Quick Search
Polyethylene Glycol 1500 is a polymer which is hydrolyzed by ethylene oxide.
Polyethylene Glycol 1500 has no toxicity and irritation.
Polyethylene Glycol 1500 is widely used in various pharmaceutical preparations.
CAS Number: 25322-68-3
Molecular Formula: (C2H4O)nH2O
EINECS Number: 500-038-2
Synonyms: Tetraethylene glycol dimethacrylate, 109-17-1, TETRAETHYLENEGLYCOL DIMETHACRYLATE, Tetraethylene glycol, dimethacrylate, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate), SR 209, Methacrylic acid, oxybis(ethyleneoxyethylene) ester, PEG-4 dimethacrylate, 2-[2-[2-[2-(2-methylprop-2-enoyloxy)ethoxy]ethoxy]ethoxy]ethyl 2-methylprop-2-enoate, Methacrylic acid, diester with tetraethylene glycol, TGM-4, 2-Propenoic acid, 2-methyl-, oxybis(2,1-ethanediyloxy-2,1-ethanediyl) ester, CT038EQF54, DTXSID6044515, NSC-84253, Te EGDMA, MFCD00081877, TGM 4, CCRIS 3435, 3,6,9-Trioxaundecamethylene dimethacrylate, EINECS 203-653-1, NSC 84253, Tetraethylene glycol dimethacrylate(7 cp(25 degrees c)), BRN 1803537, UNII-CT038EQF54, transglutaminase 5, PEG bismethacrylate, MFCD00014932, SCHEMBL15895, CHEMBL3184138, DTXCID4024515, NSC84253, Tox21_300956, NCGC00248228-01, NCGC00254858-01, BS-44110, CAS-109-17-1, Tetraethylene glycol dimethacrylate; TEGDMA, NS00019480, T3486, D84708, F20349, Q27275744, Tetraethylene Glycol Dimethacrylate (stabilized with HQ), Tetraethylene glycol dimethacrylate, technical, >=90% (GC), ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl)bis(2-methylacrylate), 14-Methyl-13-oxo-3,6,9,12-tetraoxapentadec-14-en-1-yl 2-methylacrylate #, 2-Propenoic acid, 2-methyl-, 1,1'-(oxybis(2,1-ethanediyloxy-2,1-ethanediyl)) ester, Tetraethylene glycol dimethacrylate, contains <=1500 ppm MEHQ as inhibitor, 95%, Tetraethylene glycol dimethacrylate, contains ~0.006% Hydroquinone as stabilizer, 90%, 1,2-ethanediol,homopolymer;2-ethanediyl),.alpha.-hydro-.omega.-hydroxy-Poly(oxy-1;Alcox E 160;Alcox E 30;alcoxe30;Poly(ethylene oxide),approx. M.W. 600,000;Poly(ethylene oxide),approx. M.W. 200,000;Poly(ethylene oxide),approx. M.W. 900,000.
Polyethylene Glycol 1500 is a cream matrix for preparing water-soluble drugs.
Polyethylene Glycol 1500 can also be used as a solvent for acetylsalicylic acid and caffeine, which is difficult to dissolve in water.
Drug sustained-release and immobilized enzyme carrier.
The toxicity of low molecular weight Polyethylene Glycol 1500 is relatively large.
In general, the toxicity of diols is very low.
Topical application of Polyethylene Glycol 1500, especially mucosal drug, can cause irritant pain.
In topical lotion, this product can increase the flexibility of the skin, and has a similar moisturizing effect with glycerin.
Polyethylene Glycol 1500 can occur in large doses of oral administration.
In injection, the maximum Polyethylene Glycol 1500 concentration is about 30% (V/V).
Hemolysis could occur when the concentration is more than 40% (V/V).
Polyethylene Glycol 1500 is also known as polyoxirane (PEO).
It is a linear polyether obtained by ring opening polymerization of ethylene oxide.
The main uses in the field of biomedicine are as follows:
Contact lens liquid the viscosity of polyethylene glycol solution is sensitive to the shear rate and it is not easy for bacteria to grow on polyethylene glycol.
The condensation polymer of ethylene oxide and water.
The polyethylene glycol solution is applied to the outer layer of the pill to control the diffusion of drugs in the pill so as to improve the efficacy.
Surface modification of medical polymer materials.
The biocompatibility of medical polymer materials in contact with blood can be improved by adsorption, interception and grafting of two amphiphilic copolymers containing polyethylene glycol on the surface of medical polymers.
Polyethylene Glycol 1500 can make the membrane of the alkanol contraceptive pill.
Polyethylene Glycol 1500 can make hydrophilic anticoagulant polyurethane.
Polyethylene Glycol 1500 is an osmotic laxative.
Polyethylene Glycol 1500 can increase osmotic pressure and absorb moisture in the intestinal cavity, which makes the stool soften and increase in volume, resulting in bowel movement and defecation.
Peg nontoxic and gelatinous nature can be used as a component of denture fixer.
Polyethylene Glycol 1500 and PEG 6000 are commonly used to promote cell fusion or protoplast fusion and help organisms (such as yeasts) to take DNA in transformation.
Polyethylene Glycol 1500 absorbs water from the solution, so it is also used to concentrate the solution.
Polyethylene Glycol 1500 is a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.
The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups.
The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups.
The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides.
The average molecular weight of any specific polyethylene glycol product falls within quite narrow limits (°5%).
The number of ethylene oxide units or their approximate molecular weight (e.g., PEG-4 or PEG-200) commonly designates the nomenclature of specific polyethylene glycols.
Polyethylene Glycol 1500 with a molecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.
These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Polyethylene Glycol 1500 was obtained by polymerization of ethylene oxide in an autoclave at 80-100°C using as a catalyst dipotassium alcogolate of polyethylene glycol 400.
Dipotassium alcogolate of Polyethylene Glycol 1500 was synthesized by a heating of the dry mixture of polyethylene glycol 400 and potassium hydroxide.
The molecular weight of polymer was regulated by the ratio of monomer:catalyst.
Polyethylene Glycol 1500 is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
Polyethylene Glycol 1500 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization.
X-ray diraction of protein crystals can reveal the atomic structure of the proteins.
Polyethylene Glycol 1500 is used to fuse two dierent types of cells, most often B-cells and myelomas in order to create hybridomas.
César Milstein and Georges J. F. Köhler originated this technique, which they used for antibody production, winning a Nobel Prize in Physiology or Medicine in 1984.
Polymer segments derived from Polyethylene Glycol 1500 polyols impart exibility to polyurethanes for applications such as elastomeric bers (spandex) and foam cushions.
In microbiology, Polyethylene Glycol 1500 precipitation is used to concentrate viruses.
Polyethylene Glycol 1500 also used to induce complete fusion (mixing of both inner and outer leaets) in liposomes reconstituted in vitro.
Gene therapy vectors (such as viruses) can be Polyethylene Glycol 1500-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic eect.
The size of the Polyethylene Glycol 1500 polymer has been shown to be important, with larger polymers achieving the best immune protection.
Polyethylene Glycol 1500 is a polyethylene glycol white waxy flaked solid at room temperature.
Polyethylene Glycol 1500 is soluble in water and polar organic solvents like acetone or methanol.
It displays typical chemical reactions of alcohols/diols.
This product is used for a wide variety of applications, such as polyester or polyurethane resins, leather and textile processing, cosmetic/pharmaceutical formulations, and as a lubricant and mold release agent.
Polyethylene Glycol 1500 is a form of polyethylene glycol, a polymer composed of repeating units of ethylene glycol.
It is characterized by its relatively high molecular weight, which gives it specific properties like a viscous liquid or semi-solid consistency depending on the formulation.
Polyethylene Glycol 1500 is commonly used in a variety of industrial, pharmaceutical, and cosmetic applications.
In pharmaceuticals, it serves as a vehicle or excipient for drug delivery, as it is able to dissolve or disperse active ingredients effectively.
It is often used in ointments, creams, and as a laxative in oral medications.
In the cosmetics industry, Polyethylene Glycol 1500 is valued for its ability to improve the texture of products, enhancing their smoothness and ability to moisturize the skin.
Additionally, Polyethylene Glycol 1500 can act as a stabilizer or emulsifier in different formulations, aiding in the mixing of water and oil-based ingredients.
Its chemical structure allows it to be versatile, non-toxic, and generally safe for use in both topical and internal applications when formulated appropriately.
Melting point: 64-66 °C
Boiling point: >250°C
Tg: -67
Bulk density: 400-500kg/m³
Density: 1.27 g/mL at 25 °C
Vapor density: >1 (vs air)
Vapor pressure: <0.01 mm Hg (20 °C)
Refractive index: n20/D 1.469
Flash point: 270 °C
Storage temp.: 2-8°C
Solubility: H₂O: 50 mg/mL, clear, colorless
Form: Waxy solid
Color: White to very pale yellow
Specific Gravity: 1.128
pH: 5.5-7.0 (25℃, 50mg/mL in H₂O)
Biological source: Synthetic (organic)
Viscosity (1% solution @ 25°C): 1,650-3,850cp
Viscosity (99°C): 11cs
Viscosity (99°C): 4.5cs
Viscosity (1% solution @ 25°C): 5,500-8,000cp
Viscosity (99°C): 6cs
Viscosity (99°C): 7.4cs
Viscosity (5% solution @ 25°C): 750cp
Viscosity (5% solution @ 25°C): 75cp
Viscosity (99°C): 8,000cs
Viscosity (5% solution @ 25°C): 8,800-17,600cp
Viscosity (99°C): 93cs
Water Solubility: Soluble in water.
λmax: λ: 260 nm Amax: 0.6
λ: 280 nm Amax: 0.3
Sensitive: Hygroscopic
Merck: 14,7568
α-end: Hydroxyl
Ω-end: Hydroxyl
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -0.698 at 25℃
Polyethylene Glycol 1500 polymers are formed by the reaction of ethylene oxide and water under pressure in the presence of a catalyst.
Polyethylene Glycol 1500 is the basis of many skin creams (as cetomacrogol) and personal lubricants (frequently combined with glycerin).
Polyethylene Glycol 1500 is used in a number of toothpastes[4] as a dispersant.
In this application, it binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste.
Polyethylene Glycol 1500 is also under investigation for use in body armor, and in tattoos to monitor diabetes.
In low-molecular-weight formulations (e.g. PEG 400), it is used in Hewlett-Packard designjet printers as an ink solvent and lubricant for the print heads.
PEG is also used as an anti-foaming agent in food and drinks[31] – its INS number is 1521[32] or E1521 in the EU.
A nitrate ester-plasticized polyethylene glycol (NEPE-75) is used in Trident II submarine-launched ballistic missile solid rocket fuel.
Dimethyl ethers of PEG are the key ingredient of Selexol, a solvent used by coal-burning, integrated gasication combined cycle (IGCC) power plants to remove carbon dioxide and hydrogen sulde from the gas waste stream.
Polyethylene Glycol 1500 has been used as the gate insulator in an electric double-layer transistor to induce superconductivity in an insulator.
Polyethylene Glycol 1500 is also used as a polymer host for solid polymer electrolytes.
Although not yet in commercial production, many groups around the globe are engaged in research on solid polymer electrolytes involving Polyethylene Glycol 1500, with the aim of improving their properties, and in permitting their use in batteries, electro-chromic display systems, and other products in the future.
Polyethylene Glycol 1500 is injected into industrial processes to reduce foaming in separation equipment.
Polyethylene Glycol 1500 is used as a binder in the preparation of technical ceramics.
Polyethylene Glycol 1500 is used to extend the size and durability of very large soap bubbles.
Polyethylene Glycol 1500 is the main ingredient in many personal lubricants.
PEG is considered biologically inert and safe by the FDA. However, a growing body of evidence shows the existence of a detectable level of anti-PEG antibodies in approximately 72% of the population, never treated with PEGylated drugs, based on plasma samples from 1990–1999.
The FDA has been asked to investigate the possible eects of PEG in laxatives for children.
Since 1999, the FDA has received over 1,000 incident reports from parents reporting serious or life threatening side eects after their children were given one or more doses of Polyethylene Glycol 1500 as an osmotic laxative.
Miralax has not been tested on children.
Polyethylene Glycol 1500 is not recommended to those under 18.
Unlike the low molecular weight poly(ethylene oxide)s, the high molecular weight polymers are tough and extensible.
They are highly crystalline, with a melting point of 66??C. Unlike most water-soluble polymers, the high molecular weight poly(ethylene oxide)s may be melt processed; they may be injection moulded, extruded and calendered without difficulty.
Polyethylene Glycol 1500s are soluble in an unusually broad range of solvents, which includes water; chlorinated hydrocarbons such as carbon tetrachloride and methylene dichloride; aromatic hydrocarbons such as benzene and toluene; ketones such as acetone and methyl ethyl ketone; and alcohols such as methanol and isopropanol.
There is an upper temperature limit of solubility in water for the high molecular weight poly(ethylene oxide)s; this varies with concentration and molecular weight but is usually between 90 and 100C.
Water-solubility is due to the ability of the polyether to form hydrogen bonds with water; these bonds are broken when the temperature is raised, restoring the anhydrous polymer which is precipated from the solution.
High molecular weight poly(ethylene oxide)s find use as water-soluble packaging films and capsules for such products as laundry powders, colour concentrates, tablets and seeds.
In solution, the polymers are used as thickeners in pharmaceutical and cosmetic preparations, textile sizes and latex stabilizers.
Polyethylene Glycol 1500 is heat-stable and inert to many chemical agents; Poly(ethylene glycol) will not hydrolyze or deteriorate under normal conditions.
Polyethylene Glycol 1500 has a solvent action on some plastics.
Polyethylene Glycol 1500 helps in the purification and crystal growth of proteins and nucleic acids.
Polyethylene Glycol 1500 also interacts with cell membrane, thereby allowing cell fusion.
Polyethylene Glycol 1500 has been used to preserve the painted colors on Terracotta Warriors unearthed at a UNESCO World Heritage site in China.
These painted artifacts were created during the Qin Shi Huang (rst emperor of China) era.
Within 15 seconds of the terra-cotta pieces being unearthed during excavations, the lacquer beneath the paint begins to curl after being exposed to the dry Xi'an air.
The paint would subsequently ake o in about four minutes.
The German Bavarian State Conservation Oce developed a Polyethylene Glycol 1500 preservative that when immediately applied to unearthed artifacts has aided in preserving the colors painted on the pieces of clay soldiers.
Polyethylene Glycol 1500 is often used (as an internal calibration compound) in mass spectrometry experiments, with its characteristic fragmentation pattern allowing accurate and reproducible tuning.
Polyethylene Glycol 1500 derivatives, such as narrow range ethoxylates, are used as surfactants.
Polyethylene Glycol 1500 has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes.
Polyethylene Glycol 1500 has also been used as a propellent on the UGM-133M Trident II Missile, in service with the United States Air Force.
The chemical reactivity of polyethylene glycols is mainly confined to the two terminal hydroxyl groups, which can be either esterified or etherified.
However, all grades can exhibit some oxidizing activity owing to the presence of peroxide impurities and secondary products formed by autoxidation.
Liquid and solid polyethylene glycol grades may be incompatible with some coloring agents.
The antibacterial activity of certain antibiotics is reduced in polyethylene glycol bases, particularly that of penicillin and bacitracin.
The preservative efficacy of the parabens may also be impaired owing to binding with polyethylene glycols.
Physical effects caused by polyethylene glycol bases include softening and liquefaction in mixtures with phenol, tannic acid, and salicylic acid.
Discoloration of sulfonamides and dithranol can also occur, and sorbitol may be precipitated from mixtures.
Plastics, such as polyethylene, phenolformaldehyde, polyvinyl chloride, and cellulose-ester membranes (in filters) may be softened or dissolved by polyethylene glycols.
Migration of polyethylene glycol can occur from tablet film coatings, leading to interaction with core components.
Pharmacology and Cosmetics production (as base for creams, toothpastes and lipsticks)
Detergent & Household goods production (as soap bars glue, soluble agent in detergent pastes, xing agent for odors in soaps and detergents, as additive in general cleaners, polishers, air fresheners, automatic dishwashing detergents)
Rubber goods production (non adhesive agent for forms treatment)
Uses Of Polyethylene Glycol 1500:
Poly(ethylene Glycol) molecules of approximately 2000 monomers. Poly(ethylene Glycol) is used in various applications from industrial chemistry to biological chemistry.
Recent research has shown Polyethylene Glycol 1500 m aintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals.
In rats, it has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery.
Polyethylene Glycol 1500 is industrially produced as a lubricating substance for various surfaces to reduce friction.
Polyethylene Glycol 1500 is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
Polyethylene Glycol 1500 is a binder, coating agent, dispersing agent, flavoring adjuvant, and plasticizing agent that is a clear, colorless, viscous, hygroscopic liquid resembling paraffin (white, waxy, or flakes), with a ph of 4.0–7.5 in 1:20 concentration.
Polyethylene Glycol 1500 is soluble in water (mw 1,000) and many organic solvents.
Polyethylene Glycol 1500 is a binder, solvent, plasticizing agent, and softener widely used for cosmetic cream bases and pharmaceutical ointments.
Pegs are quite humectant up to a molecular weight of 500. Beyond this weight, their water uptake diminishes.
Used in conjunction with carbon black to form a conductive composite.
Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.
Polyethylene Glycol 1500 are widely used in a variety of pharmaceutical formulations, including parenteral, topical, ophthalmic, oral, and rectal preparations.
Polyethylene Glycol 1500 has been used experimentally in biodegradable polymeric matrices used in controlled-release systems.
Polyethylene Glycol 1500s are stable, hydrophilic substances that are essentially nonirritant to the skin;They do not readily penetrate the skin, although the polyethylene glycols are water-soluble and are easily removed from the skin by washing, making them useful as ointment bases.
Solid grades are generally employed in topical ointments, with the consistency of the base being adjusted by the addition of liquid grades of polyethylene glycol.
Mixtures of Polyethylene Glycol 1500s can be used as suppository bases,for which they have many advantages over fats.
For example, the melting point of the suppository can be made higher to withstand exposure to warmer climates; release of the drug is not dependent upon melting point; the physical stability on storage is better; and suppositories are readily miscible with rectal fluids.
Polyethylene Glycol 1500 have the following disadvantages: they are chemically more reactive than fats; greater care is needed in processing to avoid inelegant contraction holes in the suppositories; the rate of release of water-soluble medications decreases with the increasing molecular weight of the polyethylene glycol; and polyethylene glycols tend to be more irritating to mucous membranes than fats.
Aqueous polyethylene glycol solutions can be used either as suspending agents or to adjust the viscosity and consistency of other suspending vehicles.
When used in conjunction with other emulsifiers, polyethylene glycols can act as emulsion stabilizers.
Liquid polyethylene glycols are used as water-miscible solvents for the contents of soft gelatin capsules.
However, they may cause hardening of the capsule shell by preferential absorption of moisture from gelatin in the shell.
In concentrations up to approximately 30% v/v, Polyethylene Glycol 1500 and PEG 400 have been used as the vehicle for parenteral dosage forms.
In solid-dosage formulations, higher-molecular-weight polyethylene glycols can enhance the effectiveness of tablet binders and impart plasticity to granules.
However, they have only limited binding action when used alone, and can prolong disintegration if present in concentrations greater than 5% w/w.
When used for thermoplastic granulations,a mixture of the powdered constituents with 10–15% w/w PEG 6000 is heated to 70–75°C.
The mass becomes pastelike and forms granules if stirred while cooling.
This technique is useful for the preparation of dosage forms such as lozenges when prolonged disintegration is required.
Polyethylene Glycol 1500s can also be used to enhance the aqueous solubility or dissolution characteristics of poorly soluble compounds by making solid dispersions with an appropriate polyethylene glycol.
Animal studies have also been performed using polyethylene glycols as solvents for steroids in osmotic pumps.
In film coatings, solid grades of polyethylene glycol can be used alone for the film-coating of tablets or can be useful as hydrophilic polishing materials.
Solid grades are also widely used as plasticizers in conjunction with film-forming polymers.
The presence of polyethylene glycols in film coats, especially of liquid grades, tends to increase their water permeability and may reduce protection against low pH in enteric-coating films.
Polyethylene Glycol 1500s are useful as plasticizers in microencapsulated products to avoid rupture of the coating film when the microcapsules are compressed into tablets.
Polyethylene Glycol 1500 grades with molecular weights of 6000 and above can be used as lubricants, particularly for soluble tablets.
The lubricant action is not as good as that of magnesium stearate, and stickiness may develop if the material becomes too warm during compression.
An antiadherent effect is also exerted, again subject to the avoidance of overheating.
Polyethylene Glycol 1500s have been used in the preparation of urethane hydrogels, which are used as controlled-release agents.
Polyethylene Glycol 1500 has also been used in insulin-loaded microparticles for the oral delivery of insulin;it has been used in inhalation preparations to improve aerosolization;polyethylene glycol nanoparticles have been used to improve the oral bioavailability of cyclosporine;it has been used in self-assembled polymeric nanoparticles as a drug carrier;and copolymer networks of polyethylene glycol grafted with poly(methacrylic acid) have been used as bioadhesive controlled drug delivery formulations.
Storage Of Polyethylene Glycol 1500:
Polyethylene Glycol 1500 are chemically stable in air and in solution, although grades with a molecular weight less than 2000 are hygroscopic.
Polyethylene Glycol 1500 do not support microbial growth, and they do not become rancid.
Polyethylene glycols and aqueous polyethylene glycol solutions can be sterilized by autoclaving, filtration, or gamma irradiation.
Sterilization of solid grades by dry heat at 150℃ for 1 hour may induce oxidation, darkening, and the formation of acidic degradation products.
Ideally, sterilization should be carried out in an inert atmosphere.
Oxidation of polyethylene glycols may also be inhibited by the inclusion of a suitable antioxidant.
If heated tanks are used to maintain normally solid polyethylene glycols in a molten state, care must be taken to avoid contamination with iron, which can lead to discoloration.
The temperature must be kept to the minimum necessary to ensure fluidity; oxidation may occur if polyethylene glycols are exposed for long periods to temperatures exceeding 50℃.
However, storage under nitrogen reduces the possibility of oxidation.
Polyethylene glycols should be stored in well-closed containers in a cool, dry place.
Stainless steel, aluminum, glass, or lined steel containers are preferred for the storage of liquid grades.
Safety Profile Of Polyethylene Glycol 1500:
When heated to decomposition it emits acrid smoke and irritating fumes.
Polyethylene Glycol 1500 are widely used in a variety of pharmaceutical formulations.
Generally, they are regarded as nontoxic and nonirritant materials.
Adverse reactions to Polyethylene Glycol 1500 have been reported, the greatest toxicity being with glycols of low molecular weight.
However, the toxicity of glycols is relatively low.
Polyethylene Glycol 1500s administered topically may cause stinging, especially when applied to mucous membranes.
Hypersensitivity reactions to Polyethylene Glycol 1500 applied topically have also been reported, including urticaria and delayed allergic reactions.
The most serious adverse effects associated with polyethylene glycols are hyperosmolarity, metabolic acidosis, and renal failure following the topical use of polyethylene glycols in burn patients.
Topical preparations containing Polyethylene Glycol 1500 should therefore be used cautiously in patients with renal failure, extensive burns, or open wounds.
Oral administration of large quantities of polyethylene glycols can have a laxative effect.
Therapeutically, up to 4 L of an aqueous mixture of electrolytes and high-molecular-weight polyethylene glycol is consumed by patients undergoing bowel cleansing.
Liquid Polyethylene Glycol 1500 may be absorbed when taken orally, but the higher-molecular-weight polyethylene glycols are not significantly absorbed from the gastrointestinal tract.
Absorbed polyethylene glycol is excreted largely unchanged in the urine, although Polyethylene Glycol 1500 of low molecular weight may be partially metabolized.
