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Polyhexamethylene Biguanidehydrochloride is best known for its broad-spectrum antimicrobial and antifungal activity.
Polyhexamethylene Biguanidehydrochloride is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions, such as Renu.
Polyhexamethylene Biguanidehydrochloride is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.
CAS: 32289-58-0
MF: (C8H17N5)n.xClH
MW: 213.32312
EINECS: 1308068-626-2
Synonyms
PHMB(20%);Polyhexamethyl;PHMB;Biguanide PHMB;Polyhexamethylene biguanidine hydrochloride,~20% in water;PHMB 98%, 20% solution (Polyhexamethylene biguanide hydrochloride);20% solution;98% powder
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic.
In dermatological use, Polyhexamethylene Biguanidehydrochloride is spelled polihexanide (INN) and sold under various brand names.
PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli, Candida albicans, Aspergillus brasiliensis, enterococci, and Klebsiella pneumoniae.
Polyhexamethylene Biguanidehydrochloride, sold under the brand name Akantior is a medication used for the treatment of Acanthamoeba keratitis.
Products containing Polyhexamethylene Biguanidehydrochloride are used for inter-operative irrigation, pre- and post-surgery skin and mucous membrane disinfection, post-operative dressings, surgical and non-surgical wound dressings, surgical bath/hydrotherapy, chronic wounds like diabetic foot ulcer and burn wound management, routine antisepsis during minor incisions, catheterization, first aid, surface disinfection, and linen disinfection.
Polyhexamethylene Biguanidehydrochloride eye drops have been used as a treatment for eyes affected by Acanthamoeba keratitis.
Polyhexamethylene Biguanidehydrochloride is sold as a swimming pool and spa disinfectant in place of chlorine or bromine based products under the name Baquacil.
Polyhexamethylene Biguanidehydrochloride is also used as an ingredient in some contact lens cleaning products, cosmetics, personal deodorants and some veterinary products.
Polyhexamethylene Biguanidehydrochloride is also used to treat clothing (Purista), purportedly to prevent the development of unpleasant odors.
The Polyhexamethylene Biguanidehydrochloride is used in the majority of formulations.
Polyhexamethylene Biguanidehydrochloride, also known as PHMB or polyhexamide, is a highly water soluble and hydrolytically stable polymeric material.
The presence of multiple hydrogen bonding and chelation sites within Polyhexamethylene Biguanidehydrochloride renders it of potential interest in the field of supramolecular chemistry.
Polyhexamethylene Biguanidehydrochloride shows activity against both Gram-positive and Gram-negative bacteria and is widely used across several sectors, typically as the hydrochloride salt, in a variety of disinfectant solutions and antiseptics.
Polyhexamethylene Biguanidehydrochloride is also available as a solid in neat.
Polyhexamethylene Biguanidehydrochloride Chemical Properties
Storage temp.: Inert atmosphere,Room Temperature
Solubility: Water
Form: Solid
Color: White to off-white
InChI: InChI=1S/C10H23N5/c1-9(11)14-7-5-3-4-6-8-15-10(12)13-2/h3-8H2,1-2H3,(H2,11,14)(H3,12,13,15)
InChIKey: SAGIGHPRUJPLKX-UHFFFAOYSA-N
CAS DataBase Reference: 32289-58-0(CAS DataBase Reference)
EPA Substance Registry System: Polyhexamethylene Biguanidehydrochloride (32289-58-0)
Polyhexamethylene Biguanidehydrochloride is also used as a surface disinfectant and is alleged to be suitable for skin disinfection.
Polyhexamethylene Biguanidehydrochloride has a slow effectand does not meet the practical requirementsfor prophylactic antiseptics in this respect.
Although Polyhexamethylene Biguanidehydrochloride is somewhat less effective than benzalkonium chloride, it is sometimes used instead of benzalkonium because Polyhexamethylene Biguanidehydrochloride is less foamproducing under use conditions.
Application
Polyhexamethylene Biguanidehydrochloride is a polymer used as a disinfectant and antiseptic.
In dermatological use, Polyhexamethylene Biguanidehydrochloride is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide.
Polyhexamethylene Biguanidehydrochloride has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).
Polyhexamethylene Biguanidehydrochloride is a new environment-friendly cationic water-soluble polymer.
Polyhexamethylene Biguanidehydrochloride is a water solution that can be used as a broad spectrum and high efficient disinfectant.
Polyhexamethylene Biguanidehydrochloride is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic.
Because of its special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.
Preparation
The preparation method of Polyhexamethylene Biguanidehydrochloride:By a certain proportion of 1; the own bisguanides of 6-and catalyst join in reaction vessel; under nitrogen protection, said mixture is heated to 80-200 DEGC and reacts, react 2-24 hour; reaction terminates; cooling blowing, obtains poly hexamethylene biguanide, poly hexamethylene biguanide aqueous acid is neutralized to pH value 5-9; and performing filtering so as to obtain a polyhexamethylene biguanidine salt.
Biological Activity
Polyhexamethylene Biguanidehydrochloride is a cationic polymer with antimicrobial and antiviral properties.
Polyhexamethylene Biguanidehydrochloride has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.
