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POLYAMINOPROPYL BIGUANIDE

Polyaminopropyl biguanide is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions for contact lenses. It is also an ingredient in many deodorant bodysprays.

CAS NO: 32289-58-0

Synonyms:
Homopolymer of N-(3-Aminopropyl)-Imidodicarbonimidic Diamide; Polyaminopropyl biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride; Poly(hexamethylenebiguanide); Polihexanide; Poly(hexamethylenebiguanide hydrochloride); Poliaminopropil Biguanid; Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride; Poliaminopropil Biguanid; Poliaminopropil Biguanid;PHMB ; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene), hydrochloride; Poliaminopropil Biguanid; Polihekzametilen biguanid; Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride; Baquacil; Caswell No. 676; Cosmocil CQ; EPA Pesticide Chemical Code 111801; Polyaminopropyl biguanide; Polihexanide ; Polihexanido; Poliaminopropil Biguanid; Poliaminopropil Biguanid; Polihexanidum; Polyhexanide; PP 073 UNII-322U039GMF; Vantocil IB; Vantocil TG; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hydrochloride; Poliaminopropil Biguanid; Polyaminopropyl biguanide; 1-(diaminomethylidene)-2-hexylguanidine; C8H19N5; Polyhexanide; Baquacil; cosmocil; Lavasept; Polyaminopropyl biguanide Polymer; polihexanide; polihexanide hydrochloride; poly (hexamethylene biguanide); poly(hexamethylenebiguanide) hydrochloride; poly (iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl); Poliaminopropil Biguanid; hydrochloride polyhexamethylen-biguanide; polyhexamethylenbiguanid; polyhexamethylenbiguanide; Polyaminopropyl biguanide; Polyaminopropyl biguanide (Polihexanid, Polyaminopropyl biguanide)hydrochloride; polyhexanide; Vantocil; Vantocil IB of Vantocil; Polyhexanide; Polyaminopropyl biguanide; POLIHEXANIDE; 28757-47-3; Polyaminopropyl biguanide; n-hexylbiguanide; 1-Hexylbiguanide; POLYXEDININE; SCHEMBL45011;Poliaminopropil Biguanid; N-Hexylimidodicarbonimidic diamide; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N```-1,6-Hexanediylbis(N`-cyanoguanidine) hexamethylenediamine polymer hydrochloride; Polyaminopropyl biguanide; Polihexanide; Poliaminopropil Biguanid; Polihekzametilen biguanid;Polyaminopropyl biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride; Poly(hexamethylenebiguanide); Polihexanide; Poly(hexamethylenebiguanide hydrochloride); Poliaminopropil Biguanid; Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride; Poliaminopropil Biguanid; Poliaminopropil Biguanid; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene), hydrochloride; Poliaminopropil Biguanid; Polihekzametilen biguanid; Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride; Baquacil; Caswell No. 676; Cosmocil CQ; EPA Pesticide Chemical Code 111801; Polyaminopropyl biguanide; Polihexanide ; Polihexanido; Poliaminopropil Biguanid; Poliaminopropil Biguanid; Polihexanidum; Polyhexanide; PP 073 UNII-322U039GMF; Vantocil IB; Vantocil TG; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hydrochloride; Poliaminopropil Biguanid; Polyaminopropyl biguanide; 1-(diaminomethylidene)-2-hexylguanidine; C8H19N5; Polyhexanide; Baquacil; cosmocil; Lavasept; Polyaminopropyl biguanide Polymer; polihexanide; polihexanide hydrochloride; poly (hexamethylene biguanide); poly(hexamethylenebiguanide) hydrochloride; poly (iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl); Poliaminopropil Biguanid; hydrochloride polyhexamethylen-biguanide; polyhexamethylenbiguanid; polyhexamethylenbiguanide; Polyaminopropyl biguanide; Polyaminopropyl biguanide (Polihexanid, Polyaminopropyl biguanide)hydrochloride; polyhexanide; Vantocil; Vantocil IB of Vantocil; Polyhexanide; Polyaminopropyl biguanide; POLIHEXANIDE; 28757-47-3; Polyaminopropyl biguanide; n-hexylbiguanide; 1-Hexylbiguanide; POLYXEDININE; SCHEMBL45011;Poliaminopropil Biguanid; N-Hexylimidodicarbonimidic diamide; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N```-1,6-Hexanediylbis(N`-cyanoguanidine) hexamethylenediamine polymer hydrochloride; Polyaminopropyl biguanide; Polihexanide; Poliaminopropil Biguanid; Polihekzametilen biguanid;Polyaminopropyl biguanide; Polyhexamethylene guanide; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene) Hydrochloride; Poly(hexamethylenebiguanide); Polihexanide; Poly(hexamethylenebiguanide hydrochloride); Poliaminopropil Biguanid; Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride; Poliaminopropil Biguanid; Poliaminopropil Biguanid; Poly(iminoimidocarbonyl-iminoimidocarbonyl-iminohexamethylene), hydrochloride; Poliaminopropil Biguanid; Polihekzametilen biguanid; Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride; Baquacil; Caswell No. 676; Cosmocil CQ; EPA Pesticide Chemical Code 111801; Polyaminopropyl biguanide; Polihexanide ; Polihexanido; Poliaminopropil Biguanid; Poliaminopropil Biguanid; Polihexanidum; Polyhexanide; PP 073 UNII-322U039GMF; Vantocil IB; Vantocil TG; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N'''-1,6-Hexanediylbis(N'-cyanoguanidine) hexamethylenediamine polymer hydrochloride; Poliaminopropil Biguanid; Polyaminopropyl biguanide; 1-(diaminomethylidene)-2-hexylguanidine; C8H19N5; Polyhexanide; Baquacil; cosmocil; Lavasept; Polyaminopropyl biguanide Polymer; polihexanide; polihexanide hydrochloride; poly (hexamethylene biguanide); poly(hexamethylenebiguanide) hydrochloride; poly (iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl); Poliaminopropil Biguanid; hydrochloride polyhexamethylen-biguanide; polyhexamethylenbiguanid; polyhexamethylenbiguanide; Polyaminopropyl biguanide; Polyaminopropyl biguanide (Polihexanid, Polyaminopropyl biguanide)hydrochloride; polyhexanide; Vantocil; Vantocil IB of Vantocil; Polyhexanide; Polyaminopropyl biguanide; POLIHEXANIDE; 28757-47-3; Polyaminopropyl biguanide; n-hexylbiguanide; 1-Hexylbiguanide; POLYXEDININE; SCHEMBL45011;Poliaminopropil Biguanid; N-Hexylimidodicarbonimidic diamide; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; N,N```-1,6-Hexanediylbis(N`-cyanoguanidine) hexamethylenediamine polymer hydrochloride; Polyaminopropyl biguanide; Polihexanide; Poliaminopropil Biguanid; Polihekzametilen biguanid; 1-(diaminomethylidene)-2-hexylguanidine; C8H19N5; Polyhexanide; Baquacil; cosmocil; Lavasept; Polyaminopropyl biguanide Polymer; polihexanide; polihexanide hydrochloride; poly (hexamethylene biguanide); poly(hexamethylenebiguanide) hydrochloride; poly (iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl); hydrochloride polyhexamethylen-biguanide; polyhexamethylenbiguanid; polyhexamethylenbiguanide; Polyaminopropyl biguanide; Polyaminopropyl biguanide hydrochloride; polyhexanide; Vantocil; Vantocil IB of Vantocil; Polyhexanide; Polyaminopropyl biguanide; POLIHEXANIDE; 28757-47-3; Polyaminopropyl biguanide; n-hexylbiguanide; 1-Hexylbiguanide; POLYXEDININE; SCHEMBL45011; N-Hexylimidodicarbonimidic diamide; Poly(iminoimidocarbonyl)iminohexamethylene hydrochloride; Polyaminopropyl biguanide; N,N```-1,6-Hexanediylbis(N`-cyanoguanidine) hexamethylenediamine polymer hydrochloride; PAPB; Polihexanide; POLYAMINOPROPYL BIGUANIDE; Polyaminopropyl biguanide; Poliaminopropil Biguanit; Poliaminopropil Biguanite

Polyaminopropyl biguanide

Polyaminopropyl biguanide
Polyaminopropyl biguanide.svg
Names
Other names
Polyamine-propyl-biguanidine
Identifiers
CAS Number
133029-32-0 check
Abbreviations   Polyaminopropyl biguanide
ChemSpider
none
ECHA InfoCard   100.118.649
UNII
DT9D8Z79ET check
Properties
Chemical formula   (C5H11N5)n
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒ verify (what is check☒ ?)
Infobox references
Polyaminopropyl biguanide is a disinfectant and a preservative used for disinfection on skin and in cleaning solutions for contact lenses. It is also an ingredient in many deodorant bodysprays.[citation needed] It is a polymer or oligomer where biguanide functional groups are connected by hexyl hydrocarbon chains, with varying chain lengths.[citation needed] Polyaminopropyl biguanide is specifically bactericidal at very low concentrations (10 mg/l) and is also fungicidal.[citation needed]
APBBiocidal activity
It has a unique method of action: the polymer strands are incorporated into the bacterial cell membrane, which disrupts the membrane and reduces its permeability, which has a lethal effect to bacteria. It is also known to bind to bacterial DNA, alter its transcription, and cause lethal DNA damage.[1]

Disinfectant
Polyaminopropyl biguanide solutions are sold for use as a general disinfectant solution to be applied onto skin. As it is not cytotoxic, it can be applied directly into wounds.[2] It is also not irritating like more traditional disinfectants such as alcohols (ethanol, isopropanol) and oxidizers (iodine).

Contact lens solution
A contact lens solution containing polyaminopropyl biguanide in combination with a borate buffer has been patented.[3] The solution is disinfecting and preservative and has a broad spectrum of bactericidal and fungicidal activity at low concentrations coupled with very low toxicity when used with soft-type contact lenses.

POLYAMINOPROPYL BIGUANIDE (Polyaminopropyl biguanide)
What is Polyaminopropyl biguanide?
“Polyaminopropyl biguanide (Polyaminopropyl biguanide), with the chemical formula (C5H11N5)n, is a polymer or oligomer where biguanide functional groups are connected by hexyl hydrocarbon chains, with varying chain lengths.”

What are the effects?
This ingredient belongs to the groups:

Organ system toxicants

Environmental hazards

Carcinogens

Irritants and allergens
Read the facts
Polyaminopropyl biguanide is a CMR substance, meaning it’s classified as carcinogenic, mutagenic or toxic for reproduction (CRM).

The European Chemicals Agency (ECHA) classifies polyaminopropyl biguanide (Polyaminopropyl biguanide) as

“fatal if inhaled, causes damage to organs through prolonged or repeated exposure, is very toxic to aquatic life with long lasting effects, is harmful if swallowed, causes serious eye damage, is suspected of causing cancer and may cause an allergic skin reaction.”

How is it used?
Polyaminopropyl biguanide (Polyaminopropyl biguanide) is being used as a preservative to prevent the growth of harmful bacteria and mould in many cosmetic⋆ and household products. Polyaminopropyl biguanide can for example be found in sanitary napkins, creams, and after-shave balms.

Polyaminopropyl biguanide is banned for use in cosmetic products in the EU since January 2015 but the substance can still sometimes be found in products, even from major brands, according to the Danish Consumer Council THINK Chemicals.

This is because industry associations, led by Cosmetics Europe, lobbied that the current law should be re-interpreted to allow low doses of Polyaminopropyl biguanide in products.

Doses of 0.1 percent Polyaminopropyl biguanide is now allowed in certain products, but as the exact dose do not have to be written on the ingredients list, it is uncertain to know just how much is in a product.

When it comes to skin care and makeup, many of us probably have a list of ingredients we would never put on our faces — some lists longer than others. But one ingredient with some heavily skewed opinions is polyaminopropyl biguanide, also known as Polyaminopropyl biguanide or Polyaminopropyl biguanide. But what is Polyaminopropyl biguanide and is it bad for you? The ingredient is used in some pretty popular products in the USA but is actually banned from use in cosmetics in other countries. So what gives? To find out a little more about this controversial ingredient and whether you should avoid it, I emailed with a few experts.

Rachel Winard, founder of Soapwalla; Holly McWhorter, co-founder of PLANT Apothecary; and Dr. Clarissa Shetler and Christine Falsetti, PhD, founders of C2 California Clean, all let me in on what Polyaminopropyl biguanide is commonly used for along with some other useful information about the ingredient so you can make a more educated decision whether to use beauty products containing it. According to Winard, Polyaminopropyl biguanide is a "synthetic polymer that is used as a broad-spectrum preservative and antimicrobial agent in skin care." Drs. Shetler and Falsetti add that it can be found in many personal-care products "including skin care, cosmetics, eye-care solutions, wound care, and surgery care."
Even though Polyaminopropyl biguanide has proven antibacterial properties, it has also been shown to be harmful. McWhorter explains: "There's evidence based on results of studies on humans and animals that [Polyaminopropyl biguanide] is carcinogenic (causing cancer), mutagenic (causing gene mutation), and toxic. It's suspected primarily of affecting the reproductive system." Yikes.

The Scientific Committee on Consumer Safety (SCCS) has also concluded that Polyaminopropyl biguanide is not safe when used as a preservative in a concentration higher than 0.3-percent in cosmetic products, say Drs. Shetler and Falsetti. And according to McWhorter, in the EU, Polyaminopropyl biguanide was banned in personal-care products after being labeled a Category 2 Carcinogenic Agent in 2015.

Not everyone seems to agree on the dangers of this preservative though. Polyaminopropyl biguanide use in personal-care products is legal in the USA, and according to Drs. Shetler and Falsetti, "There are still many debates on the safety profile of the ingredient and some companies will still insist the ingredient is safe." So even though you can still find this ingredient on the shelves in US stores, if you're worried about using products with Polyaminopropyl biguanide, check out this list of products known to include the ingredient, and always read product labels to be sure whether Polyaminopropyl biguanide (although it may also be listed as polyaminopropyl biguanide or Polyaminopropyl biguanide) is included.

PAPB is an aqueous-based cationic preservative, active against spoilage bacteria and is compatible with a wide range of aqueous based cosmetics and personal care formulations. Its gentle nature makes it ideal for both rinse-off and leave-on applications like shampoo (with cationic, nonionic or amphoteric surfactants), hair care products, skin creams, skin lotions, baby products, and wet wipes. When mildness is an important feature for your product, PAPB's gentle and protective nature could make it your solution.

Molecular Formula of Polyaminopropyl biguanide (Polihexanid, PAPB)(C8H17N5)n

Ph Level of Polyaminopropyl biguanide (Polihexanid, PAPB)4~5

Taste of Polyaminopropyl biguanide (Polihexanid, PAPB)Bitter

Purity of Polyaminopropyl biguanide (Polihexanid, PAPB) 20%

Ingredients of Polyaminopropyl biguanide (Polihexanid, PAPB) PAPB

Properties of Polyaminopropyl biguanide (Polihexanid, PAPB) PAPB (Polyaminopropyl biguanide) is a water-soluble cationic disinfectant with wide clinical, household, and industrial applications

Shelf Life of Polyaminopropyl biguanide (Polihexanid, PAPB) 2 Years

Storage of Polyaminopropyl biguanide (Polihexanid, PAPB)Room Temperature

Structural Formula of Polyaminopropyl biguanide (Polihexanid, PAPB)(C8H17N5)n

Grade of Polyaminopropyl biguanide (Polihexanid, PAPB)TECHNICAL

Product Type of Polyaminopropyl biguanide (Polihexanid, PAPB) PAPB

Application of Polyaminopropyl biguanide (Polihexanid, PAPB)Pharmaceutical

Physical Form of Polyaminopropyl biguanide (Polihexanid, PAPB)Liquid

Appearance of Polyaminopropyl biguanide (Polihexanid, PAPB)WATER WHITE

Polyaminopropyl biguanide,is Available in colorless to pale yellow form, Polyaminopropyl biguanide, PAPB is accessible in liquid form. Polyaminopropyl biguanide,tastes bitter and its purity level is 20%. Polyaminopropyl biguanide,can be stored for 24 months. Polyaminopropyl biguanide,disinfecting chemical is water soluble and it is cationic by nature. Polyaminopropyl biguanide,is suitable for household, industrial and clinical application purpose. Ph level of Polyaminopropyl biguanide, liquid substance ranges between 4 to 5. Polyaminopropyl biguanide, PAPB has been formulated under controlled temperature to preserve anti bacterial properties of Polyaminopropyl biguanide. Standard of Polyaminopropyl biguanide,liquid has been verified on the basis of composition of Polyaminopropyl biguanide,, formulation method, effectiveness, shelf life, ph value, possible toxin content, etc. ppearance: white powder; colorless liquid; colorless translucent crystals

Assay of Polyaminopropyl biguanide,: 95%;98%;20%; 25%;50%

Polyaminopropyl biguanide (Polihexanid, PAPB)can be used as disinfectant, antibacterial, bactericide, mildew-proof, algae-inhibitor, flocculant ,etc.
Polyaminopropyl biguanide (Polihexanid, PAPB)is widely used in health care, Polyaminopropyl biguanide (Polihexanid, PAPB)is widely used in chemicals, Polyaminopropyl biguanide (Polihexanid, PAPB)is widely used in textiles, Polyaminopropyl biguanide (Polihexanid, PAPB)is widely used in paper, Polyaminopropyl biguanide (Polihexanid, PAPB)is widely used in wipes,Polyaminopropyl biguanide (Polihexanid, PAPB)is widely used in livestock, aquaculture, Polyaminopropyl biguanide (Polihexanid, PAPB)is widely used in fisheries, plastics, Polyaminopropyl biguanide (Polihexanid, PAPB)is widely used in agriculture, Polyaminopropyl biguanide (Polihexanid, PAPB)is widely used in water treatment and Polyaminopropyl biguanide (Polihexanid, PAPB)is widely used in other fields.

Two equivalent CAS number of Polyaminopropyl biguanide (Polihexanid, PAPB) can be allocated depending on how the polymer is described. CAS-No 27083-27-8 expresses the Polyaminopropyl biguanide (Polihexanid, PAPB) in terms of its starting monomers (N,N’’’-1,6- hexanediylbis(N’-cyanoguanidine) and 1,6-hexanediamine). CAS-No 32289-58-0 expresses the Polyaminopropyl biguanide (Polihexanid, PAPB) as the resultant polymer.

Polyaminopropyl biguanide (Polihexanid, PAPB)(PAPB) is an antiseptic with antiviral and antibacterial properties used in several ways including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyaminopropyl biguanide (Polihexanid, PAPB) (PAPB) is not safe for consumers when used as a preservative in all cosmetic products up to the maximum concentration of 0.3%. The safe Polyaminopropyl biguanide (Polihexanid, PAPB) use could be based on a lower use concentration and/or restrictions with regard to cosmetic products' categories Polyaminopropyl biguanide (Polihexanid, PAPB) hydrochloride (PAPB) (CAS 32289-58-0 / 27083-27-8 / 28757- 47-3 / 133029-32-0) with INCI name Polyaminopropyl Biguanide, is currently listed in Annex V (entry 28) of the Regulation (EC) No. 1223/20091 (Cosmetics Regulation) as preservative to be used in all cosmetic products up to a maximum concentration of 0.3%. Polyaminopropyl biguanide (Polihexanid, PAPB)is classified as CMR 2 (Carc. 2) according to the Commission Regulation (EU) No. 944/20132 of 2 October 2013 amending for the purposes of Polyaminopropyl biguanide (Polihexanid, PAPB)adaptation to technical and scientific progress the Regulation (EC) No. 1272/20083 . The classification applies from 1st January 2015 and according to Art. 15 (1) of the Cosmetics Regulation, Polyaminopropyl biguanide (Polihexanid, PAPB)is considered prohibited as cosmetic ingredient from 1st January 2015. However, Polyaminopropyl biguanide (Polihexanid, PAPB)Art. 15 (1) of the Cosmetics Regulation states that ‘a substance classified in category 2 may be used in cosmetic products where the substance has been evaluated by the SCCS and found safe for use in cosmetic products. To these ends the Commission shall adopt the necessary measures in accordance with the regulatory procedure with scrutiny referred to in Article 32(3) of this Regulation'. The SCCS published an opinion on the safety of Polyaminopropyl biguanide (Polihexanid, PAPB)in June 2014 successively revised in July 2015 (SCCS/1535/14)4 in which they concluded that: " Polyaminopropyl biguanide (Polihexanid, PAPB) is not safe for consumers when used as a preservative in all cosmetic products up to the maximum concentration of 0.3%. The safe Polyaminopropyl biguanide (Polihexanid, PAPB)use could be based on a lower use concentration and/or restrictions with regard to cosmetic products' categories. Dermal absorption studies on additional representative cosmetic formulations are needed. On the basis of the data available, Polyaminopropyl biguanide (Polihexanid, PAPB)the SCCS concludes that Polyaminopropyl biguanide (Polihexanid, PAPB)is not safe for consumers when used as a preservative in cosmetic spray formulations up to concentration of 0.3%. Polyaminopropyl biguanide (Polihexanid, PAPB)is used in a variety of applications other than cosmetics. General exposure data from sources others than cosmetics should be submitted for the assessment of the aggregate exposure of Polyaminopropyl biguanide.

The stability of Polyaminopropyl biguanide (Polihexanid, PAPB)in deionised water has been established for at least 6 weeks. Polyaminopropyl biguanide (Polihexanid, PAPB)was stated that nominal concentrations (expressed as Vantocil, i.e. 20 % Polyaminopropyl biguanide) of 0.1, 35 and 80 mg/ml would be stable for the duration of the test. Stability analysis revealed that Polyaminopropyl biguanide (Polihexanid, PAPB)over a concentration range of 0.02 to 7.0 mg/l was stable in drinking water for a period of 7 days. PAPB is supported under the Biocides Regulation No 528/2012, which distinguishes 22 product types (PT) Directive 98/8/EC for uses as a disinfectant. Polyaminopropyl biguanide (Polihexanid, PAPB)is used as a preservative and as an antimicrobial agent. As a preservative, PAPB is used in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. In cosmetics, Polyaminopropyl biguanide (Polihexanid, PAPB)is used as a broad spectrum preservative. Polyaminopropyl biguanide (Polihexanid, PAPB)is freely water soluble and therefore widely used in water-based products which are most susceptible to microorganism growth. Polyaminopropyl biguanide (Polihexanid, PAPB)has an excellent activity against a wide range of Gram positive and Gram negative bacteria, fungi and yeasts and is particularly effective against microorganisms such as Pseudomanas species, which are difficult to control. Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to preserve wet wipes; to control odour in textiles; to prevent microbial contamination in wound irrigation and sterile dressings; to disinfect medical/dental utensil and SCCS/1581/16 Final Opinion on Polyaminopropyl biguanide (Polihexanid, PAPB)Submission III 13 trays, farm equipment, animal drinking water, and hard surfaces for food handling institutions and hospitals; and to deodorize vacuums and toilets. Polyaminopropyl biguanide (Polihexanid, PAPB)is used in antimicrobial hand washes and Polyaminopropyl biguanide (Polihexanid, PAPB)is used in rubs and Polyaminopropyl biguanide (Polihexanid, PAPB)is used in air filter treatments as an alternative to ozone. Polyaminopropyl biguanide (Polihexanid, PAPB)is also used as an active ingredient for recreational water treatment, as a chlorine-free polymeric sanitizer, which is effective against a wide variety of microorganisms. Further reported uses of Polyaminopropyl biguanide (Polihexanid, PAPB)are purification of swimming pool water, beer glass sanitisation, solid surface disinfection in breweries and short-term preservation of hides and skins. Polyaminopropyl biguanide (Polihexanid, PAPB)also known as PAPB, polyhexanide or polihexanide, is a highly water soluble and hydrolytically stable polymeric material. The presence of multiple hydrogen bond and chelation sites within Polyaminopropyl biguanide (Polihexanid, PAPB)renders Polyaminopropyl biguanide (Polihexanid, PAPB)of potential interest in the field of supramolecular chemistry.Polyaminopropyl biguanide,is Available in colorless to pale yellow form, Polyaminopropyl biguanide, PAPB is accessible in liquid form. Polyaminopropyl biguanide,tastes bitter and its purity level is 20%. Polyaminopropyl biguanide,can be stored for 24 months. Polyaminopropyl biguanide,disinfecting chemical is water soluble and it is cationic by nature. Polyaminopropyl biguanide,is suitable for household, industrial and clinical application purpose. Ph level of Polyaminopropyl biguanide, liquid substance ranges between 4 to 5. Polyaminopropyl biguanide, PAPB has been formulated under controlled temperature to preserve anti bacterial properties of Polyaminopropyl biguanide. Standard of Polyaminopropyl biguanide,liquid has been verified on the basis of composition of Polyaminopropyl biguanide,, formulation method, effectiveness, shelf life, ph value, possible toxin content, etc. ppearance: white powder; colorless liquid; colorless translucent crystals

Assay of Polyaminopropyl biguanide,: 95%;98%;20%; 25%;50%

Polyaminopropyl biguanide (Polihexanid, PAPB)can be used directly after dilution with purified water or with other additive agent compound. Reference amount 1:125~1:1000 (w/w).
Since Polyaminopropyl biguanide (Polihexanid, PAPB)in different areas of application, the product dosage are quite different, Polyaminopropyl biguanide (Polihexanid, PAPB)is recommended to use under the guidance of our professional and technical persons.

Polyhexanide (Polyaminopropyl biguanide, PAPB) is a polymer used as a disinfectant and antiseptic. In dermatological use, Polyaminopropyl biguanide (Polihexanid, PAPB)is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. Polyaminopropyl biguanide (Polihexanid, PAPB)has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).

Polyaminopropyl biguanide (Polihexanid, PAPB)containing Polyaminopropyl biguanide (Polihexanid, PAPB)are used for inter-operative irrigation, Polyaminopropyl biguanide (Polihexanid, PAPB)are used for pre- and Polyaminopropyl biguanide (Polihexanid, PAPB)are used for post-surgery skin and Polyaminopropyl biguanide (Polihexanid, PAPB)are used for mucous membrane Polyaminopropyl biguanide (Polihexanid, PAPB)are used for disinfection, Polyaminopropyl biguanide (Polihexanid, PAPB)are used for post-operative dressings, Polyaminopropyl biguanide (Polihexanid, PAPB)are used for surgical and Polyaminopropyl biguanide (Polihexanid, PAPB)are used for non-surgical wound dressings, Polyaminopropyl biguanide (Polihexanid, PAPB)are used for surgical bath/hydrotherapy,Polyaminopropyl biguanide (Polihexanid, PAPB)are used for chronic wounds like diabetic foot ulcer and burn wound management, Polyaminopropyl biguanide (Polihexanid, PAPB)are used for routine antisepsis during minor incisions, Polyaminopropyl biguanide (Polihexanid, PAPB)are used for catheterization, scopy, first aid, surface disinfection, and linen disinfection. Polyaminopropyl biguanide (Polihexanid, PAPB)eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis. Branded as Baquacil, Polyaminopropyl biguanide (Polihexanid, PAPB)also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products. Polyaminopropyl biguanide (Polihexanid, PAPB)is available as Baqua-Spa 3 sanitize, as Revacil Spa 3 sanitizer, and in the Polyaminopropyl biguanide (Polihexanid, PAPB)Leisure Time Free system.Polyaminopropyl biguanide (Polihexanid, PAPB)is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors. The Polyaminopropyl biguanide (Polihexanid, PAPB)hydrochloride salt (solution) is used in the majority of formulations. Polyaminopropyl biguanide (Polihexanid, PAPB)a related biguanide disinfectant. Polyaminopropyl biguanide (Polihexanid, PAPB)(is an antiseptic with antiviral and antibacterial properties used in a variety of products including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyaminopropyl biguanide (Polihexanid, PAPB) is an antiseptic with antiviral and antibacterial properties used in several ways including wound care dressings, contact lens cleaning solutions, perioperative cleansing products, and swimming pool cleaners. Polyaminopropyl biguanide (Polihexanid, PAPB) is also known as polyhexanide and polyaminopropyl biguanide, polymeric biguanide hydrochloride; polyhexanide biguanide. Polyaminopropyl biguanide (Polihexanid, PAPB) is a commonly applied antiseptic, Polyaminopropyl biguanide (Polihexanid, PAPB) often used as a preservative in cosmetics and Polyaminopropyl biguanide (Polihexanid, PAPB) often used as a in personal care products. Polyaminopropyl biguanide (Polihexanid, PAPB)shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.Polyaminopropyl biguanide (Polihexanid, PAPB)is available also as a solid. Polyaminopropyl biguanide (Polihexanid, PAPB)hydrochloride (PAPB) is a chemical biocide which is a polymer utilized in a wide variety of antimicrobial applications. This review provides a comprehensive literature of Polyaminopropyl biguanide (Polihexanid, PAPB)features from synthesis methods,mode of action, antimicrobial effects and safety considerations to both humans and environments. Effectiveness against cellular organisms is due to the basic biguanide group attached to a flexible spacer, a hexamethylene group. Polyaminopropyl biguanide (Polihexanid, PAPB)is a disinfectant with a broad spectrum of inducing cell death by disrupting cell membrane integrity. Polyaminopropyl biguanide (Polihexanid, PAPB)is an environmentally friendly product noncorrosive and nontoxic to both humans and animals. Polyaminopropyl biguanide (Polihexanid, PAPB)is used as a preservative in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. In cosmetics, Polyaminopropyl biguanide (Polihexanid, PAPB)the preservation of fruit and vegetables. Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to preserve wet wipes; Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to control odor in textiles;Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to prevent microbial contamination in wound irrigation and sterile dressings; to Polyaminopropyl biguanide (Polihexanid, PAPB)is also used disinfect medical/dental utensil and trays, Polyaminopropyl biguanide (Polihexanid, PAPB)is also used farm equipment, Polyaminopropyl biguanide (Polihexanid, PAPB)is also used animal drinking water, and hard surfaces for food handling institutions and hospitals; and to Polyaminopropyl biguanide (Polihexanid, PAPB)is also used deodorize vacuums and toilets. Polyaminopropyl biguanide (Polihexanid, PAPB)can work at low concentrations with very fast action with a broad spectrum of action in addition of Polyaminopropyl biguanide (Polihexanid, PAPB)wide acceptance and exploitation for potential multi-purpose functional use. Polyaminopropyl biguanide (Polihexanid, PAPB)will be promising for advanced environmental treatments including food disinfection, Polyaminopropyl biguanide (Polihexanid, PAPB)will be promising for water disinfection, Polyaminopropyl biguanide (Polihexanid, PAPB)will be promising for surface disinfection, and meet the criteria for an ideal antimicrobial agent. Disinfecting agent is a substances used to control, prevent, or destroy harmful microorganisms (i.e., bacteria, viruses, or fungi) on inanimate objects and surfaces. Polyaminopropyl biguanide (Polihexanid, PAPB)destroys or irreversibly inactivates most pathogenic microorganisms (Ewart,2001; EPA, 2004; Quinn and Markey, 2001; Kennedy et al., 2000). Chemical disinfectants were used scientifically around 150 years ago, but empiric practices can be found in ancient times . Since then several new biocides have been introduced and a significant amount of research on their activity against microorganisms has been performed. Biguanidines are an interesting class of compounds with many known or potential applications. It is bacteriostatic at lower concentrations, inhibiting membrane enzymes and promoting leakage of cellular constituents. Polyaminopropyl biguanide (Polihexanid, PAPB)hydrochloride is a chemical biocide and a member of the polymeric guanidine family is used as a disinfectant and antiseptic and general disinfecting agents in the food industry and, very successfully, for the disinfection of swimming pools. Polyaminopropyl biguanide (Polihexanid, PAPB)used biocide has been reviewed by US Environmental Protection Agency (EPA) and noted, with the exception of occupational users, as having very low aggregate risk of adverse health effects to the public or environment(EPA, 2005). Polyaminopropyl biguanide (Polihexanid, PAPB)binds to the negatively charged phosphate head groups of phospholipids at bacteria cell wall, causing increased rigidity, sinking nonpolar British Journal of Environmental Sciences Vol.4, No.1, pp.49-55, February 2016 ___Published by European Centre for Research Training and Development UK (www.eajournals.org) 50 ISSN 2055-0219(Print), ISSN 2055-0227(online) segments into hydrophobic domains, disrupting the membrane with subsequent cytoplas- mic shedding culminating in cell death (Kaehn, 2010). There have been no reported instances of bacteria acquiring resistance to Polyaminopropyl biguanide (Polihexanid, PAPB). Polyaminopropyl biguanide (Polihexanid, PAPB)is well tolerated when used topically on skin, eyes, the ciliated epithelium of the nose, and wounds (Kaehn, 2010; Kramer et al., 2004; Dissemond et al., 2009; Kramer et al., 2008). The market for Polyaminopropyl biguanide (Polihexanid, PAPB)-containing products, which now includes liquids, gels and antimicrobial dressings, is expanding rapidly. This article outlines the evidence on the antimicrobial properties of Polyaminopropyl biguanide. PAPB was firstly synthesized by Rose and Swain (1954). Polyaminopropyl biguanide (Polihexanid, PAPB)is a cationic biguanide polymer which is utilized in a wide variety of antibacterial applications (O’Malley et al., 2007). Several methods have been devised in order to prepare Polyaminopropyl biguanide. For instance, one of the current methods is to obtain Polyaminopropyl biguanide (Polihexanid, PAPB)by polycondensation of sodium dicyanamide and hexamethylenediamine in two steps (de Paula et al., 2011). Preparations of Polyaminopropyl biguanide (Polihexanid, PAPB)are polydisperse mixtures of polymeric biguanides, with a weighted average number (n) of 12 repeating hexamethylene biguanide units. The heterogeneity of the molecule is increased further by the presence of either amine, or cyanoguanidine or guanidine end-groups in any combination at the terminal positions of each chain. Equal amounts (in molar) of hexamethylenediamine and guanidine hydrochloride to be mixed in a round-bottomed three-necked flask, which is equipped with a mechanical stirrer and vacuum system. The mixture reacts at 100 °C for 60 min, and then at 170 °C for a certain time. During the reaction, by-product ammonia is neutralized by bubbling through aqueous HCl. At the end of reaction, the slightly yellow, viscous liquid solidifies upon cooling giving Polyaminopropyl biguanide (Polihexanid, PAPB)samples (Wei et al., 2009). PHMG is a new generation of disinfectant with a wide scope of applications in agriculture and food processing plants, logistics, kitchens, transport vehicles. Polyaminopropyl biguanide (Polihexanid, PAPB)is a disinfectant with a broad spectrum of activity against bacteria, viruses and fungi, inducing cell death by disrupting cell membrane integrity (Ikeda et al, 1983; Ikeda et al, 1984; Moore and Gray, 2007;). and Polyaminopropyl biguanide (Polihexanid, PAPB)shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics. Polyaminopropyl biguanide (Polihexanid, PAPB)is available also as a solid. Polyaminopropyl biguanide (Polihexanid, PAPB)hydrochloride (PAPB) is a chemical biocide which is a polymer utilized in a wide variety of antimicrobial applications. This review provides a comprehensive literature of Polyaminopropyl biguanide (Polihexanid, PAPB)features from synthesis methods,mode of action, antimicrobial effects and safety considerations to both humans and environments. Effectiveness against cellular organisms is due to the basic biguanide group attached to a flexible spacer, a hexamethylene group. Polyaminopropyl biguanide (Polihexanid, PAPB)is a disinfectant with a broad spectrum of inducing cell death by disrupting cell membrane integrity. Polyaminopropyl biguanide (Polihexanid, PAPB)is an environmentally friendly product noncorrosive and nontoxic to both humans and animals. Polyaminopropyl biguanide (Polihexanid, PAPB)is used as a preservative in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. In cosmetics, Polyaminopropyl biguanide (Polihexanid, PAPB)the preservation of fruit and vegetables. Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to preserve wet wipes; Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to control odor in textiles; Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to prevent microbial contamination in wound irrigation and sterile dressings; to Polyaminopropyl biguanide (Polihexanid, PAPB)is also used disinfect medical/dental utensil and trays, Polyaminopropyl biguanide (Polihexanid, PAPB)is also used farm equipment, Polyaminopropyl biguanide (Polihexanid, PAPB)is also used animal drinking water, and hard surfaces for food handling institutions and hospitals; and to Polyaminopropyl biguanide (Polihexanid, PAPB)is also used deodorize vacuums and toilets. Polyaminopropyl biguanide (Polihexanid, PAPB)can work at low concentrations with very fast action with a broad spectrum of action in addition of Polyaminopropyl biguanide (Polihexanid, PAPB)wide acceptance and exploitation for potential multi-purpose functional use. Polyaminopropyl biguanide (Polihexanid, PAPB)will be promising for advanced environmental treatments including food disinfection, Polyaminopropyl biguanide (Polihexanid, PAPB)will be promising for water disinfection, Polyaminopropyl biguanide (Polihexanid, PAPB)will be promising for surface disinfection, and meet the criteria for an ideal antimicrobial agent. Disinfecting agent is a substances used to control, prevent, or destroy harmful microorganisms (i.e., bacteria, viruses, or fungi) on inanimate objects and surfaces. Polyaminopropyl biguanide (Polihexanid, PAPB)is used as a preservative in cosmetics, personal care products, fabric softeners, contact lens solutions, hand washes, and more. In cosmetics, the preservation of fruit and vegetables (KoffiNevry et al., 2011; Kabara, 1984; Dugard and Mawdsley, 1982). Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to preserve wet wipes; Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to control odor in textiles; Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to prevent microbial contamination in wound irrigation, Polyaminopropyl biguanide (Polihexanid, PAPB)is also used sterile dressings; Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to deodorize vacuums and toilets (SCCS, 2005); Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to disinfect medical/dental utensil and trays, farm equipment, Polyaminopropyl biguanide (Polihexanid, PAPB)is also used animal drinking water and Polyaminopropyl biguanide (Polihexanid, PAPB)is also used hard surfaces for food handling institutions and hospitals. Polyaminopropyl biguanide (Polihexanid, PAPB)is used in antimicrobial hand washes and Polyaminopropyl biguanide (Polihexanid, PAPB)is used in rubs and Polyaminopropyl biguanide (Polihexanid, PAPB)is used in air filter treatments as an alternative to ozone. Polyaminopropyl biguanide (Polihexanid, PAPB)is also used as an active ingredient for recreational water treatment, as a chlorine free polymeric sanitizer, which is effective against a wide variety of microorganisms. Polyaminopropyl biguanide (Polihexanid, PAPB)has been used in a wide range of applications from swimming pool sanitisers to preservatives in cosmetics and contact lens solutions (Bucher,2012). Clinical studies indicate Polyaminopropyl biguanide (Polihexanid, PAPB)has a broad spectrum of activity, including against human immunodeficiency virus (HIV) (Wérthen et al, 2004; Krebs et al, 2005). Polyaminopropyl biguanide (Polihexanid, PAPB)appears to be available in presentations that provide clinicians with effective wound care modalities for most clinical scenarios and has also been used as a perioperative cleansing agent (Kramer, 1997), in mouth wash, (Rosin, 2002) in ophthalmology, (Kramer, 1997; Petrou-Binder, 2003). Petrou-Binder40 describes the germicidal effects of Polyaminopropyl biguanide (Polihexanid, PAPB)(Lavasept 0.02%) as eye drops prior to cataract surgery. Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in swimming pool sanitizers, Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in cosmetics, Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in leather preservatives, Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in contact lens disinfectants, Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in cleanser in agriculture and Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in food handling, in Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in treatment of hatching eggs, Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in fibers and Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in textiles and technical fluids like cutting oils and glues. Polyaminopropyl biguanide (Polihexanid, PAPB)is an excellent biocide that is an environmentally friendly product and expected to be used widely in future to provide valuable disinfection, cleaning and hygiene functions in a wide type of products such as cosmetics, deodorant, contact lenses solutions, fabric softeners, water treatments, wound care products and antimicrobial foam dressings. Polyaminopropyl biguanide (Polihexanid, PAPB)is expected to be; a component of pool cleaners, Polyaminopropyl biguanide (Polihexanid, PAPB)is expected to skin disinfectants and urinary catheter flush solutions; Polyaminopropyl biguanide (Polihexanid, PAPB)is expected to sanitizers in different applications; Polyaminopropyl biguanide (Polihexanid, PAPB)is expected to disinfectant in hospitals and food and equipment in contact with food. An overview of some current features and applications of Polyaminopropyl biguanide (Polihexanid, PAPB)was given and discussed. Polyaminopropyl biguanide (Polihexanid, PAPB)is an environmentally friendly biocides. Polyaminopropyl biguanide (Polihexanid, PAPB)is a new generation of disinfectant with a wide scope of applications in all aspects of life. Polyaminopropyl biguanide (Polihexanid, PAPB)is a disinfectant with a broad spectrum of activity against bacteria, viruses and fungi. Polyaminopropyl biguanide (Polihexanid, PAPB)review provides a comprehensive literature of Polyaminopropyl biguanide (Polihexanid, PAPB)from synthesis methods, antimicrobial effects and safety considerations to both humans and environments. Polyaminopropyl biguanide (Polihexanid, PAPB)is believed to continue to be used in wide ranging consumer and industrial products and by many market leading companies. Polyaminopropyl biguanide (Polihexanid, PAPB)as a disinfectant will be promising for advanced environmental treatments including food disinfection, Polyaminopropyl biguanide (Polihexanid, PAPB)as a disinfectant will be promising for water disinfection, Polyaminopropyl biguanide (Polihexanid, PAPB)as a disinfectant will be promising for surface disinfection, and meet the criteria for an ideal antimicrobial agent. Polyaminopropyl biguanide (Polihexanid, PAPB)hydrochloride has part Polyaminopropyl biguanide(2+) Polyaminopropyl biguanide (Polihexanid, PAPB)has role antibacterial agent .Polyaminopropyl biguanide (Polihexanid, PAPB)has role antifungal agent. Polyaminopropyl biguanide (Polihexanid, PAPB)has role antiseptic drug .Polyaminopropyl biguanide (Polihexanid, PAPB)has role dermatologic drug .Polyaminopropyl biguanide (Polihexanid, PAPB) has role disinfectant. Polyaminopropyl biguanide (Polihexanid, PAPB)has role ophthalmology drug .Polyaminopropyl biguanide (Polihexanid, PAPB) is a hydrochloride . The safety of Polyaminopropyl biguanide (Polihexanid, PAPB)as used as a preservative in cosmetics is reviewed in this assessment. Polyaminopropyl biguanide (Polihexanid, PAPB)is an International Nomenclature of Cosmetic Ingredients (INCI) name; Polyaminopropyl biguanide (Polihexanid, PAPB)refers to the hydrochloride salt of an amino polymer comprising hexyl biguanide repeat units (i.e., Polyaminopropyl biguanide (Polihexanid, PAPB)hydrochloride (Polyaminopropyl biguanide (Polihexanid, PAPB)HCl)). Polyaminopropyl biguanide (Polihexanid, PAPB)has a 6-carbon chain in each monomeric repeat unit, and is always supplied as the hydrochloride salt. Polyaminopropyl biguanide (Polihexanid, PAPB)identified by the chemical name polyaminopropyl biguanide is not a cosmetic ingredient. Accordingly, throughout this report, when the capitalized INCI name Polyaminopropyl biguanide (Polihexanid, PAPB)is used, Polyaminopropyl biguanide (Polihexanid, PAPB)is to be understood that Polyaminopropyl biguanide (Polihexanid, PAPB)is referring to the cosmetic ingredient that has the chemical name Polyaminopropyl biguanide (Polihexanid, PAPB)hydrochloride. Polyaminopropyl biguanide (Polihexanid, PAPB)should also be understood that Polyaminopropyl biguanide (Polihexanid, PAPB)is the ingredient with reported uses in cosmetics. Furthermore, most of the safety test data included in this report are on the chemical Polyaminopropyl biguanide (Polihexanid, PAPB)hydrochloride, as indicated by the use of the INCI name. The only exception to the exclusive use of the INCI name Polyaminopropyl biguanide (Polihexanid, PAPB)in this safety assessment relates to the summary of a cytoxicity study, in which results for Polyaminopropyl biguanide (Polihexanid, PAPB)and Polyaminopropyl biguanide (Polihexanid, PAPB)are compared. Additionally, Polyaminopropyl biguanide (Polihexanid, PAPB)has been reviewed by the United States Environmental Protection Agency (EPA). The EPA concluded that its use as a pesticide has very low aggregate risk of adverse health effects to the public or environment. According to 2017 VCRP data Polyaminopropyl biguanide (Polihexanid, PAPB)is being used in 147 cosmetic products, mostly leave-on products.The results of a concentration of use survey provided in 2017 indicate that Polyaminopropyl biguanide (Polihexanid, PAPB)is being used at concentrations up to 0.2% in leave-on products and concentrations up to 0.1% in rinse-off products (Table 3).7 Cosmetic products containing Polyaminopropyl biguanide (Polihexanid, PAPB)may be applied to the skin and hair or may come in contact with the eyes (at maximum use concentrations up to 0.2 % in eye lotions) and mucous membranes (0.006% in other personal cleanliness products). Polyaminopropyl biguanide (Polihexanid, PAPB)is being used in a lipstick product, the application of which may result in incidental ingestion; no concentration data were reported for this use. Polyaminopropyl biguanide (Polihexanid, PAPB)is also being used in baby lotions, oils, or creams at maximum use concentrations up to 0.1%. Products containing Polyaminopropyl biguanide (Polihexanid, PAPB)may be applied as frequently as several times per day and may come in contact with the skin or hair for variable periods following application. Daily or occasional use may extend over many years. Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to control odor in textiles; Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to prevent microbial contamination in wound irrigation, Polyaminopropyl biguanide (Polihexanid, PAPB)is also used sterile dressings; Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to deodorize vacuums and toilets (SCCS, 2005); Polyaminopropyl biguanide (Polihexanid, PAPB)is also used to disinfect medical/dental utensil and trays, farm equipment, Polyaminopropyl biguanide (Polihexanid, PAPB)is also used animal drinking water and Polyaminopropyl biguanide (Polihexanid, PAPB)is also used hard surfaces for food handling institutions and hospitals. Polyaminopropyl biguanide (Polihexanid, PAPB)is used in antimicrobial hand washes and Polyaminopropyl biguanide (Polihexanid, PAPB)is used in rubs and Polyaminopropyl biguanide (Polihexanid, PAPB)is used in air filter treatments as an alternative to ozone. Polyaminopropyl biguanide (Polihexanid, PAPB)is also used as an active ingredient for recreational water treatment, as a chlorine free polymeric sanitizer, which is effective against a wide variety of microorganisms. Polyaminopropyl biguanide (Polihexanid, PAPB)has been used in a wide range of applications from swimming pool sanitisers to preservatives in cosmetics and contact lens solutions (Bucher,2012). Clinical studies indicate Polyaminopropyl biguanide (Polihexanid, PAPB)has a broad spectrum of activity, including against human immunodeficiency virus (HIV) (Wérthen et al, 2004; Krebs et al, 2005). Polyaminopropyl biguanide (Polihexanid, PAPB)appears to be available in presentations that provide clinicians with effective wound care modalities for most clinical scenarios and has also been used as a perioperative cleansing agent (Kramer, 1997), in mouth wash, (Rosin, 2002) in ophthalmology, (Kramer, 1997; Petrou-Binder, 2003). Petrou-Binder40 describes the germicidal effects of Polyaminopropyl biguanide (Polihexanid, PAPB)(Lavasept 0.02%) as eye drops prior to cataract surgery. Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in swimming pool sanitizers, Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in cosmetics, Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in leather preservatives, Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in contact lens disinfectants, Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in cleanser in agriculture and Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in food handling, in Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in treatment of hatching eggs, Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in fibers and Polyaminopropyl biguanide (Polihexanid, PAPB)can be found in textiles and technical fluids like cutting oils and glues. Polyaminopropyl biguanide (Polihexanid, PAPB)is an excellent biocide that is an environmentally friendly product and expected to be used widely in future to provide valuable disinfection, cleaning and hygiene functions in a wide type of products such as cosmetics, deodorant, contact lenses solutions, fabric softeners, water treatments, wound care products and antimicrobial foam dressings. Polyaminopropyl biguanide (Polihexanid, PAPB)is expected to be; a component of pool cleaners, Polyaminopropyl biguanide (Polihexanid, PAPB)is expected to skin disinfectants and urinary catheter flush solutions; Polyaminopropyl biguanide (Polihexanid, PAPB)is expected to sanitizers in different applications; Polyaminopropyl biguanide (Polihexanid, PAPB)is expected to disinfectant in hospitals and food and equipment in contact with food. An overview of some current features and applications of Polyaminopropyl biguanide (Polihexanid, PAPB)was given and discussed. Polyaminopropyl biguanide (Polihexanid, PAPB)is an environmentally friendly biocides. Polyaminopropyl biguanide (Polihexanid, PAPB)is a new generation of disinfectant with a wide scope of applications in all aspects of life. Polyaminopropyl biguanide (Polihexanid, PAPB)is a disinfectant with a broad spectrum of activity against bacteria, viruses and fungi. Polyaminopropyl biguanide (Polihexanid, PAPB)review provides a comprehensive literature of Polyaminopropyl biguanide (Polihexanid, PAPB)from synthesis methods, antimicrobial effects and safety considerations to both humans and environments. According to the FDA VCRP, Polyaminopropyl biguanide (Polihexanid, PAPB)is used in a fragrance preparation, which may result in incidental ingredient inhalation exposure; concentration data were not reported for this use. The SCCS originally concluded that Polyaminopropyl biguanide (Polihexanid, PAPB)is not safe for consumers in all cosmetic products when used as a preservative up to the maximum concentration of 0.3%.12 In 2017, the SCCS issued a final opinion stating that “the use of Polyaminopropyl biguanide (Polihexanid, PAPB)as a preservative in all cosmetic products at concentrations up to 0.1% is safe and that its use in sprayable formulations is not advised”. 2 Polyaminopropyl biguanide (Polihexanid, PAPB)is currently listed in Annex V (entry 28) of the European Commission (EC) Regulation No. 1223/2009 (Cosmetic Regulation) as a preservative to be used in all cosmetic products at up to a maximum concentration of 0.3%.2,13 Additionally, Polyaminopropyl biguanide (Polihexanid, PAPB)is classified as CMR 2 (Carc. 2) according to the Commission Regulation (EU) No. 944/2013. CMR substances are classified as carcinogenic, mutagenic, or toxic for reproduction. Polyaminopropyl biguanide (Polihexanid, PAPB)is placed in carcinogen Category 2 (Carc. 2, suspected human carcinogens) when the evidence obtained from human and/or animal studies is not sufficiently convincing to place the the use of Polyaminopropyl biguanide (Polihexanid, PAPB)as a cosmetic ingredient is considered to be prohibited as of this date. Polyaminopropyl biguanide (Polihexanid, PAPB)has been banned from personal care products in Denmark since January of 2015, based on the European Commission’s classification of this ingredient as a CMR substance.13 Polyaminopropyl biguanide (Polihexanid, PAPB)was noted that CMR substances may be used in cosmetic products if a risk assessment shows that the use of the substance is safe. Reference was made to the SCCS’s conclusion specifying a safe level of Polyaminopropyl biguanide (Polihexanid, PAPB)in cosmetics. Polyhexanide (Polyaminopropyl biguanide, Poliaminopropil Biguanid (Poliheksanid)) is a polymer used as a disinfectant and antiseptic. In dermatological use,[1] it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide.[2] Poliaminopropil Biguanid (Poliheksanid, PAPB) has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae) (Poliaminopropil Biguanid (Poliheksanid)) (polihexametilenbiguanid) (Polyaminopropyl biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Some products containing Poliaminopropil Biguanid (Poliheksanid, PAPB) are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, scopy, first aid, surface disinfection, and linen disinfection.[4] Poliaminopropil Biguanid (Poliheksanid, PAPB) eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis(Poliaminopropil Biguanid (Poliheksanid)) (polihexametilenbiguanid) (Polyaminopropyl biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Branded as Baquacil, it also has an application as a swimming-pool and spa water sanitizer in place of chlorine- or bromine-based products. It is available as Baqua-Spa 3 sanitize, as Revacil Spa 3 sanitizer, and in the Leisure Time Free system. (Poliaminopropil Biguanid (Poliheksanid)) (polihexametilenbiguanid) (Polyaminopropyl biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)Poliaminopropil Biguanid (Poliheksanid, PAPB) is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products. It is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors. (Poliaminopropil Biguanid (Poliheksanid)) (polihexametilenbiguanid) (Polyaminopropyl biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza metilen biguanid) ( polyhexa methylene biguanide) ( polyhexa methylenebiguanide) (polyhexamethylenebiguanide)The Poliaminopropil Biguanid (Poliheksanid, PAPB) hydrochloride salt (solution) is used in the majority of formulations. (Poliaminopropil Biguanid (Poliheksanid)) (polihexametilenbiguanid) (Polyaminopropyl biguanide) (polyhexamethylene bıguanıde) ( poly hexa methylene biguanide) (poli hegza meti