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CAS Number : 25322-68-3
EC Number : 500-038-2
Molecular formula : H(OCH2CH2)nOH
INCI Name : PEG-450
Flash point : 464 °F
Product Description of Polyglykol 20000
Polyglykol 20000 is a polethylene glycol with a mean molecular weight of 20000.
Polyglykol 20000 is a solid in flake form.
Benefits of Polyglykol 20000
-Good solubility in water
-Very low water content
-Compatible with hard water
-Non-volatile
-Outstanding toxicological safety
PHYSICAL AND CHEMICAL PROPERTIES of Polyglykol 20000
Appearance : flakes
Colour : white
Odour : characteristic
Odour Threshold : not determined
pH : 5 - 7 (68 °F / 20 °C)
Concentration: 100 g/l
Method: DIN 19268
Freezing point : approx. 140 °F / 60 °C
Method: European Pharmacopoeia / 2.2.18
Boiling point : no data available
Flash point : 464 °F / 240 °C
Method: DIN 51376
Evaporation rate : not determined
Self-ignition : The substance or mixture is not classified as self heating.
Upper explosion limit / upper
flammability limit : Not applicable
Lower explosion limit / Lower flammability limit : Not applicable
Vapour pressure : < 0.01 mbar (68 °F / 20 °C)
Relative vapour density : Not applicable
Density : approx. 1.2 g/cm3 (68 °F / 20 °C)
Method: DIN 51757
Bulk density : 400 - 500 kg/m3
Solubility(ies)
Water solubility : approx. 500 g/l (68 °F / 20 °C)
Partition coefficient: noctanol/water : log Pow: < -1
Method: Calculated by Syracuse.
Auto-ignition temperature : > 608 °F / > 320 °C
Method: DIN 51794
Decomposition temperature : 680 °F / 360 °C
Viscosity
Viscosity, dynamic : 2,700 - 3,500 mPa.s (68 °F / 20 °C)
Method: DIN 53019
50 % aqueous solution
Viscosity, kinematic : 2500 - 3200 mm2/s (68 °F / 20 °C)
Method: DIN 51562
Applications of Polyglykol 20000
Polyglykol 20000 is particularly suitable for use as a milling aid in toilet soap manufacture.
Not only does it facilitate mechanical plasticization, it also improves the sharpness of the moulded bar contours.
Polyglykol 20000 stabilizes the perfume and later prevents the soap from drying out and cracking.
Initial lathering is accelerated without affecting the foaming characteristics.
Polyglykol 20000 prevents handcleansing pastes from drying out and leaves a pleasant feel on the skin.
Polyglykol 20000 is also an excellent binder when bath salts denture cleaners etc. are pressed into tablets.
Polyglykol 20000 S is also used as a chemical intermediate for paint additives.
STABILITY AND REACTIVITY of Polyglykol 20000
Reactivity : No dangerous reaction known under conditions of normal use.
Chemical stability : Stable under normal conditions.
Possibility of hazardous reactions : No dangerous reaction known under conditions of normal use.
Stable Conditions to avoid : Keep away from heat.
Keep away from flames and sparks.
Incompatible materials : not known
Hazardous decomposition products : When handled and stored appropriately, no dangerous decomposition products are known
Storage of Polyglykol 20000
Polyglykol 20000 is stable for 2 years when stored in the original sealed containers in a cool, dry place.
Furthermore the containers should not be exposed to direct sun light.
Ambient temperatures for long term storage are preferably between 10°C and 25°C and between 0°C and 30°C as maximum.
Storage at higher temperatures is possible only for a short time and should be kept below the solidification point of the products.
The most suitable material for storage tanks is stainless steel, pure aluminium, rubber-or polyethylenelined containers and storage tanks made from glass-fibre-reinforced polyester (GRP). The tank should be ventilated by means of a silica gel dryer.
Conventional steel tanks are of limited suitability because after prolonged storage the product may become discoloured owing to traces of iron.
Polyglykol 20000 is a polyethylene glycol that is used for a wide variety of applications including: reactive diol/polyether component in polyester or polyurethene resins; component of auxiliaries for leather and textile processing; cosmetic / pharmaceutical formulations (e.g. humectant or solubilizer for creams, shampoos, tooth paste); lubricant and mould release agent for rubber, plastic and elastomer processing; plasticizer and binder for ceramic and concrete manufacturing; component of lubricant formulations; water soluble, lubricating component in metalworking fluids; humectant for paper, wood and cellulose films; solvent and humectant for dyes and inks; modifier for production of regenerated viscose; and humectant and plasticizer for adhesives.
Polyglykol 20000 by Clariant acts as a slip-, solubilizer, carrier, thickener and anti-static agent.
Polyglykol 20000 possesses binding, softening and non-irritating properties.
Polyglykol 20000 offers low toxicity and no emulsifying effect.
Polyglykol 20000 has very low water content, outstanding toxicological safety and is compatible with hard water.
Polyglykol 20000 is used in skin-care products.
Polyglykol 20000, also called 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, is used for liposome preparation.
Polyglykol 20000 has become known for lipid nanoparticle (LNP) preparation for siRNA (small interfering RNA) delivery in the COVID-19 vaccine development.
Polyglykol 20000 has been used in studies for anticancer drug delivery studies for hepatocellular, gastrointestinal, neuroendocrine and adrenocortical carcinoma.
FIRST AID MEASURES of Polyglykol 20000
General advice : Remove/ Take off immediately all contaminated clothing.
Get medical advice/ attention if you feel unwell.
If inhaled : Move the victim to fresh air.
Give oxygen or artificial respiration if needed.
Get immediate medical advice/ attention.
Never give anything by mouth to an unconscious person.
In case of skin contact : Immediately flush skin under running water for at least fifteen minutes.
Seek medical attention if irritation or chemical burn is present.
In case of eye contact : Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Get medical attention immediately if irritation develops and persists.
If swallowed : Immediately call a POISON CENTER/ doctor.
Substance identity
EC / List no.: 500-038-2
CAS no.: 25322-68-3
Hazard classification & labelling of Polyglykol 20000
According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.
About Polyglykol 20000
Polyglykol 20000 is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
Polyglykol 20000 is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.
Consumer Uses of Polyglykol 20000
Polyglykol 20000 is used in the following products: cosmetics and personal care products, pharmaceuticals, polymers, air care products, finger paints and washing & cleaning products.
Release to the environment of Polyglykol 20000 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Article service life of Polyglykol 20000
Release to the environment of Polyglykol 20000 is likely to occur from: indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment) and outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials).
Polyglykol 20000 can be found in complex articles, with no release intended: vehicles and machinery, mechanical appliances and electrical/electronic products (e.g. computers, cameras, lamps, refrigerators, washing machines). This substance can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones), fabrics, textiles and apparel (e.g. clothing, mattress, curtains or carpets, textile toys) and paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper).
Widespread uses by professional workers of Polyglykol 20000
Polyglykol 20000 is used in the following products: polymers, pharmaceuticals, laboratory chemicals and washing & cleaning products.
Polyglykol 20000 is used in the following areas: health services, printing and recorded media reproduction and scientific research and development.
Polyglykol 20000 is used for the manufacture of: food products and rubber products.
release to the environment of Polyglykol 20000 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
Formulation or re-packing of Polyglykol 20000
Polyglykol 20000 is used in the following products: inks and toners, polymers, cosmetics and personal care products, textile treatment products and dyes and washing & cleaning products.
Release to the environment of Polyglykol 20000 can occur from industrial use: formulation of mixtures and formulation in materials.
Uses at industrial sites of Polyglykol 20000
Polyglykol 20000 is used in the following products: polymers, washing & cleaning products, lubricants and greases, inks and toners and textile treatment products and dyes.
Polyglykol 20000 is used in the following areas: printing and recorded media reproduction.
Polyglykol 20000 is used for the manufacture of: rubber products, plastic products, machinery and vehicles and textile, leather or fur.
Release to the environment of Polyglykol 12000 can occur from industrial use: as processing aid, in the production of articles, in processing aids at industrial sites and of substances in closed systems with minimal release.
Manufacture of Polyglykol 20000
ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.
Synonyms:
Macrogol
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated
Polyethylene oxide
polyethyleneglycol
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-
3,6,9,12,15,18,21,24,27,30,33,36,39-tridecaoxahentetracontane-1,41-diol
a,w-Hydroxypoly(ethylene oxide)
alpha-Hydro-omega-hydroxypoly(oxy-1,2-ethanediyl)
ethane-1,2-diol
Ethane-1,2-diol, ethoxylated
PEG 200
Polietilenoglicol
Poly(ethylene glycol)
Poly(ethylene glycol), flake, 600
Poly(oxy-1,2-ethanediyl) , .alpha.-hydro-.omega.-hydroxy-
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy- (90,000 mol EO average molar ratio)
Poly(oxy-1,2-ethanediyl), .alpha.-hydro-.omega.-hydroxy-Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl), a-hydro-w-hydroxy-
Poly(oxy-1,2-ethanediyl), alpha-hydro-omega-hydroxy-
Poly(oxy-1,2-ethanediyl), α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),-hydro-hydroxy- Ethane-1,2-diol,
Poly(oxy-1,2-ethanediyl),.alpha.-hydro-.omega.-hydroxy
Poly(oxy-1,2-ethanediyl),.alpha.-hydro-.omega.-hydroxy;
Poly(oxy-1,2-ethanediyl),?-hydro-?-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),??-hydro-??-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),a-hydro-?-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylate
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy- Ethane-1,2-diol, ethoxylated
Poly(oxy-1,2-ethanediyl),α-hydro-ω-hydroxy-Ethane-1,2-diol, ethoxylated
Poly(oxyethylene)
poly(oxyethylene)
poly(oxyethylene) {structure-based}
poly(oxyethylene) {structure-based}, poly(ethylene oxide) {source-based}
POLYETHYLENE GLYCOL
Polyethylene Glycol
Polyethylene glycol
polyethylene glycol
Polyethylene glycol
Polyethylene Glycol 1000
Polyethylene glycol 3,350
Polyethylene glycol 400
Polyethylene Glycol 400
Polyethyleneglycol
polyethyleneglycol
polyethylenglycol
Polyethylenglykol
Polyethylenglykole (PEG)
Polymer aus Ethylenglycol
α-Hydro-ω-hydroxypoly(oxy-1,2-ethanediyl)
α-hydroxy-ω-hydroxy-poly(oxy-1,2-ethanediyl)
Leunapon-MG
UV GLUE PEN
Glycol
Poly(oxy-1,2-ethanediyl), α-hydro-ω-hydroxy-
Polyethylene glycol
polyethyleneglycol
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