PRODUCTS

POLY(HEXAMETHYLENEBIGUANIDE)

Poly(hexamethylenebiguanide) is also used for cleaning and disinfecting objects, surfaces or premises, including in hospitals.
Poly(hexamethylenebiguanide) is suitable for use in analytical method development, method validation (AMV), Quality Control (QC) applications for Abbreviated New Drug Applications (ANDA) and commercial production of Poly(hexamethylenebiguanide).
Poly(hexamethylenebiguanide) uses and applications include: Preservative for cosmetics, in hardrigid gas-permeable lens products

CAS Number: 28757-47-3
EC Number: 923-111-4
MDL No: MFCD00217750
Molecular Formula: C8H19N5

SYNONYMS:
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Poly(hexamethylenebiguanide) is identified by CAS No. 28757-47-3 and is chemically known as IUPAC Name: 1-(diaminomethylidene)-2-hexylguanidine.
Poly(hexamethylenebiguanide) is provided with comprehensive characterization data in accordance with regulatory guidelines.
Poly(hexamethylenebiguanide) is an antimicrobial agent active against both Gram-positive and Gram-negative bacteria.

Poly(hexamethylenebiguanide) is a chemical product created at the end of the 1950s and used since the 1970s in the formulation of certain biocides.
Poly(hexamethylenebiguanide) is found in particular to kill microbes such as bacteria and viruses or fungi in water in the form of polyhexamethylene biguanide salt, a pesticide that can be used as a swimming pool disinfectant.

Poly(hexamethylenebiguanide) is a stable and therefore persistent product that remains effective in the presence of UV light and at different pH values.
Poly(hexamethylenebiguanide) is non-oxidising, cationic in solution in water and can be an alternative to other cationic biocidal treatments based on quaternary ammonium or chlorine.

Poly(hexamethylenebiguanide) uses and applications include: Preservative for cosmetics, in hardrigid gas-permeable lens products
Poly(hexamethylenebiguanide) is a broad spectrum, fast-acting antibacterial.

USES and APPLICATIONS of POLY(HEXAMETHYLENEBIGUANIDE):
Poly(hexamethylenebiguanide) is also found in some medicines in the form of polyhexamethylene biguanide hydrochloride.
Acne, disinfection of surgical wounds and/or in veterinary treatments can be treated with polyhexamethylene biguanide salts.
Poly(hexamethylenebiguanide) is used in antiseptic, disinfectant and cosmetics.

Poly(hexamethylenebiguanide) is suitable for use in analytical method development, method validation (AMV), Quality Control (QC) applications for Abbreviated New Drug Applications (ANDA) and commercial production of Poly(hexamethylenebiguanide).

Poly(hexamethylenebiguanide) is also used for cleaning and disinfecting objects, surfaces or premises, including in hospitals.
Poly(hexamethylenebiguanide) uses and applications include: Preservative for cosmetics, in hardrigid gas-permeable lens products

FUNCTIONS OF POLY(HEXAMETHYLENEBIGUANIDE):
*Anti-Microbial Agent,
*Bacteriostatic Agent,
*Preservative

BENEFIT CLAIMS OF POLY(HEXAMETHYLENEBIGUANIDE):
*Anti-Bacterial,
*Antimicrobial,
*Broad pH Stability,
*Chemical Stability,
*Compatibility,
*Conditioning,
*Low Foaming,
*Low Volatility,
*Neutral Color,
*Preservation,
*Reduces Stickiness,
*Sunlight Stability,
*Tasteless

LABELING CLAIMS OF POLY(HEXAMETHYLENEBIGUANIDE):
*Credo Clean Standard,
*Environmentally Friendly,
*Halal,
*Natural,
*Non-GMO,
*Odor-free,
*Organic,
*Sustainable,
*Ulta Beauty's Conscious Beauty,
*VOC-free, Vegan

PHYSICAL and CHEMICAL PROPERTIES of POLY(HEXAMETHYLENEBIGUANIDE):
CAS Number: 28757-47-3
Chemical formula: (C8H17N5)n
Molecular Formula: C8H19N5
Molecular Weight: 185.27 g/mol
IUPAC Name: 1-(diaminomethylidene)-2-hexylguanidine
Standard InChI: InChI=1S/C8H19N5/c1-2-3-4-5-6-12-8(11)13-7(9)10/h2-6H2,1H3,(H6,9,10,11,12,13)
Standard InChIKey: VAZJLPXFVQHDFB-UHFFFAOYSA-N
Isomeric SMILES: CCCCCCN/C(=NC(=N)N)/N
SMILES: CCCCCCN=C(N)N=C(N)N
Canonical SMILES: CCCCCCN=C(N)N=C(N)N
CBNumber: CB91074557
Molecular Formula of Hydrochloride Salt: C8H19N5.ClH
Molecular Weight of Hydrochloride Salt: 221.734
MDL Number: MFCD00242965

Chemical Name: Poly(hexamethylenebiguanide)
CAS Registry Number: 28757-47-3
PubChemID: 20977
PSA: 97.78000
LogP: 2.25570
EINECS: 923-111-4
Molecular Weight: 185.27
Density: 1.2±0.1 g/cm3
Boiling Point: 347.7±25.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.8 mmHg at 25°C
Enthalpy of Vaporization: 59.2±3.0 kJ/mol
Flash Point: 164.1±23.2 °C
Index of Refraction: 1.550

Molar Refractivity: 51.1±0.5 cm3
#H bond acceptors: 5
#H bond donors: 6
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 1
ACD/LogP: 1.36
ACD/LogD (pH 5.5): -1.17
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -1.17
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 103 Å2
Polarizability: 20.2±0.5 10-24cm3

Surface Tension: 45.7±7.0 dyne/cm
Molar Volume: 160.2±7.0 cm3
XLogP3-AA: 0.5
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 6
Exact Mass: 185.16404563
Monoisotopic Mass: 185.16404563
Topological Polar Surface Area: 103 Å²
Heavy Atom Count: 13
Formal Charge: 0
Complexity: 181
Form: Liquid
Color: Colorless to pale yellow

Odor: Odorless
pH Value (1% Solution): 4.0 – 6.0
Melting Point, °C: Not determined
Boiling Point, °C: 102 – 105°C
Flash Point: Not applicable
Ignition Temperature, °C: Product is not self-igniting
Flammability, °C:
Lower Explosion Limit: Product is not explosive
Upper Explosion Limit: Product is not explosive
Vapor Pressure @ 20°C: 23 hPa
Density @ 20°C: 1.030 – 1.060
Solubility/Miscibility In Water: Fully miscible
Partition Coefficient: n-octanol/water: Not available
Solids Content, %: 19 – 21

FIRST AID MEASURES of POLY(HEXAMETHYLENEBIGUANIDE):
-Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes.
-Skin:
Removing contaminated clothing and shoes.
-Inhalation:
Move to fresh air.

ACCIDENTAL RELEASE MEASURES of POLY(HEXAMETHYLENEBIGUANIDE):
-Spills/Leaks:
Sweep up, then place into a suitable container for disposal.

FIRE FIGHTING MEASURES of POLY(HEXAMETHYLENEBIGUANIDE):
-General Information:
*Extinguishing Media:
In case of fire, use water, dry chemical, chemical foam, or alcohol-resistant foam.

EXPOSURE CONTROLS/PERSONAL PROTECTION of POLY(HEXAMETHYLENEBIGUANIDE):
-Personal Protective Equipment:
*Eyes:
Wear safety glasses.
*Skin:
Wear appropriate protective gloves.
*Clothing:
Wear appropriate protective clothing to minimize contact with skin.

HANDLING and STORAGE of POLY(HEXAMETHYLENEBIGUANIDE):
-Handling:
Wash after handling.
Remove contaminated clothing and wash before reuse.

STABILITY and REACTIVITY of POLY(HEXAMETHYLENEBIGUANIDE):
-Chemical Stability:
Stable under normal temperatures and pressures.
-Hazardous Polymerization:
Has not been reported.