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POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED

 

 

Polysorbate 20 sorbitan monolaurate, ethoxylated is used for solubilizing membrane proteins during isolation and purification.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a wetting agent in flavored mouth drops.
Polysorbate 20 sorbitan monolaurate, ethoxylated acts as a washing agent in Western blots and ELISAs and prevents antibody binding.


CAS Number: 9005-64-5 
EC Number: 500-018-3
MDL Number: MFCD00165986
Chemical Family: Polyethoxylated Sorbitan Ester, Polysorbates
Chemical Name: Sorbitan monolaurate, ethoxylated 1 - 6.5 moles ethoxylated
E number: E432 (thickeners, ...)
Chemical formula: C58H114O26

SYNONYMS:
Polysorbate 20, Polyoxyethylene (20) sorbitan monolaurate, 7T1F30V5YH, Polyethylene glycol (44) sorbitan monolaurate, Polyethylene glycol (80) sorbitan monolaurate, Polyethylene glycol 4000 sorbitan monolaurate, Polyethylene glycol 500 sorbitan monolaurate, Polyoxyethylene (10) sorbitan monolaurate, Polyoxyethylene (44) sorbitan monolaurate, Polyoxyethylene (75) sorbitan monolaurate, Polyoxyethylene (80) sorbitan monolaurate, Polyoxyethylene 20 sorbitan monolaurate, FEMA No. 2915, POE 20 Sorbitan monolaurate, PSML, Polyethylene glycol 2000 Sorbitan Laurate, Polyoxyethylene (4) sorbitan monolaurate, Sorbimacrogol laurate 300, Sorbitan monolaurate, ethoxylated, 20s, Polysorbate, Armotan pml-20, CCRIS 699, DTXSID3031949, Dxewmulse poe-sml, E-432, EC 500-018-3, Emsorb 6915, Glycosperse L-20, Glycosperse L-20X, HSDB 7824, Hodag psml-20, INS NO.432, INS-432, Liposorb L-20, PEG-20 SORBITAN, PEG-40 Sorbitan laurate, POLY(OXY-1,2-ETHANEDIYL) DERIVATIVE, POLYSORBATA 20, POLYSORBATE 20 (EP MONOGRAPH), POLYSORBATE 20 (II), POLYSORBATE 20 (MART.), POLYSORBATE 20 (USP-RS), Peg sorbitan laurate, Peg-20 sorbitan laurate, Poly(oxy-1,2-ethanediyl) derivatives, Polyoxyethylene (40) sorbitan laurate, Polyoxyethylene 20 laurate, Polysorbate 20s, Polysorbatum 20, Protasorb L-20, Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monododecanote, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monolaurate, polyoxyethylene derivs., TWEEN-20, UNII-239B50Y732, UNII-31JQ3WOL8T, UNII-4Z93U4C2WN, UNII-59IO08SBZU, UNII-7T1F30V5YH, UNII-I42X3Q0FMF, Montanox 20, Polysorbate 20, PEG(20)sorbitan monolaurate, Alkest TW 20, Tween 20, Polyoxyethylene 20 sorbitan fatty acid ester, Tween 20, Surfacare T20, Sorbitan monolaureate, ethoxylated, Sorbitan, monododecanoate, poly(oxy-1, 2-ethanediyl) derivs., Polyoxyethylene sorbitanmonolaurate, polysorbate 2, Tween 20, Polyoxyethylene sorbitan laurate, Polyoxyethylene sorbitan laurate, Polyoxyethylene sorbitan monolaurate, Emulsifier T-20, Polyoxyethylene (20) Sorbitan Alcohol monolaurate, Polysorbate 20, TWEEN 20, SORBITAN MONOLAURATE, capmul, PEG-80 SORBITAN LAURATE, Polisorbate 20- PS 20, POLYSORBATE 21, POLYOXYETHYLENE SORBITAN MONOLAUREATE, POLYETHYLENE GLYCOL SORBITAN MONOLAURATE, Tween 20, POLYOXYETHYLENE (20) SORBITAN MONOLAURATE, Polisorbate 20- PS 20, Tween 20 (Trademark of ICI America, Inc.), Tween 20?, Tween 20 1LT, Twain 20, TWEEN(R) 20 Vetec(TM) reagent grade, 40%, ACRYL/BIS 37.5:1 PREMIXED PWD ULTRA PURE, TWEEN 20 ELECTROPHORESIS GRADE, Polyoxyethylene (20) sorbitan monolaurate, Kolliphor PS 20, Montanox 20, Polysorbate 20, PEG(20)sorbitan monolaurate, Alkest TW 20, Tween 20, Kotilen-20, Polysorbate 20, Polyoxyethylene (20) sorbitan monolaurate, 7T1F30V5YH, Polyethylene glycol (44) sorbitan monolaurate, Polyethylene glycol (80) sorbitan monolaurate, Polyethylene glycol 4000 sorbitan monolaurate, Polyethylene glycol 500 sorbitan monolaurate, Polyoxyethylene (10) sorbitan monolaurate, Polyoxyethylene (44) sorbitan monolaurate, Polyoxyethylene (75) sorbitan monolaurate, Polyoxyethylene (80) sorbitan monolaurate, Polyoxyethylene 20 sorbitan monolaurate, FEMA No. 2915, POE 20 Sorbitan monolaurate, PSML, Polyethylene glycol 2000 Sorbitan Laurate, Polyoxyethylene (4) sorbitan monolaurate, Sorbimacrogol laurate 300, Sorbitan monolaurate, ethoxylated, 20s, Polysorbate, Armotan pml-20, CCRIS 699, DTXSID3031949, Dxewmulse poe-sml, E-432, EC 500-018-3, Emsorb 6915, Glycosperse L-20, Glycosperse L-20X, HSDB 7824, Hodag psml-20, INS NO.432, INS-432, Liposorb L-20, PEG-20 SORBITAN, PEG-40 Sorbitan laurate, POLY(OXY-1,2-ETHANEDIYL) DERIVATIVE, POLYSORBATA 20, POLYSORBATE 20 (EP MONOGRAPH), POLYSORBATE 20 (II), POLYSORBATE 20 (MART.), POLYSORBATE 20 (USP-RS), Peg sorbitan laurate, Peg-20 sorbitan laurate, Poly(oxy-1,2-ethanediyl) derivatives, Polyoxyethylene (40) sorbitan laurate, Polyoxyethylene 20 laurate, Polysorbate 20s, Polysorbatum 20, Protasorb L-20, Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monododecanote, poly(oxy-1,2-ethanediyl) derivatives, Sorbitan, monolaurate, polyoxyethylene derivs., TWEEN-20, UNII-239B50Y732, UNII-31JQ3WOL8T, UNII-4Z93U4C2WN, UNII-59IO08SBZU, UNII-7T1F30V5YH, UNII-I42X3Q0FMF, E-432, FEMA NO. 2915, INS NO.432, INS-432, PEG-20 SORBITAN, PEG-20 SORBITAN [VANDF], POLY(OXY-1,2-ETHANEDIYL) DERIVATIVE, POLYOXYETHYLENE 20 SORBITAN MONOLAURATE, POLYOXYETHYLENE 20 SORBITAN MONOLAURATE [WHO-IP], POLYOXYETHYLENE SORBITAN MONOLAURATE, POLYSORBATA 20 [WHO-IP LATIN], POLYSORBATE 20, POLYSORBATE 20 [EP MONOGRAPH], POLYSORBATE 20 [FCC], POLYSORBATE 20 [FHFI], POLYSORBATE 20 [HSDB], POLYSORBATE 20 [II], POLYSORBATE 20 [MART.], POLYSORBATE 20 [USAN], POLYSORBATE 20 [USP-RS], POLYSORBATE 20 [VANDF], POLYSORBATE 20 [WHO-DD], POLYSORBATE 20 [WHO-IP], SORBIMACROGOL LAURATE 300, SORBITAN MONODODECANOATE, TWEEN 20, TWEEN-20, alkamuls PSML-20, cremophor PS 20, emasol L-120V, glycosperse L-20 KFG, hetsorb L-20, kaopan TW-L-120, liposorb L-20, lonzest SML-20, monebatt - 20, mulsifan SML-20, nikkol TL-10, norfox sorbo T-20, peg-20 sorbitan laurate, peg-20 sorbitan monolaurate, polyethylene glycol (20) sorbitan laurate, polyethylene glycol (20) sorbitan monolaurate, polyoxyethylene (20) sorbitan laurate, polyoxyethylene (20) sorbitan monolaurate, rheodol TW-L120, super refined polysorbate 20, T-maz 20K, tween 20, E 432, POE (20) Sorbitan Monolaurate, Polyoxyethylene (20) Sorbitan Monolaurate, PEG 20 Sorbitan Monolaurate, Polysorbate 20, Polysorbate 20, Polyoxyethylene (20) sorbitan monolaurate, Tween 20, PEG(20) sorbitan monolaurate, Polyoxyethylene (20) sorbitan monolaurate, Kolliphor PS 20, Montanox 20, Polysorbate 20, PEG(20)sorbitan monolaurate, Alkest TW 20, Tween 20, Kotilen-20

Polysorbate 20 sorbitan monolaurate, ethoxylated is a non-ionic surfactant derived from sorbitan monolaurate (which in turn comes from the dehydration of sorbitol) that has been ethoxylated (≈20 units of ethylene oxide) and esterified with lauric acid (C12 fatty acid) to produce a hydrophilic sorbitan moiety with a lipophilic fatty acid tail.


Industrial: Polysorbate 20 sorbitan monolaurate, ethoxylated can be used as a cleaner and defoamer in industrial uses.
Polysorbate 20 sorbitan monolaurate, ethoxylated (common commercial brand names include Kolliphor PS 20, Scattics, Alkest TW 20, Tween 20, and Kotilen-20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan monolaurate.


Its stability and relative nontoxicity allow Polysorbate 20 sorbitan monolaurate, ethoxylated to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.
As the name implies, the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.


Polysorbate 20 sorbitan monolaurate, ethoxylated is a non-ionic surfactant based on natural raw material.
It is an ethoxylated sorbitan monolaurate derivative named INCI Polysorbate 20 sorbitan monolaurate, ethoxylated.
The product is a clear yellow to brown liquid with a freezing point of -5°C.


Polysorbate 20 sorbitan monolaurate, ethoxylated contains 99% of the active substance.
Polysorbate 20 sorbitan monolaurate, ethoxylated dissolves well in water and methanol.
Polysorbate 20 sorbitan monolaurate, ethoxylated has the ability to create an O/W emulsion (oil in water).


Polysorbate 20 sorbitan monolaurate, ethoxylated (commercially called Tween 20), is derived from sorbitol, a natural sugar alcohol and forms a polysorbate-type nonionic surfactant by the ethoxylation of sorbitan (derived from the dehydration of sorbitol) before the addition of lauric acid.


Tween 20, whose common commercial names includes Alkest TW 20 and Polysorbate 20 sorbitan monolaurate, ethoxylated, is a mild nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid which is a medium-chain fatty acid found mainly in coconut oil.


Polysorbate 20 sorbitan monolaurate, ethoxylated is allowed to be used as the emulsifier, detergent, dispersant, solvent and stabilizer, etc. in a number of fields such as pharmaceutical, chemical, food, textile and other industries due to its stability and relative non-toxicity.
Polysorbate 20 sorbitan monolaurate, ethoxylated is an ethoxylated (copolymerized with approximately 20 moles of ethylene oxide) sorbitan ester (a coconut oil fatty acid ester of sorbitol).


Polysorbate 20 sorbitan monolaurate, ethoxylated is a clear liquid, soluble in water, alcohol, and methanol.
Polysorbate 20 sorbitan monolaurate, ethoxylated is insoluble in mineral oils.


Polysorbate 20 sorbitan monolaurate, ethoxylated is a popular, non-toxic hydrophilic oil-in-water emulsifier, stabilizer, and solubilizer that allows oils to dissolve into water-based formulations without alcohol.
Polysorbate 20 sorbitan monolaurate, ethoxylated is an amber, viscous, odorless ingredient for lotions, creams, and solid personal care formulations.


Polysorbate 20 sorbitan monolaurate, ethoxylated (with HLB factor 16.7) combines lipophilic and hydrophilic compounds in a single formula thanks to outstanding solubilizing and viscosity-building properties.
Polysorbate 20 sorbitan monolaurate, ethoxylated provides detergency with controlled foaming and is suitable for all applications and textures.


Polysorbate 20 sorbitan monolaurate, ethoxylated can also offer fragrance or emollient solubilization.
Polysorbate 20 sorbitan monolaurate, ethoxylated is a polyoxyethylene sorbitol ester that belongs to the polysorbate family.


Polysorbate 20 sorbitan monolaurate, ethoxylated is a nonionic detergent having a molecular weight of 1,225 daltons, assuming 20 ethylene oxide units, 1 sorbitol, and 1 lauric acid as the primary fatty acid.
Polysorbate 20 sorbitan monolaurate, ethoxylated is especially effective when used with sorbitan esters, such as sorbitan monolaurate.


This preservative-free ingredient, Polysorbate 20 sorbitan monolaurate, ethoxylated, exhibited excellent skin tolerance, including sensitive eye areas.
Polysorbate 20 sorbitan monolaurate, ethoxylated can provide anti-irritation benefits to mixed surfactant systems, reducing the irritation potential of a formulation.


This makes Polysorbate 20 sorbitan monolaurate, ethoxylated an excellent co-surfactant for applications where mildness is crucial, such as baby baths and baby shampoos.
Polysorbate 20 sorbitan monolaurate, ethoxylated is a nonionic surfactant and emulsifier derived from polyethoxylated sorbitan mono laurate.


Polysorbate 20 sorbitan monolaurate, ethoxylated is widely used in science.
Polysorbate 20 sorbitan monolaurate, ethoxylated has become an excipient in biopharmaceutical preparations, some of which may have enzymatic activity.


The effect of Polysorbate 20 sorbitan monolaurate, ethoxylated in biopharmaceuticals is based on its role as a stabiliser.
Therefore, it is necessary for the surfactant to maintain Polysorbate 20 sorbitan monolaurate, ethoxylated's structure intact.
If it becomes autoxidised, a Polysorbate 20 sorbitan monolaurate, ethoxylated side-chain cleavage will occur and ultimately short-chain acids such as formic acid will form, which may affect the stability of the biopharmaceutical product.


Other pharmaceutical uses of Polysorbate 20 sorbitan monolaurate, ethoxylated include topical analgesics, anti-rheumatic drugs, and in sunscreens.
Like Polysorbate 80, Polysorbate 20 sorbitan monolaurate, ethoxylated is listed as clarifying agent in ophthalmic preparations and as contact lens cleaners or solvents at concentrations not exceeding 1.0%.


In addition to the said uses, Polysorbate 20 sorbitan monolaurate, ethoxylated also serves as an emulsifier in fire-resistant hydraulic fluids.
These are primarily HFA, HFB, HFC and HFD-U liquids.


Polysorbate 20 sorbitan monolaurate, ethoxylated is the INCI name for sorbitan monolaurate, which has found its use primarily in the cosmetics industry but also performs similar functions in the production of pharmaceuticals, food, agricultural chemicals, and household and industrial cleaners.


Polysorbate 20 sorbitan monolaurate, ethoxylated is a gentle, oily, liquid cosmetic additive that functions as a non-ionic surfactant and wetting agent that enhances the spread-ability of liquids.
As a solubilizer, Polysorbate 20 sorbitan monolaurate, ethoxylated helps both essential oils and fragrance oils to attach to various types of cosmetic bases, including liquid, cream, and gel bases, and thereby prevents the oils and bases from separating.


Polysorbate 20 sorbitan monolaurate, ethoxylated is a nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid.
Polysorbate 20 sorbitan monolaurate, ethoxylated is a mixture of laurate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides.


Polysorbate 20 sorbitan monolaurate, ethoxylated has a faint, characteristic odor and a warm, somewhat bitter taste.
Polysorbate 20 sorbitan monolaurate, ethoxylated is a lemon to amber-coloured oily liquid at 25 °C with a faint characteristic odour.


Polysorbate 20 sorbitan monolaurate, ethoxylated or Tween 20, the abbreviation of “polyoxyethylene (20) sorbitan monolaurate”, is a nonionic surfactant and an emulsifier used much in cosmetics than in food.
The European food additive number for Polysorbate 20 sorbitan monolaurate, ethoxylated is E432.


Polysorbate 20 sorbitan monolaurate, ethoxylated is distinguished from other polysorbates due to the shortest length of the fatty acid and the highest HLB value.
The number 20 after polysorbate stands for the type of fatty acid linked to the ethoxylated sorbitan part of the molecule, here is monolaurate or lauric acid.


The number 20 following polyoxyethylene means the total number of oxyethylene groups (CH2CH2O) in the molecule of Polysorbate 20 sorbitan monolaurate, ethoxylated.
Polysorbate 20 sorbitan monolaurate, ethoxylated or Tween 20, the abbreviation of “polyoxyethylene (20) sorbitan monolaurate”, is a nonionic surfactant and an emulsifier used much in cosmetics than in food.


The European food additive number for it is E432.
Polysorbate 20 sorbitan monolaurate, ethoxylated is distinguished from other polysorbates due to the shortest length of the fatty acid and the highest HLB value.

USES and APPLICATIONS of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
Its structure allows Polysorbate 20 sorbitan monolaurate, ethoxylated to act as an emulsifier and solubilizer, because the ethoxylate chains provide hydrophilicity while the fatty acid portion provides lipophilicity.
Because Polysorbate 20 sorbitan monolaurate, ethoxylated is commercially a mixture of species, its precise molecular weight and formula are approximate (as cited above).


Polysorbate 20 sorbitan monolaurate, ethoxylated is widely used in food, cosmetics, pharmaceuticals and industrial applications thanks to its surfactant properties.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used in many applications.


Food industry: Polysorbate 20 sorbitan monolaurate, ethoxylated is used as an emulsifier, wetting agent and stabiliser in products like baked goods, confectionery, ice-cream, sauces, mouth-drops etc.
Cosmetics / personal care: Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a non-ionic emulsifier, solubiliser of fragrances, oil-in-water emulsion stabiliser, wetting agent in baby wipes etc.


Pharmaceutical / biotech: Polysorbate 20 sorbitan monolaurate, ethoxylated is used as an excipient surfactant in drug formulations, solubiliser for proteins/membrane proteins, washing agent in immunoassays (Western blot, ELISA) etc.
Industrial / cleaning / laboratory: Polysorbate 20 sorbitan monolaurate, ethoxylated is used Wetting agent for fabrics, in detergents, laboratory reagents, stamp removal in philately.


Polysorbate 20 sorbitan monolaurate, ethoxylated is an ingredient that is generally used for its emulsifying, stabilizing, wetting and dispersing properties in food, cosmetics and personal care products.
Food: Different with polysorbate 60 and 80, Polysorbate 20 sorbitan monolaurate, ethoxylated is used less as an emulsifier and stabilizer in food, and if it is in food, it is commonly used as an indirect additive instead of a direct additive.


However, in Europe, Polysorbate 20 sorbitan monolaurate, ethoxylated is a direct additive sharing the same applications with other polysorbates. 
Polysorbate 20 sorbitan monolaurate, ethoxylated is used for solubilizing membrane proteins during isolation and purification.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a wetting agent in flavored mouth drops.


Polysorbate 20 sorbitan monolaurate, ethoxylated acts as a washing agent in Western blots and ELISAs and prevents antibody binding.
Polysorbate 20 sorbitan monolaurate, ethoxylated is a solubilizing agent of membrane proteins.
In pharmaceutical chemistry, Polysorbate 20 sorbitan monolaurate, ethoxylated is used as an excipient to stabilize emulsions and suspensions.


Further, Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a dispersing agent, stabilizer, lubricator and also used in creams, salves, ointments, protective creams, balms, pomades, lipsticks, mascaras and glosses.
Pharmaceutical applications: Polysorbate 20 sorbitan monolaurate, ethoxylated is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.


Applications of Polysorbate 20 sorbitan monolaurate, ethoxylated: products for washing, care and styling of hair, cosmetics for washing and care of the body and face, make-up products and makeup removers, preparations for hair dyeing and decolourisation, after shave and other alcohol-based products, sunscreens, perfumes, body fragrances, intimate hygiene lotions and gels, lip care products, anti-acne preparations, air fresheners, nail polish and nail polish removers, fire-resistant hydraulic fluids, oils and cutting liquids, and agrochemicals.


Polysorbate 20 sorbitan monolaurate, ethoxylated is relatively nontoxic and stable therefore can be used as an emulsifier and detergent in a number of domestic, scientific, and pharmacological applications.
Polysorbate 20 sorbitan monolaurate, ethoxylated functions as a good wetting agent having food application in flavoured mouth drops, providing a spreading feeling to other added flavour ingredients.


In biochemical applications, Polysorbate 20 sorbitan monolaurate, ethoxylated finds use as washing agent in immunoassays, solubilizing agent for membrane proteins, and lysis solutions for mammalian cells.
While in the pharma sector, Polysorbate 20 sorbitan monolaurate, ethoxylated functions as an excipient helping to stabilize emulsions and suspensions.


The Cosmetics Ingredient Review (CIR) Expert Panel evaluated the scientific data and concluded that Polysorbate 20 sorbitan monolaurate, ethoxylated is safe for use in cosmetic formulations.
Polysorbate 20 sorbitan monolaurate, ethoxylated is a nonionic surfactant, wetter and emulsifier.


Polysorbate 20 sorbitan monolaurate, ethoxylated is widely applied in biological techniques and sciences, which can be added to buffers and reagents for immunohistochemistry, such as Western blots and ELISAs, helping to prevent non-specific antibody binding, decrease background staining and enhance reagent spreading.


Besides, Polysorbate 20 sorbitan monolaurate, ethoxylated also has applications in food production as a common food grade additive which are found in many consumables on the market today.
Polysorbate 20 sorbitan monolaurate, ethoxylated can also be used as a wetting agent in flavored mouth drops such as Ice Drops, in oral or non-gastrointestinal suspensions and in rubber balers in the elastomer industry.


Polysorbate 20 sorbitan monolaurate, ethoxylated is a yellow to amber-colored liquid that is soluble in water and has a variety of properties that make it useful in different applications.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a detergent and emulsifier in domestic & institutional cleaning, scientific, and pharmacological applications.


Industrial Uses: Polysorbate 20 sorbitan monolaurate, ethoxylated is used in various industrial applications, including as a lubricant and an emulsifier in the production of paints, coatings, and cleaning products.
Also known as Tween20, Polysorbate 20 sorbitan monolaurate, ethoxylated’s a great inbetweener for other emulsifiers to help cover a wide range of oil in water and water in oil emulsions.


Polysorbate 20 sorbitan monolaurate, ethoxylated is oil-in-water emulsifier, can be used as solvent, diffusant, stabilizer, lubricant and anti-static agent etc.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as emulsifier, foaming agent, lubricant, solubilizing agent, antistatic agent, washing agent, penetrating agent, dispersing agent, degreasing agent and chemical intermediate in the industry.


In metalworking, Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a component of machining fluids.
Polysorbate 20 sorbitan monolaurate, ethoxylated increases emulsion stability and improves the foaming characteristics of fluids used in metalworking processes.
In addition, commercial products containing up to 99% of Polysorbate 20 sorbitan monolaurate, ethoxylated, such as ROKwinol, are used in the agrochemical industry as an emulsifier for pesticide formulations.


-Food applications of Polysorbate 20 sorbitan monolaurate, ethoxylated:
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.
The World Health Organization has suggested acceptable daily intake limits of 0–25 mg of polyoxyethylene sorbitan esters per kg body weight.


-Biotechnical applications of Polysorbate 20 sorbitan monolaurate, ethoxylated:
In biological techniques and sciences, Polysorbate 20 sorbitan monolaurate, ethoxylated has a broad range of applications.
For example, Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a washing agent in immunoassays, such as Western blots and ELISAs.

Polysorbate 20 sorbitan monolaurate, ethoxylated  helps to prevent non-specific antibody binding.
In this major application, Polysorbate 20 sorbitan monolaurate, ethoxylated is dissolved in Tris-buffered saline or phosphate buffered saline at dilutions of 0.05% to 0.5% v/v.

These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used to saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).

Polysorbate 20 sorbitan monolaurate, ethoxylated is used to stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosis exposure.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a solubilizing agent of membrane proteins.

Polysorbate 20 sorbitan monolaurate, ethoxylated is used for lysing mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.


-Cosmetics use of Polysorbate 20 sorbitan monolaurate, ethoxylated:
Polysorbate 20 sorbitan monolaurate, ethoxylated functions as an emulsifying and surfactant in cosmetics and skin care products.
Also, Polysorbate 20 sorbitan monolaurate, ethoxylated acts as a viscosity modifier, dispersing agent, solubilizer and stabilizer to help blend oil and water together.

Mostly, Polysorbate 20 sorbitan monolaurate, ethoxylated is a solubilizing agent to distribute fragrance, colors and essential oils into water, if without it, these ingredients and water will separate.
As a high HLB emulsifier, Polysorbate 20 sorbitan monolaurate, ethoxylated can also be combined with a low HLB emulsifier (e.g. sorbitan esters) to provide either oil in water, or water in oil emulsion.

Following cosmetic products may contain Polysorbate 20 sorbitan monolaurate, ethoxylated:
*skin care products
*hair products
*Bath oils
*shampoos
*body sprays
*face wash
*Lotions
*deodorant


-Cosmetic and Personal Care Uses of Polysorbate 20 sorbitan monolaurate, ethoxylated:
Polysorbate 20 sorbitan monolaurate, ethoxylated is commonly used in the cosmetic and personal care industries.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as an emulsifier and a solubilizer in a variety of products, such as shampoos, conditioners, lotions, and creams.

Polysorbate 20 sorbitan monolaurate, ethoxylated is also used as a dispersing agent to help ingredients mix evenly in a product.
Polysorbate 20 sorbitan monolaurate, ethoxylated is known for its ability to reduce surface tension, making it easier to spread and apply on the skin.


-Pharmaceutical and Medical Uses of Polysorbate 20 sorbitan monolaurate, ethoxylated:
Polysorbate 20 sorbitan monolaurate, ethoxylated is also used in the pharmaceutical and medical industries.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as an excipient, a substance that is added to a medication to improve its stability and delivery.
Polysorbate 20 sorbitan monolaurate, ethoxylated is commonly used in vaccines and other injectable medications as a stabilizer and emulsifier.


-Food and Beverage Uses of Polysorbate 20 sorbitan monolaurate, ethoxylated:
Polysorbate 20 sorbitan monolaurate, ethoxylated is used in the food and beverage industries as an emulsifier and stabilizer.
Polysorbate 20 sorbitan monolaurate, ethoxylated is commonly used in ice cream, whipped cream, and other dairy products to improve texture and prevent separation.


-Food uses of Polysorbate 20 sorbitan monolaurate, ethoxylated:
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.

Biotechnology: Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a washing agent in immunoassays, such as Western blots and ELISAs.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used to saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA)

Polysorbate 20 sorbitan monolaurate, ethoxylated is used to stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosis exposure
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a solubilizing agent of membrane proteins


-Pharmaceutical uses of Polysorbate 20 sorbitan monolaurate, ethoxylated: 
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.
Industrial: Polysorbate 20 sorbitan monolaurate, ethoxylated is used in many brands of baby wipes.

Polysorbate 20 sorbitan monolaurate, ethoxylated is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.

Polysorbate 20 sorbitan monolaurate, ethoxylated is used as wetting agent in rubber balers in the elastomer industry.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used as a shape directing agent to synthesize spheroidal magnetite nano-assemblies.


-Industrial and domestic applications of Polysorbate 20 sorbitan monolaurate, ethoxylated: 
Polysorbate 20 sorbitan monolaurate, ethoxylated is used in many brands of baby wipes.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.

Polysorbate 20 sorbitan monolaurate, ethoxylated is also used as wetting agent in rubber balers in the elastomer industry.
Polysorbate 20 sorbitan monolaurate, ethoxylated has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies.

BENEFITS & CHARACTERISTICS of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
*Highly effective emulsifier/solubiliser: 
Because of its high HLB (~16.7), Polysorbate 20 sorbitan monolaurate, ethoxylated is suitable for oil-in-water emulsions, effectively solubilising oils, fragrances and actives.


*Relatively low toxicity: 
Many studies show polysorbates have low acute toxicity; for Polysorbate 20 sorbitan monolaurate, ethoxylated specifically, LD50 values and genotoxicity data show low concern.


*Versatile across industries: 
Polysorbate 20 sorbitan monolaurate, ethoxylated can be used in food, cosmetics, pharma, labs and industry — broad compatibility with aqueous systems and many oils.


*Good functional stability: 
Polysorbate 20 sorbitan monolaurate, ethoxylated is stable under normal usage conditions; works well in emulsions, washable systems, wetting contexts.
Polysorbate 20 sorbitan monolaurate, ethoxylated improves formulation performance: e.g., better spreading/wetting, improved incorporation of actives or fragrances, improved texture/feel in cosmetics.

ALTERNATIVE PARENTS of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
*Tetrahydrofurans 
*Carboxylic acid esters 
*Oxacyclic compounds 
*Monocarboxylic acids and derivatives 
*Dialkyl ethers 
*Primary alcohols 
*Organic oxides 
*Hydrocarbon derivatives 
*Carbonyl compounds 

CHEMICAL PROPERTIES of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
Polysorbate 20 sorbitan monolaurate, ethoxylated is a mixture of laurate partial esters of sorbitol and sorbitol anhydrides condensed with approximately 20 mole of ethylene oxide (C2H4O) for each mole of sorbitol and its mono- and dianhydrides.
Polysorbate 20 sorbitan monolaurate, ethoxylated has a faint, characteristic odor and a warm, somewhat bitter taste.

SUBSTITUENTS of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
*Fatty acid ester
*Tetrahydrofuran
*Carboxylic acid ester
*Carboxylic acid derivative
*Dialkyl ether
*Ether
*Monocarboxylic acid or derivatives
*Organoheterocyclic compound
*Oxacycle
*Organic oxide
*Carbonyl group
*Alcohol
*Organooxygen compound
*Primary alcohol
*Hydrocarbon derivative
*Organic oxygen compound
*Aliphatic heteromonocyclic compound

ADVANTAGES of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
strong emulsifying properties,
content of the active substance in the product at the level of 99%,
high solubility in water and methanol,
safe for the water environment,
biodegradable product.

HOW IS POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED MADE?
Generally, it is produced by the reaction among sorbitol, lauric acid and ethylene oxide.
The manufacturing process is similar with that of polysorbate 80, esterification between sorbitol and lauric acid first to synthesize sorbitan esters and then condensed with ethylene oxide OR by reacting sorbitol and ethylene oxide initially then esterified with lauric acid.

Lauric Acid
Lauric acid (C12H24O2) is a saturated fatty acid found naturally and the following are its common food sources:
*coconut oil
*palm kernel oil
*yeast extract
*butter

Commercial lauric acid is not pure and is a mixture of several fatty acids.
Lauric acid is the shortest length compared with the other three following fatty acids that are linked to the ethoxylated sorbitan part to produce polysorbate 40, 60, 65, 80.

*Oleic Acid (C18H34O2)
*Stearic acid (C18H36O2)
*Palmitic acid (C16H32O2)

PROPERTIES of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
Polysorbate 20 sorbitan monolaurate, ethoxylated is a polysorbate and nonionic surfactant sold under the heritage brand of Tween.
Polysorbate 20 sorbitan monolaurate, ethoxylated is named after the number of repeat polyethylene glycol units in the molecule.

Polysorbate 20 sorbitan monolaurate, ethoxylated (common commercial brand names include Scattics, Alkest TW 20, and Tween 20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid.

Its stability and relative nontoxicity allow Polysorbate 20 sorbitan monolaurate, ethoxylated to be used as a detergent and Emulsifier in several domestic, scientific, and pharmacological applications.

Tween-20 is also called Polysorbate 20 sorbitan monolaurate, ethoxylated.
Polysorbate 20 sorbitan monolaurate, ethoxylated is an amber oily liquid.

Polysorbate 20 sorbitan monolaurate, ethoxylated is soluble in water, methanol, ethanol, isopropanol, propylene glycol, ethylene glycol, cottonseed oil, etc.
HLB value of Polysorbate 20 sorbitan monolaurate, ethoxylated is 16.7.

Polysorbate 20 sorbitan monolaurate, ethoxylated has many applications, such as food, biotechnical, pharmaceutical, and industrial and domestic applications.

Polysorbate 20 sorbitan monolaurate, ethoxylated is an oil-in-water emulsifier.
Polysorbate 20 sorbitan monolaurate, ethoxylated can be used as a solvent, diffusant, stabilizer, lubricant, antistatic agent, etc.

FUNCTIONS AND EFFECTS of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED IN COSMETICS:
The most common application for Polysorbate 20 sorbitan monolaurate, ethoxylated is in all kinds of cosmetic and personal care products.
Polysorbate 20 sorbitan monolaurate, ethoxylated is used, among others, as a solvent for other components of cosmetic formulations, as an emulsifier that allows combining hydrophilic and hydrophobic components (mainly used in oil-in-water emulsions).

Polysorbate 20 sorbitan monolaurate, ethoxylated also acts as a stabiliser to the product obtained (preventing phase separation in the emulsion) and the resulting foam.
Polysorbate 20 sorbitan monolaurate, ethoxylated is also used to reduce the viscosity of surfactant solutions.

Polysorbate 20 sorbitan monolaurate, ethoxylated is considered a mild cleaning detergent that does not cause irritation.
Polysorbate 20 sorbitan monolaurate, ethoxylated as a cosmetic ingredient lubricates and soothes the skin.

Polysorbate 20 sorbitan monolaurate, ethoxylated reduces potential irritating and drying properties of other cosmetic ingredients.
Polysorbate 20 sorbitan monolaurate, ethoxylated was even used in the first shampoos designed for children.

Polysorbate 20 sorbitan monolaurate, ethoxylated is an effective microemulsifier and solubiliser for dissolving compounds such as essential oils and perfumes in water.
Of all the compounds in the Polysorbate group, Polysorbate 20 sorbitan monolaurate, ethoxylated has the mildest effect.

PRODUCTS CONTAINING POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
*lotions,
*liquid soaps,
*hair conditioners,
*shampoos,
*body scrubs,
*body mists,
*hair styling products,
*mouthwashes.

MANUFACTURE of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
Polysorbate 20 sorbitan monolaurate, ethoxylated is made by the reaction of sorbitol and polyol with ethylene oxide.
The number 20 here represents the number of molecules of ethylene oxide that were reacted.

PROPERTIES of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
Appearance
Polysorbate 20 sorbitan monolaurate, ethoxylated is a clear, yellow to yellow-green viscous liquid.

Hydrophilic – Lipophilic Balance (HLB)
16.7, oil-in-water (O/W) emulsion

Solubility
Polysorbate 20 sorbitan monolaurate, ethoxylated is soluble in water
Polysorbate 20 sorbitan monolaurate, ethoxylated is soluble in ethanol, methanol, and ethyl acetate.

PROPERTIES of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
Polysorbate 20 sorbitan monolaurate, ethoxylated emulsifies all types of oils and works in combination with lipophilic emulsifiers.
Solubilizing agent for fat-soluble compounds and oily fragrances in continuous aqueous mediums (including make-up removers, gels, shampoos, etc.).
Polysorbate 20 sorbitan monolaurate, ethoxylated can be used in a wide range of textures, from spray to butter.
Polysorbate 20 sorbitan monolaurate, ethoxylated provides lightweight-neutral feel.

GENERAL CHARACTERISTICS of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
Polysorbate 20 sorbitan monolaurate, ethoxylated is a non-ionic surfactant and emulsifier used mainly in the cosmetics industry.
The common chemical name of Polysorbate 20 sorbitan monolaurate, ethoxylated is ethoxylated sorbitan monolaurate.
Polysorbate 20 sorbitan monolaurate, ethoxylated's CAS number is 9005-64-5.

Polysorbate 20 sorbitan monolaurate, ethoxylated is an amphipathic compound consisting of polyoxyethylene sorbitan fatty acid esters.
Polysorbate 20 sorbitan monolaurate, ethoxylated is a complex material given the number of possible compounds and structural isomers that can be formed during synthesis.

CHARACTERISTICS of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
*an oily, viscous liquid,
*lemon to amber in colour,
*faint, distinctive scent,
*soluble in water (cold or hot), methanol, ethanol, ethyl acetate and dioxane,
*insoluble in mineral oil and petroleum ether,
*stable in the presence of weak acids and bases,
*hygroscopic (the material may contain up to 3% water by weight),
*prolonged storage can lead to the formation of peroxides,
*biodegradable,
*highly effective in oil-in-water emulsions (O/W emulsions),
*may reduce the effectiveness of preservatives containing parabens,
*demonstrates resistance in hard water,
*non-toxic.

PHYSICAL and CHEMICAL PROPERTIES of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
Melting point: 98.9 °C (decomposition)
Boiling point: 100 °C
Density: 1.11 g/mL at 20 °C
Vapor pressure: <1.4 hPa (20 °C)
FEMA: 2915 | POLYSORBATE 20
Refractive index: n20/D 1.468 (literature value)
Flash point: >230 °F
Storage temperature: Store below +30°C
Solubility: 100 g/L
Form: Viscous liquid

Color: Amber
Specific Gravity: 1.090 to 1.130 (20/20℃)
pH: 6-8 (50g/l, H2O, 20℃)
pH Range: 7
Odor: Mild alcohol odor
Odor Type: Alcoholic
Water Solubility: 100 g/L
Hydrophilic-Lipophilic Balance (HLB): 16.7
Stability: Stable. Incompatible with strong oxidizing agents

Substances Added to Food (formerly EAFUS): POLYSORBATE 20
EWG's Food Scores: 3-8
FDA UNII: PEG-80 SORBITAN LAURATE (239B50Y732), PEG-75 SORBITAN LAURATE (31JQ3WOL8T), 
PEG-10 SORBITAN LAURATE (4Z93U4C2WN), POLYSORBATE 21 (59IO08SBZU), POLYSORBATE 20 (7T1F30V5YH)
EPA Substance Registry System: Polysorbate 20 (9005-64-5)
Cosmetics Info: Polysorbate 20
Chemical formula: C58H114O26
Molar mass: 1226 g/mol

Appearance: Clear, yellow to yellow-green viscous liquid
Density: 1.1 g/mL (approximate)
Boiling point: > 100 °C (212 °F; 373 K)
Surface tension:
CMC: 8.04×10^−5 M at 21 °C
HLB: 16.7
Relative Density: About 1.10
Viscosity: About 400 mPa s at 25°C
IUPAC: Polyoxyethylene (20) sorbitan monooleate
INCI: POLYSORBATE 20

CAS: 9005-64-5
Molar mass: 522.70 g/mol
Density: 1.10 g/mL at 20 °C
Solubility: Soluble in water, alcohols, glycerol ethers, 
glycols, esters, ketones, aromatic and aliphatic hydrocarbons
CBNumber: CB3462544
Molecular Formula: C26H50O10
Molecular Weight: 522.6692 g/mol

MDL Number: MFCD00165986
MOL File: 9005-64-5.mol
Appearance: Pale yellow clear viscous liquid (estimated)
Assay: 96.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 1.09100 to 1.09600 @ 25.00 °C
Pounds per Gallon - (estimated): 9.078 to 9.120

Refractive Index: 1.45900 to 1.47000 @ 20.00 °C
Acid Value: 3.00 max. KOH/g
pH Number: 5.71
Flash Point: > 230.00 °F. TCC (> 110.00 °C)
Shelf Life: 24.00 month(s) or longer if stored properly
Storage: Store in cool, dry place in tightly sealed containers, 
protected from heat and light
Soluble in: alcohol, oils, water
Appearance at 25ºC: Clear liquid

Active content %: 97
Nature: Nonionic
Acid value mg KOH/gm max: 2
Color gardner: 3
Hydroxyl value mg KOH/gm: 96-108
% Moisture content by KF: 3
pH: 5-7
Saponification value: 40-50
Molecular Formula: C58H114O26

Molecular Weight: 1127.48
Grade: Pharmaceutical Excipients
Description: This product is an amber viscous liquid with a 
slight special odor and slightly bitter taste.
UNII: 7T1F30V5YH
Chemical Name: Polyoxyethylene 20 sorbitan monolaurate
CAS Number: 9005-64-5

Product Name: Polyoxyethylene sorbitan monolaurate
CAS No.: 9005-64-5
InChIKeys: HMFKFHLTUCJZJO-UHFFFAOYSA-N
Molecular Weight: 346.459991455078
Exact Mass: 604.418640
EC Number: 500-018-3
DSSTox ID: DTXSID3031949
Color/Form: Lemon- to amber-colored liquid

HScode: 34021300
Categories: Emulsifier
PSA: 133.14000
XLogP3: 5.37
Appearance: Amber viscous liquid
Density: 1.1±0.1 g/cm3
Melting Point: 98.9 °C (decomp)
Boiling Point: 100 °C

Flash Point: >230 °F
Refractive Index: 1.502
Water Solubility: 100 g/L
Storage Conditions: 0-6°C
Vapor Pressure: <1.4 hPa (20 °C)
Odor: Characteristic odor
Taste: Bitter

Melting point: 98.9 °C (decomposition)
Boiling point: 100 °C
Density: 1.11 g/mL at 20 °C
Vapor pressure: <1.4 hPa (20 °C)
FEMA: 2915 | POLYSORBATE 20
Refractive index: n20/D 1.468 (literature value)
Flash point: >230 °F
Storage temperature: Store below +30°C
Solubility: 100 g/L

Form: Viscous liquid
Color: Amber
Specific Gravity: 1.090 to 1.130 (20/20℃)
pH: 6-8 (50g/l, H2O, 20℃)
pH Range: 7
Odor: Mild alcohol odor
Odor Type: Alcoholic
Water Solubility: 100 g/L

Hydrophilic-Lipophilic Balance (HLB): 16.7
Stability: Stable. Incompatible with strong oxidizing agents
Substances Added to Food (formerly EAFUS): POLYSORBATE 20
EWG's Food Scores: 3-8
FDA UNII: PEG-80 SORBITAN LAURATE (239B50Y732), PEG-75 SORBITAN LAURATE (31JQ3WOL8T), 
PEG-10 SORBITAN LAURATE (4Z93U4C2WN), POLYSORBATE 21 (59IO08SBZU), POLYSORBATE 20 (7T1F30V5YH)
EPA Substance Registry System: Polysorbate 20 (9005-64-5)

Cosmetics Info: Polysorbate 20
Chemical formula: C58H114O26
Molar mass: 1226 g/mol
Appearance: Clear, yellow to yellow-green viscous liquid
Density: 1.1 g/mL (approximate)
Boiling point: > 100 °C (212 °F; 373 K)
Surface tension:
CMC: 8.04×10^−5 M at 21 °C
HLB: 16.7

Relative Density: About 1.10
Viscosity: About 400 mPa s at 25°C
IUPAC: Polyoxyethylene (20) sorbitan monooleate
INCI: POLYSORBATE 20
CAS: 9005-64-5
Molar mass: 522.70 g/mol
Density: 1.10 g/mL at 20 °C
Solubility: Soluble in water, alcohols, glycerol ethers, 
glycols, esters, ketones, aromatic and aliphatic hydrocarbons

CBNumber: CB3462544
Molecular Formula: C26H50O10
Molecular Weight: 522.6692 g/mol
MDL Number: MFCD00165986
MOL File: 9005-64-5.mol
Appearance: Pale yellow clear viscous liquid (estimated)

Assay: 96.00 to 100.00
Food Chemicals Codex Listed: No
Specific Gravity: 1.09100 to 1.09600 @ 25.00 °C
Pounds per Gallon - (estimated): 9.078 to 9.120
Refractive Index: 1.45900 to 1.47000 @ 20.00 °C
Acid Value: 3.00 max. KOH/g
pH Number: 5.71
Flash Point: > 230.00 °F. TCC (> 110.00 °C)
Shelf Life: 24.00 month(s) or longer if stored properly

Storage: Store in cool, dry place in tightly sealed containers, 
protected from heat and light
Soluble in: alcohol, oils, water
Appearance at 25ºC: Clear liquid
Active content %: 97
Nature: Nonionic
Acid value mg KOH/gm max: 2
Color gardner: 3
Hydroxyl value mg KOH/gm: 96-108

% Moisture content by KF: 3
pH: 5-7
Saponification value: 40-50
Molecular Formula: C58H114O26
Molecular Weight: 1127.48
Grade: Pharmaceutical Excipients
Description: This product is an amber viscous liquid with a 
slight special odor and slightly bitter taste.
UNII: 7T1F30V5YH
Chemical Name: Polyoxyethylene 20 sorbitan monolaurate
CAS Number: 9005-64-5

Chemical Formula: C58H114O26
Molar mass: 1226 g/mol
Appearance: Clear, yellow to yellow-green viscous liquid.
Density: 1.1 g/mL (approximate)
Boiling point: > 100 °C (212 °F; 373 K)
Surface tension: CMC 8.04×10−5 M at 21 °C
HLB: 16.7
Water Solubility: 0.018 g/L
logP: 2.75
logP: 2.39
logS: -4.5

pKa (Strongest Acidic): 14.64
pKa (Strongest Basic): -2.7
Physiological Charge: 0
Hydrogen Acceptor Count: 9
Hydrogen Donor Count: 3
Polar Surface Area: 133.14 Ų
Rotatable Bond Count: 26
Refractivity: 134.25 m³•mol⁻¹
Polarizability: 60.33 ų
Number of Rings: 1

Bioavailability: No
Rule of Five: No
Ghose Filter: No
Veber's Rule: No
MDDR-like Rule: No
Chemical Formula: C26H50O10
IUPAC name: 2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate
InChI Identifier: InChI=1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3
InChI Key: HMFKFHLTUCJZJO-UHFFFAOYSA-N
Isomeric SMILES: CCCCCCCCCCCC(=O)OCCOCC(OCCO)C1OCC(OCCO)C1OCCO
Average Molecular Weight: 522.6692
Monoisotopic Molecular Weight: 522.34039782

Chemical name: Sorbitan monolaurate, ethoxylated (commonly “Polysorbate 20”) 
CAS Number: 9005-64-5 
EC / EINECS number: 500-018-3 
Molecular formula: On Wikipedia the formula is listed as C₅₈H₁₁₄O₂₆ (for a representative species) 
Molar mass (approximate): ~1,226 g·mol⁻¹ (as given on Wikipedia for the average mixture)
Appearance / physical state: According to sources, a viscous liquid, typically pale yellow to yellow-green oily liquid. 
Density: Approx. 1.1 g·cm⁻³ at ~20 °C (Wikipedia) 

Solubility / miscibility: Soluble/miscible with water, ethanol, methanol, ethyl acetate; insoluble or limited in some non-polar oils depending on grade. 
HLB (Hydrophile-Lipophile Balance): Approx. 16.7 (makes it suitable for O/W emulsions) 
Boiling point / volatility: Boiling point listed as “>100 °C”; vapour pressure <1.4 hPa at 20 °C in one listing. 
Stability / reactivity: Described as stable under normal handling/storage conditions. 
Water solubility: On one table water solubility <2.0 g·L⁻¹ under certain conditions. 
Other: The ingredient is a mixture of polyoxyethylene (≈20 units) chains esterified to sorbitan with a lauric acid fatty acid moiety (dominant ~C12) plus minor fatty acids.

FIRST AID MEASURES of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
-Description of first-aid measures:
*After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with water/ shower.
*After eye contact: 
Rinse out with plenty of water. 
Remove contact lenses.
*After swallowing: 
Make victim drink water (two glasses at most). 

ACCIDENTAL RELEASE MEASURES of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Take up with liquid-absorbent material.
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
-Extinguishing media:
*Suitable extinguishing media:
Foam 
Carbon dioxide (CO2) 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use Safety glasses.
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,4 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 30 min
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Store at room temperature.
-Specific end use(s):
No other specific uses are stipulated

STABILITY and REACTIVITY of POLYSORBATE 20 SORBITAN MONOLAURATE, ETHOXYLATED:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .

 
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