Quick Search
POLYETHYLENE GLYCOL 8000 = MACROGOL 8000 = ETHYLENE GLYCOL 8000 POLYMER
CAS No.: 25322-68-3
EC-No. : 500-038-2
Linear Formula: H(OCH2CH2)nOH
Polyethylene glycol 8000 is soluble in water (500 g/l at 20° C), aromatic hydrocarbons (very soluble), aliphatic hydrocarbons (slightly soluble), and organic solvents.
Polyethylene glycol 8000 is suitable as a medium for the fusion of mammalian cells.
Polyethylene glycol 8000 (PEG 8000) has a wide range of uses including cell fusion for the formation of hybridomas, precipitation of DNA, and to create macromolecular crowding in solutions.
Ultrapure white crystals for molecular biology applications such as precipitation of DNA, nucleic acids, hybridization and fusion of mammalian cells.
Working concentrations of PEG (polyethylene glycol) range from 13% to 40% (w/v).
Prepare the appropriate concentration by dissolving Polyethylene glycol 8000 in sterile H2O, warming if necessary.
Sterilize the solution by passing Polyethylene glycol 8000 through a 0.22-μm filter.
Store the solution at room temperature.
Polyethylene glycol 8000 is a water-soluble, waxy solid that is used extensively in the several industries.
Polyethylene glycol 8000 is a polyethylene glycol having white to off white color and available in solid flakes or powder form.
Polyethylene glycol 8000 used as a base in the formulation of soap sticks.
Polyethylene glycol 8000 has low glycol content and higher crystalinity.
The high molecular weight Polyethylene glycol 8000 is soluble in water and organic solvents such as alcohols.
Polyethylene glycol 8000 can blend with other PEG molecular weights to achieve the desired viscosity properties.
Polyethylene glycol 8000 is quite stable and does not support microbial growth, even in aqueous solutions.
Ultrapure white crystals for molecular biology applications such as precipitation of DNA, nucleic acids, hybridization and fusion of mammalian cells.
Soluble in water.
Store at room temperature.
Polyethylene glycol 8000 is white granular.
Soluble in water, soluble in some organic solvents.
The solution has high viscosity at low concentration, and Polyethylene glycol 8000 can be processed by calendering, extrusion, casting, etc.
Polyethylene glycol 8000 is a thermoplastic resin with good compatibility with other resins.
Resistant to bacterial erosion, moisture absorption in the atmosphere is weak.
Polyethylene glycol 8000 is a mixture of ethylene oxide and water polycondensation.
The molecular formula is expressed as HO(CH2CH2O)NH, where n represents the average number of oxyethylene groups.
Polyethylene glycol 8000 is a colorless or almost colorless viscous liquid, or a translucent waxy soft object; Slightly odorless.
Polyethylene glycol 8000 is soluble in water or ethanol, insoluble in ether.
freezing point
The freezing point of Polyethylene glycol 8000 is 33~38°C.
Polyethylene glycol 8000, a hydrophilic polymer, is easily synthesized by the anionic ring opening polymerization of ethylene oxide, into a range molecular weights and variety of end groups.
On being incorporated into networks by crosslinking, Polyethylene glycol 8000 can have high water content, forming “hydrogels”.
Hydrogel formation can be initiated by either crosslinking Polyethylene glycol 8000 by ionizing radiation or by covalent crosslinking of Polyethylene glycol 8000 macromers with reactive chain ends.
Polyethylene glycol 8000 is hygroscopic.
Polyethylene glycol 8000 is water soluble and also soluble in many organic solvents like aromatic hydrocarbons.
Characteristic of POLYETHYLENE GLYCOL 8000:
. Highly compatible to various kinds of organic compounds.
. High boiling point.
. Easy control of the degree of condensation.
. Controllable hygroscopic property.
. Less toxicity, PEG is characterized by less toxicity and less skin irritation.
. There is no damage in case of contact with skin or lips.
USES and APPLICATIONS of POLYETHYLENE GLYCOL 8000:
-Laboratory chemicals
-Manufacture of substances
-Adhesives
-Ceramic Binder
-Chemical Intermediates
-Detergents and Household Cleaners
-Dye Carrier
-Lubricants
-Mining
-Mold Release Agent
-Plasticizer
-Wood Treating
-Rubber
-Textile
-Paper
-Metal
-Wood
-Pharmaceutical
-Cosmetics
-Coating
-Polyethylene glycol 8000 is a compound used to modify therapeutic proteins and peptides to increase their solubility.
-Polyethylene glycol 8000 is also used to precipitate bacteriophage from lysed cell supernatants.
-Polyethylene glycol 8000 is often used as a polar stationary phase for Gas Chromatorgraphy.
-Polyethylene glycol 8000 is commonly also used in mass spec experiments.
-As a dispersant, Polyethylene Glycol 8000 is used in toothpastes.
-In fabricating elastomers, Polyethylene glycol 8000 can be used as a lubricant and mold releasing agent.
-In pharmaceuticals, Polyethylene glycol 8000 can function as a tablet and capsule lubricant.
-Polyethylene Glycol 8000 are produced to meet the requirements for use under Food Additive Regulations for indirect use as components of articles intended for use in contact with food.
-Crystallization grade Polyethylene glycol 8000 for formulating screens or for optimization.
-Polyethylene glycol 8000 is used in the modification of therapeutic proteins and peptides to enhance Polyethylene Glycol 8000's solubility.
-In gas chromatography, Polyethylene Glycol 8000 is used as a polar stationary phase.
-Polyethylene Glycol 8000 finds application in blood banking as a potentiator, which is used to detect antigens and antibodies.
-In pharmaceutical industry, Polyethylene Glycol 8000 is used as tablet and capsule lubricant.
-Polyethylene Glycol 8000 is also used in the fabrication of bioactive and immuno isolating barriers for encapsulation of cells.
-Polyethylene Glycol 8000, NF acts as a lubricant, coating the surfaces in aqueous and non-aqueous environments.
-Research or further manufacturing, Polyethylene Glycol 8000 is used only, not for food or drug use.
-Polyethylene Glycol 8000 is widely used as a mould release agents and lubricants for rubber industry.
-Polyethylene glycol 8000 is also used to preserve objects that have been retrieved from the ocean.
-Polyethylene Glycol 8000 can be easily applied and removed since they are water-soluble.
-Polyethylene Glycol 8000 are also used as binder and dry lubricant for manufacturer of pills and tablets for certain pharmaceutical products.
-Polyethylene Glycol 8000 is used as mold release agent and lubricant in fabricating elastomers.
-Polyethylene glycol 8000 resins are high molecular weight homopolymers of ethylene oxide via heterogeneously catalyzed ring-opening polymerization.
Usually can be divided into the relative molecular mass of 2 × 1 04 above and tens of thousands of above, the former is called polyethylene glycol, the latter is called polyethylene oxide.
Polyethylene oxide with flocculation, thickening, slow release, lubrication, dispersion, retention, water retention and other properties, suitable for medicine, fertilizer, paper, ceramics, detergents, cosmetics, heat treatment, water treatment, fire, oil exploitation and other industries, the product is non-toxic and non-irritating, and will not remain, deposit or breed volatile matter in the process of product generation.
As a papermaking additive, the retention rate of the filler and the fine fiber can be improved, and the dispersant is particularly suitable for the long fiber, and the beating time can be shortened.
-The kinetic of the ligation in the cloning of DNA-fragments into bacteriophage M13-vectors can be improved by the inclusion of 5% Polyethylene glycol 8000 (PEG 8000).
Especially for the cloning with 'blunt-ended' DNA, the concentration of 'blunt'-DNA-ends plays a crucial role for the successful cloning.
Substances, that increase the so-called 'macromolecular crowding' and condense DNA molecules into aggregates, concentrate the
DNA and increase the possibility, that DNA ends will meet and thereby improve the cloning result.
So, the DNA and enzyme concentration can be reduced.
Besides, such substances reduce the intramolecular ligation (religation).
For 'blunt end' cloning the recommended Polyethylene glycol 8000 concentration is 15%.
Stock solutions of Polyethylene glycol 8000 (40%) are prepared with deionized water and stored at -20°C in small aliquots.
-Polyethylene Glycol 8000 (PEG 8000) is a safe solvent and carrier for use in cosmetics can act as a solvent in many substances.
-Polyethylene Glycol 8000 is also a secure carrier.
-Polyethylene Glycol 8000 is used as a solvent (solvent) or a conductor (carrier) in all kinds of cosmetics.
-Polyethylene glycol 8000's high molecular weight mainly prompts Polyethylene glycol 8000's use in pharmaceutical formulations as solvent for oral, topical and parenteral preparations.
-Polyethylene glycol 8000 that has wide application ranging from industrial manufacturing and medicine.
-Polyethylene glycol 8000 is generally used in the precipitation of phage.
-Polyethylene glycol 8000 is used for the isolation of plasmid DNA and the precipitation of phage.
-Polyethylene glycol 8000 is used as matrix in pharmaceutical and cosmetic industry to regulate viscosity and melting point.
-Polyethylene glycol 8000 is used as lubricant and coolant in rubber and metal processing industry, dispersant and emulsifier in pesticide and pigment industry production.
-Polyethylene glycol 8000 is used as antistatic agent and lubricant in textile industry.
-Polyethylene Glycol 8000 (PEG 8000) is a safe solvent and carrier for use in cosmetics can act as a solvent in many substances.
-Polyethylene glycol 8000 is also a secure carrier.
-Polyethylene glycol 8000 is also used as a fusogen (induces cell hybridization) to obtain hybridomas for monoclonal antibody production.
-Additionally, photopolymerized Polyethylene glycol 8000 hydrogels have emerging applications in the fabrication of bioactive and immune-isolating barriers for encapsulation of cells.
-Polyethylene glycol 8000 is a suitable compound with a wide scope in biological applications since Polyethylene glycol 8000 does not elicit any immune responses.
-Polyethylene glycol 8000 has been shown to modify therapeutic proteins and peptides for enhanced solubility.
-Polyethylene glycol 8000 is vastly used for the isolation of plasmid DNA and the precipitation of phage.
PHYSICAL and CHEMICAL PROPERTIES of POLYETHYLENE GLYCOL 8000:
Molecular Weight: 7000-9000
Appearance Form: solid
Color: light yellow
Odor: No data available
Odor Threshold: No data available
pH: No data available
Melting point/freezing point:
Melting point/range: 57,5 °C
Initial boiling point and boiling range: 205,7 °C at 977,6 hPa - OECD Test Guideline 103
Flash point: 138,6 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapor pressure: < 0,01 hPa at 20 °C
Vapor density: No data available
Density: 1,116 g/cm3 at 20 °C at 975,5 hPa
Relative density: No data available
Water solubility: 256,084 g/l at 25 °C
Partition coefficient: n-octanol/water
log Pow: -0,698 at 30 °C - Bioaccumulation is not expected.
Autoignition temperature: 360 °C
Decomposition temperature: No data available
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available
Physical Form: Solid
Average Number of Repeating Oxyethylene Units: 181
Range of Average Molecular Weight: 7000 – 9000
Range of Average Hydroxyl Number, mg KOH/g: 12 – 16
Density, g/cm3 at 70°C: 1.07
Melting or Freezing Range, °C: 55 – 62
Solubility in Water at 20°C, % by weight: 63
Viscosity at 100°C: cSt 500 - 900
Heat of Fusion: Cal/g 41
FIRST AID MEASURES of POLYETHYLENE GLYCOL 8000:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact: rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available
ACCIDENTAL RELEASE MEASURES of POLYETHYLENE GLYCOL 8000:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Take up dry.
Clean up affected area.
FIRE FIGHTING MEASURES of POLYETHYLENE GLYCOL 8000:
-Extinguishing media:
*Suitable extinguishing media:
Water Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Special hazards arising from the substance or mixture:
Nature of decomposition products not known.
-Advice for firefighters:
In the event of fire, wear self-contained breathing apparatus.
EXPOSURE CONTROLS/PERSONAL PROTECTION of POLYETHYLENE GLYCOL 8000:
-Control parameters:
Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Safety glasses.
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of POLYETHYLENE GLYCOL 8000:
-Conditions for safe storage, including any incompatibilities:
Storage conditions:
Tightly closed.
Dry.
Stored at room temperature.
But close the lid of the bottle tightly.
The product has a shelf life of at least 2 years.
STABILITY and REACTIVITY of POLYETHYLENE GLYCOL 8000:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions: No data available
SYNONYMS:
PEG
Poly(ethylene glycol)
Polyethyleneglycol 8000
Macrogol 8000
Macrogols 8000
Poly(ethylene glycol)
Polyethyleneglycol 8000
PEG 8k
Polyethylene glycol
Poly(ethylene glycol)
Polyethylene glycol
polyethylene oxide standard 511000
Poly(ethylene oxide)
macrogol
poly(oxyethylene)
Polyethylene glycol PEG
Aquacide III
PEG 1000
PEG 6000, MB Grade (1.12033)
Ethylene glycol 8000 polymer
Polyethyleneglycol
Polyethylene Glycol 5000000
PolyethyleneoxideMW
PEG 200-8000
Tri-(2,3-Dibromopropyl) Phosphate
Polyethylene glycol - 6000 grade
PEG 200
PEG 400
PEG 6000
Poly(ethylene oxide)
PEO
PEG 600
Polyethyleneoxidemonomethacryloxymonotrimethylsiloxyterminated
O-Methacryloxy(polyethyleneoxy)trimethylsilane
PEG
Poly ethylene glycol
Carmowax
carbowax
PEG 8000
Polyethylene glycol series
Polyethylene Glycol
Polyethylene glygcol
