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Poly(hexamethylenebiguanide) (PHMB) is a cationic polymer with broad-spectrum antimicrobial properties, widely used in medical, pharmaceutical, personal care, and industrial applications.
Poly(hexamethylenebiguanide) (PHMB) is valued for its effectiveness at low concentrations and its ability to inhibit the growth of bacteria, fungi, and viruses on various surfaces and in solutions.
Poly(hexamethylenebiguanide) (PHMB) is commonly utilized in wound care, water treatment, and surface disinfection due to its high efficacy and low cytotoxicity.
CAS Number: 27083-27-8
EC Number: 608-723-9
Molecular Formula: (C8H18N6)n (polymeric structure)
Molecular Weight: Variable, depending on polymer length
Synonyms: PHMB, Poly(hexamethylenebiguanide) Hydrochloride, Polyhexanide, Polybiguanide, Antimicrobial Polybiguanide, Biguanide Polymer, Polyaminopropyl Biguanide
APPLICATIONS
Poly(hexamethylenebiguanide) (PHMB) is extensively used in wound care products, including wound dressings and antiseptic solutions, where it provides effective antimicrobial protection without damaging healthy tissue.
Poly(hexamethylenebiguanide) (PHMB) is applied in contact lens cleaning solutions, where it serves as a disinfectant, effectively killing bacteria and fungi, and ensuring safe contact lens wear.
Poly(hexamethylenebiguanide) (PHMB) is used in skin and wound antiseptic sprays, providing broad-spectrum antimicrobial protection against potential infection in both healthcare and consumer settings.
Poly(hexamethylenebiguanide) (PHMB) is a critical ingredient in hospital disinfectants and sanitizers, providing effective pathogen control on non-porous surfaces and high-touch areas.
Poly(hexamethylenebiguanide) (PHMB) is incorporated into veterinary disinfectants and wound care products, where it protects animals from infection while promoting healing.
Poly(hexamethylenebiguanide) (PHMB) is found in household disinfectants and surface cleaners, providing antimicrobial activity for daily hygiene and protection.
Poly(hexamethylenebiguanide) (PHMB) is utilized in industrial water treatment systems, where it controls bacterial growth in cooling towers, swimming pools, and water storage facilities.
Poly(hexamethylenebiguanide) (PHMB) is applied in textile and fabric treatments, where it provides antimicrobial protection to medical textiles, sportswear, and other fabrics requiring durable antimicrobial properties.
Poly(hexamethylenebiguanide) (PHMB) is used in personal care products, such as body washes and deodorants, where it helps control body odor by reducing microbial growth on the skin.
Poly(hexamethylenebiguanide) (PHMB) is essential in hand sanitizers and antimicrobial wipes, offering long-lasting protection without the skin-drying effects commonly associated with alcohol-based sanitizers.
Poly(hexamethylenebiguanide) (PHMB) is found in dental care products like mouthwashes, where it helps reduce oral bacterial load, promoting gum health and preventing plaque buildup.
Poly(hexamethylenebiguanide) (PHMB) is used in cosmetic preservatives, where it prevents microbial contamination and extends product shelf life in formulations like creams, lotions, and serums.
Poly(hexamethylenebiguanide) (PHMB) is applied in animal hygiene products, such as disinfectants for kennels and stables, where it controls microbial growth and reduces disease transmission.
Poly(hexamethylenebiguanide) (PHMB) is used in the food industry for surface disinfection and equipment sanitation, ensuring compliance with hygiene standards and preventing foodborne illnesses.
Poly(hexamethylenebiguanide) (PHMB) is found in aquaculture systems, where it prevents microbial contamination in fish farming tanks, maintaining water quality and reducing fish disease.
DESCRIPTION
Poly(hexamethylenebiguanide) (PHMB) is a polymeric antimicrobial agent known for its cationic charge, which enables it to bind to negatively charged microbial cell membranes, disrupting and killing the cells.
Poly(hexamethylenebiguanide) (PHMB) is widely used in healthcare and hygiene products, offering strong antimicrobial action with minimal irritation to human tissue, making it ideal for wound care and surface disinfection.
Poly(hexamethylenebiguanide) (PHMB) is effective at low concentrations, which enhances its appeal as a safe and cost-effective solution for microbial control in multiple sectors.
Poly(hexamethylenebiguanide) (PHMB) has a persistent effect, meaning it continues to provide antimicrobial protection over time, even after application.
The stability and compatibility of Poly(hexamethylenebiguanide) (PHMB) with other ingredients make it a versatile choice for use in personal care products, medical devices, and cleaning formulations.
Poly(hexamethylenebiguanide) (PHMB) is biodegradable and environmentally friendly, aligning with the growing trend towards sustainable and safe antimicrobial solutions.
PROPERTIES
Chemical Formula: (C8H18N6)n
Molecular Weight: Variable (polymeric)
Common Name: Poly(hexamethylenebiguanide) (PHMB)
Appearance: Clear to pale yellow solution (when in solution); white solid (pure form)
Density: 1.01-1.02 g/cm³ (in solution)
Boiling Point: N/A
Melting Point: N/A
Solubility: Soluble in water; insoluble in most organic solvents
Flash Point: >100°C (in solution)
Reactivity: Stable under normal conditions; avoid contact with strong oxidizing agents
Chemical Stability: Stable under recommended storage conditions
Storage Temperature: Store in a cool, dry place away from direct sunlight
Vapor Pressure: Low
FIRST AID
Inhalation:
If Poly(hexamethylenebiguanide) (PHMB) is inhaled, move the affected person to fresh air immediately.
If breathing difficulties persist, seek immediate medical attention.
If the person is not breathing, administer artificial respiration.
Keep the affected person warm and at rest.
Skin Contact:
Wash the affected area with soap and water.
If skin irritation or rash develops, seek medical attention.
Eye Contact:
In case of eye contact, flush the eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids.
Seek immediate medical attention if irritation or redness persists.
Remove contact lenses if present and easy to do; continue rinsing.
Ingestion:
If Poly(hexamethylenebiguanide) (PHMB) is ingested, do not induce vomiting unless directed to do so by medical personnel.
Rinse the mouth thoroughly with water.
Seek immediate medical attention.
If the person is conscious, give small sips of water to drink.
Note to Physicians:
Treat symptomatically.
No specific antidote.
Provide supportive care.
HANDLING AND STORAGE
Handling:
Personal Protection:
Wear appropriate personal protective equipment (PPE) such as gloves and safety goggles when handling large quantities of Poly(hexamethylenebiguanide) (PHMB).
Use in a well-ventilated area to avoid inhalation of vapors.
Ventilation:
Ensure adequate ventilation when handling large amounts of Poly(hexamethylenebiguanide) (PHMB) to control airborne concentrations below occupational exposure limits.
Avoidance:
Avoid direct contact with eyes and prolonged skin contact.
Do not eat, drink, or smoke while handling Poly(hexamethylenebiguanide) (PHMB).
Wash hands thoroughly after handling.
Spill and Leak Procedures:
Contain spills to prevent further release and minimize exposure.
Absorb with inert material (e.g., sand, vermiculite) and collect for disposal.
Dispose of in accordance with local regulations.
Storage:
Store Poly(hexamethylenebiguanide) (PHMB) in a cool, dry, well-ventilated area away from incompatible materials such as strong oxidizers.
Keep containers tightly closed when not in use to prevent contamination.
Store away from heat sources, direct sunlight, and moisture.
Handling Cautions:
Avoid inhalation of vapors and direct contact with skin and eyes.
Use explosion-proof equipment in areas where vapors may be present.
