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Polyhexamethylene guanidine (PHMG) can be widely used in textile, animal husbandry, aquaculture, medical sterilization, and daily disinfectant.
Polyhexamethylene guanidine (PHMG) is odorless and easily dissolved in water to form a tasteless, colorless transparent solution.
Polyhexamethylene guanidine (PHMG) can be used as a disinfectant for almost all kinds of bacteria.
CAS Number: 31961-54-3
Molecular Formula: C21H45N9X2
Molecular Weight: 423.65
Synonyms: polyhexamethyleneguanidine, 31961-54-3, PHMG-p, PHMGu, polyhexamethylene guanidine hydrochloride, polyhexamethyleneguanidine hydrochloride, polyhexamethyleneguanidine phosphate, Polyhexamethylene guanidine phosphate, Polysept C060540.
Polyhexamethylene guanidine (PHMG) is environmental-friendly and free from iodine, chlorine, aldehyde and alcohol.
Polyhexamethylene guanidine (PHMG) (PHMG) is an antibacterial polymer containing a guanidine group in its main chain.
Because of its unique bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.
Polyhexamethylene guanidine (PHMG) disinfectant is a high molecular polymer that can easily be washed away.
It is non-corrosive to the skin and can not be easily absorbed by human organs.
Polyhexamethylene guanidine (PHMG) performs good biocompatibility.
Polyhexamethylene guanidine (PHMG) is a chemical compound that has been used primarily as a disinfectant and antimicrobial agent in various applications.
It is known for its effectiveness in killing a wide range of microorganisms, including bacteria, viruses, and fungi.
Polyhexamethylene guanidine (PHMG) is a polymer composed of repeating units of hexamethylene guanidine, which is a compound that consists of a guanidine group (an amino compound) and a hexamethylene group (a chain of six carbon atoms).
Polyhexamethylene guanidine (PHMG) gained attention as a disinfectant and antimicrobial agent due to its broad-spectrum activity and relatively low toxicity compared to some other disinfectants.
It has been used in various industries and settings, including healthcare, agriculture, and household products.
Polyhexamethylene guanidine (PHMG)-based disinfectants have been used to control microbial growth on surfaces, textiles, and even in water treatment.
However, it's worth noting that there have been concerns and controversies surrounding the use of Polyhexamethylene guanidine (PHMG).
In some instances, there have been reports of adverse health effects associated with its use, including respiratory issues and skin irritation.
Regulatory agencies in different countries have evaluated the safety of Polyhexamethylene guanidine (PHMG)-containing products, and in some cases, restrictions or bans have been imposed on their use due to potential health risks.
Polyhexamethylene guanidine (PHMG) 50% Solution has been widely used as a new generation of guanidine disinfectants, its derivatives.
In recent years, there are many research reports at home and abroad.
But the bactericidal effect is more excellent, which has been widely used in medical and health institutions, family life, food industry, animal husbandry and other fields.
Through more and more scholars' research on the properties and efficacy of guanidine disinfectant, its application has been developed continuously.
Polyhexamethylene guanidine (PHMG) is a polymer composed of repeating units of hexamethylene guanidine.
Each repeating unit consists of a hexamethylene chain (a chain of six carbon atoms) linked to a guanidine group, which is a functional group containing a terminal amino group (NH2).
The specific chemical structure of PHMG allows it to have both Polyhexamethylene guanidine (PHMG), which contributes to its effectiveness in various applications.
Polyhexamethylene guanidine (PHMG) Solution has high activity, which makes the polymer positive electric and easy to be adsorbed by bacteria and virus, thus inhibiting the division function of bacteria and virus and making it lose the ability of reproduction.
Moreover, the formation of Polyhexamethylene guanidine (PHMG) Solution blocks the respiration channel of microorganism and makes microorganism suffocate and die.
Polyhexamethylene guanidine (PHMG) is known for its potent antimicrobial properties, meaning it has the ability to inhibit or kill microorganisms such as bacteria, viruses, and fungi.
It is effective against a wide range of microorganisms, making it a versatile disinfectant.
Polyhexamethylene guanidine (PHMG) remains active after being heated at 280℃ for 15 min.
Polyhexamethylene guanidine (PHMG) is non-corrosive to copper, stainless steel, carbon steel, and other metals.
The guanidine group in Polyhexamethylene guanidine (PHMG) performs a high activity, and the polymer itself is cationic.
Since bacteria and viruses are usually anionic, they are easily absorbed by Polyhexamethylene guanidine (PHMG), cannot divide and reproduce, and finally turn inactive.
Polyhexamethylene guanidine (PHMG) collapses the cell membrane structure and forms transmembrane stomata.
Ultimately, it causes cell membrane rupture, disrupts the energy metabolism of the organism, and disables the bacteria and virus.
The polymer forms a film that closes off the breathing passages of microorganisms, causing them to suffocate and die.
Polyhexamethylene guanidine (PHMG) has a wide spectrum of antimicrobial action, is capable of destroying bacteria dangerous to humans, including mycobacterium tuberculosis, legionellosis, E. coli bacteria, staphylococcus, streptococcus, salmonella, etc.
Polyhexamethylene guanidine (PHMG) dissolves in water easily and forms into colorless, odorless solution.
Polyhexamethylene guanidine (PHMG) can be used as a broad-spectrum and high-efficiency disinfectant.
Polyhexamethylene guanidine (PHMG) is low toxic, steady, non-flammable, non-explosive, and non-corrosive to stainless steel, copper, carbon steel, wood, and plastic.
Polyhexamethylene guanidine (PHMG) is a white powdered solid, and as all polyguanidine salts, readily soluble in water.
Polyhexamethylene guanidine (PHMG) is a kind of colorless liquid.
Polyhexamethylene guanidine (PHMG) is soluble in water and free of erosion.
Studies have shown that Polyhexamethylene guanidine (PHMG) in solution has fungicidal as well as bactericidal activity against both Gram-positive and Gram-negative bacteria.
Polyhexamethylene guanidine (PHMG) is a guanidine derivative that is used as a biocidal disinfectant, often in the form of its salt polyhexamethylene guanidine phosphate (PHMG-P).
Polyhexamethylene guanidine (PHMG) also has detergent, anti-corrosive, and flocculant properties and prevents biofouling.
Appearance: Colorless or light yellow liquid
Active content: 25% Min.-99% Min.
Odor: None-Weak amine odor
pH: 5-9 (25℃)-10-11 (25% water solution)
Water solubility: Complete
Water insoluable: 0.1% Max.
Moisture: 0.5% Max.
Ash: 0.005%
Appearance
Active Components: 25%
Solubility in Water: Complete
Odor: No
Decomposition Temperature: >400 ° C
Taste (0.1% in Water): Slightly bitter
Polyhexamethylene guanidine (PHMG) was initially developed as an antimicrobial agent and disinfectant in the late 20th century.
It gained attention for its broad-spectrum antimicrobial properties and its potential to be used in various applications where controlling microbial growth is important.
The antimicrobial action of Polyhexamethylene guanidine (PHMG) is thought to involve disruption of the cell membranes of microorganisms.
Polyhexamethylene guanidine (PHMG) molecules can interact with the lipid layers of cell membranes, leading to membrane destabilization and leakage of cellular components.
This disruption ultimately causes cell death.
Polyhexamethylene guanidine (PHMG) has demonstrated effectiveness against a wide range of microorganisms, including bacteria (both Gram-positive and Gram-negative), viruses, and fungi.
Polyhexamethylene guanidine (PHMG)s broad-spectrum activity makes it useful for controlling different types of microbial infections and contamination.
Regulatory approaches to PHMG have varied by country and jurisdiction.
In some cases, Polyhexamethylene guanidine (PHMG)-containing products have been approved for use as disinfectants and antimicrobial agents, while in others, concerns about potential health risks have led to restrictions or bans on their use.
The damage mechanism of Polyhexamethylene guanidine (PHMG) to Escherichia coli cell membrane was studied by β-galactosidase activity analysis, fluorescein isothiocyanate confocal laser scanning microscope, automatic scanning electron microscope and transmission electron microscope.
The results showed that low dose Polyhexamethylene guanidine (PHMG) had slight damage to bacterial outer membrane and increased the permeability of cell membrane, but no fine particles were found the cells had obvious morphological damage.
High dose of Polyhexamethylene guanidine (PHMG) Solution can collapse the membrane structure, lead to the formation of transmembrane stomata, seriously damage the structure of the cell, break the cell membrane, and release the substances inside the cell.
Polyhexamethylene guanidine (PHMG) group has high activity, can make the polymer become positively charged, it is easy to be adsorbed by all kinds of bacteria and viruses that are negatively charged, thereby inhibiting the division function of bacteria and viruses, causing them to lose their reproductive ability.
Another active ingredient, hydrochloric acid, enhances the bactericidal ability.
Polyhexamethylene guanidine (PHMG) is stable properties, excellent performance of being easily soluble in water; can be used at room temperature; With feature of low effective concentration; fast action speed.
It has no side effects; non-corrosive; colorless and odorless; non-flammable and non-explosive.
Polyhexamethylene guanidine (PHMG) is a stable polymer, it is not volatile and does not decompose; Be stored for a long time, and after the polyhexamethylene guanidine solution is dried, it can form a The thin polymer layer of the disinfectant can maintain the best state of the object after sterilization and prevent secondary pollution of the object.
Polyhexamethylene guanidine (PHMG) is a high molecular polymer, it is not easily absorbed by animal tissues, which greatly reduces the toxicity of polyhexamethylene guanidine and makes polyhexamethylene guanidine effective in higher organisms.
The cells have basically no effect. In addition, experiments have proved that polyhexamethylene guanidine can be degraded naturally and will not cause pollution to the environment.
Uses Of Polyhexamethylene guanidine (PHMG):
Polyhexamethylene guanidine (PHMG) has been used in water treatment processes to control microbial growth in water systems such as cooling towers, swimming pools, and industrial water supply systems.
Polyhexamethylene guanidine (PHMG) can help prevent the buildup of harmful bacteria and algae.
Polyhexamethylene guanidine (PHMG) products have been used in agriculture to protect crops from bacterial and fungal infections.
Some household cleaning products, personal care items (like shampoos and soaps), and disinfectant sprays have contained Polyhexamethylene guanidine (PHMG) as an antimicrobial agent to ensure the products' effectiveness against various microorganisms.
Polyhexamethylene guanidine (PHMG) has been used in air fresheners and sprays to neutralize odors by eliminating the bacteria that cause them.
Polyhexamethylene guanidine (PHMG) has found use in various industrial applications where microbial control is important to maintain product quality and safety.
It can be used in manufacturing processes and to disinfect equipment and facilities.
In regions where access to clean water and sanitation is limited, PHMG has been explored as a potential means to improve water quality and reduce the spread of waterborne diseases.
Polyhexamethylene guanidine (PHMG) Solution to disinfect tableware can make the total number of bacteria and coliform group on the tableware surface meet the requirements of relevant national health standards.
After 30 minutes, the value of E.coli pair on the surface of cucumber was decreased by 3.35, and the killing effect of natural bacteria on the surface of fruits and vegetables was also very good.
Compared with chlorine containing disinfectant or peroxide disinfectant, Polyhexamethylene guanidine (PHMG) Solution is much less toxic, corrosive and irritant, which is more beneficial to environmental protection.
Polyhexamethylene guanidine (PHMG) is also widely used in the production of beverages, beer and food in foreign countries to disinfect pipes, containers and plant floors, and to remove algae from lakes, ponds, cooling towers and fountains.
Polyhexamethylene guanidine (PHMG) can also be used in oil exploitation and mildew prevention of interior and surface of various building materials.
Polyhexamethylene guanidine (PHMG) has been used for its antimicrobial properties, concerns have arisen regarding its potential health effects.
Reports of respiratory issues, skin irritation, and other adverse reactions have led to regulatory scrutiny in various countries.
Some studies have suggested that prolonged or excessive exposure to Polyhexamethylene guanidine (PHMG) could pose risks to human health.
Polyhexamethylene guanidine (PHMG) is a new type of polymer antibacterial agent, which is widely used in plastics, rubber, paints, adhesives, ceramics, fibers, textiles, home appliances, synthetic resins, and various PP, PVC, PE, PA, ABS, PS, PET and other plastics.
Polyhexamethylene guanidine (PHMG) used plastic products with antibacterial functions, such as refrigerator plastic shells, liners, telephone housings, computer keyboards, washing machine plastic parts, plastic switches, plastic cutting boards, chairs, fruit plates, children's toys, etc.
Polyhexamethylene guanidine (PHMG) used various daily-use enamel, ceramics, glass products with antibacterial function, such as bowls, plates, sanitary ware, drinking utensils, etc.
Polyhexamethylene guanidine (PHMG) used various chemical building materials: such as paint, paint, wallpaper, decorative materials, etc.
Polyhexamethylene guanidine (PHMG) disinfectants have been used to sanitize surfaces, equipment, and textiles.
They are commonly used in healthcare settings, food processing facilities, and other industries where microbial control is essential.
Polyhexamethylene guanidine (PHMG) has been used in water treatment processes to control microbial growth in water systems, including cooling towers, swimming pools, and industrial water supply systems.
Polyhexamethylene guanidine (PHMG)-based products have been used to protect crops from bacterial and fungal infections, providing a means of disease control in agriculture.
Some household cleaning products and personal care items, such as shampoos and hand sanitizers, have included PHMG as an antimicrobial ingredient.
The environmental impact of Polyhexamethylene guanidine (PHMG)-containing products has also been a subject of concern.
Depending on their formulation and usage, these products can enter wastewater systems and potentially affect aquatic ecosystems.
Proper disposal and wastewater treatment are important considerations when using Polyhexamethylene guanidine (PHMG)-based products.
Polyhexamethylene guanidine (PHMG) was used in Russia to disinfect hospitals and from 2001 on, it was widely used in South Korea as a disinfectant to prevent microbial contamination in household humidifiers.
Polyhexamethylene guanidine (PHMG) was originally marketed for cleaning a humidifier's water tank but instead used by the public as a water additive to suppress microbial growth.
Polyhexamethylene guanidine (PHMG) can efficiently kill bacterial propagules, fungi, and some viruses.
Polyhexamethylene guanidine (PHMG) can kill 99.0% E.coli on dishware after reacting for 1-5 min.
It is increasingly used in disinfection products in daily life.
Polyhexamethylene guanidine (PHMG) can also be used in disinfection of fruits and vegetables.
Since fruits and vegetables are directly edible products, non-irritating is necessary for disinfection in this field.
Compared with other chemical disinfection, Polyhexamethylene guanidine (PHMG) is much more suitable.
As a Polyhexamethylene guanidine (PHMG) for the production of disinfectants; As a basis for the release of anti-mold products; In medical and veterinary disinfection; For disinfection in the food industry; For water purification and disinfection; For surface disinfection; To create biocidal paints, etc.
Polyhexamethylene guanidine (PHMG) is used for disinfection of premises in children's and educational institutions, in hospitals, in transport, cleaning companies , as well as as an active ingredient in disinfectants in various industries: in agriculture; in the petrochemical industry;in the food industry; in animal husbandry;in construction; in the production of paintwork materials.
Polyhexamethylene guanidine (PHMG) Solution has good bactericidal effect on bacteria, fungi and some viruses.
However, due to the influence of many factors, Polyhexamethylene guanidine (PHMG) compounds as medical disinfectants are mainly compounded with alcohols and other synergistic components.
Polyhexamethylene guanidine (PHMG) disinfectant not only improves the germicidal efficacy, but also reduces the adverse reactions, which is more convenient for popularization and application.
Some scholars have studied the possibility of the compound of Polyhexamethylene guanidine (PHMG) Solution and didecyldimethyl ammonium chloride, benzalkonium bromide, ethanol, chlorhexidine acetate.
The results show that the Polyhexamethylene guanidine (PHMG) disinfectant has better germicidal efficacy.
Polyhexamethylene guanidine (PHMG)products have been used to disinfect surfaces in a variety of settings, including healthcare facilities, laboratories, and public spaces.
Polyhexamethylene guanidine (PHMG)s are intended to kill or inhibit the growth of microorganisms on surfaces to prevent the spread of infections.
Polyhexamethylene guanidine (PHMG) has been incorporated into textiles and fabrics, such as hospital linens, uniforms, and carpets, to impart antimicrobial properties.
This helps prevent the growth of microorganisms on these surfaces, which can be particularly important in healthcare environments.
Safety Profile Of Polyhexamethylene guanidine (PHMG):
Some individuals may develop allergic reactions to Polyhexamethylene guanidine (PHMG).
Skin contact with products containing Polyhexamethylene guanidine (PHMG) can lead to skin irritation, redness, itching, and rashes.
These reactions can be more common in individuals with sensitive skin or those who are predisposed to allergies.
Polyhexamethylene guanidine (PHMG)-containing products, particularly those in aerosolized forms like sprays or mists, have been linked to respiratory irritation.
Exposure to these products in poorly ventilated areas or in high concentrations can lead to symptoms such as coughing, wheezing, shortness of breath, and chest discomfort.
Unlike the related polymer polyhexanide (PHMB), Polyhexamethylene guanidine (PHMG) has been described as a relatively new compound with properties, potency, and effects being not yet fully recognized.
Preliminary findings indicate that Polyhexamethylene guanidine (PHMG) and its derivatives primarily rely on damaging the cell membrane by inhibiting the activity of cellular dehydrogenases.
When Polyhexamethylene guanidine (PHMG) is aerosolized and inhaled, it harms the lungs, causing death of the cells lining the bronchioles and widespread damage to alveoli, along with bronchiolitis obliterans, an often fatal form of non-reversible obstructive lung disease in which the bronchiole are compressed and narrowed by fibrosis (scar tissue) and/or inflammation.
