobial hand wash and sanitization and in air filtration treatment as an alternative to ozone.
Poly(hexamethylene) biguanide hydrochloride is also used as an active ingredient for recreational water treatment.

Poly(hexamethylene) biguanide hydrochloride is also used as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms.
Skin care: Found in antibacterial soaps, hand sanitizers, and body washes for Poly(hexamethylene) biguanide hydrochloride's ability to kill bacteria and fungi without causing skin irritation.

Cosmetics: Poly(hexamethylene) biguanide hydrochloride is used as a preservative in cosmetics and skincare products to prevent microbial contamination and extend product shelf life.
As a preservative, Poly(hexamethylene) biguanide hydrochloride is used in cosmetics.

As a preservative, Poly(hexamethylene) biguanide hydrochloride is used in personal care products.
Poly(hexamethylene) biguanide hydrochloride may also be used as an antiseptic, sanitizer or deodorizer in textiles, pet litter, wet wipes, air filter treatments and veterinary products, recreational water treatment, and preservation of hides and skins.

Poly(hexamethylene) biguanide hydrochloride may also be used as an antiseptic, sanitizer or deodorizer in disinfectant solutions and wet wipes.
Poly(hexamethylene) biguanide hydrochloride may also be found in food if the food preparation surface has been treated with sanitizers and disinfectants that contain PHMB.

Poly(hexamethylene) biguanide hydrochloride is a polymer used as a disinfectant and antiseptic.
In dermatological use, Poly(hexamethylene) biguanide hydrochloride is spelled polihexanide (INN) and sold under various brand names.
Poly(hexamethylene) biguanide hydrochloride has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumoniae.

Products containing Poly(hexamethylene) biguanide hydrochloride are used for inter-operative irrigation.
Products containing Poly(hexamethylene) biguanide hydrochloride are used for pre- and post-surgery skin and mucous membrane disinfection.
Poly(hexamethylene) biguanide hydrochloride's found in a wide range of products available to consumers.

Poly(hexamethylene) biguanide hydrochloride's used as an antimicrobial agent or preservative in fabric softeners, medical devices, cosmetics, such as deodorants, and moisturizers.
Poly(hexamethylene) biguanide hydrochloride is also used as an ingredient in personal deodorants.

Poly(hexamethylene) biguanide hydrochloride's used as an antimicrobial agent or preservative in cosmetics, such as bath products, cosmetics, such as nail care products, cosmetics, such as hair styling products, cosmetics, such as shampoos and conditioners, cosmetics, such as cleansers and make-up removers, contact lens solutions.

Products containing Poly(hexamethylene) biguanide hydrochloride are used for post-operative dressings.
Poly(hexamethylene) biguanide hydrochloride is used as an antimicrobial agent or preservative in non-prescription drugs, natural health products, hand washes, sanitizers and rubs.

Products containing Poly(hexamethylene) biguanide hydrochloride are used for surgical and non-surgical wound dressings.
Products containing Poly(hexamethylene) biguanide hydrochloride are used for surgical bath/hydrotherapy.
Poly(hexamethylene) biguanide hydrochloride eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.

Poly(hexamethylene) biguanide hydrochloride is sold as a swimming pool and spa disinfectant in place of chlorine or bromine based products under the name Baquacil.
Poly(hexamethylene) biguanide hydrochloride is also used as an ingredient in some contact lens cleaning products.

Poly(hexamethylene) biguanide hydrochloride is also used as an ingredient in cosmetics.
Poly(hexamethylene) biguanide hydrochloride is used in the majority of formulations.
As a sanitizer, Poly(hexamethylene) biguanide hydrochloride is used to control odour in textiles.

As a sanitizer, Poly(hexamethylene) biguanide hydrochloride is used to prevent microbial contamination in wound irrigation and sterile dressings.
As a sanitizer, Poly(hexamethylene) biguanide hydrochloride is used to disinfect medical/dental utensil and trays.

Poly(hexamethylene) biguanide hydrochloride is also used as an ingredient in personal deodorants.
Poly(hexamethylene) biguanide hydrochloride is also used as an ingredient in some veterinary products.
Poly(hexamethylene) biguanide hydrochloride is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors.

Poly(hexamethylene) biguanide hydrochloride is used in Acanthamoeba keratitis treatment.
Poly(hexamethylene) biguanide hydrochloride is indicated for the treatment of Acanthamoeba keratitis in people aged 12 years of age and older.
Poly(hexamethylene) biguanide hydrochloride is a polymer used as a sanitizer or preservative to kill bacteria.

As a sanitizer, Poly(hexamethylene) biguanide hydrochloride is used to preserve wet wipes.
As a preservative, Poly(hexamethylene) biguanide hydrochloride is used in fabric softeners.
Poly(hexamethylene) biguanide hydrochloride is widely used in medical, clothing and household textiles, and cosmetic fields.

As a preservative, Poly(hexamethylene) biguanide hydrochloride is used in contact lens solutions.
As a sanitizer, Poly(hexamethylene) biguanide hydrochloride is used to sterilize institutions such as hospitals and schools.
As a sanitizer, Poly(hexamethylene) biguanide hydrochloride is used to deodorize vacuums machines and toilets.

As a preservative, Poly(hexamethylene) biguanide hydrochloride is used in more products.
Poly(hexamethylene) biguanide hydrochloride is widely used in environmental disinfection including hospitals, schools, hotels, and public places.

As a sanitizer, Poly(hexamethylene) biguanide hydrochloride is used to sterilize farm equipment.
As a sanitizer, Poly(hexamethylene) biguanide hydrochloride is used to sterilize animal drinking water.
As a sanitizer, Poly(hexamethylene) biguanide hydrochloride is used to sterilize hard surfaces for food handling.

Products containing Poly(hexamethylene) biguanide hydrochloride are used for chronic wounds like diabetic foot ulcer and burn wound management.
Products containing Poly(hexamethylene) biguanide hydrochloride are used for routine antisepsis during minor incisions.

Products containing Poly(hexamethylene) biguanide hydrochloride are used for catheterization, first aid, surface disinfection, linen disinfection.
Poly(hexamethylene) biguanide hydrochloride is a polymer used as a disinfectant and antiseptic.

In dermatological use, Poly(hexamethylene) biguanide hydrochloride is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide.

Poly(hexamethylene) biguanide hydrochloride has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).
Uses of Poly(hexamethylene) biguanide hydrochloride: Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes

-Industrial and environmental applications of Poly(hexamethylene) biguanide hydrochloride:
*Water treatment: 
Poly(hexamethylene) biguanide hydrochloride is employed in water purification systems to control microbial growth and maintain water quality.

*Textiles: 
Poly(hexamethylene) biguanide hydrochloride is incorporated into fabrics and textiles to impart antimicrobial properties, reducing odor-causing bacteria and fungi.

PROPERTIES AND APPLICATIONS of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
Poly(hexamethylene) biguanide hydrochloride is a new environment-friendly cationic water-soluble polymer.
Poly(hexamethylene) biguanide hydrochloride is a water solution that can be used as a broad spectrum and high efficient disinfectant.

Poly(hexamethylene) biguanide hydrochloride is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic.
Because of Poly(hexamethylene) biguanide hydrochloride's special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.

PHYSICOCHEMICAL PROPERTIES of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
Some of the key physicochemical properties of polyhexamethylene biguanide hydrochloride include:

Molecular formula: 
The molecular formula of Poly(hexamethylene) biguanide hydrochloride is (C8H17N5)n•(HCl)x, n=12-16.

Solubility: 
Polyhexamethylene biguanide hydrochloride is highly soluble in water, which allows it to be easily dispersed in aqueous solutions.

Appearance: 
Poly(hexamethylene) biguanide hydrochloride typically appears as a colorless to slightly yellowish liquid or solid, depending on its concentration and form.

Stability: 
Poly(hexamethylene) biguanide hydrochloride is stable under normal conditions but may degrade when exposed to high temperatures or ultraviolet light.

pH: 
The pH of solutions containing Poly(hexamethylene) biguanide hydrochloride may vary depending on the concentration and formulation; however, it is typically acidic due to the presence of hydrochloride ions.

Viscosity: 
Poly(hexamethylene) biguanide hydrochloride solutions exhibit viscosity, which can vary based on the concentration and temperature of the solution.

Chemical structure: 
Poly(hexamethylene) biguanide hydrochloride is a polymeric compound consisting of repeating units of hexamethylene biguanide monomers linked by amide bonds.
Overall, Poly(hexamethylene) biguanide hydrochloride possesses physicochemical properties that make it suitable for various applications, including use as a disinfectant, preservative, and antimicrobial agent in a wide range of products and industries.

CHEMICAL PROPERTIES of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
Poly(hexamethylene) biguanide hydrochloride is  a colorless to pale yellow solution
Poly(hexamethylene) biguanide hydrochloride is also used as a surface disinfectant and is alleged to be suitable for skin disinfection.
Poly(hexamethylene) biguanide hydrochloride has a slow effectand does not meet the practical requirementsfor prophylactic antiseptics in this respect.
Although Poly(hexamethylene) biguanide hydrochloride is somewhat less effective than benzalkonium chloride, it is sometimes used instead of benzalkonium because it is less foamproducing under use conditions.

PREPARATION of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
The preparation method of Poly(hexamethylene) biguanide hydrochloride:By a certain proportion of 1; the own bisguanides of 6-and catalyst join in reaction vessel; under nitrogen protection, said mixture is heated to 80-200 DEGC and reacts, react 2-24 hour; reaction terminates; cooling blowing, obtains poly hexamethylene biguanide, poly hexamethylene biguanide aqueous acid is neutralized to pH value 5-9; and performing filtering so as to obtain a polyhexamethylene biguanidine salt.

BIOLOGICAL ACTIVITY of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
Poly(hexamethylene) biguanide hydrochloride is a cationic polymer with antimicrobial and antiviral properties.
It has been commonly accepted that the antimicrobial activity is due to the ability of Poly(hexamethylene) biguanide hydrochloride to perforate the bacterial phospholipid membrane leading ultimately to its death.

CURRENT RESEARCH AND FUTURE DIRECTIONS of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
Ongoing research on Poly(hexamethylene) biguanide hydrochloride focuses on:
*Enhancing efficacy: 
Developing novel formulations and delivery systems to improve antimicrobial efficacy and stability.

*Biomedical applications: 
Exploring new medical applications, such as drug delivery systems and tissue engineering scaffolds.

*Environmental impact: 
Assessing the environmental fate of Poly(hexamethylene) biguanide hydrochloride and developing eco-friendly alternatives or mitigation strategies.

CHEMICAL STRUCTURE AND COMPOSITION of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
Poly(hexamethylene) biguanide hydrochloride belongs to the family of polymeric biguanides, characterized by repeating units of biguanide groups linked together.
The chemical structure of Poly(hexamethylene) biguanide hydrochloride consists of alternating hexamethylene and biguanide groups, typically in a linear polymer form.
The molecular formula of Poly(hexamethylene) biguanide hydrochloride can be represented as (C8H17N5) n·HCl, where n denotes the number of repeating units in the polymer chain.

MECHANISMS OF ACTION of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
Poly(hexamethylene) biguanide hydrochloride exhibits its antimicrobial activity through several mechanisms:
*Cell membrane disruption: 
Poly(hexamethylene) biguanide hydrochloride interacts with microbial cell membranes, leading to disruption of membrane integrity.
This disruption results in leakage of cellular contents and eventual cell death.

*Binding to nucleic acids: 
Poly(hexamethylene) biguanide hydrochloride can also bind to microbial nucleic acids like Deoxyribonucleic Acid (DNA) Ribonucleic Acid and (RNA), interfering with their replication and transcription processes, thereby inhibiting microbial growth.

*Biofilm disruption: 
Poly(hexamethylene) biguanide hydrochloride has been shown to disrupt biofilms formed by bacteria, fungi, and other microorganisms.
Biofilms are communities of microorganisms embedded within a protective matrix, and their disruption is critical in medical and industrial settings.

SAFETY CONSIDERATIONS of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
While Poly(hexamethylene) biguanide hydrochloride is generally considered safe for its intended uses, several factors warrant consideration:

*Skin sensitization: 
Some individuals may experience skin irritation or allergic reactions, although Poly(hexamethylene) biguanide hydrochloride is less sensitizing compared to other antimicrobial agents.

*Environmental impact: 
Concerns exist regarding the environmental persistence of PHMB and its potential effects on aquatic ecosystems.
Regulations and guidelines are in place to manage its use and disposal.

*Resistance development: 
Like other antimicrobial agents, there is a potential for microorganisms to develop resistance to PHMB over time.
Proper use and management strategies are essential to mitigate this risk.

PHYSICAL and CHEMICAL PROPERTIES of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
CAS No.: 32289-58-0
Molecular Formula: (C8H18N5Cl)n   n=12-16
Appearance: White powder, colorless translucent crystals, colorless liquid
Purity: 95%, 98%, ≥98%, 20%, 25%, 50%
Density (20℃): 1.039~1.046g/cm3
pH value (20℃): 4.0~6.0
Absorbance (237nm): ≥400
Absorbance (237nm/222nm): 1.2~1.6
Active substance: Polyhexamethylene biguanide Hydrochloride (PHMB) 
CAS 32289-58-0 

Poly(hexamethylenebiguanide) Hcl
Content (wt%): 20
Water (wt%): 80 max.
Total metal (ppm): 100 max.
Odor: No odor
Boiling point (°C): 102-103
Specific gravity @25°C (g/cm3): 1.03-1.05
Solubility in water (20°C): Very good
HS Code: 29121900

Color of Liquid: Clear to Slight Haze
Water Solubility: Miscible
Application: Biocides, Water Treatment, Disinfectant
Appearance: Colorless or light-yellow solid
Active ingredient: ≥99%
Water soluble: 100% soluble
Odor: Light ammonia smell
Moisture content: ≤0.5%
Water insoluble matter: ≤0.1%

PH in 1% aqueous solution: >4
Ash: 0.05%
Active substance: Polyhexamethylene biguanide Hydrochloride (PHMB) 
CAS: 32289-58-0 Poly(hexamethylenebiguanide) Hcl
Appearance: slightly yellow to colorless & clear
Content (wt%): 20
Water (wt%): 80max.
Total metal (ppm): 100max
Ordor: no ordor. PH (20% water): 3.0-5.5

Boling point(°C): 102-103
Specific gravity @25°C (g/cm3):1.03-1.05
Solubility in water (20°C): very good
Appearance: Colorless or pale-yellow transparent liquid
Boiling point(℃): 102
Content (%): 19.0-21.0
Relative density(g/ml,25℃): 1.04
pH: 4.0-6.0
Name: Polyhexamethylene biguanide hydrochloride; PHMB 

CAS No.: 32289-58-0 
Formula: (C8H17N5)n•xHCl
Molecular Weight: ≥1,600～2,600
CAS: 32289-58-0 Poly(hexamethylenebiguanide) Hcl
Appearance: slightly yellow to colorless & clear
Content (wt%): 20
Water (wt%): 80max.
Total metal (ppm): 100max

Ordor: no ordor. PH (20% water): 3.0-5.5
Boling point(°C): 102-103
Specific gravity @25°C (g/cm3):1.03-1.05
Solubility in water (20°C): very good
Appearance: Colorless or pale-yellow transparent liquid
Boiling point(℃): 102
Content (%): 19.0-21.0
Relative density(g/ml,25℃): 1.04
pH: 4.0-6.0

Name: Polyhexamethylene biguanide hydrochloride; PHMB 
CAS No.: 32289-58-0 
Formula: (C8H17N5)n•xHCl
Molecular Weight: ≥1,600～2,600
CAS No.: 32289-58-0
Molecular Formula: (C8H18N5Cl)n   n=12-16
Appearance: White powder, colorless translucent crystals, colorless liquid
Purity: 95%, 98%, ≥98%, 20%, 25%, 50%
Density (20℃): 1.039~1.046g/cm3

pH value (20℃): 4.0~6.0
Absorbance (237nm): ≥400
Absorbance (237nm/222nm): 1.2~1.6
Active substance: Polyhexamethylene biguanide Hydrochloride (PHMB) 
CAS 32289-58-0 
Poly(hexamethylenebiguanide) Hcl
Content (wt%): 20
Water (wt%): 80 max.
Total metal (ppm): 100 max.

Odor: No odor
Boiling point (°C): 102-103
Specific gravity @25°C (g/cm3): 1.03-1.05
Solubility in water (20°C): Very good
HS Code: 29121900
Color of Liquid: Clear to Slight Haze
Water Solubility: Miscible
Application: Biocides, Water Treatment, Disinfectant
Appearance: Colorless or light-yellow solid

Active ingredient: ≥99%
Water soluble: 100% soluble
Odor: Light ammonia smell
Moisture content: ≤0.5%
Water insoluble matter: ≤0.1%
PH in 1% aqueous solution: >4
Ash: 0.05%
Active substance: Polyhexamethylene biguanide Hydrochloride (PHMB) 

FIRST AID MEASURES of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
-Description of first-aid measures:
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Make victim drink water (two glasses at most). 
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
-Environmental precautions
Do not let product enter drains.
-Methods and materials for containment and cleaning up
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
-Extinguishing media:
*Suitable extinguishing media:
Water 
Foam 
Carbon dioxide (CO2) 
Dry powder
*Unsuitable extinguishing media.
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Respiratory protection
Recommended Filter type: Filter type P1
-Control of environmental exposure
Do not let product enter drains.

HANDLING and STORAGE of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of POLY(HEXAMETHYLENE) BIGUANIDE HYDROCHLORIDE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Conditions to avoid:
no information available
-Incompatible materials:
No data available