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Polyglycol 300 is a clear viscous liquid polyethylene glycol at room temperature.
Polyglycol 300 is soluble in water and polar organic solvents like acetone and methanol.
Polyglycol 300 displays typical chemical reactions of alcohols/diols.
CAS Number: 25322-68-3
Molecular Formula: (C2H4O)nH2O
EINECS Number: 500-038-2
Synonyms: Reaction mass of 156065-02-0 and 25322-68-3 and 68937-54-2, 937-250-3, 1,2-ethanediol, homopolymer, 2-ethanediyl),.alpha.-hydro-.omega.-hydroxy-Poly(oxy-1, Alcox E 160, Alcox E 30;alcoxe30, Poly(ethylene oxide), approx. M.W. 600,000, Poly(ethylene oxide), approx. M.W. 200,000, Poly(ethylene oxide), approx. M.W. 900,000
Polyglycol 300 is recommended for hand dishwashing detergents, wool and fine-fabric washing powders for manual washing, hand and all-purpose wash pastes, hard surface cleaners, all liquid wash and cleaning agents, especially suited for highly concentrated products, viscosity regulators, detergent boosters, and solubilizers.
Polyglycol 300s are a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.
The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups.
The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups.
The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides.
The average molecular weight of any specific polyethylene glycol product falls within quite narrow limits (°5%).
The number of ethylene oxide units or their approximate molecular weight (e.g., PEG-4 or PEG-200) commonly designates the nomenclature of specific polyethylene glycols.
Polyglycol 300s with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.
These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Polyglycol 300 is a solubilizer, humectant, fixative and viscosity modifier.
This versatile polymer offers mildness.
Polyglycol 300 is suitable for color cosmetics, sun-, baby-, skin- & hair care and bath & shower applications.
Polyglycol 300 is used as an additive in lubricants and adhesives, as well as as a dye carrier and binder in paints and inks.
Polyglycol 300 commonly referred to as PEG 300, is a polyether compound that is used in a wide variety of fields including pharmaceutical manufacturing as an excipient and active ingredient.
Due to its low toxicity it can be used as a lubricating coating for various surfaces in aqueous and non-aqueous environments, a reagent in biochemistry to create very high osmotic pressures, a polar stationary phase for gas chromatography and as a binder.
Polyglycol 300 is a polyethylene glycol (PEG) polymer with an average molecular weight of approximately 300 g/mol, making it a slightly higher molecular weight variant than Polyglycol 300.
It is a water-soluble, non-ionic, and biodegradable polymer that exhibits excellent lubricating, moisturizing, and solubilizing properties, making it highly versatile across a wide range of industrial and commercial applications.
Polyglycol 300 is a clear, colorless to pale yellow, viscous liquid with a mild odor and a slightly sweet taste.
It has hygroscopic properties, meaning it can absorb moisture from the surrounding environment, which makes it particularly useful in applications requiring moisture retention.
Being a non-volatile, thermally stable, and chemically inert substance, it is widely used in formulations that demand long-term stability and compatibility with other ingredients.
Polyglycol 300 is a polyethylene glycol (PEG) polymer with an average molecular weight of 200 g/mol.
Polyglycol 300 functions as an outstanding solubilizer for hexachlorophene and dimethyl phthalate azulene.
Polyglycol 300 has very low water content, good biodegradability and is compatible with hard water.
Polyglycol 300 is used in toothpaste where it improves consistency and storage stability.
Polyglycol 300 can also be used in bath oils and foam baths to assist the solubilizing action of the active substances for perfum.
Polyglycol 300 has a shelf life of 2 years.
Polyglycol 300 is a liquid PEG excipient grade product, produced under IPEC GMP conditions.
Polyglycol 300 is specied according to the requirements of the main international ICH guidelines and monographs.
Polyglycol 300 is clear viscous liquid at room temperature.
Polyglycol 300 can be supplied in tank trucks or in steel drums.
Polyglycol 300's two hydroxy end groups as well as its ether groups mainly control the physical and chemical properties of Pol.
Therefore Polyglycol 300 is soluble in water and polar organic solvents like aceton or methanol.
Polyglycol 300 is insoluble in pure hydrocarbons.
Polyglycol 300 displays typical chemical reactions of alc ohols/diols.
The solidication point, of Polyglycol 300 is about 50°C.
Besides standard grade Polyglycol 300 special quality Polyglycol 300 USP with very low concentration of monoethylenglycol a diethyleneglycol for pharamaceutical applications is available.
Polyglycol 300s are made of condensed ethylene oxide and water.
They are widely used in cosmetic products as surfactants, emulsifiers, cleansing agents, humectants, and skin conditioners.
Polyglycol 300 is often used as a defoaming agent, lubricant and viscosity modifier.
It is also used as a coating for fresh fruit, as a solvent in metal working fluids, as a binder and modifier in latex paints, and as a humectant in inks and abrasives.
Polyglycol 300, Solid detergent concentrates are used in crayons and watercolors.
Polyglycol 300 is used as a humectant, wetting and dispersing agent.
Polyglycol 300 is a petroleum-based product
Polyglycol 300 is used in the manufacture of creams and ointments.
Polyglycol 300 is an ingredient used in cosmetics and hair care products.
Polyglycol 300 is used in a number of toothpastes as a dispersant.
Polyglycol 300 is commonly used as a base fluid in industrial lubricants, hydraulic fluids, and heat transfer fluids, where it helps reduce friction, wear, and overheating in mechanical components.
Due to its excellent thermal stability and lubricating properties, it is widely used in applications involving metalworking, gear lubrication, and compressor fluids.
In the pharmaceutical industry, Polyglycol 300 functions as an excipient, solubilizer, and humectant, ensuring even dispersion of active ingredients in oral, topical, and injectable drug formulations.
In personal care products such as lotions, creams, shampoos, and toothpaste, it acts as a moisturizer and emulsifier, improving the product's texture, stability, and ability to retain moisture on the skin and hair.
The textile industry makes use of Polyglycol 300 as an anti-static agent, softener, and lubricant, which enhances fabric feel, prevents static buildup, and improves textile processing efficiency.
In leather manufacturing, it is used to increase flexibility and softness, resulting in a smoother and more durable leather finish.
Melting point: 64-66 °C
Boiling point: >250°C
Tg: -67
Density: 1.27 g/mL at 25 °C
Bulk density: 400-500kg/m³
Vapor density: >1 (vs air)
Vapor pressure: <0.01 mm Hg (20 °C)
Refractive index: n20/D 1.469
Flash point: 270 °C
Storage temp.: 2-8°C
Solubility: H2O: 50 mg/mL, clear, colorless
Form: waxy solid
Color: White to very pale yellow
Specific Gravity: 1.128
pH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Viscosity: 1,650-3,850cp (1% solution @ 25°C)
Viscosity: 11cs (99°C)
Viscosity: 4.5cs (99°C)
Viscosity: 5,500-8,000cp (1% solution @ 25°C)
Viscosity: 6cs (99°C)
Viscosity: 7.4cs (99°C)
Viscosity: 750cp (5% solution @ 25°C)
Viscosity: 75cp (5% solution @ 25°C)
Viscosity: 8,000cs (99°C)
Viscosity: 8,800-17,600cp (5% solution @ 25°C)
Viscosity: 93cs (99°C)
Biological source: synthetic (organic)
Water solubility: Soluble in water.
λmax: λ: 260 nm Amax: 0.6
λ: 280 nm Amax: 0.3
Sensitive: Hygroscopic
Merck: 14,7568
α-end: hydroxyl
Ω-end: hydroxyl
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -0.698 at 25℃
Surface tension: 43.5mN/m at 20°C
In agriculture, Polyglycol 300 is utilized as a carrier and dispersing agent in pesticide and herbicide formulations.
Polyglycol 300 ensures even distribution of active ingredients over plant surfaces, improving the absorption and overall effectiveness of crop protection chemicals.
As a plasticizer and processing aid, Polyglycol 300 helps modify the flexibility and durability of plastics, rubbers, and elastomers, making them easier to process and mold.
Polyglycol 300 serves as a mold-release agent, preventing materials from sticking to molds during the production of plastic and rubber products.
In adhesives, it enhances bonding strength and flexibility, leading to better adhesion between surfaces.
In paint, ink, and coating formulations, Polyglycol 300 functions as a dispersant, humectant, and viscosity modifier, helping to maintain a smooth, even consistency while preventing premature drying or thickening.
Polyglycol 300 also improves pigment dispersion in inks, ensuring a uniform application and long-lasting color stability.
Polyglycol 300 is used as an intermediate in chemical synthesis.
Polyglycol 300 is used in Electroplating processes.
Polyglycol 300s of low molecular weight, i.e. below about 3000, are generally prepared by passing ethylene oxide into ethylene glycol at 120-150C and about 0.3 MPa (3 atmospheres) pressure, using an alkaline initiator such as sodium hydroxide.
The polymers produced by these methods are thus terminated mainly by hydroxy groups (a few unsaturated end-groups are also formed) and are often referred to as poly(ethylene glycol)s.
Polyglycol 300s with molecular weights in the range 200-600 are viscous liquids which find use as surfactants in inks and paints and as humectants.
At molecular weights above about 600, poly(ethylene glycol)s are low-melting waxy solids, uses of which include pharmaceutical and cosmetic bases, lubricants and mould release agents.
It may be noted that homogeneous cationic polymerization of ethylene oxide also generally leads to low molecular weight products; typical initiators include aluminium chloride, boron trifluoride and titanium tetrachloride.
Systems of this type are not utilized on a commercial scale.
Polyglycol 300s of molecular weight ranging from about 100000 to 5 x 106 and above are available.
Details of the techniques used to manufacture these polymers have not been disclosed, but the essential feature is the use of (generally) heterogeneous initiator systems.
Effective initiators are mainly of two types, namely alkaline earth compounds (e.g. carbonates and oxides of calcium, barium and strontium) and organometallic compounds (e.g. aluminium and zinc alkyls and alkoxides, commonly with added coinitiators).
The precise modes of action of these initiators have not, as yet, been fully resolved.
However, Polyglycol 300 is now generally thought that polymerization occurs through a co-ordinated anionic mechanism, in which the ethylene oxide is coordinated to the initiator through an unshared electron pair on the oxirane oxygen atom.
Unlike the low molecular weight poly(ethylene oxide)s, the high molecular weight polymers are tough and extensible.
They are highly crystalline, with a melting point of 66C.
Unlike most water-soluble polymers, the high molecular weight poly(ethylene oxide)s may be melt processed; they may be injection moulded, extruded and calendered without difficulty.
Polyglycol 300 is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
The structure of PEG is commonly expressed as H−(O−CH2−CH2)n−OH.
Polyglycol 300 is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms.
Polyglycol 300 used in medicines for treating disimpaction and maintenance therapy for children with constipation
Polyglycol 300 is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
Polyglycol 300 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization.
X-ray diraction of protein crystals can reveal the atomic structure of the proteins.
Polyglycol 300 is the basis of many skin creams (as cetomacrogol) and personal lubricants (frequently combined with glycerin).
Polyglycol 300, commonly known as PEG 200, is a highly adaptable and stable product that is essential in many diverse industries for its lubricating and hydrating properties.
It is a key component in many different applications including industrial, lubricants, adhesives, pharmaceuticals and personal care products.
Polyglycol 300 as being an addition polymer of ethylene oxide and water.
Polyglycol 300 are liquids; grades 1000 and above are solids at ambient temperatures.
Liquid grades (PEG 200–600) occur as clear, colorless or slightly yellow-colored, viscous liquids.
They have a slight but characteristic odor and a bitter, slightly burning taste.
Polyglycol 300 can occur as a solid at ambient temperatures.
Solid grades (PEG>1000) are white or off-white in color, and range in consistency from pastes to waxy flakes.
Polyglycol 300 is a highly versatile and multifunctional polymer with applications across various industries, from pharmaceuticals and cosmetics to lubricants, plastics, and agriculture.
Polyglycol 300s ability to act as a solubilizer, moisturizer, dispersant, and processing aid makes it an invaluable ingredient in numerous formulations.
Its non-toxic, biodegradable, and environmentally friendly nature further enhances its appeal for industries looking for sustainable and efficient solutions.
Uses Of Polyglycol 300:
Polyglycol 300 is extensively used as a base fluid in industrial lubricants and hydraulic systems, where its low volatility, excellent lubricity, and thermal stability help enhance the efficiency and lifespan of mechanical components.
Polyglycol 300 plays a crucial role in metalworking fluids, gear lubricants, and compressor oils, where it reduces friction and wear between moving parts, ensuring smooth operation under extreme pressure and temperature conditions.
Additionally, its use in heat transfer fluids allows for efficient thermal regulation in industrial equipment, preventing overheating and improving overall system performance.
In the pharmaceutical industry, Polyglycol 300 serves as a humectant, solubilizer, and stabilizing agent in the formulation of various oral, topical, and injectable medications.
Polyglycol 300 helps to improve the solubility of active ingredients, ensuring even distribution and consistent drug efficacy.
In personal care and cosmetic products such as moisturizing creams, body lotions, shampoos, and toothpastes, Polyglycol 300 acts as a hydrating agent that retains moisture on the skin and hair, preventing dryness while improving the overall texture and feel of the product.
Polyglycol 300s non-toxic and non-irritating nature makes it suitable for sensitive skin formulations.
Polyglycol 300 is used as a dough thickener in the textile industry.
They can be used as solvent and dispersant media in the paint and ceramic industry.
Polyglycol 300 is used as a solvent and dispersant.
Polyglycol 300 is used as a viscosity adjuster.
Polyglycol 300 is used in the Rubber industry.
Polyglycol 300 is used as a plasticizer, dehumidier and impregnation agent.
Polyglycol 300 is used as a lubricant and a mold release agent.
Polyglycol 300 is used as an intermediate in chemical synthesis.
Polyglycol 300 is used in Electroplating processes.
Used in conjunction with carbon black to form a conductive composite.
Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.
Polyglycol 300 is also known as polyoxirane (PEO).
In the textile manufacturing industry, Polyglycol 300 is widely used as a softener, anti-static agent, and lubricant, helping to improve the feel, durability, and processability of fabrics.
Its ability to reduce static electricity is particularly beneficial in the production of synthetic fibers, ensuring smooth handling during weaving and processing.
Additionally, in the leather industry, Polyglycol 300 is used to enhance the softness, flexibility, and smooth finish of leather products, making them more comfortable and durable for use in clothing, footwear, and accessories.
Polyglycol 300 plays a critical role in agricultural formulations, particularly in pesticides, herbicides, and fungicides, where it acts as a carrier, dispersant, and wetting agent.
Polyglycol 300 ensures that active chemical ingredients are evenly distributed across plant surfaces, allowing for better absorption and increased effectiveness in controlling pests and diseases.
Its ability to enhance the stability and solubility of agrochemical formulations makes it a preferred ingredient in environmentally friendly and sustainable farming practices.
Due to its plasticizing and mold-release properties, Polyglycol 300 is used in the production of plastics, rubbers, and elastomers to improve their flexibility, durability, and processing efficiency.
By modifying the material’s texture and mechanical properties, it enhances ease of molding and shaping, making it valuable in the production of plastic films, synthetic rubbers, and industrial components.
Additionally, it is widely used in adhesive formulations, where it acts as a viscosity modifier and bonding enhancer, ensuring that adhesives maintain proper consistency while improving adhesion between surfaces.
Polyglycol 300 can make the membrane of the alkanol contraceptive pill.
It can make hydrophilic anticoagulant polyurethane.
Polyglycol 300 is an osmotic laxative.
It can increase osmotic pressure and absorb moisture in the intestinal cavity, which makes the stool soften and increase in volume, resulting in bowel movement and defecation.
Polyglycol 300 nontoxic and gelatinous nature can be used as a component of denture fixer.
Polyglycol 300 and PEG 6000 are commonly used to promote cell fusion or protoplast fusion and help organisms (such as yeasts) to take DNA in transformation.
Polyglycol 300 absorbs water from the solution, so it is also used to concentrate the solution.
Polyglycol 300 are widely used in a variety of pharmaceutical formulations, including parenteral, topical, ophthalmic, oral, and rectal preparations.
Polyglycol 300 has been used experimentally in biodegradable polymeric matrices used in controlled-release systems.
Polyglycol 300s are stable, hydrophilic substances that are essentially nonirritant to the skin; They do not readily penetrate the skin, although the polyethylene glycols are water-soluble and are easily removed from the skin by washing, making them useful as ointment bases.
Solid grades are generally employed in topical ointments, with the consistency of the base being adjusted by the addition of liquid grades of polyethylene glycol.
Mixtures of Polyglycol 300s can be used as suppository bases,for which they have many advantages over fats.
For example, the melting point of the suppository can be made higher to withstand exposure to warmer climates; release of the drug is not dependent upon melting point; the physical stability on storage is better; and suppositories are readily miscible with rectal fluids.
Polyglycol 300s have the following disadvantages: they are chemically more reactive than fats; greater care is needed in processing to avoid inelegant contraction holes in the suppositories; the rate of release of water-soluble medications decreases with the increasing molecular weight of the polyethylene glycol; and polyethylene glycols tend to be more irritating to mucous membranes than fats.
Polyglycol 300 is commonly found in paint, ink, and coating formulations, where it functions as a dispersant, humectant, and viscosity stabilizer.
In paints and coatings, it helps to improve pigment dispersion, flow properties, and application smoothness, resulting in a more even and long-lasting finish.
In the printing ink industry, it prevents premature drying and thickening, ensuring that inks maintain their intended consistency and spread evenly on paper or other surfaces for high-quality print output.
Polyglycol 300 is a versatile and multifunctional polymer with a wide range of applications in industries such as pharmaceuticals, cosmetics, textiles, agriculture, plastics, coatings, and industrial lubricants.
Its excellent solubility, moisture-retention properties, lubricity, and non-toxic nature make it an essential ingredient in numerous formulations that require stability, efficiency, and long-term performance.
Furthermore, its biodegradability and environmentally friendly profile enhance its appeal in sustainable industrial applications, making it a preferred choice for manufacturers seeking safe and effective solutions for various commercial and technical products.
Safety Profile Of Polyglycol 300:
Polyglycol 300 is typically non-irritating to the skin, but prolonged or repeated exposure may cause mild irritation or dryness, especially in sensitive individuals.
Polyglycol 300 is advisable to wear gloves when handling large quantities.
Although not classified as a severe irritant, direct contact with the eyes may cause temporary irritation, redness, or discomfort.
Polyglycol 300 is recommended to rinse eyes thoroughly with clean water if exposure occurs.
Polyglycol 300 has a low vapor pressure, making inhalation exposure unlikely under normal conditions.
However, mists or vapors generated during industrial processing may cause mild respiratory irritation if inhaled in large amounts.
Proper ventilation should be ensured in workplaces where it is used in heated or aerosolized forms.
Polyglycol 300 is considered to have low oral toxicity, and small amounts are generally not harmful if ingested.
However, excessive ingestion may cause mild gastrointestinal discomfort, such as nausea or diarrhea.
Polyglycol 300 is not classified as a flammable liquid, but it can burn when exposed to high temperatures or open flames.
When heated to high temperatures, it may decompose, producing irritating fumes, carbon monoxide (CO), and carbon dioxide (CO₂).
In case of fire, use water spray, foam, dry chemical, or CO₂ extinguishers.
Firefighters should wear protective gear and self-contained breathing apparatus to avoid inhaling combustion fumes.
Hypersensitivity reactions to Polyglycol 300 applied topically have also been reported, including urticaria and delayed allergic reactions.
The most serious adverse effects associated with Polyglycol 300 are hyperosmolarity, metabolic acidosis, and renal failure following the topical use of polyethylene glycols in burn patients.
Topical preparations containing polyethylene glycols should therefore be used cautiously in patients with renal failure, extensive burns, or open wounds.
