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Polyethylene Glycol Monomethyl Ether is the main material for producing water reducing agent of polycarboxylate high effective cement. With well water-solubility, wettability, lubricity, physiologically inert characteristics, incitingless and moderate characteristics, Polyethylene Glycol Monomethyl Ether is widely used in cosmetics and pharmaceutical industry.
CAS Number: 9004-74-4
SYNONYM:
Methoxy PEG-100; Methoxy PEG-16; Methoxy PEG-40; Monomethoxypolyethylene glycol; PEG-6 Methyl ether; Polyethylene glycol 100 monomethyl ether; Polyethylene glycol 16 monomethyl ether; Polyethylene glycol 2000 monomethyl ether; Polyethylene glycol 300 methyl ether; Polyethylene glycol 500 monomethyl ether; Polyoxyethylene 10 monomethyl ether; Polyoxyethylene methyl ether; Carbowax Sentry Methoxypolyethylene Glycol; Ethylene oxide adduct of diethylene glycol monomethyl ether; MPEG; Methoxy polyethylene glycol; Poly(oxy-1,2-ethanediyl), alpha-methyl-omega-hydroxy
Polyethylene Glycol Monomethyl Ether, or methyl cellosolve, is an organic compound with formula C3H8O2 that is used mainly as a solvent. Polyethylene Glycol Monomethyl Ether is a clear, colorless liquid with an ether-like odor. Polyethylene Glycol Monomethyl Ether is in a class of solvents known as glycol ethers which are notable for their ability to dissolve a variety of different types of chemical compounds and for their miscibility with water and other solvents. Polyethylene Glycol Monomethyl Ether can be formed by the nucleophilic attack of methanol on protonated ethylene oxide followed by proton transfer: C2H5O++ CH3OH → C3H8O2 + H+
Polyethylene Glycol Monomethyl Ether is used as a solvent for many different purposes such as varnishes, dyes, and resins.
Polyethylene Glycol Monomethyl Ether is also used as an additive in airplane deicing solutions. In organometallic chemistry Polyethylene Glycol Monomethyl Ether is commonly used for the synthesis of Vaska's complex and related compounds such as carbonylchlorohydridotris (triphenylphosphine) ruthenium (II). During these reactions the alcohol acts as a source of hydride and carbon monoxide.Polyethylene Glycol Monomethyl Ether is toxic to the bone marrow and testicles. Workers exposed to high levels are at risk for granulocytopenia, macrocytic anemia, oligospermia, and azoospermia. The methoxyethanol is converted by alcohol dehydrogenase into methoxyacetic acid which is the substance which causes the harmful effects.
Both ethanol and acetate have a protecting effect. The methoxyacetate can enter the Krebs cycle where Polyethylene Glycol Monomethyl Ether forms methoxycitrate. Polyethylene Glycol Monomethyl Ether are a group of solvents based on alkyl ethers of ethylene glycol or propylene glycol commonly used in paints and cleaners. Polyethylene Glycol Monomethyl Ether typically have a higher boiling point, together with the favorable solvent properties of lower-molecular weight ethers and alcohols.
IUPAC NAME:
Poly(oxy-1,2-ethanediyl); α-methyl-ω-hydroxy; 2-methoxyethanol; 1-Hydroxy-2-methoxyethane;
TRADE NAME:
Ceriton; Eposis; Shanpoetin; Epofer; Epox; Eprex; Epotop; LG Espogen; Erypro Safe; Vintor 3000; Wepox; Eprex (Prefilled Syringe); Hemax; Mircera
OTHER NAME:
102868-77-9; 1034004-69-7; 104841-59-0; 1059605-03-6; 1059605-05-8; 114740-40-8; 1173722-69-4; 1238333-93-1; 12623-96-0; 126966-17-4; 134919-42-9; 138753-86-3; 1392446-65-9; 142172-77-8;1427524-96-6;
The word "Cellosolve" was registered in 1924 as a United States trademark by Carbide & Carbon Chemicals Corp. for "Solvents for Gums, Resins, Cellulose Esters, and the Like".Typically, Polyethylene Glycol Monomethyl Ether are found in pharmaceuticals, sunscreens, cosmetics, inks, dyes and water-based paints, while Polyethylene Glycol Monomethyl Ether are used in degreasers, cleaners, aerosol paints and adhesives.
Polyethylene Glycol Monomethyl Ether can be used as intermediates that undergo further chemical reactions, producing glycol diethers and glycol ether acetates. The main physicochemical properties of Polyethylene Glycol Monomethyl Ethers in a wide temperature range were determined. The effect exerted on the main quality indices of brake fluids by the introduction of Polyethylene Glycol Monomethyl Ethers borates was studied. The use of these ethers as the main component of DOT-5.1 brake fluids was analyzed.
Advances in electronics and life sciences have generated interest in “lab-on-a-chip” systems utilizing complementary metal oxide semiconductor circuitry for low-power, portable, and cost-effective biosensing platforms. Here, we present a simple and reliable approach for coating “high-κ” metal oxide dielectric materials with “non-fouling” (protein- and cell-resistant) Polyethylene Glycol Monomethyl Ether polymer brushes as biointerfacial coatings to improve their relevance for biosensing applications utilizing advanced electronic components.
By using a surface-initiated “grafting from” strategy, Polyethylene Glycol Monomethyl Ether films were reliably grown on each material, as confirmed by ellipsometric measurements and X-ray photoelectron spectroscopy analysis. The electrical behavior of these Polyethylene Glycol Monomethyl Ether films was also studied to determine the potential impact on surrounding electronic devices, yielding information on relative permittivity and breakdown field for Polyethylene Glycol Monomethyl Ether in both dry and hydrated states.
We show that the incorporation of Polyethylene Glycol Monomethyl Ether coatings significantly reduced levels of nonspecific protein adsorption compared to uncoated high-κ dielectric oxide surfaces as shown by protein resistance assays. These attributes, combined with the robust dielectric properties of Polyethylene Glycol Monomethyl Ether brushes on high-κ surfaces open the way to incorporate this protein and cell resistant polymer interface into CMOS devices for biomolecular detection in a complex liquid milieu.
Polyethylene Glycol Monomethyl Ether is a polyether compound that consists of repeating units of ethylene oxide. Polyethylene Glycol Monomethyl Ether is a safe compound that is used in a wide variety of application including food additives, as an excipient in pharmaceutical products, and as a stealth coating in biomedical applications to reduce non-specific binding and to evade the body’s immune system. The Polyethylene Glycol Monomethyl Ether surface is the most stable of our surfaces in buffers containing high salt concentrations found in culture media or other high ionic buffers. The Polyethylene Glycol Monomethyl Ether surface functionality disperses very well in water and protic solvents, increasing compatibility in biological systems.
The methoxy Polyethylene Glycol Monomethyl Ether surface has a slightly negative to neutral surface charge which is advantageous for in-vivo or in-vitro applications.Polyethylene Glycol Monomethyl Ether provides two different Polyethylene Glycol Monomethyl Ether functionalizations, either a lipoic acid derivative of Polyethylene Glycol Monomethyl Ether with a terminal acid group a 5 kDa methoxy polyethylene glycol sulfhydryl Polyethylene Glycol Monomethyl Ether.
The methoxy terminated Polyethylene Glycol Monomethyl Ether is available on both gold and silver nanoparticles increasing particle stability in a wide range of solvents. Our Polyethylene Glycol Monomethyl Ether functionalized metal particles have the highest salt stability of any of our surfacesPolyethylene Glycol Monomethyl Ether are important biomedical materials with particular use in drug delivery and tissue engineering. Modelling the underlying polymer network of these gels is of key importance in understanding the mechanical, diffusive, and swelling properties that dictate hydrogel behavior and performance in application.
The gels are often assumed to have a network structure that lead them to follow neo-Hookean elastic models, from which network parameters such as crosslink density and network mesh size are calculated. However, several groups have used scattering techniques to demonstrate significant heterogeneity of Polyethylene Glycol Monomethyl Ether networks. Because such specialized techniques are not feasible to be applied to biomedical hydrogel networks generally,
Polyethylene Glycol Monomethyl Ether is still common to calculate network parameters assuming the validity of the neo-Hookean model despite the underlying heterogeneity. Thus a systematic study of Polyethylene Glycol Monomethyl Ether mechanical properties was performed to evaluate the validity of the neo-Hookean model on Polyethylene Glycol Monomethyl Ether and the ability to predict network structure from macroscopic mechanical tests using both the neo-Hookean and Mooney-Rivlin models.
Mechanical properties of Polyethylene Glycol Monomethyl Ether were determined. Hydrogels of Polyethylene Glycol Monomethyl Ether concentrations from 7 - 30 wt. % were prepared and synthesized via photoinitiation at a wavelength of 312 nm with the photoinitiator lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP). Hydrogels were molded into disks, swollen to equilibrium in deionized water, and evaluated using uniaxial compression tests to determine stress versus strain relationships as well as the elastic modulus (E) and shear modulus (G) for each gel under neo-Hookean assumptions.
The swelling degree (Q) was also determined from the ratio of wet to dry weights of each gel. Gel properties were shown to vary widely across polymer concentration with neo-Hookean elastic moduli increasing with concentration and ranging from 81.0 kPa to 2620 kPa and 51.6 kPa to 1030 kPa for Polyethylene Glycol Monomethyl Ether, respectively. Swelling degree decreased with composition and ranged from 9.20 to 3.00 and 14.7 to 5.46 for Polyethylene Glycol Monomethyl Ether, respectively. Further evaluation using the Mooney-Rivlin network model highlighted the heterogeneity of these network structures, and suggests that these gels are deviating from neo-Hookean behavior.
Gels with low polymer content approached neo-Hookean behavior and behaved as apparent Mooney-Rivlin solids, while high polymer content gels behaved similarly to networks that follow constrained polymer chain models with notable transition behavior for hydrogel networks with compositions near the polymer overlap volume fraction. These results suggest that low molecular weight Polyethylene Glycol Monomethyl Ether deviate significantly from the neo-Hookean model and correlation of moduli to Polyethylene Glycol Monomethyl Ether network parameters is limited.Polyethylene Glycol Monomethyl Ether is a colorless, neutral, weakly liquid with a mild pleasant odor.
Polyethylene Glycol Monomethyl Ether is miscible in any ratio with water and the usual organic solvents (except for saturated hydrocarbons, e. g. special boiling point petroleum spirits). Polyethylene Glycol Monomethyl Ether enters into the typical alcohol reactions like esterification, etherification, oxidation, acetal and alcoholate formation. Therefore Polyethylene Glycol Monomethyl Ether is used as a starting material for syntheses of organic intermediates. Polyethylene Glycol Monomethyl Ether is also used as an antifreeze in aviation fuels for jet aircrafts (about 0.10 - 0.15 % by volume, relative to the fuel). The technical characteristics of Polyethylene Glycol Monomethyl Ether enable it to meet the requirements stipulated for the technical Supply Conditions as drawn up in accordance with MIL-DTL-2786G in addition with an antioxidant.
Polyethylene Glycol Monomethyl Ether and their derivatives tend to form peroxides in the presence of air or oxygen. To prevent the formation of peroxides the product should be stored under an inert nitrogen atmosphere. Despite the very mild odor of Polyethylene Glycol Monomethyl Ether, the general precautionary measures for the handling of solvents must always be observed.
For further informations please refer to the safety datasheet. Storage tanks should be made from norm-steel or stainless steel. Aluminium and other light metals are not suitable due to alcoholate formation with Polyethylene Glycol Monomethyl Ether. We found the following materials suitable.
Polyethylene Glycol Monomethyl Ether is a polyether compound, meaning that it consists of multiple ether groups. Depending on its molecular weight, Polyethylene Glycol Monomethyl Ether may have different appearances. Below a molecular weight of 700, it is an opaque liquid. At molecular weights between 700 and 900, Polyethylene Glycol Monomethyl Ether is a semisolid. Over a molecular weight of 900, it can be a white waxy solid, flakes or a powder. Polyethylene Glycol Monomethyl Ether appears in a large range of chemical, biological, commercial, industrial and medical applications.
Polyethylene Glycol Monomethyl Ether is a flexible, water-soluble polymer, Polyethylene Glycol Monomethyl Ether can be used to create very high osmotic pressures. Polyethylene Glycol Monomethyl Ether is widely used as a polar stationary phase for gas chromatography as well as a heat transfer fluid in electronic testers. Polyethylene Glycol Monomethyl Ether is used as an emulsifier, lubricant and mold release agent in a wide variety of industries.
Polyethylene Glycol Monomethyl Ether is used as solvent, dispersant. Polyethylene Glycol Monomethyl Ether is used as a viscosity adjuster. Polyethylene Glycol Monomethyl Ether is used in the rubber industry. Polyethylene Glycol Monomethyl Ether is used as a plasticizer, dehumidifier and impregnation agent. Polyethylene Glycol Monomethyl Ether is used as a lubricant and mold release agent. Polyethylene Glycol Monomethyl Ether is used as an intermediate in chemical synthesis. Polyethylene Glycol Monomethyl Ether is used in electroplating processes. Solid detergent concentrates crayon paints are used in watercolors.Polyethylene Glycol Monomethyl Ether production first started in 1859.
Both AV Laurence and Charles Adolphe Wurtz independently isolated the products with Polyethylene Glycol Monomethyl Ether. Polyethylene Glycol Monomethyl Ether is produced by interaction with polyethylene oxide, water, ethylene glycol or ethylene glycol oligomers. The reaction is catalyzed by acidic or basic catalysts. Polyethylene Glycol Monomethyl Ether oligomers are preferred as a starting material instead of water, as they allow the production of polymers with low polydispersity (narrow molecular weight distribution). Polymer chain length depends on the ratio of reactants.
Alkaline catalysts are used to prepare a low molecular weight Polyethylene Glycol Monomethyl Ether such as sodium hydroxide (NaOH), potassium hydroxide (KOH) or sodium carbonate (Na2CO3). Since Polyethylene Glycol Monomethyl Ether is a hydrophilic molecule, Polyethylene Glycol Monomethyl Ether is used to inactivate microscope glass slides to prevent non-specific adhesion of proteins in single molecule fluorescence studies. Polyethylene glycol has low toxicity and is used in a variety of products. Polyethylene Glycol Monomethyl Ether is used as a lubricating coating for various surfaces in polymer, aqueous and non-aqueous media.
Because Polyethylene Glycol Monomethyl Ether is a flexible, water-soluble polymer, Polyethylene Glycol Monomethyl Ether can be used to generate very high osmotic pressures.Polyethylene Glycol Monomethyl Ether is widely used as a heat transfer fluid in electronic test equipment as well as a polar stationary phase for gas chromatography.Polyethylene Glycol Monomethyl Ether is often used in mass spectrometry experiments, with its characteristic fragmentation pattern that allows accurate and repeatable adjustment.
Polyethylene Glycol Monomethyl Ether derivatives such as narrow field ethoxylates are used as surfactants. Polyethylene Glycol Monomethyl Ether was used as a hydrophilic block of amphiphilic block copolymers used to form some polymers. Polyethylene Glycol Monomethyl Ether is the basis for a number of preparations. Polyethylene Glycol Monomethyl Ether is used for whole bowel irrigation with polyethylene glycol and additional electrolytes, bowel preparation before surgery or colonoscopy. Polyethylene Glycol Monomethyl Ether is also used as an excipient in many pharmaceutical products.
When bound to various protein drugs, Polyethylene Glycol Monomethyl Ether allows the transported protein to slow down in the blood. Polyethylene Glycol Monomethyl Ether is widely used as a crowding agent in in vitro experiments to mimic highly crowded cellular conditions.Polyethylene Glycol Monomethyl Ether is commonly used as a precipitate for plasmid DNA isolation and protein crystallization. X-ray diffraction of protein crystals can reveal the atomic structure of proteins. Polyethylene Glycol Monomethyl Ether is used to fuse two different types of cells, mostly B-cells and myelomas, to form hybridomas.
Polyurethanes derived from Polyethylene Glycol Monomethyl Ether polyols provide flexibility to polyurethanes for applications such as elastomeric fibers (spandex) and foam pillows.In microbiology, Polyethylene Glycol Monomethyl Ether precipitation is used to concentrate viruses. Gene therapy vectors (such as viruses) are coated with Polyethylene Glycol Monomethyl Ether to protect them from being inactivated by the immune system, and can remove them from organs and prevent them from being targeted where they could be toxic.
Nitrate ester plasticized Polyethylene Glycol Monomethyl Ether Trident II submarine launch ballistic missile is used in solid rocket fuel.Dimethyl ethers of Polyethylene Glycol Monomethyl Ether are the key component of Selexol, a solvent used by coal combustion, integrated gasification combined cycle (IGCC) power plants to remove carbon dioxide and hydrogen sulfide from the gas waste stream.
Polyethylene Glycol Monomethyl Ether was used as a gate insulator in an electric double layer transistor to induce superconductivity in an insulator.Polyethylene Glycol Monomethyl Ether is also used as a polymer host for solid polymer electrolytes. Although not yet in commercial production, many groups around the world are researching solid polymer electrolytes containing Polyethylene Glycol Monomethyl Ether to improve their properties and allow the use of other products in batteries, electrochromic display systems and other products.
Polyethylene Glycol Monomethyl Ether is injected into industrial processes to reduce foaming in separation equipment. Polyethylene Glycol Monomethyl Ether is used as a binder in the preparation of technical ceramics. Polyethylene Glycol Monomethyl Ether is the basis of many skin creams (as cetomacrogol) and personal lubricants (often combined with glycerin). Polyethylene Glycol Monomethyl Ether is used as a dispersant in a number of toothpastes. In this application, Polyethylene Glycol Monomethyl Ether binds water and helps the xanthan gum to be evenly distributed throughout the toothpaste.
Polyethylene Glycol Monomethyl Ether is also being studied in body armor and tattoos used to monitor diabetes.Polyethylene Glycol Monomethyl Ether is used in Hewlett-Packard design jet printers as an ink solvent and lubricant for printheads in low molecular weight formulations.Polyethylene Glycol Monomethyl Ether used in bowel cleansing before colonoscopy is effective in chronic constipation use. Polyethylene Glycol Monomethyl Ether is toxic if swallowed.
Polyethylene glycol is the most important glycol available and produced in the world. Polyethylene Glycol Monomethyl Ether can be used in the production of an antifreeze and coolant, hydraulic fluids and low-freezing dynamites and resins. Polyethylene Glycol Monomethyl Ether is a polyether compound with many applications. Polyethylene Glycol Monomethyl Ether can be used in industrial and pharmaceutical production.Polyethylene Glycol Monomethyl Ether is the basis for a number of preparations. Polyethylene Glycol Monomethyl Ether is used as an excipient in many pharmaceutical products. Low molecular weight variants of Polyethylene Glycol Monomethyl Ether are used as solvents in oral fluids and soft capsules.
Polyethylene Glycol Monomethyl Ether, while its solid variants are used as ointment bases, tablet binders, film coatings and lubricants. Polyethylene Glycol Monomethyl Ether enhances recovery from spinal injuries in dogs. Polyethylene Glycol Monomethyl Ether will aid nerve repair. In recent years, Polyethylene Glycol Monomethyl Ether has been proven to give better results than tegaserod in constipation patients.
Polyethylene Glycol Monomethyl Ether can be used to create very high osmotic pressures with its flexible, water-soluble polymer feature. In Polyethylene Glycol Monomethyl Ether, there is no possibility of specific interaction with biological chemicals. Polyethylene Glycol Monomethyl Ether is one of the most useful molecules for applying osmotic pressure in biochemical experiments, especially when using the osmotic stress technique. Polyethylene glycol is produced to meet the requirements for use under food. Polyethylene Glycol Monomethyl Ether is used in the Regulations for additives for indirect use as components of articles intended to be used in contact with food.Polyethylene Glycol Monomethyl Ethers are hydrophilic substances commonly used in various formulations.
Liquid Polyethylene Glycol Monomethyl Ether is well suited for water-miscible solvents in soft gelatin capsules, while high-molecular Polyethylene Glycol Monomethyl Ethers work in solid dosage forms to provide binding and lubricating functions. Polyethylene Glycol Monomethyl Ether is a softening and mold release agent. Polyethylene Glycol Monomethyl Ether It is a water-soluble carrier material. Polyethylene Glycol Monomethyl Ether provides a moisture-balancing effect in creams and leaves a pleasant feeling on the skin.Polyethylene Glycol Monomethyl Ether can be used in transparent toothpastes.
Polyethylene Glycol Monomethyl Ether is well compatible with cetyl alcohol, glycerol, stearic acid, polyvinyl pyrrolidone, casein and vegetable albumin. Polyethylene Glycol Monomethyl Ether Does not show emulsifying effect. A long chain Polyethylene Glycol Monomethyl Ether is available in a wide variety of molecular weights. Polyethylene Glycol Monomethyl Ether humectant, moisturizing and dispersing agent, petroleum based; Used in cream ointment, cosmetics and hair care products.
Polyethylene Glycol Monomethyl Ether does not hydrolyze or degrade at low vapor pressures. The density of the ink can be controlled using a mixture of solid and liquid Polyethylene Glycol Monomethyl Ether grades. Polyethylene Glycol Monomethyl Ether varieties can be used as solvents for basic dyes in flexographic inks. Similarly, Polyethylene Glycol Monomethyl Ether can be used as a solvent and dispersant medium in liquid and pulp pigment preparations, dough thickeners in textiles, paint and saramic industries.
Polyethylene Glycol Monomethyl Ether is a substance commonly used in antifreeze and anti-icing agents. Polyethylene Glycol Monomethyl Ether is the most important glycol product used in the chemical industry. When Polyethylene Glycol Monomethyl Ether is mixed with water, its melting point drops even more. Polyethylene Glycol Monomethyl Ether can compound with water, alcohol, acetone. Polyethylene Glycol Monomethyl Ether is insoluble in ether.
Polyethylene Glycol Monomethyl Ether is soluble in most organic solvents. After ethylene is passed through chlorinated water, ethylene chlorohydrin is formed. Polyethylene Glycol Monomethyl Ether is hydrolyzed with sodium bicarbonate aqueous solution. Another method is chemical treatment of ethylene oxide with cold and dilute hydrochloric acid.Polyethylene Glycol Monomethyl Ether is the preferred material when vegetable oils are incompatible with active ingredient carriers. The main reason for this is that the Polyethylene Glycol Monomethyl Ether is stable and not easily degraded, and the injection containing Polyethylene Glycol Monomethyl Ether is safe and stable when heated to 150 degrees.
In addition, high molecular weight Polyethylene Glycol Monomethyl Ether can be mixed and the mixture has good solubility and good drug compatibility.
Polyethylene Glycol Monomethyl Ether is suitable for use in stencil and pad inks. Polyethylene Glycol Monomethyl Ether can also be used to adjust the viscosity of the ink in ballpoint pen inks. Polyethylene Glycol Monomethyl Ether is used as a dispersant to increase vulcanization in the rubber industry.
Polyethylene Glycol Monomethyl Ether is used as a dispersant for carbon black filler. Polyethylene Glycol Monomethyl Ether is used for tablets, capsules, film coatings, drops pills, suppositories and the like. Also used as a water-soluble ointment and suppository matrix, the matrix of high relative molecular weight solid waxy Polyethylene Glycol Monomethyl Ether is used to increase Polyethylene Glycol Monomethyl Ether viscosity and low molecular weight liquid to solid and other drugs. Polyethylene Glycol Monomethyl Ether, water insoluble drugs, this product can be used as solid dispersant carrier to obtain solid dispersion.
Polyethylene Glycol Monomethyl Ether is used in the papermaking industry as a finishing agent to increase the brightness and smoothness of the paper Polyethylene Glycol Monomethyl Ether is used as a lubricant and coolant in the metal processing industry, as a dispersant and emulsifier in the production of pesticides and pigments, to increase the lubricity and plasticity of rubber products, reduce power consumption in the processing process, extend the service life of rubber products.
Polyethylene Glycol Monomethyl Ether does not belong to hazardous chemicals. Store in a cool, dry and ventilated place. Avoid moisture, direct sunlight and collision. Polyethylene Glycol Monomethyl Ether can be turned into dry preparations with the help of organic objects (fresh preparations, long immersion in water). Originally moist objects (in water, alcohol or formalin) are soaked either for a long time or in a vacuum in a Polyethylene Glycol Monomethyl Ether solution.
Thanks to the use of different Polyethylene Glycol Monomethyl Ether molecule sizes, most of the original liquid is replaced by Polyethylene Glycol Monomethyl Ether. In modern animal preparation, a mixing process is used due to shrinkage due to the drying process, where conventional preparation methods are included.Polyethylene Glycol Monomethyl Ether is a white to slightly yellowish flake. Polyethylene Glycol Monomethyl Ether is soluble in water and polar organic solvents like acetone or methanol.
Polyethylene Glycol Monomethyl Ether can be considered as high molecular alcohol and therefore displays typical chemical reactions of alcohols. With isocyanates and polyester they act as endcap and hydrophilic component. When reacted with unsaturated monomers like acrylic or methacrylic acid esters are formed which can be copolymerized in order to increase hydrophilicity and improves dispersing properties of polymers in water.Polyethylene Glycol Monomethyl Ether has good water solubility, wettability, lubricity, physiological inertia, no stimulation to human body, mild, and is widely used in cosmetics and pharmaceutical industry.
Polyethylene Glycol Monomethyl Ether with different molecular weight fractions can be selected to change the viscosity, hygroscopicity and structure of the products. Polyethylene Glycol Monomethyl Ether with relatively low molecular weight (molecular weight less than 2000) are suitable for wetting agents and consistency regulators for cream, lotion, toothpaste, and cream. The Polyethylene Glycol Monomethyl Ether with relatively high molecular weight are suitable for lipstick, deodorant stick, soap, pick up soap, foundation and cosmetics. Polyethylene Glycol Monomethyl Ether is also used as suspension agent and thickener in cleaning agent.
In the pharmaceutical industry, Polyethylene Glycol Monomethyl Ether is used as the matrix of ointment, emulsion, ointment, lotion and suppository. Polyethylene Glycol Monomethyl Ether is also the main monomer raw material for the preparation of polycarboxylate superplasticizer by synthesizing esters with acrylic acid and other polymers containing polymerizable binary reactions to increase their reactivity.If refined raw materials and special catalysts are used, the impurity content of Polyethylene Glycol Monomethyl Ether can be controlled to a low content. Moreover, the hydroxyl activity at the end of the molecular chain was retained to the greatest extent, with good hydrophilicity and hydroxyl reaction activity.
Polyethylene Glycol Monomethyl Ether is a long-acting erythropoietin receptor activator indicated for the treatment of patients with anaemia associated with chronic kidney disease. Polyethylene Glycol Monomethyl Ether is the first approved, chemically modified erythropoiesis-stimulating agent. Polyethylene Glycol Monomethyl Ether is supplied as a solution in pre-filled syringes for intravenous or subcutaneous administration. Polyethylene Glycol Monomethyl Ether was approved for use in Europe in July 2007 by the European Commission, in September 2007 by the Swissmedic, and in November 2007 by the U.S. Food and Drug Administration for use in the United States.
Polyethylene Glycol Monomethyl Ether is made from erythropoietin by chemically linking the N-terminal amino group or the ε-amino group of any lysine present in the protein with methoxy polyethylene glycol butanoic acid. The average molecular weight is approximately 60 kDa. The drug stimulates erythropoiesis by interacting with the erythropoietin receptor on progenitor cells in the bone marrow. Polyethylene Glycol Monomethyl Ether has a reduced receptor binding activity compared to other ESAs and but retains in vivo activity due to an extended serum half-life. Polyethylene Glycol Monomethyl Ether has an in vivo half-life of around 135 hours (5.6 days) as compared to darbepoetin alfa which has a half life of around 21 to 70 hours, the half life of which is three times that of the naturally occurring erthropoietin in the body.
When liquid Polyethylene Glycol Monomethyl Ether are mixed with water, there is a reduction in volume. When equal parts by weight are mixed with Polyethylene Glycol Monomethyl Ether and water, this shrinkage is about 2.5%. At the same time comes a certain heat effect. When equal parts by weight of Polyethylene Glycol Monomethyl Ether and water are obtained. Even the solid Polyethylene Glycol Monomethyl Ether grades are soluble in water.
75 parts by weight of Polyethylene Glycol Monomethyl Ether can dissolve only 25 media by room weight. Although the solubility in water decreases slightly as the molar mass increases, it does not drop below 50% even in the case of Polyethylene Glycol Monomethyl Ether. The dissolution process can be greatly accelerated by heating the melting point to the environment. Polyethylene Glycol Monomethyl Ether exhibit non-ionic behavior in aqueous solution. They are not sensitive to electrolytes and are therefore compatible with hard water.
Polyethylene Glycol Monomethyl Ether are non-volatile and are an important factor that can be considered in connection with their use as plasticizers and moisturizers. If a certain weight loss is detected although the Polyethylene Glycol Monomethyl Ether are non-volatile when kept at a constant temperature of 150 ° C and above (eg when used as heating bath fluids), this is not due to evaporation but to the loss of volatile decomposition products. .
The degradation products of Polyethylene Glycol Monomethyl Ether can vary depending on the air intake; Simple alcohols, acids and glycol esters are formed as well as water, carbon dioxide and aldehydes. The irritating fumes from decomposition products are not known to have a negative health effect.Since low Polyethylene Glycol Monomethyl Ether grades are hygroscopic, moisture can be reabsorbed in the event of extremely long periods of inactivity. At temperatures above 100 ° C, it is important to add a suitable antioxidant to the Polyethylene Glycol Monomethyl Ether.
A type of antioxidant quality is determined by the requirements applied to the Polyethylene Glycol Monomethyl Ether. Therefore, not only the temperature and residence time of the antioxidant must be taken into account, but also its physiological properties and water solubility or insolubility. In situations where high thermal stress is involved, up to 3% antioxidants should be added.Liquid Polyethylene Glycol Monomethyl Ether grades are hygroscopic, although not to the same extent as, for example, diethylene glycol or glycerol. As the molar mass increases, the ability to absorb water decreases.
A rule of thumb is; With a relative humidity of about 50%, Polyethylene Glycol Monomethyl Ether has about of the hygroscopicity of glycerol. Polyethylene Glycol Monomethyl Ether and higher grades are no longer hygroscopic. Polyethylene Glycol Monomethyl Ether absorb moisture from the air until equilibrium is reached. The absorption isotherm is obtained by plotting the water content of the equilibrium substance as a function of relative humidity. The moisture absorption of lower glycols such as monoethylene glycol, diethylene glycol or 1,2-propylene glycol roughly corresponds to that of glycerol.
An adaptable medium hygroscopicity may be advantageous for a conditioning agent because products treated with Polyethylene Glycol Monomethyl Ether are less susceptible to climatic changes and have better storage stability.Polyethylene Glycol Monomethyl Ether is a white, wax-like chemical similar to paraffin. Polyethylene Glycol Monomethyl Ether, a solid at room temperature, melts at 104 ° F, has an average molecular weight of 1000, readily soluble in warm water, non-toxic, non-corrosive, odorless, colorless, and has a very high flash point (580 ° F).
Although chemically associated with the common antifreeze (ethylene glycol, a monomer), Polyethylene Glycol Monomethyl Ether is a polymer more closely related to various other polyethylene glycol polymers with largely higher or lower molecular weights and different properties (many monomer units bonded to form larger molecules ). Polyethylene Glycol Monomethyl Ether has its own unique properties that others don't. Accordingly, none of the relevant chemicals can be successfully substituted for Polyethylene Glycol Monomethyl Ether in the processing of wood or wood products.
Polyethylene Glycol Monomethyl Ether by using triglycol monomethyl ether and tetraethylene glycol as raw materials, carrying out sulfonylation reaction to obtain a sulfonylation product, reacting under the action of sodium hydride to obtain an Polyethylene Glycol Monomethyl Ether crude product, carrying out reaction on the Polyethylene Glycol Monomethyl Ether crude product and benzoyl chloride to obtain a benzoyl protected product, and finally, carrying out deprotection under alkaline conditions to obtain the Polyethylene Glycol Monomethyl Ether pure product. In the preparation method, the Polyethylene Glycol Monomethyl Ether crude product is benzoylated, so that the product can absorb UV, and is convenient for separation and purification by column chromatography and finally, the deprotection is performed to obtain the.
Polyethylene Glycol Monomethyl Ether, thereby greatly lowering the product purification difficulty, enhancing the product purity and satisfying the quality requirements in the field of drugs.Polyethylene Glycol Monomethyl Ether contains two active end groups, easily causes less desirable crosslinking, thus at present in the drug modification research of Polyethylene Glycol Monomethyl Ether, be used mostly is the Polyethylene Glycol Monomethyl Ether only with an active end group when chemical modification.
But, how to efficiently synthesize Polyethylene Glycol Monomethyl Ether and be still when the next difficult problem being difficult to and capturing. Synthetic route the most on the market generally exists at present following difficult point; synthesis step is many, and productivity is low, product purification difficult, currently without the report of Polyethylene Glycol Monomethyl Ether synthetic route of more than 2500da, the longest Polyethylene Glycol Monomethyl Ether chain be the 2484da, 4000da of the Livingston team research and development being in the news recently be the minimum requirements that Polyethylene Glycol Monomethyl Ether series plays recessive effect in terms of bio-pharmaceuticals, PEG mono-functionalized needs the Polyethylene Glycol Monomethyl Ether (up to 10eq) of big excess, and the reagent of costliness, loaded down with trivial details operation.
