POLYOXYL CASTOR OIL

Polyoxyl castor oil is used as wetting and/or solubilizing agents, emulsifying agents and lubricants.
Polyoxyl castor oil plays an important role in the Pharmaceuticals, Cosmetics sector, where Polyoxyl castor oil is commonly prescribed and formulated for its effectiveness and reliability.

CAS Number: 61791-12-6 
Primary EC Number: 500-151-7 (registered on ECHA for the ethoxylated castor oil UVCB substance) 
IUPAC Name: Castor oil, ethoxylated (reflects castor oil backbone with ethylene oxide chains) 
Chemical Family: Non-ionic surfactant / ethoxylated vegetable oil derivative 
Basic Formula: C57H104O9(CH2CH2O)n (where n = average ethylene oxide units)

SYNONYMS:
Ethoxylated castor oil, Castor oil ethoxylate, PEG-castor oil, Polyoxyethylene castor oil, Polyoxyl 35 castor oil, Polyoxyl 40 castor oil, Castor oil polyoxyethylene ether, Castor oil polyethoxylate, Kolliphor EL, Cremophor EL, PEG-40 castor oil, Emulsifier EL, Rokacet R40, Eumulgin RH 40, Eumulgin RO 40, Acconon CA 15, Berol 199, Agnique CSO 30, AQ 250, HCO 505, Polyoxyl 35 Castor Oil, Alpicare co 36, Chemax co-36, Ethox co-36, Eumulgin ro 35, Hetoxide c-36, Mergital el 35, PEG-35 Castor oil, PEG-36 Castor Oil, RefChem:45933, Unipeg-co-36, 6D4M1DAL6O, Etocas 35, Emulphor EL620, Emulphor EL-620, GF873K38RZ, VXP26NM2XX, Acconon, Arlatone, Cremophor, Etocas, Eumulgin, Jeechem, Lipocol, macrogolglyceroli hydroxystearas, macrogolglyceroli ricinoleas, Mapeg, Marlowet, Nikkol, Protachem, Simulsol, 1161X, AQ 250, Acconon CA 15, Actinol CS 40, Agnique CSO 30, Alkamuls OR 36, Arlatone 285, Atlas G 1281, Berol 199, Bio-Soft HR 40, Blaunon BR 410, C 125, CO 10, Castor oil polyoxyethylene ether, Cemulsol BR, Chemax CO, Cremophor ELP, EL 30 (emulsifier), Emalex C 50, Emulan ELH, Eumulgin PRT 33, Eumulgin RH 40, Eumulgin RO 40, Eumulgin RT 40, G 1300, GS 2, GS 2 (surfactant), HCO 505, Hairikku AQ 250, Hedipin R 200, Heliwet EO 33, Hextoxide C 15, Hyric AQ 120, Hyric AQ 250, Incrocas 30, Incrocas 35, Incrocas 40, KECAS 40, Kolliphor EL, Kolliphor ELP, Koremul CO 17, Leunapon ER 40, Lipal 200C, Lumulse CO 25, Lumulse CO 40, Lyscil 25C, Mapeg CO 8, Mergital EL 33, Mulgoven EL 719, Mulsifan RT 163, Nalco 2395, Newcol 1500S, Newkalgen D 212, Newpol CZ 300, Nikkol CO, Peregal C 125, Pionin D 212, Press-Wet OC 20A, Protachem CA 30, RT 40, Rhodasurf 870, Ricinox 80, Rokacet R 40, Simulsol 1285, Slovasol EL, Soprophor B, Sorpol CA 20, Sorpol CA 42, Sunaptol CA 350, Surfactol 318, Surfom R 400, Surfonic CO 36, Synlube 106, TRYLOX CO 40, Tagat R, Tanemul KS, Teric 380, Termul 1284, Texofor D 30, Tipal 52C, Toxanon AH, Toximul 8240, Trylox 5900, UR 34, Ukanil 2507, Unitop FFT 40, Vibsol EL 40, Visco L 357, Wettol EM 31, Witconol 5909, Polyoxyl (40) Hydrogenated Castor Oil, PEG(40) Hydrogenated Castor Oil, Polyoxyethylene Hydrogenated Castor Oil 40, EP(MACROGOLGLYCEROL HYDROOXYSTEARA TE), NF (Polyoxyl 40 Hydrogenated Castor Oil), Castor oil, ethoxylated, Castor oil ethoxylate, Castor oil polyoxyethylene ether, Cremophor EL Castor Oil, Ethoxylated ricinol, AQ 250, Acconon CA 15, Actinol CS 40, Agnique CSO 30, Alkamuls OR 36, Arlatone 285, Atlas G 1281, Berol 199, Bio-Soft HR 40, C 125, CO 10, Castor oil polyoxyethylene ether, Cemulsol BR, Chemax CO, Cremophor ELP, EL 30 (emulsifier), Emalex C 50, Eumulgin PRT 33, Eumulgin RH 40, Eumulgin RO 40, Eumulgin RT 40, G 1300, GS 2, GS 2 (surfactant), HCO 505, Hairikku AQ 250, Hedipin R 200, Heliwet EO 33, Hextoxide C 15, Hyric AQ 120, Hyric AQ 250, Incrocas 30, Incrocas 35, Incrocas 40, KECAS 40, Kolliphor EL, Kolliphor ELP, Koremul CO 17, Leunapon ER 40, Lipal 200C, Lumulse CO 25, Lumulse CO 40, Lyscil 25C, Mapeg CO 8, Mergital EL 33, Mulgoven EL 719, Mulsifan RT 163, Nalco 2395, Newkalgen D 212, Newpol CZ 300, Nikkol CO, Peregal C 125, Pionin D 212, Press-Wet OC 20A, Protachem CA 30, RT 40, Rhodasurf 870, Ricinox 80, Rokacet R 40, Simulsol 1285, Slovasol EL, Soprophor B, Sorpol CA 20, Sorpol CA 42, Sunaptol CA 350, Surfactol 318, Surfom R 400, Surfonic CO 36, Synlube 106, TRYLOX CO 40, Tagat R, Tanemul KS, Teric 380, Termul 1284, Texofor D 30, Tipal 52C, Toxanon AH, Toximul 8240, Trylox 5900, UR 34, Ukanil 2507, Unitop FFT 40, Vibsol EL 40, Visco L 357, Wettol EM 31, 1161X, Blaunon BR 410, Emulan ELH, Newcol 1500S, Witconol 5909

Polyoxyl castor oil is a yellow, oily liquid, having a faint, characteristic odor and a somewhat bitter taste.
Polyoxyl castor oil is a white to yellowish paste or pasty liquid, having a faint odor and a slight taste.
Polyoxyl castor oil is very soluble in water, producing a practically odorless and colorless solution, soluble in alcohol and in ethyl acetate; insoluble in mineral oils.

Polyoxyl castor oil refers to castor oil that has been chemically reacted with ethylene oxide (EO) to produce a series of non-ionic surfactants/emulsifiers composed of polyoxyethylene chains grafted onto castor oil triglycerides.
The degree of ethoxylation (number of EO units added) can vary (commonly between ~10–40 EO units), giving different grades with different properties and HLB values.

Polyoxyl castor oil is a non-ionic solubiliser and emulsifying agent for the human and veterinary pharmaceutical industries.
Polyoxyl castor oil is made by reacting castor oil with ethylene oxide in a molar ratio of 1:35.
At room temperature, Polyoxyl castor oil appears as pale-yellow oily liquid.

Polyoxyl castor oil forms clear solutions in water.
Polyoxyl castor oil is typically used into formulations such as Topicals (Cream, Hot processing), Solid orals (Hot melt extrusion, Spray drying, Hard shell capsules, Soft shell capsules, Tablets, Instant release), Liquid preparations (Solution).

Polyoxyl castor oil occurs as a pale yellow, oily liquid that is clear at temperatures above 26℃.
Polyoxyl castor oil has a faint but characteristic odor and can be completely liquefied by heating to 26℃.
Polyoxyl castor oil occurs as a white to yellowish, semisolid paste at 20℃ that liquefies at 30℃.

Polyoxyl castor oil has a very faint characteristic odor and is almost tasteless in aqueous solution.
Polyoxyl castor oil occurs as a white paste at room temperature.
Polyoxyl castor oil has little taste or odor in aqueous solution.

USES and APPLICATIONS of POLYOXYL CASTOR OIL:
Polyoxyl castor oil is used as wetting and/or solubilizing agents, emulsifying agents and lubricants.
Polyoxyl castor oil is a widely recognized Excipient that belongs to the class of Specialty Chemical (Non-ionic Surfactant).
Polyoxyl castor oil plays an important role in the Pharmaceuticals, Cosmetics sector, where Polyoxyl castor oil is commonly prescribed and formulated for its effectiveness and reliability.

With its established safety and therapeutic profile, Polyoxyl castor oil is frequently used in various treatments and applications, making it a trusted choice among healthcare professionals and manufacturers alike.
Polyoxyl castor oil's consistent demand highlights its value in supporting health and wellness through well-researched and proven benefits.

In oral formulations, Polyoxyl castor oil tastes banana.
Polyoxyl castor oil has been used as a solvent for patented injections such as diazepam, propanidine, and alfaxalon containing alfadolone acetate.

Polyoxyl 35 castor oil is also used in glycerin suppositories.
Veterinary Polyoxyl castor oil emulsifies cod liver oil, oil and fat, mixed into animal food.
In cosmetics, Polyoxyl castor oil is mainly used as a solubilizer for fragrances and volatile oils in a medium containing 30~50% v/v alcohol (ethanol or propylene glycol).

Polyoxyl castor oil can be used in place of castor oil in hand washes.
Polyoxyl castor oil is preferred in oral formulations.
Polyoxyl castor oil is used to increase the solubility of vitamins, essential oils, and certain pharmaceuticals in hydroalcoholic or total aqueous solutions.

Using 1 mL of 25% (v/v) Polyoxyl castor oil in water, approximately 88 mg of vitamin A palmitate can be solubilized.
Using 1 mL of 25% (v/v) Polyoxyl castor oil in water, approximately 160 mg of vitamin A propionate can be solubilized.
Polyoxyl castor oil can also increase the solubility of other drugs, such as alfadolone, alfaxalon, hexachlorophene, hexetidine, levomepromazine, miconazole, propanidine, thiopental, etc.

In the aerosol medium containing water, adding Polyoxyl castor oil can improve the solubility of the propellant in the water phase.
Polyoxyl castor oil is suitable for increasing the solubility of mixtures of dichlorodifluoromethane and propane/butane.
When there are bubbles in the hydroalcoholic solution containing Polyoxyl castor oil, adding a small amount of polypropylene glycol 2000 can eliminate the bubbles.

Polyoxyl 40 hydrogenated castor oil is also used to emulsify fatty acids and fatty alcohols.
Polyoxyl castor oil is prepared by reacting 35 moles of ethylene oxide with each mole of castor oil.
Polyoxyl castor oil is a synthetic, nonionic surfactant.

Polyoxyl castor oil's utility comes from its ability to stabilize emulsions of nonpolar materials in aqueous systems.
Polyoxyl castor oil is a mixture of polyoxyethylated triglycerides, by reacting castor oil with ethylene oxide in a molar ratio of 1:35.
Polyoxyl castor oil acts as a nonionic surfactant and serves as a formulation vehicle for poorly-water soluble pharmacological agents.

Polyoxyl castor oil is commonly used amount and the maximum amount: Maximum dosage of each administration route: oral: 160 μg; General external preparation: 15 mg/g; Dental external and oral medicine: 9 mg/g; Rectum, duct and urethra 60.0 mg/g.
Polyoxyl castor oil is a nonionic solubilizer and emulsifying agent used in various solid, liquid and semi-solid formulations.

Polyoxyl castor oil is a castor oil derivative, resulting from the reaction of glycerol ricinoleate and 35 mols of ethylene oxide.
Polyoxyl castor oil is a liquid nonionic solubiliser and emulsifier, characteristic of a slightly yellow hue, and is intended for use in parenteral, ophthalmic, oral, and topical applications.

Cosmetics & Personal Care: Polyoxyl castor oil is used in shampoos, conditioners, lotions, creams, makeup removers for emulsification and texture control.
Pharmaceuticals: Polyoxyl castor oil is used as excipient or solubilizer in drug formulations (e.g., Kolliphor EL).

Industrial Uses of Polyoxyl castor oil: Textile auxiliaries, metal cleaners, lubricants, pesticide formulations, dispersants.
Polyoxyl castor oil is widely used as a solubilizer, emulsifier, dispersant, wetting agent, and surfactant across cosmetics, pharmaceuticals, personal care, agriculture, household products, industrial cleaners, and textile applications.

-Applications of Polyoxyl castor oil:
Polyoxyl castor oil derivatives are nonionic surfactants used in oral, topical and injectable dosage forms.
They are also used in cosmetics and animal food.

Polyoxyl castor oil is mainly used as an emulsifier and solubilizer, especially suitable for the preparation of aqueous solutions containing volatile oils, fat-soluble vitamins, and other hydrophobic substances.

When solubilizing fat-soluble vitamins, the drug or components should first be dissolved in Polyoxyl castor oil.
Then slowly add water and stir vigorously.

When water is added, the viscosity increases.
When the water content reaches about 40% (v/v), there is a maximum viscosity.
For a short time, heating to about 60°C or adding polyethylene glycol and/or propylene glycol can increase the solubilizing power.

SOURCE AND PREPARATION of POLYOXYL CASTOR OIL:
Polyoxyl castor oil derivatives are prepared by reacting ethylene oxide with castor oil or hydrogenated castor oil under certain conditions.
Polyoxyethylene 35 hydrogenated castor oil  is produced by reacting 1 moL castor oil with 35-40 moL ethylene oxide.
Polyoxyethylene 40 hydrogenated castor oil is prepared by reacting 1 moL of hydrogenated castor oil with 40-45 moL of ethylene oxide.
Polyoxyethylene 60 hydrogenated castor oil is prepared by reacting 1 moL hydrogenated castor oil with 60 moL ethylene oxide.

BENEFITS of POLYOXYL CASTOR OIL:
Polyoxyl castor oil increases bioavailability when used in SEDDS.
Polyoxyl castor oil emulsifies or solubilizes the fat-soluble vitamins A, D, E and K in aqueous solutions for oral and topical administration.
Aqueous solutions of hydrophobic drugs (e.g. Miconazole, Hexedetine, Clotrimazole, Benzocaine etc.) can be prepared using Polyoxyl castor oil.,

FUNCTIONAL PROPERTIES & BENEFITS of POLYOXYL CASTOR OIL:
*Surfactant/Emulsifier
Strong non-ionic surfactant with wetting, emulsifying, and dispersing ability.
Useful in oil-in-water and water-in-oil systems depending on grade.

*Solubilizer
Polyoxyl castor oil еnhances solubility of poorly water-soluble ingredients in aqueous systems (cosmetics, pharmaceuticals, agrochemicals).  

*Compatibility
Polyoxyl castor oil is compatible with a wide range of formulation types (aqueous, organic, personal care, agrochemical).

*Biodegradability & Environment
Generally biodegradable; Polyoxyl castor oil is often chosen as an eco-friendly emulsifier option.

FUNCTIONS of POLYOXYL CASTOR OIL:
*Bioprocessing
*Emulsifier
*Excipient
*Nonionic surfactant
*Self-emulsifying drug delivery
*Solubiliser

SOURCE AND PREPARATION of POLYOXYL CASTOR OIL:
Polyoxyl castor oil is prepared by the reaction of 1 mol of hydrogenated castor oil with 40~45 mol ethylene oxide.
Polyoxyl castor oil mainly contains the trihydroxy-stearate ester of oxyethylene glycerol.
Polyoxyl castor oil contains a small amount of polyethylene trihydroxy-stearate ester and the corresponding free alcohol.

FUNCTIONAL PROPERTIES & BENEFITS of POLYOXYL CASTOR OIL:
*Surfactant/Emulsifier: 
Strong non-ionic surfactant with wetting, emulsifying, and dispersing ability.

*Surfactant/Emulsifier: 
Useful in oil-in-water and water-in-oil systems depending on grade.

*Solubilizer: 
Enhances solubility of poorly water-soluble ingredients in aqueous systems (cosmetics, pharmaceuticals, agrochemicals).

*Compatibility: 
Compatible with a wide range of formulation types (aqueous, organic, personal care, agrochemical).

*Biodegradability & Environment: 
Generally biodegradable;  often chosen as an eco-friendly emulsifier option.

PHYSICAL and CHEMICAL PROPERTIES of POLYOXYL CASTOR OIL:
Physical State & Appearance: Pale yellow-to-amber viscous liquid, paste, or soft solid depending on EO content.
Odor: Mild characteristic odor.
Solubility: Soluble or dispersible in water (solubility improves with higher EO content).
Solubility: Soluble in alcohols and many organic solvents; 
miscible with oils and fatty acids.
Density: ~1.05–1.10 g/cm³ (20 °C) typical for PEG-40 grades.
Viscosity: Typically 500–1500 mPa·s (varies by grade).
pH (1% aqueous solution): Around 5.0–7.0.

Flash/Boiling Points: Flash point >150 °C; 
boiling characteristics depend on EO content and are not discrete due to mixture nature.
Hydrophile-Lipophile Balance (HLB): Typical HLB ~9–15 (e.g., ~13.3) depending on ethoxylation level; 
higher EO gives higher HLB.
Structural Notes: A complex UVCB substance (Unknown or Variable composition, 
Complex reaction products or Biological materials).
Physical state: liquid, clear

Color: light yellow
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available

Decomposition temperature: ca. 300 °C
pH: 6 - 8 at 100 g/l at 20 °C
Viscosity: Viscosity, kinematic: No data available
Viscosity: Viscosity, dynamic: No data available
Water solubility: 100 g/l at 20 °C
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: 1,050 g/cm3

Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Compound Canonicalized: Yes

FIRST AID MEASURES of POLYOXYL CASTOR OIL:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of POLYOXYL CASTOR OIL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of POLYOXYL CASTOR OIL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of POLYOXYL CASTOR OIL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of POLYOXYL CASTOR OIL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of POLYOXYL CASTOR OIL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available