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CAS NUMBER: 25322-68-3
EC NUMBER: 500-038-2
DESCRIPTION:
Polyethylene glycol 2000 is a high quality polymer of ethelyne glycol used for research applications only: chemical synthesis, biochemical research, molecular biology research and more.
Polyethylene glycol 2000 is a biocompatible, synthetic, hydrophilic polyether compound that has many applications, mostly in the medical industry, but also in the chemical and industrial sectors.
The structure of the compound is known as H−(O−CH2−CH2)n−OH.
Polyethylene glycol 2000 is a flaked PEG excipient grade product, produced under IPEC GMP conditions.
Polyethylene glycol 2000 is used in the field of pharmaceuticals, cosmetics, paper, rubber and ceramics and in wood processing.
Polyethylene glycol 2000 is also used in the manufacture of surfactants, dispersant resin and plastics.
Polyethylene glycol 2000 acts as a dye carrier in paints and inks; soldering fluxes with good spreading property and as a softener and antistatic agent for textiles.
Polyethylene glycol 2000 is also one of the main materials of ester type surface active agent.
Polyethylene glycol 2000 is widely used in a variety of pharmaceutical formulations, including parenteral, topical, ophthalmic, oral, and rectal preparations.
Polyethylene glycol 2000 has been used experimentally in biodegradable polymeric matrices used in controlled-release systems.
Polyethylene glycol 2000 is stable, hydrophilic substances that are essentially nonirritant to the skin.
They do not readily penetrate the skin, although the polyethylene glycols are water-soluble and are easily removed from the skin by washing, making them useful as ointment bases.
Solid grades are generally employed in topical ointments, with the consistency of the base being adjusted by the addition of liquid grades of polyethylene glycol.
Mixtures of polyethylene glycols can be used as suppository bases,for which they have many advantages over fats.
For example, the melting point of the suppository can be made higher to withstand exposure to warmer climates; release of the drug is not dependent upon melting point; the physical stability on storage is better; and suppositories are readily miscible with rectal fluids.
Polyethylene glycol 2000 has the following disadvantages: they are chemically more reactive than fats; greater care is needed in processing to avoid inelegant contraction holes in the suppositories; the rate of release of water-soluble medications decreases with the increasing molecular weight of the polyethylene glycol; and polyethylene glycols tend to be more irritating to mucous membranes than fats.
Aqueous polyethylene glycol solutions can be used either as suspending agents or to adjust the viscosity and consistency of other suspending vehicles.
When used in conjunction with other emulsifiers, polyethylene glycols can act as emulsion stabilizers.
Polyethylene glycol 2000 is used as water-miscible solvents for the contents of soft gelatin capsules.
However, they may cause hardening of the capsule shell by preferential absorption of moisture from gelatin in the shell.
In concentrations up to approximately 30% v/v, Polyethylene glycol 2000 has been used as the vehicle for parenteral dosage forms.
In solid-dosage formulations, higher-molecular-weight polyethylene glycols can enhance the effectiveness of tablet binders and impart plasticity to granules.
However, they have only limited binding action when used alone, and can prolong disintegration if present in concentrations greater than 5% w/w.
When used for thermoplastic granulations,a mixture of the powdered constituents with 10–15% w/w PEG 6000 is heated to 70–75°C.
The mass becomes pastelike and forms granules if stirred while cooling.
This technique is useful for the preparation of dosage forms such as lozenges when prolonged disintegration is required.
Polyethylene glycol 2000 can also be used to enhance the aqueous solubility or dissolution characteristics of poorly soluble compounds by making solid dispersions with an appropriate polyethylene glycol.
In film coatings, solid grades of polyethylene glycol can be used alone for the film-coating of tablets or can be useful as hydrophilic polishing materials.
Solid grades are also widely used as plasticizers in conjunction with film-forming polymers.
The presence of polyethylene glycols in film coats, especially of liquid grades, tends to increase their water permeability and may reduce protection against low pH in enteric-coating films.
Polyethylene glycol 2000 is useful as plasticizers in microencapsulated products to avoid rupture of the coating film when the microcapsules are compressed into tablets.
Polyethylene glycol 2000 grades with molecular weights of 6000 and above can be used as lubricants, particularly for soluble tablets.
The lubricant action is not as good as that of magnesium stearate, and stickiness may develop if the material becomes too warm during compression.
An antiadherent effect is also exerted, again subject to the avoidance of overheating.
Polyethylene glycol 2000 has been used in the preparation of urethane hydrogels, which are used as controlled-release agents.
Polyethylene glycol 2000 has also been used in insulin-loaded microparticles for the oral delivery of insulin.
Polyethylene glycol 2000 has been used in inhalation preparations to improve aerosolization
Polyethylene glycol 2000 nanoparticles have been used to improve the oral bioavailability of cyclosporine.
Polyethylene glycol 2000 has been used in self-assembled polymeric nanoparticles as a drug carrier;and copolymer networks of polyethylene glycol grafted with poly(methacrylic acid) have been used as bioadhesive controlled drug delivery formulations.
APPLICATION:
Polyethylene glycol 2000 is a hydrophilic linear polymer that can be used as:
-An organic additive in the synthesis of metal nanoparticles to control the size and morphology of nanostructure.
-A carbon source to prepare acidophilic highly fluorescent carbon dots (CDs) via the one-pot hydrothermal method.
-A dispersion stabilizer to synthesize amorphous Fe2O3 nanoparticles by microwave irradiation method. During the synthesis, PEG-2000 inhibits nonhomogeneous precipitation to obtain homogeneous precipitation of the metal nanoparticles.
PHYSICAL AND CHEMICAL PROPERTIES:
-Density: 1.21 g/cm3 (20 °C)
-Flash point: 138.6 °C
-Ignition temperature: 420 °C
-Melting Point: 57.5 °C
-pH value: 4 - 7 (100 g/l, H₂O, 20 °C)
-Vapor pressure: <0.1 hPa (20 °C)
-Viscosity kinematic: 46 - 55 mm2/s (20 °C) (50% solution)
-Bulk density: 400 - 500 kg/m3
-Solubility: 600 g/l
SPECIFICATION:
-Hydroxyl value: 51 - 63
-Melting range (lower value): ≥ 50 °C
-Melting range (upper value): ≤ 55 °C
-Average molecular mass: 1900 - 2200
-Identity (IR): passes test
PROPERTIES:
-vapor pressure: <0.1 hPa
-Quality Level: 200
-form: flakes
-autoignition temp.: 420 °C
-potency: 28000 mg/kg LD50, oral (Rat), >20000 mg/kg LD50, skin (Rabbit)
-pH: 4-7 (20 °C, 100 g/L in H2O)
-kinematic viscosity: 46-55 cSt(20 °C) (50% solution)
-mp: 49-52 °C
-transition temp: flash point 250 °C
-solubility: 600 g/L
STORAGE:
Room temperature.
SYNONYM:
Polyethylene Glycol 200
Polyethylene Glycol
PEG-200
ETHYLENE GLYCOL
Ethane-1,2-diol
1,2-ethanediol
107-21-1
glycol
monoethylene glycol
1,2-Dihydroxyethane
2-hydroxyethanol
Glycol alcohol
Ethylene alcohol
polyethylene glycol
Macrogol
Fridex
Tescol
Ethylene dihydrate
Norkool
Macrogol 400 BPC
Dowtherm SR 1
ethanediol
Zerex
Poly(ethylene glycol)
Ucar 17
Lutrol-9
Polyethylene glycol 200
ethyleneglycol
Aethylenglykol
Ethylenglycol
1,2-Ethandiol
1,2-ethylene glycol
ethylen glycol
ethylene-glycol
Polyethylene glycol 600
146AR
Polyethylene glycol 1000
Lutrol 9
Carbowax 300
PEG 200
1,2-dihydroxy ethane
M.e.g.
Polyethylene glycol 20000
CHEBI:30742
1, 2-Ethanediol
H(OCH2CH2)nOH
Glycol, ethylene-
Glycol, polyethylene
Glycols, polyethylene
Caswell No. 441
Aethylenglykol [German]
Polyethylene oxide
Carbowax 20
CAS-107-21-1
Polyethylene Glycols
Carbowax 400
Carbowax 1000
CCRIS 3744
Dowtherm 4000
HSDB 5012
Ethylene glycol polymer
NCI-C00920
PEG 3350
EINECS 203-473-3
Ethylene glycol homopolymer
Polyethylene Glycol 6000
EPA Pesticide Chemical Code 042203
1,2-Ethanediol homopolymer
ethyleneglycole
Athylenglykol
ehtylene glycol
etylene glycol
AI3-03050
2-ethanediol
Polyaethylenglykol
Ilexan E
4-vinyl cathecol
Polyaethylenglykole
MEG 100
Solbanon (TN)
1,2-ethane diol
1,2-ethane-diol
ethane-1.2-diol
PEG 1000
PEG 4000
1,2-ethyleneglycol
ethan-1,2-diol
mono-ethylene glycol
Macrogol 400
Mono Ethylene Glycol
Carbowax 1540
1,2-ethylene-glycol
Lutrol E (TN)
Ethylene glycol-[d6]
alpha-Hydro-omega-hydroxypoly(oxyethylene)
polyethylene glycol-400
Macrogol 400 (TN)
Polyethylene oxide (NF)
Polyethylene glycol (NF)
Ethyleneglycol, ReagentPlus
Macrogol 1500 (TN)
Macrogol 4000 (TN)
Macrogol 6000 (TN)
EC 203-473-3
Macrogol ointment (JP17)
Glycol, polyethylene(300)
HO(CH2)2OH
Macrogol 400 (JP17)
Polyethylene glycol 2000 NF
alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl)
Macrogol 1500 (JP17)
Macrogol 4000 (JP17)
Macrogol 6000 (JP17)
Poly(ethylene glycol) methyl ether
Polyethylene glycol 3350 (USP)
Ethylene glycol, p.a., 99.5%
1,2-ETHANEDIOL (GLYCOL)
poly (ethylene glycol) methyl ether
Ethylene glycol, analytical standard
Ethane-1,2-diol (Ethylene Glycol)
alpha,omega-hydroxypoly(ethylene oxide)
Ethylene glycol, Spectrophotometric grade
Oxirane, 2,2'-((1-methylethylidene)bis(4,1-phenyleneoxymethylene))bis-, polymer with alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl)
Dihydrocarveol, (-)-, mixture of isomers
ETHYLENE GLYCOL HIGH PURITY GRD 1L
Ethylene glycol
1,2-Ethane-1,1,2,2-d4-diol-d2(9ci)
Ethylene glycol
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-
ethylene glycol1,2-ethanediol
ethane-1,2-diol;
glycolethylene glycol;ethanediol;
ethylene glycol 1,2-ethanediol ethane-1,2-diol glycolethylene glycol ethanediol
