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CAS NUMBER: 25322-68-3
EC NUMBER: 500-038-2
DESCRIPTION:
Polyethylene glycol 300, a neutral polymer of molecular weight 300, is a water-soluble, low immunogenic and biocompatible polymer formed by repeating units of ethylene glycol.
Polyethylene glycol 300 is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.
Polyethylene glycol 300 is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
The structure of Polyethylene glycol 300 is commonly expressed as H−(O−CH2−CH2)n−OH.
Polyethylene glycol (PEG) is one of the most commonly used chemical polyethers in manufacturing, medicine and many other applications.
Polyethylene glycol 300 is available in multiple forms for various uses.
The most common way of differentiating between Polyethylene glycol 300 is by molecular weight.
Polyethylene glycol 300 is used as a base for skin creams and other personal care products, as well as a solvent and viscosity modifier in soaps and detergents.
Polyethylene glycol 300 is also used to process rubber, plastics and textiles, as an additive in lubricants and grease, and as a humectant, dye carrier and binder in paints and inks.
Polyethylene glycol 300 is colorless, almost odorless and tasteless liquid at room temperature.
Polyethylene glycol 300 is manufactured by alkali-catalysed polymerization of ethylene oxide with subsequent neutralization of the catalyst.
Polyethylene glycol 300 is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointment and suppository base, and tablet and capsule lubricant.
Polyethylene glycol 300 has low toxicity with systemic absorption less than 0.5%.
Polyethylene glycol 300 occurs when PEGs are attached to various protein medications, allowing for greater solubility for certain drugs.
Examples of Polyethylene glycol 300 medications include PEG-interferon alpha (Pegintron) and PEG-filgrastim.
Polyethylene glycol 300 is also available as a bowel prep for colonoscopy procedures and as a laxative.
Polyethylene glycol 300 indicates the average molecular weight of the specific PEG at 400.PEG 3350 is a laxative.
Polyethylene glycol 300 is a liquid PEG excipient grade product, produced under IPEC GMP conditions.
Polyethylene glycol 300 is a polyether compound with many applications from industrial manufacturing to medicine.
Polyethylene glycol 300 commonly referred to as PEG 300, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Due to its low toxicity, Polyethylene glycol 300 can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Polyethylene glycol 300 is a water-miscible polyether widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries.
Polyethylene glycol 300 serves as a kind of solubilizer, excipient, lubricant, and chemical reagent.
Polyethylene glycol 300 is a clear, colorless liquid that is made from sugar cane waste so it is naturally derived and renewable.
Polyethylene glycol 300 is completely soluble in water and has an average molecular weight of 288 - 311.
Polyethylene glycol 300 is another group of products with an incredibly long list of uses and applications from industrial uses to food and pharma, and everything in between.
Polyethylene glycol 300 is PEG-6-based plasticizer and mold release agent.
Polyethylene glycol 300 possesses lubricity and humectant properties.
Polyethylene glycol 300 maintains wet-tack strength.
Polyethylene glycol 300 is used in pressure sensitive and thermoplastic adhesives.
Polyethylene glycol 300 is a water-miscible polyether with an average molecular weight of 300 g/mol.
Polyethylene glycol 300 is a clear viscous liquid at room temperature with non-volatile, stable properties.
Polyethylene glycol 300 is widely used in biochemistry, structural biology, and medicine in addition to pharmaceutical and chemical industries.
They serve as solubilizers, excipients, lubricants, and chemical reagents.
Low molecular weight glycols are observed to exhibit antibacterial properties as well.
Polyethylene glycol 300 is found in eye drops as a lubricant to temporarily relieve redness, burning and irritation of the eyes.
Polyethylene glycol 300 is a neutral and biocompatible hydrophilic polymer.
Polyethylene glycol 300 is usually used to modify therapeutic proteins and peptides to increase their solubility.
Polyethylene glycol 300 is used as a moisturizer, solubiliser in antiperspirant and deodorants, shampoos and liquid soap, hair styling products, bar soaps and oral care products as a stabilizer and wetting agent for drilling.
Polyethylene glycol 300 is a polymer which is hydrolyzed by ethylene oxide.
Polyethylene glycol 300 has no toxicity and irritation.
Polyethylene glycol 300 is widely used in various pharmaceutical preparations.
The toxicity of low molecular weight polyethylene glycol is relatively large.
In general, the toxicity of diols is very low.
Topical application of Polyethylene glycol 300, especially mucosal drug, can cause irritant pain.
In topical lotion, Polyethylene glycol 300 can increase the flexibility of the skin, and has a similar moisturizing effect with glycerin.
Polyethylene glycol 300 is a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.
The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups.
The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups.
The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides.
The average molecular weight of any specific polyethylene glycol product falls within quite narrow limits (°5%).
The number of ethylene oxide units or their approximate molecular weight commonly designates the nomenclature of specific polyethylene glycols.
Polyethylene glycol 300 with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.
These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Polyethylene glycol 300 is a binder, coating agent, dispersing agent, flavoring adjuvant, and plasticizing agent that is a clear, colorless, viscous, hygroscopic liquid resembling paraffin (white, waxy, or flakes), with a ph of 4.0–7.5 in 1:20 concentration.
Polyethylene glycol 300 is soluble in water (mw 1,000) and many organic solvents.
Polyethylene glycol 300 molecules of approximately 2000 monomers.
Polyethylene glycol 300 is used in various applications from industrial chemistry to biological chemistry.
Recent research has shown Polyethylene glycol 300 maintains the ability to aid the spinal cord injury recovery process, helping the nerve impulse conduction process in animals.
Polyethylene glycol 300 has been shown to aid in the repair of severed sciatic axons, helping with nerve damage recovery.
Polyethylene glycol 300 is industrially produced as a lubricating substance for various surfaces to reduce friction.
Polyethylene glycol 300 is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
PHYSICAL AND CHEMICAL PROPERTIES:
-Boiling point: >200 °C (1013 hPa) decomposes
-Density: 1.13 g/cm3 (20 °C)
-Flash point: 138.6 °C
-Ignition temperature: 370 °C
-Melting Point: -15 - -10 °C
-pH value: 4 - 7 (100 g/l, H₂O, 20 °C)
-Vapor pressure: <0.1 hPa (20 °C)
USES:
-Medical Uses:
-Pharmaceutical-grade Polyethylene glycol 300 is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms.
-Polyethylene glycol 300 is the basis of a number of laxatives.
-Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy.
-Polyethylene glycol 300 is used in medicines for treating disimpaction and maintenance therapy for children with constipation.
-When attached to various protein medications or drug carriers, polyethylene glycol of suitable length slows down their clearance from the blood.
-The possibility that Polyethylene glycol 300 could be used to fuse axons is being explored by researchers studying peripheral nerve and spinal cord injury.
-An example of Polyethylene glycol 300 hydrogels in a therapeutic has been theorized by Ma et al.
-They propose using the hydrogel to address periodontitis by encapsulating stem cells in the gel that promote healing in the gums.
-The gel and encapsulated stem cells was to be injected to the site of disease and crosslinked to create the microenvironment required for the stem cells to function.
-Polyethylene glycol 300 of adenoviruses for gene therapy can help prevent adverse reactions due to pre-existing adenovirus immunity.
-Chemical Uses:
-Because Polyethylene glycol 300 is a hydrophilic molecule, it has been used to passivate microscope glass slides for avoiding non-specific sticking of proteins in single-molecule fluorescence studies.
-Polyethylene glycol 300 has a low toxicity and is used in a variety of products.
-The polymer is used as a lubricating coating for various surfaces in aqueous and non-aqueous environments.
-Since Polyethylene glycol 300 is a flexible, water-soluble polymer, it can be used to create very high osmotic pressures (on the order of tens of atmospheres).
-Polyethylene glycol 300 also is unlikely to have specific interactions with biological chemicals.
-These properties make PEG one of the most useful molecules for applying osmotic pressure in biochemistry and biomembranes experiments, in particular when using the osmotic stress technique.
-Polyethylene glycol is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers.
-Polyethylene glycol 300 replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when it dries.
-In addition, Polyethylene glycol 300 is used when working with green wood as a stabilizer, and to prevent shrinkage.
-Polyethylene glycol 300 has been used to preserve the painted colors.
-These painted artifacts were created during.
-Within 15 seconds of the terra-cotta pieces being unearthed during excavations, the lacquer beneath the paint begins to curl after being exposed to the dry.
-The paint would subsequently flake off in about four minutes.
-Polyethylene glycol 300 is often used (as an internal calibration compound) in mass spectrometry experiments, with its characteristic fragmentation pattern allowing accurate and reproducible tuning.
-Polyethylene glycol 300 derivatives, such as narrow range ethoxylates, are used as surfactants.
-Polyethylene glycol 300 has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes.
-Biological uses:
-Polyethylene glycol 300 is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
-Polyethylene glycol 300 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization. X-ray diffraction of protein crystals can reveal the atomic structure of the proteins.
-Polyethylene glycol 300 is used to fuse two different types of cells, most often B-cells and myelomas in order to create hybridomas.
-Polymer segments derived from PEG polyols impart flexibility to polyurethanes for applications such as elastomeric fibers (spandex) and foam cushions.
-In microbiology, PEG precipitation is used to concentrate viruses.
-Polyethylene glycol 300 is also used to induce complete fusion (mixing of both inner and outer leaflets) in liposomes reconstituted in vitro.
-Gene therapy vectors (such as viruses) can be PEG-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic effect.
-The size of the PEG polymer has been shown to be important, with larger polymers achieving the best immune protection.
-Polyethylene glycol 300 is a component of stable nucleic acid lipid particles used to package siRNA for use in vivo.
-In blood banking, Polyethylene glycol 300 is used as a potentiator to enhance detection of antigens and antibodies.
-Commercial uses:
-Polyethylene glycol 300 is the basis of many skin creams (as cetomacrogol) and personal lubricants (frequently combined with glycerin).
-Polyethylene glycol 300 is used in a number of toothpastes[5] as a dispersant.
-In this application, Polyethylene glycol 300 binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste.
-Polyethylene glycol 300 is also under investigation for use in body armor, and in tattoos to monitor diabetes.
-In low-molecular-weight formulations (e.g. PEG 400), Polyethylene glycol 300 is used in Hewlett-Packard designjet printers as an ink solvent and lubricant for the print heads.
-Polyethylene glycol 300 is also used as an anti-foaming agent in food and drinks.
-Industrial uses:
-Dimethyl ethers of Polyethylene glycol 300 are the key ingredient of Selexol, a solvent used by coal-burning, integrated gasification combined cycle (IGCC) power plants to remove carbon dioxide and hydrogen sulfide from the syngas stream.
-Polyethylene glycol 300 has been used as the gate insulator in an electric double-layer transistor to induce superconductivity in an insulator.
-Polyethylene glycol 300 is also used as a polymer host for solid polymer electrolytes.
-Although not yet in commercial production, many groups around the globe are engaged in research on solid polymer electrolytes involving PEG, with the aim of improving their properties, and in permitting their use in batteries, electro-chromic display systems, and other products in the future.
-Polyethylene glycol 300 is injected into industrial processes to reduce foaming in separation equipment.
-Polyethylene glycol 300 is used as a binder in the preparation of technical ceramics.
-Polyethylene glycol 300 was used as an additive to silver halide photographic emulsions.
-Entertainment uses:
-Polyethylene glycol 300 is used to extend the size and durability of very large soap bubbles.
-Polyethylene glycol 300 is the main ingredient in many personal lubricants. (Not to be confused with propylene glycol.)
-Polyethylene glycol 300 is the main ingredient in the paint
APPLICATION:
-Contact lens liquid. The viscosity of polyethylene glycol solution is sensitive to the shear rate and it is not easy for bacteria to grow on polyethylene glycol.
-Synthetic lubricants. The condensation polymer of ethylene oxide and water. It is a cream matrix for preparing water-soluble drugs. It can also be used as a solvent for acetylsalicylic acid and caffeine, which is difficult to dissolve in water.
-Drug sustained-release and immobilized enzyme carrier. The polyethylene glycol solution is applied to the outer layer of the pill to control the diffusion of drugs in the pill so as to improve the efficacy.
-Surface modification of medical polymer materials. The biocompatibility of medical polymer materials in contact with blood can be improved by adsorption, interception and grafting of two amphiphilic copolymers containing polyethylene glycol on the surface of medical polymers.
-It can make the membrane of the alkanol contraceptive pill.
-It can make hydrophilic anticoagulant polyurethane.
-Polyethylene glycol 4000 is an osmotic laxative. It can increase osmotic pressure and absorb moisture in the intestinal cavity, which makes the stool soften and increase in volume, resulting in bowel movement and defecation.
-Denture fixing agent. Peg nontoxic and gelatinous nature can be used as a component of denture fixer.
-PEG 4000 and PEG 6000 are commonly used to promote cell fusion or protoplast fusion and help organisms (such as yeasts) to take DNA in transformation. PEG absorbs water from the solution, so it is also used to concentrate the solution.
PRODUCTION:
Polyethylene glycol 300 is produced by the interaction of ethylene oxide with water, ethylene glycol, or ethylene glycol oligomers.
The reaction is catalyzed by acidic or basic catalysts.
Ethylene glycol and its oligomers are preferable as a starting material instead of water, because they allow the creation of polymers with a low polydispersity (narrow molecular weight distribution).
Polymer chain length depends on the ratio of reactants.
HOCH2CH2OH + n(CH2CH2O) → HO(CH2CH2O)n+1H
Depending on the catalyst type, the mechanism of polymerization can be cationic or anionic.
The anionic mechanism is preferable because it allows one to obtain PEG with a low polydispersity.
Polymerization of ethylene oxide is an exothermic process.
Overheating or contaminating ethylene oxide with catalysts such as alkalis or metal oxides can lead to runaway polymerization, which can end in an explosion after a few hours.
Polyethylene oxide, or high-molecular-weight polyethylene glycol, is synthesized by suspension polymerization.
Polyethylene glycol 300 is necessary to hold the growing polymer chain in solution in the course of the polycondensation process.
The reaction is catalyzed by magnesium-, aluminium-, or calcium-organoelement compounds.
To prevent coagulation of polymer chains from solution, chelating additives such as dimethylglyoxime are used.
Alkaline catalysts such as sodium hydroxide (NaOH), potassium hydroxide (KOH), or sodium carbonate (Na2CO3) are used to prepare low-molecular-weight polyethylene glycol.
APPLICATION:
-Lubricants
-Adhesives
-Antistatic agent and humectant
-Chemical intermediates
-Inks and dye carrier
-Mold release agent
-Plasticizer
SOLUBILITY:
PEG 300 is readily soluble in water, ethanol, acetone, glycols and chloroform and insoluble in ether, paraffin, oils and fats.
FUNCTION:
-Solvent
-Humectant
-Coating agent
-Viscosity Enhancer
BENEFITS:
-Completely soluble in water
-Molecularly stable and non-volatile
-Excellent hygroscopicity
-Low toxicity
-High lubricity and solvency
TYPICAL PROPERTIES:
-% Actives: 100%
-Contains Inhibitor: No
-End Use: Industrial
-Form: Liquid
TYPICAL APPLICATION:
-Adhesives
-Antistatic Agent and Humectant
-Chemical Intermediates
-Inks and Dye Carrier
-Lubricants
-Mold Release Agent
-Plasticizer
SPECIFICATION:
-Hydroxyl value: 356 - 394
-Density (d 20 °C/ 4 °C): 1.125 - 1.127
-Average molecular mass: 285 - 315
-Identity (IR): passes test
PROPERTIES:
-Melting point: 64-66 °C
-Boiling point: 1.27 g/mL at 25 °C
-vapor density: >1 (vs air)
-vapor pressure: <0.01 mm Hg ( 20 °C)
-refractive index: n20/D 1.469
-Fp: 270 °C
-storage temp.: 2-8°C
-solubility: H2O: 50 mg/mL, clear, colorless
-form: waxy solid
-color: White to very pale yellow
-Specific Gravity: 1.128
-PH: 5.5-7.0 (25℃, 50mg/mL in H2O)
-Water Solubility: Soluble in water.
STORAGE:
4°C, sealed storage, away from moisture.
SYNONYMS:
Polyethylene Glycol 200
Polyethylene Glycol
PEG-200
ETHYLENE GLYCOL
Ethane-1,2-diol
1,2-ethanediol
107-21-1
glycol
monoethylene glycol
1,2-Dihydroxyethane
2-hydroxyethanol
Glycol alcohol
Ethylene alcohol
polyethylene glycol
Macrogol
Fridex
Tescol
Ethylene dihydrate
Norkool
Macrogol 400 BPC
Dowtherm SR 1
ethanediol
Zerex
Poly(ethylene glycol)
Ucar 17
Lutrol-9
Polyethylene glycol 200
ethyleneglycol
Aethylenglykol
Ethylenglycol
1,2-Ethandiol
1,2-ethylene glycol
ethylen glycol
ethylene-glycol
Polyethylene glycol 600
146AR
Polyethylene glycol 1000
Lutrol 9
Carbowax 300
PEG 200
1,2-dihydroxy ethane
M.e.g.
Polyethylene Glycol 4000
CHEBI:30742
1, 2-Ethanediol
H(OCH2CH2)nOH
Glycol, ethylene-
Glycol, polyethylene
Glycols, polyethylene
Caswell No. 441
Aethylenglykol [German]
Polyethylene oxide
Carbowax 20
CAS-107-21-1
Polyethylene Glycols
Carbowax 400
Carbowax 1000
CCRIS 3744
Dowtherm 4000
HSDB 5012
Ethylene glycol polymer
NCI-C00920
PEG 3350
EINECS 203-473-3
Ethylene glycol homopolymer
Polyethylene Glycol 6000
EPA Pesticide Chemical Code 042203
1,2-Ethanediol homopolymer
ethyleneglycole
Athylenglykol
ehtylene glycol
etylene glycol
AI3-03050
2-ethanediol
Polyaethylenglykol
Ilexan E
4-vinyl cathecol
Polyaethylenglykole
MEG 100
Solbanon (TN)
1,2-ethane diol
1,2-ethane-diol
ethane-1.2-diol
PEG 1000
PEG 4000
1,2-ethyleneglycol
ethan-1,2-diol
mono-ethylene glycol
Macrogol 400
Mono Ethylene Glycol
Carbowax 1540
1,2-ethylene-glycol
Lutrol E (TN)
Ethylene glycol-[d6]
alpha-Hydro-omega-hydroxypoly(oxyethylene)
polyethylene glycol-400
Macrogol 400 (TN)
Polyethylene oxide (NF)
Polyethylene glycol (NF)
Ethyleneglycol, ReagentPlus
Macrogol 1500 (TN)
Macrogol 4000 (TN)
Macrogol 6000 (TN)
EC 203-473-3
Macrogol ointment (JP17)
Glycol, polyethylene(300)
HO(CH2)2OH
Macrogol 400 (JP17)
Polyethylene Glycol 300 NF
alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl)
Macrogol 1500 (JP17)
Macrogol 4000 (JP17)
Macrogol 6000 (JP17)
Poly(ethylene glycol) methyl ether
Polyethylene glycol 3350 (USP)
Ethylene glycol, p.a., 99.5%
1,2-ETHANEDIOL (GLYCOL)
poly (ethylene glycol) methyl ether
Ethylene glycol, analytical standard
Ethane-1,2-diol (Ethylene Glycol)
alpha,omega-hydroxypoly(ethylene oxide)
Ethylene glycol, Spectrophotometric grade
Oxirane, 2,2'-((1-methylethylidene)bis(4,1-phenyleneoxymethylene))bis-, polymer with alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl)
Dihydrocarveol, (-)-, mixture of isomers
ETHYLENE GLYCOL HIGH PURITY GRD 1L
Ethylene glycol
1,2-Ethane-1,1,2,2-d4-diol-d2(9ci)
Ethylene glycol
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-
ethylene glycol1,2-ethanediol
ethane-1,2-diol;
glycolethylene glycol;ethanediol;
ethylene glycol 1,2-ethanediol ethane-1,2-diol glycolethylene glycol ethanediol
