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Polyglycol 6000 can be dissolved in warm water at 80-90°C with no adverse eects.
Polyglycol 6000 is a water-soluble, non-ionic surfactant used in various industrial and pharmaceutical applications.
Polyglycol 6000 acts as a moisturizer in antiperspirants, shampoos and liquid soaps, hair styling products and bar soap.
CAS Number: 25322-68-3
Molecular Formula: (C2H4O)nH2O
EINECS Number: 500-038-2
Synonyms: Reaction mass of 156065-02-0 and 25322-68-3 and 68937-54-2, 937-250-3, 1,2-ethanediol, homopolymer, 2-ethanediyl),.alpha.-hydro-.omega.-hydroxy-Poly(oxy-1, Alcox E 160, Alcox E 30;alcoxe30, Poly(ethylene oxide), approx. M.W. 600,000, Poly(ethylene oxide), approx. M.W. 200,000, Poly(ethylene oxide), approx. M.W. 900,000
Polyglycol 6000s are a family of linear polymers formed by a base-catalyzed condensation reaction with repeating ethylene oxide units being added to ethylene.
The molecular formula is (C2H4O)multH2O where mult denotes the average number of oxyethylene groups.
The molecular weight can range from 200 to several million corresponding to the number of oxyethylene groups.
The higher-molecular-weight materials (100 000 to 5 000 000) are also referred to as polyethylene oxides.
The average molecular weight of any specific polyethylene glycol product falls within quite narrow limits (°5%).
The number of ethylene oxide units or their approximate molecular weight (e.g., PEG-4 or PEG-200) commonly designates the nomenclature of specific polyethylene glycols.
Polyglycol 6000 is used as a carrier for sodium stearate & sodium aluminum hydroxylapatite in deodorants and perfumes.
Polyglycol 6000 is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.
Polyglycol 6000 is a polyether compound with many applications from industrial manufacturing to medicine.
Polyglycol 6000s with amolecular weight less than 600 are liquid, whereas those of molecular weight 1000 and above are solid.
These materials are nonvolatile, water-soluble, tasteless, and odorless.
They are miscible with water, alcohols, esters, ketones, aromatic solvents, and chlorinated hydrocarbons, but immiscible with alkanes, paraffins, waxes, and ethers.
Polyglycol 6000 is a polymer which is hydrolyzed by ethylene oxide.
Polyglycol 6000 has no toxicity and irritation.
It is widely used in various pharmaceutical preparations.
The toxicity of low molecular weight polyethylene glycol is relatively large.
In general, the toxicity of diols is very low.
Topical application of polyethylene glycol, especially mucosal drug, can cause irritant pain.
In topical lotion, Polyglycol 6000 can increase the flexibility of the skin, and has a similar moisturizing effect with glycerin.
Diarrhoea can occur in large doses of oral administration.
In injection, the maximum Polyglycol 6000 concentration is about 30% (V/V).
Hemolysis could occur when the concentration is more than 40% (V/V).
Polyglycol 6000 is a polyethylene glycol (PEG) polymer with an average molecular weight of 200 g/mol.
Polyglycol 6000 functions as an outstanding solubilizer for hexachlorophene and dimethyl phthalate azulene.
Polyglycol 6000 has very low water content, good biodegradability and is compatible with hard water.
Polyglycol 6000 is used in toothpaste where it improves consistency and storage stability.
Polyglycol 6000 can also be used in bath oils and foam baths to assist the solubilizing action of the active substances for perfum.
Polyglycol 6000 can be dissolved in warm water at 80-90°C with no adverse eects.
Polyglycol 6000 is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.
Polyglycol 6000 is a polyether compound with many applications from industrial manufacturing to medicine.
Polyglycol 6000 is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
Polyglycol 6000 produces a faintly sweet, clear, and colorless viscous liquid that is soluble in water, alcohol, and chloroform.
Polyglycol 6000 has a shelf life of 2 years.
Polyglycol 6000 is a liquid PEG excipient grade product, produced under IPEC GMP conditions.
Polyglycol 6000 is specied according to the requirements of the main international ICH guidelines and monographs.
Polyglycol 6000 is clear viscous liquid at room temperature.
Polyglycol 6000 can be supplied in tank trucks or in steel drums.
Polyglycol 6000's two hydroxy end groups as well as its ether groups mainly control the physical and chemical properties of Pol.
Therefore Polyglycol 6000 is soluble in water and polar organic solvents like aceton or methanol.
Polyglycol 6000 is insoluble in pure hydrocarbons.
Polyglycol 6000 displays typical chemical reactions of alc ohols/diols.
The solidication point, of Polyglycol 6000 is about 50°C.
Besides standard grade Polyglycol 6000 special quality Polyglycol 6000 USP with very low concentration of monoethylenglycol a diethyleneglycol for pharamaceutical applications is available.
Polyglycol 6000s are made of condensed ethylene oxide and water.
They are widely used in cosmetic products as surfactants, emulsifiers, cleansing agents, humectants, and skin conditioners.
Polyglycol 6000 is often used as a defoaming agent, lubricant and viscosity modifier.
It is also used as a coating for fresh fruit, as a solvent in metal working fluids, as a binder and modifier in latex paints, and as a humectant in inks and abrasives.
Polyglycol 6000, Solid detergent concentrates are used in crayons and watercolors.
Polyglycol 6000 is used as a humectant, wetting and dispersing agent.
Polyglycol 6000 is a petroleum-based product.
Melting point: 64-66 °C
Boiling point: >250°C
Tg: -67
Density: 1.27 g/mL at 25 °C
Bulk density: 400-500kg/m³
Vapor density: >1 (vs air)
Vapor pressure: <0.01 mm Hg (20 °C)
Refractive index: n20/D 1.469
Flash point: 270 °C
Storage temp.: 2-8°C
Solubility: H2O: 50 mg/mL, clear, colorless
Form: waxy solid
Color: White to very pale yellow
Specific Gravity: 1.128
pH: 5.5-7.0 (25℃, 50mg/mL in H2O)
Viscosity: 1,650-3,850cp (1% solution @ 25°C)
Viscosity: 11cs (99°C)
Viscosity: 4.5cs (99°C)
Viscosity: 5,500-8,000cp (1% solution @ 25°C)
Viscosity: 6cs (99°C)
Viscosity: 7.4cs (99°C)
Viscosity: 750cp (5% solution @ 25°C)
Viscosity: 75cp (5% solution @ 25°C)
Viscosity: 8,000cs (99°C)
Viscosity: 8,800-17,600cp (5% solution @ 25°C)
Viscosity: 93cs (99°C)
Biological source: synthetic (organic)
Water solubility: Soluble in water.
λmax: λ: 260 nm Amax: 0.6
λ: 280 nm Amax: 0.3
Sensitive: Hygroscopic
Merck: 14,7568
α-end: hydroxyl
Ω-end: hydroxyl
Stability: Stable. Incompatible with strong oxidizing agents.
LogP: -0.698 at 25℃
Surface tension: 43.5mN/m at 20°C
Polyglycol 6000 is white granular.
Polyglycol 6000 is a thermoplastic resin with good compatibility with other resins.
Polyglycol 6000 is used as an intermediate in chemical synthesis.
Polyglycol 6000 is used in Electroplating processes.
Polyglycol 6000 is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
The structure of PEG is commonly expressed as H−(O−CH2−CH2)n−OH.
Polyglycol 6000 is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms.
Polyglycol 6000 used in medicines for treating disimpaction and maintenance therapy for children with constipation
Polyglycol 6000 is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
Polyglycol 6000 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization.
X-ray diraction of protein crystals can reveal the atomic structure of the proteins.
Polyglycol 6000 is the basis of many skin creams (as cetomacrogol) and personal lubricants (frequently combined with glycerin).
Polyglycol 6000, commonly known as PEG 200, is a highly adaptable and stable product that is essential in many diverse industries for its lubricating and hydrating properties.
It is a key component in many different applications including industrial, lubricants, adhesives, pharmaceuticals and personal care products.
Polyglycol 6000 as being an addition polymer of ethylene oxide and water.
Polyglycol 6000 are liquids; grades 1000 and above are solids at ambient temperatures.
Liquid grades (PEG 200–600) occur as clear, colorless or slightly yellow-colored, viscous liquids.
They have a slight but characteristic odor and a bitter, slightly burning taste.
Polyglycol 6000 can occur as a solid at ambient temperatures.
Solid grades (PEG>1000) are white or off-white in color, and range in consistency from pastes to waxy flakes.
Grades of Polyglycol 6000 and above are available as freeflowing milled powders.
Any of several condensa-tion polymers of ethylene glycol with thegeneral formula HOCH2(CH2OCH2)nCH2OH orH(OCH2CH2)nOH.
Average molecular weightsrange from 200 to 6000 properties vary with molec-ular weight.
A structure-directing agent to synthesize iron vanadate (FeVO4) nanoparticles via co-precipitation method.
An organic additive to prepare crystalline nanorods of calcium tungstate (CaWO4) using calcium chloride and sodium tungstate via solvothermal process.
A surface modifier in the synthesis of calcium peroxide nanoparticles using CaCl2 as a precursor via hydrolysis-precipitation method.
A green solvent in combination with H2O in the preparation of 4-sulfanylcoumarins by sulfanylation of 4-tosyloxycoumarins with thiourea and alkyl halides.
Polyglycol 6000s with molecular weights in the range 200-600 are viscous liquids which find use as surfactants in inks and paints and as humectants.
At molecular weights above about 600, poly(ethylene glycol)s are low-melting waxy solids, uses of which include pharmaceutical and cosmetic bases, lubricants and mould release agents.
It may be noted that homogeneous cationic polymerization of ethylene oxide also generally leads to low molecular weight products; typical initiators include aluminium chloride, boron trifluoride and titanium tetrachloride.
Systems of this type are not utilized on a commercial scale.
Polyglycol 6000s of molecular weight ranging from about 100000 to 5 x 106 and above are available.
Details of the techniques used to manufacture these polymers have not been disclosed, but the essential feature is the use of (generally) heterogeneous initiator systems.
Effective initiators are mainly of two types, namely alkaline earth compounds (e.g. carbonates and oxides of calcium, barium and strontium) and organometallic compounds (e.g. aluminium and zinc alkyls and alkoxides, commonly with added coinitiators).
The precise modes of action of these initiators have not, as yet, been fully resolved.
However, Polyglycol 6000 is now generally thought that polymerization occurs through a co-ordinated anionic mechanism, in which the ethylene oxide is coordinated to the initiator through an unshared electron pair on the oxirane oxygen atom.
Unlike the low molecular weight poly(ethylene oxide)s, the high molecular weight polymers are tough and extensible.
They are highly crystalline, with a melting point of 66??C.
Unlike most water-soluble polymers, the high molecular weight poly(ethylene oxide)s may be melt processed; they may be injection moulded, extruded and calendered without difficulty.
The ring-opening polymerization of ethylene oxide is readily effected by a variety of ionic reagents and several types of polymer have been prepared.
For commercial purposes, poly(ethylene oxide)s of low molecular weight and of very high molecular weight are of interest.
Polyglycol 6000s of low molecular weight, i.e. below about 3000, are generally prepared by passing ethylene oxide into ethylene glycol at 120-150C and about 0.3 MPa (3 atmospheres) pressure, using an alkaline initiator such as sodium hydroxide.
Anionic polymerization proceeds according to the following scheme:
The polymers produced by these methods are thus terminated mainly by hydroxy groups (a few unsaturated end-groups are also formed) and are often referred to as poly(ethylene glycol)s.
Resistant to bacterial erosion, moisture absorption in the atmosphere is weak.
Polyglycol 6000 is a mixture of ethylene oxide and water polycondensation.
Polyglycol 6000 is also used as a polymer host for solid polymer electrolytes.
Polyglycol 6000 is used as a binder in the preparation of technical ceramics.
Polyglycol 6000 is used to extend the size and durability of very large soap bubbles.
Polyglycol 6000 is the main ingredient in many personal lubricants.
Polyglycol 6000 is the main ingredient in the paint in paintballs.
Polyglycol 6000 has a wide range of potential uses.
Polyglycol 6000 is also used as a coating for fresh fruit, as a solvent in metal working uids, as a binder and modier in latex paints, and as a humectant in inks and abrasives.
Uses Of Polyglycol 6000:
Polyglycol 6000 is used in the following products: cosmetics and personal care products, pharmaceuticals, polymers, air care products, nger paints and washing & cleaning products.
Other release to the environment of Polyglycol 6000 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Other release to the environment of Polyglycol 6000 is likely to occur from: indoor use in long-life materials with low release rate (e.g. ooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).
Polyglycol 6000 can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines).
Polyglycol 6000 can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys) and paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper).
Polyglycol 6000 is used in the following products: polymers, pharmaceuticals, laboratory chemicals and washing & cleaning products.
Polyglycol 6000 is used in the following areas: health services, printing and recorded media reproduction and scientic research and development.
Polyglycol 6000 is used for the manufacture of: food products and rubber products.
Other release to the environment of Polyglycol 6000 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Polyglycol 6000 is used in the following products: inks and toners, polymers, cosmetics and personal care products, textile treatment products and dyes and washing & cleaning products.
Release to the environment of Polyethylene Glycol (PEG) 6000 can occur from industrial use: formulation of mixtures and formulation in materials.
Polyglycol 6000 is also used in the preparation of vesicle transport systems in with application towards diagnostic procedures or drug delivery methods.
Polyglycol 6000 is a binder, coating agent, dispersing agent, flavoring adjuvant, and plasticizing agent that is a clear, colorless, viscous, hygroscopic liquid resembling paraffin (white, waxy, or flakes), with a ph of 4.0–7.5 in 1:20 concentration.
Polyglycol 6000 is soluble in water (mw 1,000) and many organic solvents.
Polyglycol 6000 is a binder, solvent, plasticizing agent, and softener widely used for cosmetic cream bases and pharmaceutical ointments.
Polyglycol 6000s are quite humectant up to a molecular weight of 500 beyond this weight, their water uptake diminishes.
Polyglycol 6000 is used as a dough thickener in the textile industry.
They can be used as solvent and dispersant media in the paint and ceramic industry.
Polyglycol 6000 is used as a solvent and dispersant.
Polyglycol 6000 is used as a viscosity adjuster.
Polyglycol 6000 is used in the Rubber industry.
Polyglycol 6000 is used as a plasticizer, dehumidier and impregnation agent.
Polyglycol 6000 is used as a lubricant and a mold release agent.
Polyglycol 6000 is used as an intermediate in chemical synthesis.
Polyglycol 6000 is used in Electroplating processes.
Used in conjunction with carbon black to form a conductive composite.
Polymer nanospheres of poly(ethylene glycol) were used for drug delivery.
Polyglycol 6000 is also known as polyoxirane (PEO).
Polyglycol 6000 is a linear polyether obtained by ring opening polymerization of ethylene oxide.
The main uses in the field of biomedicine are as follows: Contact lens liquid.
The viscosity of Polyglycol 6000 solution is sensitive to the shear rate and it is not easy for bacteria to grow on polyethylene glycol.
Polyglycol 6000 is used in the following products: polymers, washing & cleaning products, lubricants and greases, inks and toners and textile treatment products and dyes.
Polyglycol 6000 can also be used to enhance the aqueous solubility or dissolution characteristics of poorly soluble compounds by making solid dispersions with an appropriate polyethylene glycol.
Animal studies have also been performed using polyethylene glycols as solvents for steroids in osmotic pumps.
In film coatings, solid grades of polyethylene glycol can be used alone for the film-coating of tablets or can be useful as hydrophilic polishing materials.
Solid grades are also widely used as plasticizers in conjunction with film-forming polymers.
The presence of polyethylene glycols in film coats, especially of liquid grades, tends to increase their water permeability and may reduce protection against low pH in enteric-coating films.
Polyglycol 6000s are useful as plasticizers in microencapsulated products to avoid rupture of the coating film when the microcapsules are compressed into tablets.
Polyglycol 6000 grades with molecular weights of 6000 and above can be used as lubricants, particularly for soluble tablets.
The lubricant action is not as good as that of magnesium stearate, and stickiness may develop if the material becomes too warm during compression.
An antiadherent effect is also exerted, again subject to the avoidance of overheating.
Polyethylene glycols have been used in the preparation of urethane hydrogels, which are used as controlled-release agents.
Polyglycol 6000 has also been used in insulin-loaded microparticles for the oral delivery of insulin;it has been used in inhalation preparations to improve aerosolization;polyethylene glycol nanoparticles have been used to improve the oral bioavailability of cyclosporine;it has been used in self-assembled polymeric nanoparticles as a drug carrier;and copolymer networks of polyethylene glycol grafted with poly(methacrylic acid) have been used as bioadhesive controlled drug delivery formulations.
Polyglycol 6000 is commonly used as a base fluid in metalworking applications, hydraulic fluids, and heat transfer fluids, where it helps reduce friction, wear, and overheating in mechanical systems.
Its ability to form a stable lubricating film makes it suitable for various industrial and automotive applications.
In the pharmaceutical industry, Polyglycol 6000 is frequently used as a solubilizer, humectant, or excipient in oral, topical, and injectable drug formulations, ensuring proper drug dispersion and absorption.
In cosmetics and personal care products, Polyglycol 6000 is used in creams, lotions, and shampoos to improve texture, moisture retention, and the overall sensory experience.
The textile industry utilizes Polyglycol 6000 as an anti-static agent, lubricant, and softener, helping to enhance the feel and durability of fabrics.
In leather processing, it is used to improve the flexibility and smoothness of leather products.
Polyglycol 6000 is used in the following areas: printing and recorded media reproduction.
Polyglycol 6000 is used for the manufacture of: rubber products, plastic products, machinery and vehicles and textile, leather or fur.
Release to the environment of Polyglycol 6000 can occur from industrial use: as processing aid, in the production of articles, in processing aids at industrial sites and of substances in closed systems with minimal release.
The condensation polymer of ethylene oxide and water.
Polyglycol 6000 is a cream matrix for preparing water-soluble drugs.
Polyglycol 6000 can also be used as a solvent for acetylsalicylic acid and caffeine, which is difficult to dissolve in water.
Drug sustained-release and immobilized enzyme carrier.
The polyethylene glycol solution is applied to the outer layer of the pill to control the diffusion of drugs in the pill so as to improve the efficacy.
Surface modification of medical polymer materials.
The biocompatibility of medical polymer materials in contact with blood can be improved by adsorption, interception and grafting of two amphiphilic copolymers containing polyethylene glycol on the surface of medical polymers.
Polyglycol 6000 can make the membrane of the alkanol contraceptive pill.
It can make hydrophilic anticoagulant polyurethane.
Polyglycol 6000 is an osmotic laxative.
It can increase osmotic pressure and absorb moisture in the intestinal cavity, which makes the stool soften and increase in volume, resulting in bowel movement and defecation.
Polyglycol 6000 nontoxic and gelatinous nature can be used as a component of denture fixer.
Polyglycol 6000 and PEG 6000 are commonly used to promote cell fusion or protoplast fusion and help organisms (such as yeasts) to take DNA in transformation.
Polyglycol 6000 absorbs water from the solution, so it is also used to concentrate the solution.
Polyglycol 6000 are widely used in a variety of pharmaceutical formulations, including parenteral, topical, ophthalmic, oral, and rectal preparations.
Safety Profile Of Polyglycol 6000:
Polyglycol 6000 administered topically may cause stinging, especially when applied to mucous membranes.
Hypersensitivity reactions to Polyglycol 6000 applied topically have also been reported, including urticaria and delayed allergic reactions.
The most serious adverse effects associated with Polyglycol 6000 are hyperosmolarity, metabolic acidosis, and renal failure following the topical use of polyethylene glycols in burn patients.
Topical preparations containing polyethylene glycols should therefore be used cautiously in patients with renal failure, extensive burns, or open wounds.
Oral administration of large quantities of Polyglycol 6000 can have a laxative effect.
Therapeutically, up to 4 L of an aqueous mixture of electrolytes and high-molecular-weight polyethylene glycol is consumed by patients undergoing bowel cleansing.
When heated to decomposition it emits acrid smoke and irritating fumes.
Polyglycol 6000s are widely used in a variety of pharmaceutical formulations.
Generally, they are regarded as nontoxic and nonirritant materials.
Adverse reactions to Polyglycol 6000 have been reported, the greatest toxicity being with glycols of low molecular weight.
However, the toxicity of glycols is relatively low.
