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EC / List no.: 931-909-9
CAS no.: 9003-21-8
Polymethyl acrylate (PMA) is a hydrophobic synthetic acrylate polymer.
Polymethyl acrylate, though softer than polymethyl methacrylate (PMMA), is tough, leathery, and flexible.
Polymethyl acrylate has a low glass-transition temperature about 10 °C (12.5 °C in case of PMA38).
High-energy radiation leads to cross linking in Polymethyl acrylate.
However in polymethyl methacrylate (PMMA), a compound similar to Polymethyl acrylate, degradation occurs instead.
Polymethyl acrylate is soluble in dimethyl sulfoxide (DMSO).
Polymethyl acrylate is water-sensitive and unlike PMMA, is not stable against alkalies.
Polymethyl acrylate is used as macroinitiator to initiate the copolymerisation of HEMA and DMAEMA.
Also used in leather finishing and textiles.
Chemical Properties
Polymethyl acrylate are synthetic cationic and anionic polymers of dimethylaminoethyl methacrylates, methacrylic acid, and methacrylic acid esters in varying ratios.
Several different types are commercially available and may be obtained as the dry powder, as an aqueous dispersion, or as an organic solution.
A (60 : 40) mixture of acetone and propan-2-ol is most commonly used as the organic solvent.
Polymethyl acrylate is a cationic polymer based on dimethylaminoethyl methacrylate and other neutral methacrylic acid esters.
Polymethyl acrylate (PMA) is soluble in gastric fluid as well as in weakly acidic buffer solutions (up to pH≈5).
Polymethyl acrylate is available as a 12.5% ready-to-use solution in propan-2-ol–acetone (60 : 40).
Polymethyl acrylate (PMA) is light yellow in color with the characteristic odor of the solvents.
Solvent-free granules contain ≈98% dried weight content of Eudragit E.
Polymethyl acrylateis a white free-flowing powder with at least 95% of dry polymer.
Polymethyl acrylate, also referred to as methacrylic acid copolymers in the USP32–NF27 monograph, are anionic copolymerization products of methacrylic acid and methyl methacrylate.
The ratio of free carboxyl groups to the ester is approximately 1 : 1 in Eudragit L (Type A) and approximately 1 : 2 in Eudragit S (Type B).
Both polymers are readily soluble in neutral to weakly alkaline conditions (pH 6–7) and form salts with alkalis, thus affording film coats that are resistant to gastric media but soluble in intestinal fluid.
They are available as a 12.5% solution in propan-2-ol without plasticizer (Eudragit L 12.5 and S 12.5); and as a 12.5% ready-to-use solution in propan-2-ol with 1.25% dibutyl phthalate as plasticizer.
Solutions are colorless, with the characteristic odor of the solvent.
Polymethyl acrylate and Eudragit S-100 are white free-flowing powders with at least 95% of dry polymers.
Eudragit FS 30 D is the aqueous dispersion of an anionic copolymer based on methyl acrylate, methyl methacrylate, and methacrylic acid.
The ratio of free carboxyl groups to ester groups is approximately 1 : 10.
Polymethyl acrylate (PMA) is a highly flexible polymer, designed for use in enteric-coated solid-dosage forms, and dissolves in aqueous systems at pH >7.
Polymethyl acrylate and Eudragit RS, also referred to as ammonio methacrylate copolymers in the USP32–NF27 monograph, are copolymers synthesized from acrylic acid and methacrylic acid esters, with Eudragit RL (Type A) having 10% of functional quaternary ammonium groups and Eudragit RS (Type B) having 5% of functional quaternary ammonium groups.
The ammonium groups are present as salts and give rise to pH-independent permeability of the polymers.
Both polymers are water-insoluble, and films prepared from Eudragit RL are freely permeable to water, whereas, films prepared from Eudragit RS are only slightly permeable to water.
They are available as 12.5% ready-to-use solutions in propan-2-ol–acetone (60 : 40).
Solutions are colorless or slightly yellow in color, and may be clear or slightly turbid; they have an odor characteristic of the solvents.
Solvent-free granules (Eudragit RL 100 and Eudragit RS 100) contain 597% of the dried weight content of the polymer.
Polymethyl acrylate is fine, white powders with a slight amine-like odor.
They are characteristically the same polymers as Eudragit RL and RS.
They contain 597% of dry polymer.
Polymethyl acrylate and Eudragit RS 30 D are aqueous dispersions of copolymers of acrylic acid and methacrylic acid esters with a low content of quaternary ammonium groups.
The dispersions contain 30% polymer.
The quaternary groups occur as salts and are responsible for the permeability of films made from these polymers.
Films prepared from Eudragit RL 30 D are readily permeable to water and to dissolved active substances, whereas films prepared from Eudragit RS 30 D are less permeable to water.
Film coatings prepared from both polymers give pH-independent release of active substance.
Plasticizers are usually added to improve film properties.
Eudragit NE 30 D and Eudragit NE 40 D are aqueous dispersions of a neutral copolymer consisting of polymethacrylic acid esters.
The dispersions are milky-white liquids of low viscosity and have a weak aromatic odor.
Films prepared from the lacquer swell in water, to which they become permeable.
Thus, films produced are insoluble in water, but give pH-independent drug release.
Polymethyl acrylate is an aqueous dispersion of a neutral copolymer based on ethyl acrylate and methyl methacrylate, and is of identical monomer composition to Polymethyl acrylate.
Polymethyl acrylate is an aqueous dispersion of an anionic copolymer based on methacrylic acid and ethyl acrylate.
The copolymer corresponds to USP32–NF27 methacrylic acid copolymer, Type C.
The ratio of free-carboxyl groups to ester groups is 1 : 1.
Films prepared from the copolymers dissolve above pH 5.5, forming salts with alkalis, thus affording coatings that are insoluble in gastric media but soluble in the small intestine.
Polymethyl acrylate is also aqueous dispersions of the anionic copolymer based on methacrylic acid and ethyl acrylate.
The copolymer also corresponds to USP32–NF27 methacrylic acid copolymer, Type C.
The ratio of free-carboxyl groups to ester groups is 1 : 1. Films prepared from the copolymers dissolve above pH 5.5, forming salts with alkalis, thus affording coatings that are insoluble in gastric media but soluble in the small intestine.
Polymethyl acrylate is a white, free-flowing powder that is redispersible in water to form a latex that has properties similar to those of Eudragit L 30 D- 55.
Polymethyl acrylate is also commercially available as redispersible powder forms, which are designed for enteric coating of tablets and beads, respectively.
Uses:
PMA/methylamine borane (MeAB) composites, prepared by solution blending process finds uses as a hydrogen storage material with better dehydrogenation property compared to MeAB.
Definition
ChEBI: An acrylate macromolecule composed of repeating methoxycarbonylethylene units.
Production Methods
Prepared by the polymerization of acrylic and methacrylic acids or their esters, e.g. butyl ester or dimethylaminoethyl ester
Preparation
The structure of methyl acrylate is H2C=CH-COOCH3.
The monomer used to prepare poly(methyl acrylate) is produced by the oxidation of propylene.
Poly(methyl acrylate) resins vary from soft, elastic, film-forming materials to hard plastics.
Dry powder polymer forms are stable at temperatures less than 30°C.
Above this temperature, powders tend to form clumps, although this does not affect the quality of the substance and the clumps can be readily broken up.
Dry powders are stable for at least 3 years if stored in a tightly closed container at less than 30°C.
Dispersions are sensitive to extreme temperatures and phase separation occurs below 0°C.
Dispersions should therefore be stored at temperatures between 5 and 25°C and are stable for at least 18 months after shipping from the manufacturer’s warehouse if stored in a tightly closed container at the above conditions.
Purification Methods
Precipitate it from a 2% solution in acetone by addition of water.
Incompatibilities
Incompatibilities occur with certain polymethacrylate dispersions depending upon the ionic and physical properties of the polymer and solvent.
For example, coagulation may be caused by soluble electrolytes, pH changes, some organic solvents, and extremes of temperature.
For example, dispersions of Eudragit L 30 D, RL 30 D, L 100-55, and RS 30 D are incompatible with magnesium stearate.
Eastacryl 30 D, Kollicoat MAE 100 P, and Kollicoat MAE 30 DP are also incompatible with magnesium stearate.
Interactions between polymethacrylates and some drugs can occur, although solid polymethacrylates and organic solutions are generally more compatible than aqueous dispersions.
PMA/methylamine borane (MeAB) composites, prepared by solution blending process finds uses as a hydrogen storage material with better dehydrogenation property compared to MeAB.
Appearance: Clear Liquid
Boiling Point: 110 °C
CAS Number: 9003-21-8
ChEBI: 53780
Density: 1.22 g/mL
Main Hazards: Flammable, Irritant
Refractive: 1.494 n/D
PMA (Polymethyl Acrylate) technology can boost the viscosity index and shear stability performance for driveline and industrial performance lubricants.
Poly(methyl acrylate) is a hydrophobic synthetic acrylate polymer.
PMA (Polymethyl Acrylate), though softer than polymethyl methacrylate, is tough, leathery, and flexible.
PMA (Polymethyl Acrylate) has a low glass-transition temperature about 10°C. High-energy radiation leads to cross linking in PMA.
However in polymethyl methacrylate, a compound similar to PMA, degradation occurs instead.
PMA (Polymethyl Acrylate) is soluble in dimethyl sulfoxide.
PMA (Polymethyl Acrylate) is water-sensitive and unlike PMMA, is not stable against alkalies.
PMA (Polymethyl Acrylate) is used as macroinitiator to initiate the copolymerisation of HEMA and DMAEMA.
Also used in leather finishing and textiles.
IUPAC NAMES:
Polymethyl Acrylate
SYNONYMS:
Polymethacrylates;
POLY(METHYL ACRYLATE);
Poly(methyleacrylate);
METHYL ACRYLATE LATEX;
METHYL ACRYLATE RESIN;
Methylacrylatehomopolymer;
Polymethyl-acrylate paste;
Microparticles based on PMAA;
Polymethyl methacrylate,color;
poly(methyl acrylate) solution
