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Polyglycol 1000 is a water-soluble linear polymer formed by the addition reaction of ethylene oxide with a molecular weight of 950 to 1050.
Polyglycol 1000 is commonly used in cosmetics as cleansing agents, emulsi-ers, skin conditioners, surfactants.
Polyglycol 1000 is a polyethylene glycol (PEG) polymer with an average molecular weight of 200 g/mol.
CAS Number: 25322-68-3
Molecular Formula: (C2H4O)nH2O
EINECS Number: 500-038-2
Synonyms: Reaction mass of 156065-02-0 and 25322-68-3 and 68937-54-2, 937-250-3, 1,2-ethanediol, homopolymer, 2-ethanediyl),.alpha.-hydro-.omega.-hydroxy-Poly(oxy-1, Alcox E 160, Alcox E 30;alcoxe30, Poly(ethylene oxide), approx. M.W. 600,000, Poly(ethylene oxide), approx. M.W. 200,000, Poly(ethylene oxide), approx. M.W. 900,000
Polyglycol 1000 is a white waxy solid at room temperature.
Its two hydroxy end groups as well as its ether groups mainly control the physical and chemical properties of Polyglycol 1000.
Polyglycol 1000 is a water-soluble, non-ionic surfactant used in various industrial and pharmaceutical applications.
Polyglycol 1000 acts as a moisturizer in antiperspirants, shampoos and liquid soaps, hair styling products and bar soap.
Polyglycol 1000s with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.
These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Polyglycol 1000 is a polymer which is hydrolyzed by ethylene oxide.
Polyglycol 1000 has no toxicity and irritation.
It is widely used in various pharmaceutical preparations.
Polyglycol 1000 is used as a carrier for sodium stearate & sodium aluminum hydroxylapatite in deodorants and perfumes.
Therefore Polyglycol 1000 is soluble in water and polar organic solvents like aceton or methanol.
Polyglycol 1000 is insoluble in pure hydrocarbons.
Polyglycol 1000 displays typical chemical reactions of alcohols/diols.
The solidication point of Polyglycol 1000 is about 38 °C.
Polyglycol 1000 functions as an outstanding solubilizer for hexachlorophene and dimethyl phthalate azulene.
Polyglycol 1000 has very low water content, good biodegradability and is compatible with hard water.
Polyglycol 1000 is a polyethylene glycol (PEG) with an average molecular weight of 1000 g/mol, classified as a water-soluble, non-ionic polymer.
Polyglycol 1000 appears as a waxy solid or a highly viscous liquid, depending on temperature.
Polyglycol 1000 is known for its lubricating, emulsifying, moisture-retaining, and solubilizing properties.
Due to its low toxicity, biodegradability, and compatibility with a wide range of substances, Polyglycol 1000 is widely used in industries such as pharmaceuticals, cosmetics, personal care, food processing, and industrial applications.
It is commonly found in ointments, creams, coatings, lubricants, and chemical formulations that require a stable and water-soluble base.
Polyglycol 1000 is used in toothpaste where it improves consistency and storage stability.
Polyglycol 1000 can also be used in bath oils and foam baths to assist the solubilizing action of the active substances for perfum.
Polyglycol 1000 has a shelf life of 2 years.
Polyglycol 1000 is a liquid PEG excipient grade product, produced under IPEC GMP conditions.
Polyglycol 1000 is specied according to the requirements of the main international ICH guidelines and monographs.
Polyglycol 1000 is clear viscous liquid at room temperature.
Polyglycol 1000 can be supplied in tank trucks or in steel drums.
Polyglycol 1000's two hydroxy end groups as well as its ether groups mainly control the physical and chemical properties of Pol.
Therefore Polyglycol 1000 is soluble in water and polar organic solvents like aceton or methanol.
Polyglycol 1000 is insoluble in pure hydrocarbons.
Polyglycol 1000 displays typical chemical reactions of alc ohols/diols.
The solidication point, of Polyglycol 1000 is about 50°C.
Besides standard grade Polyglycol 1000 special quality Polyglycol 1000 USP with very low concentration of monoethylenglycol a diethyleneglycol for pharamaceutical applications is available.
Polyglycol 1000 used in the pharmaceutical, textile, cosmetics industry as a matrix or lubricant, softener; used as a dispersant in the coating industry; improve the water dispersibility, exibility of the resin, the amount is 20~ 30%; the ink can improve the solubility of the dye and reduce its volatility.
Polyglycol 1000 is especially suitable for use in wax paper and printing pad ink.
Polyglycol 1000 is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
Polyglycol 1000 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization.
X-ray diraction of protein crystals can reveal the atomic structure of the proteins.
Polyglycol 1000 is the basis of many skin creams (as cetomacrogol) and personal lubricants (frequently combined with glycerin).
Polyglycol 1000, commonly known as PEG 200, is a highly adaptable and stable product that is essential in many diverse industries for its lubricating and hydrating properties.
It is a key component in many different applications including industrial, lubricants, adhesives, pharmaceuticals and personal care products.
Polyglycol 1000 can also be used to adjust the ink viscosity in ballpoint pen ink.
Polyglycol 1000 is used as a dispersant in the rubber industry to promote vulcanization.
Polyglycol 1000 is used as a dispersant for carbon black ller.
Melting point: 64-66 °C
Boiling point: >250°C
Tg: -67
Density: 1.27 g/mL at 25 °C
Bulk density: 400-500kg/m³
Vapor density: >1 (vs air)
Vapor pressure: <0.01 mm Hg (20 °C)
Refractive index: n20/D 1.469
Flash point: 270 °C
Storage temp.: 2-8°C
Solubility: H2O: 50 mg/mL, clear, colorless
Form: waxy solid
Color: White to very pale yellow
Specific Gravity: 1.128
pH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Viscosity: 1,650-3,850cp (1% solution @ 25°C)
Viscosity: 11cs (99°C)
Viscosity: 4.5cs (99°C)
Viscosity: 5,500-8,000cp (1% solution @ 25°C)
Viscosity: 6cs (99°C)
Viscosity: 7.4cs (99°C)
Viscosity: 750cp (5% solution @ 25°C)
Viscosity: 75cp (5% solution @ 25°C)
Viscosity: 8,000cs (99°C)
Viscosity: 8,800-17,600cp (5% solution @ 25°C)
Viscosity: 93cs (99°C)
Biological source: synthetic (organic)
Water solubility: Soluble in water.
λmax: λ: 260 nm Amax: 0.6
λ: 280 nm Amax: 0.3
Sensitive: Hygroscopic
Merck: 14,7568
α-end: hydroxyl
Ω-end: hydroxyl
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -0.698 at 25℃
Surface tension: 43.5mN/m at 20°C
Polyglycol 1000 acts as an anticaking agent.
Polyglycol 1000 is a polymer of ethylene oxide, having low toxicity, mild irritancy and compatibility with various substances.
Polyglycol 1000 is widely used throughout the cosmetic industry in personal care and cosmetic products like in creams, lotions, hair care products etc.
Polyglycol 1000s are non-volatile, a factor of consider able importance in connection with their use as plasticizers and humectants.
If a certain weight loss is established despite the non-volatility of PEGs when maintained at a constant temperature of 150°C and above (e.g. when used as heating bath liquids), this is due not to evaporation but to loss of volatile products of decomposition.
The breakdown products of PEGs may vary, depending on the ingress of air; apart from water, carbon dioxide and aldehydes, simple alcohols, acids and glycol esters are formed.
Troublesome fumes from decomposition products have not been known to have an adverse eect on health.
Polyglycol 1000 is a synthetic polymer produced via polymerization of ethylene oxide molecules to make joining units of ethylene glycol by an ether linkage.
Polyglycol 1000s are water-soluble polymers that can form hydrogen bonds in a ratio of 100 water molecules per one PEG molecule.
Polyglycol 1000 vary by time of the polymerization process and the molecular weight represents the weighted average of the individual PEG molecules.
Polyglycol 1000 dier in their physical and chemical properties depending on their molecular weight:
Polyglycol 1000 are liquids when molecular weights are <1000 and the molecule turns to waxy solids with increasing molecular weights.
The most common preparations of PEGs include PEG 3350 and PEG 400.
Polyglycol 1000 have various applications in many elds, ranging from medical to industrial areas.
Polyglycol 1000 have a long history of gastroenterology: PEG 3350 is a common over-the-counter osmotic laxative used to relieve occasional constipation.
Polyglycol 1000 is also used for cleansing of the colon in preparation for colonoscopy in adults.
The rationale of using Polyglycol 1000 in gastroenterology is due to the physical properties of the compound: its potent water-binding capacity, negligible intestinal absorption with increasing molecular mass, lack of signicant toxicity, and limited intestinal enzymatic degradation or bacterial metabolism all make PEG a useful therapeutic agent for the treatment of occasional constipation and bowel cleansing for preparation in colonoscopy.
Polyglycol 1000, NF acts as a lubricant, coating the surfaces in aqueous and non-aqueous environments.
All Spectrum Chemical NF products, including all NF polyethylene glycol products are manufactured, packaged and stored under current Good Manufacturing Practices (cGMP) per 21CFR part 211 in FDA registered and inspected facilities.
Polyglycol 1000 is used as an excipent in pharmaceutical products.
Polyglycol 1000 is used in the precipitation of proteins as well as in the separation and purication of biomolecules and in the induction of cell hybridization.
Polyglycol 1000 acts as a fusing agent to enhance the eect of macrophages on hybridoma; as a vascular agent in preclinical work; as an anti-foaming agent in food and as the gate insulator in an electric double-layer transistor to enhance superconductivity in an insulator.
Polyglycol 1000 has been used to preserve the painted colors on Terracotta Warriors unearthed at a UNESCO World Heritage site in China.
These painted artifacts were created during the Qin Shi Huang (rst emperor of China) era.
Within 15 seconds of the terra-cotta pieces being unearthed during excavations, the lacquer beneath the paint begins to curl after being exposed to the dry Xi'an air.
The paint would subsequently ake o in about four minutes.
The German Bavarian State Conservation Oce developed a PEG preservative that when immediately applied to unearthed artifacts has aided in preserving the colors painted on the pieces of clay soldiers.
Polyglycol 1000 is often used (as an internal calibration compound) in mass spectrometry experiments, with its characteristic fragmentation pattern allowing accurate and reproducible tuning.
Polyglycol 1000 derivatives, such as narrow range ethoxylates, are used as surfactants.
Polyglycol 1000 has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes.
Polyglycol 1000 has also been used as a propellent on the UGM-133M Trident II Missile, in service with the United States Air Force.
Polyglycol 1000 is used as an excipent in pharmaceutical products.
It is used in the precipitation of proteins as well as in the separation and purication of biomolecules and in the induction of cell hybridization.
It acts as a fusing agent to enhance the eect of macrophages on hybridoma; as a vascular agent in preclinical work; as an anti-foaming agent in food and as the gate insulator in an electric double-layer transistor to enhance superconductivity in an insulator.
Uses Of Polyglycol 1000:
Polyglycol 1000 is used as an excipent in pharmaceutical products.
PEG 1000 is used in the precipitation of proteins as well as in the separation and purication of biomolecules and in the induction of cell hybridization.
PEG 1000 acts as a fusing agent to enhance the eect of macrophages on hybridoma; as a vascular agent in preclinical work; as an anti-foaming agent in food and as the gate insulator in an electric double-layer transistor to enhance superconductivity in an insulator.
Polyglycol 1000 plays an important role in the pharmaceutical industry, where it is primarily used as an excipient (inactive substance) in various formulations.
Its biocompatibility, non-toxicity, and solubility make it an ideal choice for many pharmaceutical products:
Polyglycol 1000 is used as a base in skin ointments and creams, helping to improve the texture and spreadability of the formulation.
Polyglycol 1000 also helps to retain moisture in the skin and can enhance the absorption of active ingredients.
In oral formulations, it acts as a binder and viscosity modifier, helping to maintain the uniform dispersion of active pharmaceutical ingredients (APIs) in liquids and suspensions.
Polyglycol 1000 is utilized in injectable formulations to stabilize the solution and improve the solubility of poorly soluble drugs, ensuring better delivery and bioavailability of the medication.
Polyglycol 1000 is also used in the formulation of suppositories, where it helps in achieving the correct consistency and facilitates the controlled release of active ingredients.
Polyglycol 1000 is industrially produced as a lubricating substance for various surfaces to reduce friction.
Polyglycol 1000 is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
Polyglycol 1000 is a binder, coating agent, dispersing agent, flavoring adjuvant, and plasticizing agent that is a clear, colorless, viscous, hygroscopic liquid resembling paraffin (white, waxy, or flakes), with a ph of 4.0–7.5 in 1:20 concentration.
Polyglycol 1000 is soluble in water (mw 1,000) and many organic solvents.
Polyglycol 1000 is a binder, solvent, plasticizing agent, and softener widely used for cosmetic cream bases and pharmaceutical ointments.
Polyglycol 1000s are quite humectant up to a molecular weight of 500 beyond this weight, their water uptake diminishes.
Polyglycol 1000 is used as a dough thickener in the textile industry.
They can be used as solvent and dispersant media in the paint and ceramic industry.
Polyglycol 1000 is used as a solvent and dispersant.
Polyglycol 1000 is used as a viscosity adjuster.
Polyglycol 1000 is used in the Rubber industry.
Polyglycol 1000 is used as a plasticizer, dehumidier and impregnation agent.
Polyglycol 1000 is used as a lubricant and a mold release agent.
Polyglycol 1000 is used as an intermediate in chemical synthesis.
Polyglycol 1000 is used in Electroplating processes.
Used in conjunction with carbon black to form a conductive composite.
Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.
Polyglycol 1000 is also known as polyoxirane (PEO).
Polyglycol 1000 is also used as a polymer host for solid polymer electrolytes.
Although not yet in commercial production, many groups around the globe are engaged in research on solid polymer electrolytes involving PEG, with the aim of improving their properties, and in permitting their use in batteries, electro-chromic display systems, and other products in the future.
Polyglycol 1000 is injected into industrial processes to reduce foaming in separation equipment.
Polyglycol 1000 is used as a binder in the preparation of technical ceramics.
Polyglycol 1000 is a widely used ingredient in the cosmetic and personal care industry due to its moisturizing, emulsifying, and stabilizing properties.
Polyglycol 1000 is found in products where a smooth, non-greasy texture is desirable.
As a humectant, it helps to retain moisture in the skin, preventing dryness and enhancing hydration.
Polyglycol 1000 also acts as a thickener, improving the texture and stability of lotions and creams.
Polyglycol 1000 is used in hair care products to help retain moisture in the hair, making it softer and more manageable.
It also serves as a viscosity modifier, ensuring the product is easy to apply.
Polyglycol 1000 is included in oral care products to help maintain a smooth texture and prevent the product from drying out.
It acts as an emulsifier and stabilizer, helping to mix water-based and oil-based ingredients in lotions, sunscreens, and makeup products.
In the food sector, Polyglycol 1000 is used as an approved food additive due to its non-toxicity and compatibility with food ingredients.
It is used in confectionery, chocolates, and gums to prevent crystallization of sugars, enhance texture, and improve mouthfeel.
Polyglycol 1000 is used in the production of edible coatings and glazes for fruits, nuts, and other food products, where it forms a moisture-resistant layer, thereby extending shelf life and improving the appearance of the food.
It helps to solubilize and stabilize flavoring agents, ensuring even distribution of flavors in beverages, syrups, and other processed food products.
Polyglycol 1000 is also used in food processing machinery as a lubricant, facilitating smooth operation during the production of processed food.
Polyglycol 1000 is used as a base fluid or additive in lubricants, where it provides low friction, thermal stability, and resistance to oxidation, which is ideal for machinery operating under high temperatures or extreme pressure.
In metalworking and machining operations, it is used in cutting fluids and coolants, where it helps to reduce friction and heat buildup, leading to smoother cutting operations and longer tool life.
Polyglycol 1000 is used in the formulation of paints, coatings, and inks to improve viscosity, prevent drying out, and help disperse pigments evenly.
In the textile industry, Polyglycol 1000 is utilized as a lubricant for fibers and a wetting agent, facilitating the smooth processing of fabrics and reducing friction between fibers during manufacturing.
Safety Profile Of Polyglycol 1000:
Polyglycol 1000 is generally considered to be a low-hazard compound under normal usage, due to its biodegradability, low toxicity, and non-irritating nature.
However, as with any chemical substance, improper handling, excessive exposure, or specific industrial applications may still pose certain health, environmental, and fire-related hazards.
When heated to decomposition it emits acrid smoke and irritating fumes.
Polyglycol 1000s are widely used in a variety of pharmaceutical formulations.
Generally, they are regarded as nontoxic and nonirritant materials.
Polyglycol 1000 is generally non-irritating to the skin and is commonly used in cosmetics, pharmaceuticals, and topical formulations.
However, in rare cases, prolonged or repeated exposure to large quantities of the substance could cause skin dryness or mild irritation, especially in sensitive individuals.
Polyglycol 1000 is recommended to wear protective gloves when handling large amounts of Polyglycol 1000 in industrial or laboratory settings, especially when working with heated or concentrated forms.
Direct contact with the eyes can cause temporary irritation, such as redness, watering, or discomfort.
However, Polyglycol 1000 is not considered a severe eye irritant.
In case of eye contact, flush the eyes with plenty of water for at least 15 minutes. Seek medical attention if irritation persists.
Polyglycol 1000 is low volatility and does not easily form vapors or aerosols under normal conditions.
However, inhalation of mists or heated vapors generated during industrial processing may cause mild respiratory irritation or discomfort.
Ensure adequate ventilation in areas where mists or vapors may be present.
Use respiratory protection (such as a dust mask or fume hood) if working with Polyglycol 1000 in aerosolized form or at elevated temperatures.
