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Polyoxyl 20 Cetostearyl Ether is a white solid whose consistency resembles wax.
Polyoxyl 20 Cetostearyl Ether is chemical structure is derived from the family of ethoxylated fatty alcohols.
Polyoxyl 20 Cetostearyl Ether is an oil-in-water emulsifier that is used for the production of ointments, creams, liquid emulsions, gels and other cosmetic formulations.
CAS Number: 68439-49-6
Molecular Formula: C18H38O
EINECS Number: 939-518-5
Polyoxyl 20 Cetostearyl Ether is supplied in the form of free-flowing, non-dusting micro-granules, and is an efficient protective colloid that can increase the stability of dispersed systems.
This research grade product is intended for use in R&D only.
Polyoxyl 20 Cetostearyl Ether is provided as delivered and specified by the issuing Pharmacopoeia.
All information provided in support of Polyoxyl 20 Cetostearyl Ether, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
Polyoxyl 20 Cetostearyl Ether is a compound commonly used in the pharmaceutical and cosmetic industries.
Polyoxyl 20 Cetostearyl Ether is a non-ionic surfactant and emulsifying agent that belongs to the class of polyoxyethylene ethers.
The term "Polyoxyl" indicates the presence of a polyethylene glycol (PEG) chain in the molecule.
Polyoxyl 20 Cetostearyl Ether can be used as an excipient, such as Emulsifier and solubilizer for emulsions and creams, etc.
Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients.
Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations.
Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs.
Polyoxyl 20 Cetostearyl Ether is a white, wax-like, non-ionic emulsifier with mild odor.
Delivered in pellet form, Polyoxyl 20 Cetostearyl Ether is used widely for pharmaceutical oil-in-water emulsions and delivers good sensory properties during product application.
The final product has 20 ethoxy groups which form the hydrophilic portion of the surfactant structure.
Polyoxyl 20 Cetostearyl Ether is suitable for emulsions & creams as well as foams, can be formulated in hot processes and phase inversion technology (PIT), and is stable over a broad pH range.
Being a nonionic emulsifier, Polyoxyl 20 Cetostearyl Ether has also found success in solubility enhancement and emulsification of actives in topical and dermal delivery systems.
Polyoxyl 20 Cetostearyl Ether is the INCI name of a cosmetic ingredient, a non-ionic surfactant.
Chemically, the substance is a mixture of cetyl and stearic alcohols ethoxylated with 20 moles of ethylene oxide.
Polyoxyl 20 Cetostearyl Ether is most frequently obtained from vegetable sources and Ceteareth-20 is a fully vegan ingredient without any components of animal origin.
As it complies with the quality requirements of the pharmacy code published in the European Pharmacopoeia, the product is classified in the Macrogol Cetostearyl Ether group.
The CAS global identification number of Polyoxyl 20 Cetostearyl Ether is 68439-49-6.
Polyoxyl 20 Cetostearyl Ether has exceptionally good dispersing, solubilizing (i.e. enhancing solubility) and thickening properties.
The substance exhibits high stability in the presence of electrolytes and hard water, but it is sensitive to specific changes of the environment it is in.
If Polyoxyl 20 Cetostearyl Ether is solution is acidified, it undergoes hydrolysis and breaks up into smaller portions.
The very high degree of ethoxylation of Polyoxyl 20 Cetostearyl Ether shows strong hydrophilic properties of the substances.
Thus Polyoxyl 20 Cetostearyl Etheris an excellent stabilising agent and O/W (oil-in-water) emulsifier.
This means it can combine two independent – water and oil – phases of a formulation and thus ensure the appropriate form of the final product.
Polyoxyl 20 Cetostearyl Ether is a foaming substance which stabilises and improves the quality of foam in compositions that use its combination with anionic surfactants, since mixed micelles are formed there.
Polyoxyl 20 Cetostearyl Ether can act as a solubilizer, i.e. an agent which can introduce hardly soluble substances (e.g. plant extracts and oils or olfactory compositions) into aqueous solutions.
As regards the varied sensitivity of active substances to high temperatures, Polyoxyl 20 Cetostearyl Ether can be used as an ingredient in the emulsification process already at room temperature due to its high emulsifying properties.
In turn, with its high dispersing and stabilising properties, Polyoxyl 20 Cetostearyl Ether enhances the production of formulations that are available as solids, e.g. in ointments.
Polyoxyl 20 Cetostearyl Ether can improve the consistency as it is a rheology modifier.
Polyoxyl 20 Cetostearyl Ether also ensures very good and even dispersing of the active substance in spray compositions.
According to Global Organisations that conduct research of active substances, Polyoxyl 20 Cetostearyl Ether is considered a safe agent with no restrictions applied to its use.
Polyoxyl 20 Cetostearyl Ether is non-allergenic and non-comedogenic so it is not excluded for people with acne or problematic skin.
This indicates the presence of 20 units of ethylene oxide in the polyethylene glycol chain.
This refers to the combination of cetyl alcohol and stearyl alcohol.
Cetyl alcohol and stearyl alcohol are fatty alcohols derived from coconut or palm oil and are often used in the production of emollients and emulsifiers in cosmetic and pharmaceutical formulations.
Polyoxyl 20 Cetostearyl Ether is known for its ability to act as an emulsifying agent, helping to stabilize oil-in-water emulsions.
Polyoxyl 20 Cetostearyl Ether is often used in creams, lotions, ointments, and other topical formulations in the pharmaceutical and cosmetic industries.
Polyoxyl 20 Cetostearyl Ether is emulsifying properties make it useful for blending water and oil-based ingredients, ensuring a stable and uniform product.
Boiling point: 330-400℃ at 101kPa
Density: 0.87g/cm3 at 21℃
vapor pressure: 0-5Pa at 20℃
Flash point: 243℃
solubility: H2O: 1 g/10 mL, clear, colorless
form: Notspecified
Odor: at 100.00?%. mild waxy
LogP: 5.91-8.43 at 22-25℃ and pH5.25-7
Polyoxyl 20 Cetostearyl Ether is a non-ionic polyoxyethylene ether of higher saturated fatty alcohols (cetyl/stearyl alcohol).
HLB value 15-17 (gives oil-in-water emulsions). Universal emulsifier to make o/w emulsions, compatible with all kinds of oils & active ingredients.
Very effective protective colloid that stabilizes all kinds of dispersed systems.
In some formulations, especially in cosmetic products like creams and foams, Polyoxyl 20 Cetostearyl Ether may contribute to stabilizing the foam structure, improving the overall sensory experience during application.
Depending on the formulation and concentration, Polyoxyl 20 Cetostearyl Ether can also function as a thickening agent, adding viscosity to the product.
This is particularly useful in creams and lotions to achieve the desired consistency.
Polyoxyl 20 Cetostearyl Ether is sometimes included in the formulation of shampoos, where it helps in emulsifying and dispersing oily substances, contributing to the cleansing properties of the product.
Polyoxyl 20 Cetostearyl Ether makes it suitable for use in formulations intended for application to the skin or hair.
Polyoxyl 20 Cetostearyl Ether value of this compound is designed to be suitable for forming stable emulsions.
Polyoxyl 20 Cetostearyl Ether balance is an important parameter in selecting surfactants for specific formulations.
Polyoxyl 20 Cetostearyl Ether is versatility in terms of compatibility with various ingredients allows formulators flexibility in designing cosmetic and pharmaceutical products with specific properties.
The stability of formulations containing Polyoxyl 20 cetostearyl ether contributes to the extended shelf life of cosmetic and pharmaceutical products.
In pharmaceutical formulations, this ingredient is used in compliance with regulatory requirements for drug products, ensuring safety and efficacy.
In cosmetic creams and lotions, Polyoxyl 20 Cetostearyl Ether can contribute to improved spreadability, making the application of the product more user-friendly.
The use of this surfactant can contribute to formulations with reduced sensory residue, meaning that the product is less likely to leave a greasy or sticky feeling on the skin after application.
Polyoxyl 20 Cetostearyl Ether is a white, wax-like, non-ionic emulsifier with mild odor; prepared by the ethoxylation of cetyl (C16) and stearyl (C18) alcohols.
Delivered in pellet form, it is used widely for pharmaceutical oil-in-water emulsions and delivers good sensory properties during product application.
The final product has 20 ethoxy groups which form the hydrophilic portion of the surfactant structure.
Polyoxyl 20 Cetostearyl Ether is suitable for emulsions & creams as well as foams.
Polyoxyl 20 Cetostearyl Ether can be formulated in hot processes and phase inversion technology (PIT) and is stable with a broad pH range.
Polyoxyl 20 Cetostearyl Ether is the polyethylene glycol ether of cetearyl alcohol; may contain potentially toxic impurities such as 1,4-dioxane.
The compound has emollient properties, meaning it helps to soften and smooth the skin.
This makes it a valuable ingredient in creams, lotions, and other skincare products.
As an emulsifying agent, it plays a crucial role in stabilizing emulsions by preventing the separation of water and oil phases in formulations.
This is particularly important in the development of stable and well-textured cosmetic products.
Polyoxyl 20 Cetostearyl Ether can enhance the absorption of certain ingredients into the skin.
This property is beneficial in pharmaceutical formulations where the delivery of active ingredients through the skin is desired.
Polyoxyl 20 Cetostearyl Ether is compatible with a wide range of cosmetic and pharmaceutical ingredients, contributing to the versatility of its use in different formulations.
Polyoxyl 20 Cetostearyl Ether helps improve the texture and consistency of formulations, providing a smooth and desirable feel to cosmetic and pharmaceutical products.
Polyoxyl 20 Cetostearyl Ether are often chosen for their mildness and reduced potential to cause skin irritation compared to some ionic surfactants.
Polyoxyl 20 Cetostearyl Ether can act as a solubilizing agent, aiding in the dispersion of poorly soluble substances in formulations.
Polyoxyl 20 Cetostearyl Ether can contribute to the hydration of the skin by forming a barrier that helps to reduce water loss.
Polyoxyl 20 Cetostearyl Ether is often used in combination with other surfactants to achieve specific properties and improve the overall performance of formulations.
The use of Polyoxyl 20 Cetostearyl Ether in cosmetic and pharmaceutical products is subject to regulatory standards and guidelines to ensure safety and efficacy.
Uses Of Polyoxyl 20 Cetostearyl Ether:
Polyoxyl 20 Cetostearyl Ether is a polymer used in cosmetics formulations. An oil-In-water emulsifier that can function in ointment, cream, gel and other cosmetics formulations.
Reagent in liquid crystal nanoparticle formulations as an oral drug delivery system for liver specific distributions.
Polyoxyl 20 Cetostearyl Ether is a valuable ingredient, a washing substance which removes impurities from both the hair and skin.
Polyoxyl 20 Cetostearyl Ether can remove any dirt and make-up thoroughly so it is used in the formulations of face washing products and make-up removers.
Due to its softening and conditioning properties, Polyoxyl 20 Cetostearyl Ether is used in body lotions, hand and foot creams and hair masks and conditioners.
As Polyoxyl 20 Cetostearyl Ether is an excellent dispersant for the active ingredients in spray formulations.
Since it is based on the structure of Polyoxyl 20 Cetostearyl Ether, it enhances the permeability of active substances into the skin, by improving transepidermal permeability, and thus it is a valuable ingredient of face creams and oils.
Polyoxyl 20 Cetostearyl Ether is used in some sunscreen formulations to help disperse both water-soluble and oil-soluble sunscreen agents, contributing to the overall stability and effectiveness of the product.
Found in the formulation of various makeup and foundation products, where it helps create smooth textures, improve spreadability, and enhance the overall application experience.
Included in some after-shave lotions and creams for its emollient properties, providing a soothing effect on the skin.
Polyoxyl 20 Cetostearyl Ether is used in certain hair styling products, such as gels or creams, where it helps in the even distribution of styling agents and contributes to the product's texture.
Included in lip balms and other lip care products for its emollient properties, helping to moisturize and soften the lips.
Employed in dermatological creams for various skin conditions, where it aids in the delivery of active ingredients and provides a suitable base for application.
Polyoxyl 20 Cetostearyl Ether is used in some wound care formulations to aid in the application and spreadability of ointments and creams.
Found in certain anti-aging creams and serums, contributing to the formulation's texture and the delivery of key active ingredients.
Included in some pre-shave products, such as creams or gels, where it can help provide a smooth surface for shaving.
Polyoxyl 20 Cetostearyl Ether is used in the formulation of pre-moistened cleansing wipes for their emulsifying properties and ability to deliver active ingredients to the skin.
Incorporated into hand creams and lotions for its emollient qualities, helping to soften and hydrate the skin.
Polyoxyl 20 Cetostearyl Ether is used in formulations for foot creams or balms, providing emollient and moisturizing properties for the skin on the feet.
In some formulations of nutraceuticals or dietary supplements, Polyoxyl 20 Cetostearyl Ether may be used as a solubilizing agent for certain fat-soluble vitamins or other active ingredients.
Polyoxyl 20 Cetostearyl Ether is commonly used in the formulation of pharmaceutical creams and ointments, providing emulsifying properties for the stable incorporation of both water-soluble and oil-soluble active ingredients.
Polyoxyl 20 Cetostearyl Ether is employed in the formulation of skin lotions and creams, contributing to their emollient properties and ensuring a smooth and stable texture.
Polyoxyl 20 Cetostearyl Ether can be found in facial cleansers where it aids in emulsifying oils and dirt, facilitating their removal during cleansing.
Polyoxyl 20 Cetostearyl Ether is used in hair care products, it helps to emulsify oils and condition the hair, contributing to the overall performance of shampoos and conditioners.
In cleansers and foaming products, Polyoxyl 20 Cetostearyl Ether may contribute to the stability of the foam, improving the user experience during application.
Included in topical medications such as anti-inflammatory creams and antifungal ointments.
Polyoxyl 20 Cetostearyl Ether is utilized in the formulation of body lotions to provide a smooth texture and improve the spreadability of the product.
Found in some deodorant formulations where it helps in stabilizing the product and providing a desirable texture.
Polyoxyl 20 Cetostearyl Ether is used in some formulations of intimate washes for its emulsifying and mild cleansing properties.
Included in formulations for baby lotions and creams due to its gentle nature and emollient properties.
Polyoxyl 20 Cetostearyl Ether may be used in topical preparations for medical devices, such as wound dressings or patches.
Included in some formulations for topical treatments for animals, such as skin creams for pets.
Polyoxyl 20 Cetostearyl Ether is used in formulations where compliance with regulatory standards for pharmaceuticals and cosmetics is essential.
Safety Profile Of Polyoxyl 20 Cetostearyl Ether:
Some individuals may be sensitive or allergic to certain ingredients, and skin irritation or sensitization can occur.
Polyoxyl 20 Cetostearyl Ether's advisable to perform patch tests before using products containing this ingredient, especially for individuals with sensitive skin.
Contact with the eyes may cause irritation.
In case of contact, rinse eyes thoroughly with water. If irritation persists, seek medical attention.
While not typically an issue in normal use, inhaling high concentrations of aerosolized forms of products containing this ingredient may lead to respiratory irritation.
Adequate ventilation during manufacturing processes is recommended.
Ingesting significant amounts of the Polyoxyl 20 Cetostearyl Ether is not common due to its use in topical formulations.
However, ingestion could lead to gastrointestinal discomfort.
Ingestion is not an intended route of exposure.
The quality of the ingredient may vary depending on the source and manufacturing process.
Impurities in the substance or in the raw materials used could pose additional risks.
Synonyms Of Polyoxyl 20 Cetostearyl Ether:
POLYOXYL 20 CETOSTEARYL ETHER
68439-49-6
CETEARETH 20
CETEARETH 20 [VANDF]
CETEARETH-20
CETEARETH-20 [INCI]
CETEARYL-20
CETEARYL-20 [VANDF]
MACROGOL CETOSTEARYL ETHER 20 [EP IMPURITY]
PEG-20 CETYL/STEARYL ETHER
PEREGAL O-20
POLYOXYL 20 CETOSTEARYL ETHER [II]
POLYOXYL 20 CETOSTEARYL ETHER [MART.]
POLYOXYL 20 CETOSTEARYL ETHER [NF]
POLYOXYL 20 CETOSTEARYL ETHER [USP-RS]
YRC528SWUY
