PRODUCTS

POLYETHYLENE GLYCOL 3000

Polyethylene glycol 3000 is widely used as a solvent, excipient, plasticizer, binder, lubricant, emollient, viscosity modifier and formulation aid in pharmaceutical, cosmetic, industrial, and chemical applications.
Polyethylene glycol 3000 exhibits low toxicity, water solubility, and relatively neutral chemical reactivity under normal conditions, making it highly versatile for many formulation and processing uses.

CAS Number: 25322‑68‑3
EC Number: 500‑038‑2
Molecular Formula: Generally written as H(OCH₂CH₂)ₙOH; a polymer with repeating ethylene oxide units where n varies to give average MW ~3000 g/mol.
Molecular Weight / Molar Mass: ~3000 g/mol (average)
Linear Formula: H(OCH₂CH₂)ₙOH

SYNONYMS:
Polyethylene glycol 3000, Poly(ethylene glycol) 3000, PEG 3000, Polyglycol, Polyethylene oxide, Polyoxyethylene, PEG, PEG‑3000, Poly(ethylene glycol), Polyethylene glycol 3000, Polyglycol, Polyethylene oxide, Polyoxy ethylene, PEG 3000, PEG, Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy, Glycols,polyethylene, Ethylene oxide,homopolymer, Oxide Wax AN, Oxide Wax A, Polyox WSR 301, Polyethylene glycol, Bradsyn PEG, Carbowax 6000, Polyethylene oxide, Poly(ethylene ether) glycol, DD 3002, Carbowax 4000, Polyox (polyglycol), Poly-G 600, Poly(oxyethylene) glycol, Polyox, Carbowax 100, Carbowax 600, Ethylene glycol polymer, Ethylene oxide polymer, Gafanol E 200, Gafanol E 300, PEG, PEG 6000, Postonal, WSR 35, PEO 18, WSR 205, Emkapol 4200, Carbowax E 9000, Carbowax 1540, Carbowax 200, Carbowax 300, Ethylene glycol homopolymer, Macrogol, Oxyethylene polymer, PEG 400, PEO 10, PEO 16, Polyox WSR 205, α-Hydro-ω-hydroxypoly(oxyethylene), α-Hydro-ω-hydroxypoly(oxy-1,2-ethanediyl), WSR 301, Polyox WSR 31, Carbowax 1000, PEG 600, Polyox WSR-N 80, Polydiol 200, Polyox FRA, Nycoline, Solbase, Polyox 30, Polyox WSR-N 750, Polyglycol 6000, Polyglycol 12000, Macrogol 6000, Ethylene polyoxide, Polyglycol 600, Carbowax 1500, Polyox WSR, PEG 1000, Polyglycol 4000, WSR-N 3000, Polyox WSR 1105, Polyox Coagulant, Emkapol 150, Emkapol 200, PEG 20000, Polyox WSR-N 60, Polyox 100, Modopeg, Polyox WSR-N 10, Polyox WSR-N 3000, Aquaffin, Swasconol D 60, Swasconol D 80, HM 500, Plastigen PR 8086, Deactivator H, Polyox 1, PEG 4, PEG 75, Poly(vinyl oxide), PEG 2M, PEG 6, Ucar 4C, Oxirane,homopolymer, Polyox WSR 35, Nosilen, Polyoxyethylenediol, WSR-N 10, Pluriol E 200, Pluriol E 300, Pluriol E 400, Pluriol E 800, Pluriol E 4000, Pluriol E 9000, 8038-37-7, 9081-95-2, 9085-02-3, 9085-03-4, 12676-74-3, 12770-93-3, 25104-58-9, 25609-81-8, 34802-42-1, 37361-15-2, 50809-04-6, 50809-59-1, 51312-32-4, 54510-95-1, 54847-64-2, 59763-40-5, 60894-12-4, 61840-14-0, 64441-68-5, 64640-28-4, 67411-64-7, 70926-57-7, 75285-02-8, 75285-03-9, 77986-38-0, 79964-26-4, 80341-53-3, 85399-22-0, 85945-29-5, 88077-80-9, 88747-22-2, 90597-70-9, 99264-61-6, 99333-89-8, 101677-86-5, 106186-24-7, 107502-63-6, 107529-96-4, 109550-27-8, 112384-37-9, 112895-21-3, 113041-64-8, 114323-93-2, 116549-90-7, Macrogol 3000, Polyethylene oxide 3000, poly(ethylene glycol) 3000

Polyethylene Glycol 3000 (PEG 3000) is a high-molecular-weight polymer in the polyethylene glycol family.
Polyethylene glycol 3000 is a polyether compound composed of repeating ethylene oxide units terminated with hydroxyl groups.
PEGs are typically named by their average molecular weight; PEG 3000 has an average molecular mass of approximately 3,000 g/mol.

Polyethylene glycol 3000 is a hydrophilic polymer with very low volatility, high water affinity, and minimal vapor pressure under ambient conditions.
Polyethylene glycol 3000 is a solvent for a large number of substances.

Polyethylene glycol 3000 is prepared from the addition of ethylene oxide to monoethylene glycol (MEG) over an alkaline catalyst.
Polyethylene glycol 3000 is one of the common grades of PEG, and in this article, we will explore its various attributes and applications.
Polyethylene glycol 3000 is a hydrophilic, non-toxic, and non-ionic polymer.

Polyethylene glycol 3000 is highly viscous and has high water-holding capacity.
Polyethylene glycol 3000 is stable in high temperatures and pH conditions.
Density: The density of Polyethylene glycol 3000 ranges from 1.08 – 1.13 g/cm3, depending on the molecular weight and temperature.

Polyethylene glycol 3000 is a versatile polymer that finds numerous applications in various industries.
Polyethylene glycol 3000 has unique characteristics that make it an excellent solubilizer, emulsifier, moisturizer, and lubricant.

Its low toxicity profile makes Polyethylene glycol 3000 suitable for use in pharmaceutical and food-grade products.
Polyethylene glycol 3000 is synthesized by the polymerization of ethylene oxide and can be transported in bulk containers or bags.

USES and APPLICATIONS of POLYETHYLENE GLYCOL 3000:
Pharmaceuticals & Healthcare: Polyethylene glycol 3000 is used excipient for oral, topical, vaginal and rectal formulations; ointment and suppository base; tablet/ capsule lubricant; solubilizer.
Cosmetics & Personal Care: Polyethylene glycol 3000 is used humectant and binder in creams, lotions, shampoos, conditioners.

Industrial & Chemical: Polyethylene glycol 3000 is used solvent, processing aid, coating agent, antistatic agent, viscosity regulator, dispersant.
Specialized Applications: Polyethylene glycol 3000 is used surface surface modifications (e.g., nanoparticles), phase-transfer catalyst roles, membrane additives.

Polyethylene glycol 3000 can be used as a carrier material and modifying agent.
Polyethylene glycol 3000 is widely used in a variety of pharmaceutical formulations.
Polyethylene glycol 3000 is used in the manufacture of cleaning products and detergents; as a solubilizer, viscosity regulator, antistatic agent, softener, gellatant, granulating tableting auxiliary substances.

-Pharmaceuticals uses of Polyethylene glycol 3000:
Polyethylene glycol 3000 is a common ingredient in many pharmaceutical formulations.
Polyethylene glycol 3000 is used as a base for gels, emulsions, creams, and ointments.
Polyethylene glycol 3000 also serves as a solubilizer for poorly soluble drugs.

-Cosmetics uses of Polyethylene glycol 3000:
Polyethylene glycol 3000 is used in cosmetic applications as an emulsifier, lubricant, and moisturizer.
Polyethylene glycol 3000 is found in many personal care products, including lotions, face creams, and shampoos.

-Food uses of Polyethylene glycol 3000:
Polyethylene glycol 3000 is approved for use as a food additive in some countries.
Polyethylene glycol 3000 is used as a thickener, emulsifier, and stabilizer in many food products.

-Industrial uses of Polyethylene glycol 3000:
Polyethylene glycol 3000 is used in metalworking as a lubricant and coolant.
Polyethylene glycol 3000 also serves as a dispersing agent for pigments and dyes in the textile industry.

-Packaging and Transportation uses of Polyethylene glycol 3000:
Polyethylene glycol 3000 is a stable compound that can be transported in bulk containers or bags.
Polyethylene glycol 3000 is advisable to protect it from moisture and sunlight to prevent degradation.

-Manufacture Procedures use of Polyethylene glycol 3000:
Polyethylene glycol 3000 is synthesized by the polymerization of ethylene oxide in the presence of a catalyst.
The molecular weight of Polyethylene glycol 3000 can be controlled by varying the reaction conditions, such as temperature, pressure, and the ratio of reactants.

MAIN PROPERTIES of POLYETHYLENE GLYCOL 3000:
Water solubility with strong hygroscopic character.
Viscosity modifier and solid/gel former.
Non-volatile and chemically inert in many environments.
Binder, plasticizer, solvent, humectant properties.
Low toxicity and relatively high biocompatibility when used as excipient.
Thermally stable at moderate processing temperatures.

BENEFITS of POLYETHYLENE GLYCOL 3000:
The following benefits account for the widespread use of Polyethylene glycol 3000:
Polyethylene glycol 3000 enhances solubility and dispersion of active ingredients.
Polyethylene glycol 3000 serves as a binder/solvent in pharmaceutical and industrial products.
Polyethylene glycol 3000 acts as a lubricant/plasticizer in tablet and capsule manufacturing.

Polyethylene glycol 3000 provides controlled viscosity in formulations.
Polyethylene glycol 3000 functions as a film-forming and coating agent.
Polyethylene glycol 3000 supports emulsion stability and wettability in personal care products.

CHEMICAL CHARACTERISTICS of POLYETHYLENE GLYCOL 3000:
Polyethylene Glycol 3000 belongs to the class of polyethers, consisting of repeated ethylene oxide units (-CH₂CH₂O-).
Polyethylene glycol 3000 is a linear polymer with two terminal hydroxyl groups, which confer a degree of chemical reactivity (e.g., esterification or etherification under specific conditions).

Its structure makes Polyethylene glycol 3000:
*Highly hydrophilic and water-soluble;
*Chemically stable under neutral conditions;
*Reactive with strong acids/bases or high temperatures under catalytic conditions;
*A versatile formulation base due to multiple functional groups;

CHARACTERISTICS of POLYETHYLENE GLYCOL 3000:
Polyethylene glycol 3000 has several unique characteristics that make it a useful polymer in many applications.
Polyethylene glycol 3000 is a high-molecular-weight polymer with a low toxicity profile, making it safe for medical and food-grade applications.
Polyethylene glycol 3000 is also an excellent solubilizer and emulsifier, and its high water-holding capacity makes it suitable for moisturizing and lubricating formulations.

WHAT IS IT?
Polyethylene glycol, referred to as PEG, is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointments, and suppository base, and tablet and capsule lubricant.
PEG has low toxicity with systemic absorption less than 0.5%.

PEGylation occurs when PEGs are attached to various protein medications, allowing for greater solubility for certain drugs.
Examples of PEGylated medications include PEG-interferon alpha (Pegintron) and PEG-filgrastim (Neulasta).
PEG is also available as a bowel prep for colonoscopy procedures and as a laxative.

PEG 400 indicates the average molecular weight of the specific PEG at 400.
PEG 3350 is a laxative available over-the-counter by the name of Miralax.
In this case, PEG is considered an "active" ingredient, even though systemic absorption is less than 0.5%.

PHYSICAL and CHEMICAL PROPERTIES of POLYETHYLENE GLYCOL 3000:
CAS Number: 25322‑68‑3
EC Number: 500‑038‑2
Molecular Formula: H(OCH₂CH₂)ₙOH
Molecular Weight / Molar Mass: ~3000 g/mol (average)
Linear Formula: H(OCH₂CH₂)ₙOH
Appearance: Clear to slightly hazy viscous liquid or waxy solid
Color: Colorless to pale
Odor: Essentially odorless
Density: ~1.21 g/cm³ at 20 °C
Melting Point / Freezing Point: 55–59 °C; Freezing point < −14.08 °C at 973.5 hPa (ECHA)

Flash Point: 138–270 °C (depending on measurement method); 138.6 °C closed cup
Autoignition Temperature: ~360–420 °C
Vapor Pressure: <0.1 hPa at 20 °C
Solubility: Highly soluble in water (~550 g/L at 20 °C); 256.084 g/L at 25 °C (OECD Test Guideline 105)
pH: ~4–7 (100 g/L aqueous solution at 20 °C)
Bulk Density: ~400–500 kg/m³
Hydroxyl Value: ~34–42 mg KOH/g
Partition Coefficient (n-octanol/water): log Pow −0.698 at 30 °C; Bioaccumulation is not expected
Physical State: scales

Color: colorless
Odor: No data available
Initial Boiling Point and Boiling Range: 205.7 °C at 977.6 hPa (OECD Test Guideline 103)
Flammability (solid, gas): No data available
Upper / Lower Flammability or Explosive Limits: No data available
Decomposition Temperature: No data available
Viscosity, dynamic: No data available
Viscosity, kinematic: No data available
Density: 1.116 g/cm³ at 20 °C at 975.5 hPa (OECD Test Guideline 109)

Relative Density: No data available
Relative Vapor Density: No data available
Particle Characteristics: No data available
Explosive Properties: No data available
Oxidizing Properties: none
CAS Number: 25322-68-3
NACRES: NA.22
EC Index Number: 500-038-2
UNSPSC Code: 13111021

MDL Number: MFCD00081839
CAS Number: 25322‑68‑3
EC Number: 500‑038‑2
Molecular Formula: HO(C2H4O)ₙH
Molecular Weight / Molar Mass: ~3000 g/mol (average)
Appearance: White powder or flakes; Flakes or waxy dense mass of white, yellow or grayish color
Appearance of 25% aqueous solution: Transparent liquid free from solids
Color at 25% aqueous solution, Hazen, max.: 25
Odor: Essentially odorless

Density: ~1.21 g/cm³ at 20 °C
Bulk Density: 400–500 kg/m³
Melting Point: 50–58 °C; typical 52–57 °C
Flash Point: 138–270 °C (depending on measurement method)
Autoignition Temperature: ~360–420 °C
Vapor Pressure: <0.1 hPa at 20 °C
Solubility: Highly soluble in water, ethanol, and acetone; soluble in chloroform and benzene; insoluble in diethyl ether and oils
pH (water-methanol solution of the basic substance): 5.5–7.5
Hydroxyl Number: 30–40 mg KOH/g

Kinematic Viscosity at 100 °C: 45–85 m²/s
Water Content: ≤0.5%
Partition Coefficient (n-octanol/water): log Pow −0.698 at 30 °C; Bioaccumulation is not expected
Physical State: Solid, flakes or waxy mass
Color: White to pale yellow or grayish
Odor: No data available
CAS Number: 25322-68-3
NACRES: NA.22
EC Index Number: 500-038-2
UNSPSC Code: 13111021
MDL Number: MFCD00081839

FIRST AID MEASURES of POLYETHYLENE GLYCOL 3000:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of POLYETHYLENE GLYCOL 3000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of POLYETHYLENE GLYCOL 3000:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of POLYETHYLENE GLYCOL 3000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of POLYETHYLENE GLYCOL 3000:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of POLYETHYLENE GLYCOL 3000:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available