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Polyglycol 3350 is polyethylene glycol, supplied as a white powder.
Polyglycol 3350 is soluble in water and polar organic solvents like acetone or methanol.
Polyglycol 3350 has a wide range of applications across several industries for its excellent properties as a solvent, humectant, and plasticizer.
CAS Number: 25322-68-3
Molecular Formula: (C2H4O)nH2O
EINECS Number: 500-038-2
Synonyms: Reaction mass of 156065-02-0 and 25322-68-3 and 68937-54-2, 937-250-3, 1,2-ethanediol, homopolymer, 2-ethanediyl),.alpha.-hydro-.omega.-hydroxy-Poly(oxy-1, Alcox E 160, Alcox E 30;alcoxe30, Poly(ethylene oxide), approx. M.W. 600,000, Poly(ethylene oxide), approx. M.W. 200,000, Poly(ethylene oxide), approx. M.W. 900,000
Polyglycol 3350 is used to treat occasional constipation.
Polyglycol 3350 is in a class of medications called osmotic laxatives.
It works by causing water to be retained with the stool.
This increases the number of bowel movements and softens the stool so it is easier to pass.
Polyglycol 3350 is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms.
Polyglycol 3350 used in medicines for treating disimpaction and maintenance therapy for children with constipation
Polyglycol 3350 is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
Polyglycol 3350 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization.
Polyglycol 3350 is polyethylene glycol, supplied as a white powder.
Polyglycol 3350 is soluble in water and polar organic solvents like acetone or methanol.
Polyglycol 3350s are a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.
The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups.
The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups.
The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides.
The average molecular weight of any specific polyethylene glycol product falls within quite narrow limits (°5%).
The number of ethylene oxide units or their approximate molecular weight (e.g., PEG-4 or PEG-200) commonly designates the nomenclature of specific polyethylene glycols.
Polyglycol 3350s with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.
These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Polyglycol 3350 has a wide range of applications across several industries for Polyglycol 3350 excellent properties as a solvent, humectant, and plasticizer.
Polyglycol 3350, also known as Polyethylene Glycol 3350 (PEG 3350), is a water-soluble polymer with a relatively high molecular weight, typically around 3350 g/mol.
It belongs to the Polyglycol 3350 family, which is a group of synthetic polymers that are known for their ability to dissolve in water and form smooth, viscous solutions.
Polyglycol 3350 is a white, odorless, waxy solid at room temperature that can melt into a viscous liquid when heated.
Polyglycol 3350 that provides enhanced solvency, lubricity, hygroscopicity and other important functional properties in a wide range of formulations.
Polyglycol 3350 is a polyethylene glycol (PEG) polymer with an average molecular weight of 200 g/mol.
Polyglycol 3350 functions as an outstanding solubilizer for hexachlorophene and dimethyl phthalate azulene.
Polyglycol 3350 has very low water content, good biodegradability and is compatible with hard water.
Polyglycol 3350 is used in toothpaste where it improves consistency and storage stability.
Polyglycol 3350 can also be used in bath oils and foam baths to assist the solubilizing action of the active substances for perfum.
Polyglycol 3350 has a shelf life of 2 years.
Melting point: 64-66 °C
Boiling point: >250°C
Tg: -67
Density: 1.27 g/mL at 25 °C
Bulk density: 400-500kg/m³
Vapor density: >1 (vs air)
Vapor pressure: <0.01 mm Hg (20 °C)
Refractive index: n20/D 1.469
Flash point: 270 °C
Storage temp.: 2-8°C
Solubility: H2O: 50 mg/mL, clear, colorless
Form: waxy solid
Color: White to very pale yellow
Specific Gravity: 1.128
pH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Viscosity: 1,650-3,850cp (1% solution @ 25°C)
Viscosity: 11cs (99°C)
Viscosity: 4.5cs (99°C)
Viscosity: 5,500-8,000cp (1% solution @ 25°C)
Viscosity: 6cs (99°C)
Viscosity: 7.4cs (99°C)
Viscosity: 750cp (5% solution @ 25°C)
Viscosity: 75cp (5% solution @ 25°C)
Viscosity: 8,000cs (99°C)
Viscosity: 8,800-17,600cp (5% solution @ 25°C)
Viscosity: 93cs (99°C)
Biological source: synthetic (organic)
Water solubility: Soluble in water.
λmax: λ: 260 nm Amax: 0.6
λ: 280 nm Amax: 0.3
Sensitive: Hygroscopic
Merck: 14,7568
α-end: hydroxyl
Ω-end: hydroxyl
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -0.698 at 25℃
Surface tension: 43.5mN/m at 20°C
Polyglycol 3350 is a liquid PEG excipient grade product, produced under IPEC GMP conditions.
Polyglycol 3350 is specied according to the requirements of the main international ICH guidelines and monographs.
Polyglycol 3350 is clear viscous liquid at room temperature.
Polyglycol 3350 can be supplied in tank trucks or in steel drums.
Polyglycol 3350's two hydroxy end groups as well as its ether groups mainly control the physical and chemical properties of Pol.
Therefore Polyglycol 3350 is soluble in water and polar organic solvents like aceton or methanol.
Polyglycol 3350 is insoluble in pure hydrocarbons.
Polyglycol 3350 displays typical chemical reactions of alc ohols/diols.
The solidication point, of Polyglycol 3350 is about 50°C.
Besides standard grade Polyglycol 3350 special quality Polyglycol 3350 USP with very low concentration of monoethylenglycol a diethyleneglycol for pharamaceutical applications is available.
Polyglycol 3350s are made of condensed ethylene oxide and water.
They are widely used in cosmetic products as surfactants, emulsifiers, cleansing agents, humectants, and skin conditioners.
Polyglycol 3350 is often used as a defoaming agent, lubricant and viscosity modifier.
It is also used as a coating for fresh fruit, as a solvent in metal working fluids, as a binder and modifier in latex paints, and as a humectant in inks and abrasives.
Polyglycol 3350, Solid detergent concentrates are used in crayons and watercolors.
Polyglycol 3350 is used as a humectant, wetting and dispersing agent.
Polyglycol 3350 is a petroleum-based product
Polyglycol 3350 is an osmotic agent for the treatment of constipation.
Polyglycol 3350 is non-volatile, slip and mold-release agent, solubilizer, thickener and anti-static agent.
Polyglycol 3350 oers non-irritating, binding and softening properties.
Polyglycol 3350 provides low toxicity and no emulsifying eect.
Polyglycol 3350 oers very low water content and is compatible with hard water.
Polyglycol 3350 is also used as a binder in bath salts and denture cleaners.
Polyglycol 3350 is used in skin-care products.
Polyglycol 3350 has a shelf life of 2 years.
Polyglycol 3350 can occur as a solid at ambient temperatures.
Solid grades (PEG>1000) are white or off-white in color, and range in consistency from pastes to waxy flakes.
Grades of Polyglycol 3350 and above are available as freeflowing milled powders.
Any of several condensa-tion polymers of ethylene glycol with thegeneral formula HOCH2(CH2OCH2)nCH2OH orH(OCH2CH2)nOH.
Average molecular weightsrange from 200 to 6000 properties vary with molec-ular weight.
A structure-directing agent to synthesize iron vanadate (FeVO4) nanoparticles via co-precipitation method.
An organic additive to prepare crystalline nanorods of calcium tungstate (CaWO4) using calcium chloride and sodium tungstate via solvothermal process.
A surface modifier in the synthesis of calcium peroxide nanoparticles using CaCl2 as a precursor via hydrolysis-precipitation method.
A green solvent in combination with H2O in the preparation of 4-sulfanylcoumarins by sulfanylation of 4-tosyloxycoumarins with thiourea and alkyl halides.
The ring-opening polymerization of ethylene oxide is readily effected by a variety of ionic reagents and several types of polymer have been prepared.
For commercial purposes, poly(ethylene oxide)s of low molecular weight and of very high molecular weight are of interest.
Polyglycol 3350 of low molecular weight, i.e. below about 3000, are generally prepared by passing ethylene oxide into ethylene glycol at 120-150C and about 0.3 MPa (3 atmospheres) pressure, using an alkaline initiator such as sodium hydroxide.
Anionic polymerization proceeds according to the following scheme:
The polymers produced by these methods are thus terminated mainly by hydroxy groups (a few unsaturated end-groups are also formed) and are often referred to as poly(ethylene glycol)s.
Polyglycol 3350 with molecular weights in the range 200-600 are viscous liquids which find use as surfactants in inks and paints and as humectants.
At molecular weights above about 600, poly(ethylene glycol)s are low-melting waxy solids, uses of which include pharmaceutical and cosmetic bases, lubricants and mould release agents.
It may be noted that homogeneous cationic polymerization of ethylene oxide also generally leads to low molecular weight products; typical initiators include aluminum chloride, boron trifluoride and titanium tetrachloride.
Polyglycol 3350 is a biocompatible inert synthetic polymer with repeating units of ether oxygen (-CH2-CH2-O-).
Polyglycol 3350 can be synthesized via anionic polymerization of ethylene oxide.
Polyglycol 3350 is extensively used in biological and medical applications due to Polyglycol 3350 non-immunogenicity and high water solubility.
Polyglycol 3350 is used in skin care.
Polyglycol 3350 is acts as a slip and mold-release agent, solubilizer, carrier, thickener and antistatic agent.
Polyglycol 3350 is polyethylene glycol, supplied as a white powder.
Polyglycol 3350 is soluble in water and polar organic solvents like acetone or methanol.
Polyglycol 3350 has a wide range of applications across several industries for Polyglycol 3350 excellent properties as a solvent, humectant, and plasticizer.
Polyglycol 3350 can be used to functionalize magnetite nanoparticles.
The coating of the magnetic core with Polyglycol 3350 provides good stabilization while maintaining the magnetic properties of the nanoparticles.
Polyglycol 3350 can be used to modify the surface of photocatalytic TiO2 nanopowder for Polyglycol 3350 application in self-cleaning paints.
Polyglycol 3350-coated TiO2 nanopowder can be prepared under mild conditions and show excellent colloidal stability.
Polyglycol 3350 can be used as a cross-linker to prepare poly(N-isopropylacrylamide) based thermosensitive injectable hydrogels.
The addition of Polyglycol 3350 improves the chemical and mechanical properties of hydrogel and prevents Polyglycol 3350 from dissolving in the swelling medium.
Polyglycol 3350 Inhibited is a solid, water soluble polymer that enhances solvency, lubricity, hygroscopicity and other important functional properties in a wide range of formulations.
Polyglycol 3350 is recommended for excipient applications, topical creams, lotions, personal care products and solid oral dose.
Polyglycol 3350 is considered to be a non-toxic, biodegradable substance, making it safe for various industrial, pharmaceutical, and cosmetic applications.
Its key feature is its hydrophilic nature, which allows it to interact easily with water molecules and form stable solutions.
This makes it valuable in formulations that require moisture retention, solubility, or emulsification.
Uses Of Polyglycol 3350:
Polyglycol 3350 is commonly used in the pharmaceutical industry due to its ability to form stable, non-toxic, and water-soluble solutions.
Its use in drug delivery systems, particularly for oral medications, is widespread because of its non-irritating and mild properties:
Polyglycol 3350 is most notably used as the active ingredient in over-the-counter laxatives, such as MiraLAX.
Polyglycol 3350 works by increasing the water content in the stool, which helps to soften it and promotes regular bowel movements.
It is a gentle, non-habit forming, and effective treatment for constipation.
In pharmaceutical formulations, Polyglycol 3350 is used as a binder, disintegrant, or vehicle for delivering active ingredients in oral dosage forms like tablets, capsules, and suspensions.
Polyglycol 3350 can also be used to enhance the solubility of poorly water-soluble drugs, allowing them to be more easily absorbed by the body.
Polyglycol 3350 is incorporated into topical ointments and creams due to its ability to improve the texture and viscosity of the product.
It helps to provide smooth application and is non-irritating, making it suitable for sensitive skin.
Due to its high molecular weight, Polyglycol 3350 is also used in controlled-release formulations for drugs, where it aids in providing a slow, sustained release of active ingredients over time.
Polyglycol 3350 attracts moisture to the skin, helping to hydrate and maintain skin softness.
It is commonly used in moisturizers, lotions, and creams to prevent dry skin and to retain skin moisture over time.
Polyglycol 3350 is often used in formulations of creams, gels, and ointments because of its ability to stabilize emulsions, making it easier to combine water and oil-based ingredients into a smooth, homogenous mixture.
Additionally, its viscosity-enhancing qualities help to improve the thickness and consistency of products like shampoos, conditioners, and toothpastes.
Polyglycol 3350 is used as a solvent for active ingredients in cosmetic products, helping to dissolve and evenly distribute substances like vitamins, peptides, and other active compounds in formulations like serums and lip balms.
Polyglycol 3350 is used in hair care products like shampoos, conditioners, and styling gels due to its ability to provide smooth spreadability and its conditioning properties that help maintain hair moisture and shine.
Polyglycol 3350 is industrially produced as a lubricating substance for various surfaces to reduce friction.
Polyglycol 3350 is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
Polyglycol 3350 is a binder, coating agent, dispersing agent, flavoring adjuvant, and plasticizing agent that is a clear, colorless, viscous, hygroscopic liquid resembling paraffin (white, waxy, or flakes), with a ph of 4.0–7.5 in 1:20 concentration.
Polyglycol 3350 is soluble in water (mw 1,000) and many organic solvents.
Polyglycol 3350 is a binder, solvent, plasticizing agent, and softener widely used for cosmetic cream bases and pharmaceutical ointments.
Polyglycol 3350s are quite humectant up to a molecular weight of 500 beyond this weight, their water uptake diminishes.
Polyglycol 3350 is used as a dough thickener in the textile industry.
They can be used as solvent and dispersant media in the paint and ceramic industry.
Polyglycol 3350 is used as a solvent and dispersant.
Polyglycol 3350 is used as a viscosity adjuster.
Polyglycol 3350 is used in the Rubber industry.
Polyglycol 3350 is used as a plasticizer, dehumidier and impregnation agent.
Polyglycol 3350 is used as a lubricant and a mold release agent.
Polyglycol 3350 is used as an intermediate in chemical synthesis.
Polyglycol 3350 is used in Electroplating processes.
Used in conjunction with carbon black to form a conductive composite.
Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.
Polyglycol 3350 is also known as polyoxirane (PEO).
In the machinery and automotive industries, Polyglycol 3350 is used as an additive in lubricants and cutting fluids.
It helps to reduce friction and wear on moving parts, improving the performance and lifetime of machines.
Its ability to enhance the viscosity of lubricants makes it especially useful in high-temperature or heavy-duty applications.
Polyglycol 3350 is used in paints, coatings, and inks as a viscosity modifier and stabilizer.
Polyglycol 3350 helps to ensure a smooth and even application, preventing clumping and improving the uniformity of the coating.
In ink formulations, Polyglycol 3350 helps to improve the flow properties and color distribution.
Polyglycol 3350 is used as a softening agent for fabrics and as an emulsifier in the production of dyes and finishes.
It helps improve the feel and durability of the final product, making textiles more flexible and resistant to damage.
Polyglycol 3350 serves as a plasticizer in the production of certain plastics and synthetic materials, improving their flexibility and workability.
This makes it valuable in the production of PVC (polyvinyl chloride) and other polymeric materials that require softening or enhanced durability.
Polyglycol 3350 can be used as an anti-caking agent or lubricant in powdered foods or food processing equipment.
Polyglycol 3350 prevents ingredients from clumping together and improves the flowability of powdered products like sugar or spices.
Polyglycol 3350 can be used as an emulsifying agent in food products, helping to blend water-based and oil-based ingredients to form stable emulsions.
It is occasionally used in processed foods that require a uniform texture.
Polyglycol 3350 is sometimes used in the agriculture industry for its ability to function as a wetting agent or stabilizer:
It can act as a solvent or stabilizer in pesticide or herbicide formulations, helping to enhance the solubility of active ingredients and improve the distribution of the product when applied to crops or plants.
Polyglycol 3350 is also used in veterinary medicine, particularly in the form of oral solutions for treating constipation in animals.
Polyglycol 3350 works similarly to its use in human medicine by increasing the water content in the intestines and helping animals pass stools more easily.
Safety Profile Of Polyglycol 3350:
Polyglycol 3350 is non-irritating to the skin, and it is often used in topical formulations like creams and ointments.
However, prolonged or repeated contact with large amounts could lead to mild irritation or dryness.
People with sensitive skin may experience slight discomfort.
Polyglycol 3350 is advisable to wear protective gloves when handling large quantities or in industrial environments to avoid skin contact for prolonged periods.
Direct contact with Polyglycol 3350 in the eyes may cause temporary irritation, such as redness, watering, or discomfort.
However, it is generally not considered a severe irritant to the eyes.
In case of eye contact, rinse the eyes immediately with plenty of water for at least 15 minutes if irritation persists, seek medical attention.
Polyglycol 3350 is a low-volatility substance, meaning that it does not produce harmful fumes or vapors under normal conditions.
However, if it is heated or aerosolized during processing, inhaling any resulting mist or dust could cause mild irritation to the respiratory system or throat.
Use adequate ventilation in areas where Polyglycol 3350 might be heated or aerosolized.
Respiratory protection may be needed in environments where airborne particulates or mist are generated.
