POLYETHYLENE GLYCOL-15-HYDROXYSTEARATE

Polyethylene glycol-15-hydroxystearate is a yellowish-white, almost odorless waxy mass or paste at room temperature, which becomes liquid at approximately 30°C.
Polyethylene glycol-15-hydroxystearate is a polymeric surfactant.
Polyethylene glycol-15-hydroxystearate is produced by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxystearic acid.

CAS:70142-34-6
MF:(C18H36O3.(C2H4O)nH2O)x

Synonyms
Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl);POLYETHYLENEGLYCOL-30DIPOLYHYDROXYSTEARATE;12-HYDROXYSTEARICACID-POLYETHYLENEGLYCOLCOPOLYMER;SOLUTOL(R);12-Hydroxystearinsure, ethoxyliert 16,6 EO (mittleres Molekulargewicht ca. 1070);Polyoxyl 15 Hydroxystearate (500 mg);Polyoxyethylated 12-hydroxystearic acid;Polyoxyl 15 hydroxystearate

Polyethylene glycol-15-hydroxystearate is a yellowish white paste at room temperature that becomes a liquid at approximately 30 °C. 
Polyethylene glycol-15-hydroxystearate dissolves in water, ethanol and 2-propanol to form clear solutions. 
Polyethylene glycol-15-hydroxystearate's solubility in water decreases with increasing temperatures. 
Polyethylene glycol-15-hydroxystearate is insoluble in liquid paraffin.

Polyethylene glycol-15-hydroxystearate Chemical Properties
Fp: 272℃
Storage temp.: Refrigerator
Solubility: Very soluble in water, soluble in ethanol (96 per cent), insoluble in liquid paraffin. It solidifies at about 25 °C.
Form: Solid
Color: Clear Colourless Oil to Off-White
Odor: magnolia white flower fresh citrus natural
PH: 5.0-7.0 (1g/10 mL in H2O)
EPA Substance Registry System: Octadecanoic acid, 12-hydroxy-, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl) (70142-34-6)

Polyethylene glycol-15-hydroxystearate is a nonionic surfactant and emulsifier. 
Polyethylene glycol-15-hydroxystearate is used for improving the solubility and dissolution of poorly watersoluble drugs.

Pharmaceutical Applications    
Polyethylene glycol-15-hydroxystearate is frequently used in preclinical testing of drugs, mainly for IV and other parenteral applications. 
The solubilizing capacity for some tested drugs (clotrimazole, carbamazepine, 17 β-estradiol, sulfathiazole, and piroxicam) increases almost linearly with increasing concentration of solubilizing agent. 
Polyethylene glycol-15-hydroxystearate is due to the formation of spherical micelles even at high concentrations of macrogol 15 hydroxystearate. 
Similarly, tests have revealed that viscosity increases with increasing amount of solubilizer, but the amount of solubilized drugs does not have any additional influence on the kinematic viscosity. 
Lipid nanocapsules comprising Polyethylene glycol-15-hydroxystearate and soybean phosphatidylcholine containing 3% docetaxel have been successfully prepared by a solvent-free inversion process.

Polyethylene glycol-15-hydroxystearate has been used in the manufacture of aqueous parenteral preparations with vitamin A, D, E and K, and a number of other lipophilic pharmaceutical active agents, such as propanidid, miconazole, alfadolone, and alfaxalone. 
Polyethylene glycol-15-hydroxystearate is very efficient at solubilizing substances like fat-soluble vitamins and active ingredients of hydrophobic nature. 
Polyethylene glycol-15-hydroxystearate is also an excellent solubilizer for parenteral use, at a concentration of 20%, and the water solubility of different drugs may be enhanced by a factor of 10–100, depending on the structure of the drug molecule.