POLYSORBATE 20

CAS No.: 9005-64-5
EC No.: 500-018-3

Synonyms:
POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; Tween 20; 9005-64-5; Polyoxyethylene (20) sorbitan monolaurate; POLYOXYETHYLENE SORBITAN MONOLAURATE; Polyoxyethylenesorbitan monolaurate; Polysorbate (INN); 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate; 2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate; 2-(2-(3,4-Bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl dodecanoate; 2-[2-[3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate; 9005-66-7; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; Alkest TW 20; Polysorbate 20 (NF); Polysorbate 40 (NF); Polysorbate 60 (NF); Tween(R) 20; tween (R) 20; Tween 20 (TN); Tween 40 (TN); Tween 60 (TN); SCHEMBL118527; POE (6) sorbitol monolaurate; POE(20) sorbitan monolaurate; CHEMBL371631; Ethoxylated Sorbitan monolaurate; POE (20) sorbitan monolaurate; DTXSID60922815; E432; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; Polyoxyethylene Sorbitan Monolaurate Kosher; FT-0645136; Polyoxyethylene Sorbitan Monolaurate 20 NF; C11624; D05565; D05566; D05567; 3,6-Anhydro-1-O-[2-(dodecanoyloxy)ethyl]-2,4,5-tris-O-(2-hydroxyethyl)hexitol; 1052273-76-3; 118955-40-1; Polisorbate 20- PS 20; Tween 20 (Trademark of ICI America, Inc.); Tween 20 ; Tween 20 1LT; Twain 20; TWEEN(R) 20 Vetec(TM) reagent grade, 40%; ACRYL/BIS 37.5:1 PREMIXED PWD ULTRA PURE; TWEEN 20 ELECTROPHORESIS GRADE; psml; capmul; TWEEN 20; Twain 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; FEMA 2915; 'TWEEN' 20; emsorb6915; TWEEN(R) 20; TWEEN(R) 21; TWEEN 20(R); TWEEN NO 20; TWEEN(TM) 20; TWEEN(TM) 21; TWEEN-20(TM); hodagpsml-20; liposorbl-20; Tween 20 1LT; TWEEN 20PURE; Tween(rg 20; Tween 20 ; protasorbl-20; armotanpml-20; EMALEX ET-2020; POLYSORBATE 20; POLYSORBATE 21; EmulsifierT-20; glycospersel-20; TWEEN(-1)(R) 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; TWEEN 20 EP, NF; POLYSORBATUM 20; emulsifier(t20); dxewmulsepoe-sml; glycospersel-20x; TWEEN 20 BP GRADE; POLYSORBATE,20,NF; Polysorbate 20/80; Tween-20(Tween20); POLYSORBATE,20,FCC; POLYSORBATE,20(BULK; Polysorbate 20, USP; SURFACT-AMPS(TM) 20; SORBITAN MONOLAURATE; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; Polysorbate 20 (2 g); Polisorbate 20- PS 20; POLYSORBAT 20, PH EUR; Tween20=Polysorbate20; PROTEIN SOLUBILIZER 20; TWEEN(R) 20 POLYSORBATE; TWEEN(R) POLYSORBATE 20; sorbimacrogollaurate300; PEG-10 SORBITAN LAURATE; PEG-40 SORBITAN LAURATE; PEG-44 SORBITAN LAURATE; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; PEG-75 SORBITAN LAURATE; PEG-80 SORBITAN LAURATE; Tween 20, Ph. Eur. & USP; POLYSORBATE 20 extrapure; Tween 20, synthesis grade; Polysorbate 20 (2 g) (AS); TWEEN(R) 20 250-450 MPA.S; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; Tween(R) 20,Ph. Eur. & USP; ZYP-5052 AUTOINDUCTION MEDIA; TWEEN 20 CELL CULTURE REAGENT; POE (20) SORBITAN MONOLAURATE; TWEEN 20 ELECTROPHORESIS GRADE; PESTLE AND TUBE 1.5ML ASSORTED; TWEEN 20MOLECULAR BIOLOGY GRADE; Polysorbatum 20, Tween(R) 20; SURFACTANTS(glyceryl monosterate; POLYOXYETHYLENE (20) MONOLAURATE; SORBITANPOLYOXYETHYLENEMONOLAURATE; TWEEN(R) 20 BIOXTRA, VISCOUS LIQUID; POLYOXYETHYLENESORBITAN MONOLAURATE; POLYOXYETHYLENE SORBITAN MONOLAUREATE; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYOXYLETHYLENE SORBITAN MONOLAURATE; POLYOXYETHYLENE(2)SORBITANMONOLAURATE; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYOXETHYLENE(20)SORBITANMONOLAURATE; POLYOXYETHYLENE(6)SORBITANMONOLAURATE; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; Polysorbate 20, Electrophoresis Grade; Tween(R) 20 (Polysorbate), NF, Ph Eur; Sorbitanmonolaurat, ethoxyliert, 20-EO; POLYETHOXYETHANOL SORBITAN MONOLAUREATE; POLY(OXYTHEYLENE)N-SORBITAN-MONOLAURATE; POLYETHYLENE GLYCOL SORBITAN MONOLAURATE; POLYOXYETHYLENE (4) SORBITAN MONOLAURATE; POLYOXYETHYLENE(80) SORBITAN MONOLAURAT&; Polysorbate 20,Polysorbatum 20, Tween 20; TWEEN(R) 20 Vetec(TM) reagent grade, 40%; ACRYL/BIS 37.5:1 PREMIXED PWD ULTRA PURE; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; Tween 20 (Trademark of ICI America, Inc.); Sorbitan monolaureate, ethoxylated (4 EO); POLYOXYETHYLENE (20) SORBITAN MONOLAURATE; POLYOXYETHYLENE (80) SORBITAN MONOLAURATE; POLYOXYLETHYLENE (20) SORBITAN MONOLAURATE; ProteinSolubilizer20,ReadytouseAmpules,Sterile; polyoxyethylene sorbitan monolauric acid ester; Polyoxyethylene sorbitan monolaurate (Tween 20); Tween20(Polyoxyethylene-20-SorbitanMonolaurate); POLYOXYETHYLENESORBITAN MONOLAURATE*(TWE EN 21); POLYOXYETHYLENESORBITAN MONOLAURATE*SIGM AULTRA; Tween 20 (=Polyoxyethylene Sorbitan Monolaurate); polyethylene glycol sorbitan monolaurate solution; polyoxyethylene (20)sorbitan monolaurate solution; polyoxyethylene (80) sorbitan monolaurate solution; POLYOXYETHYLENESORBITAN MONOLAURATE*ELEC TROPHORESIS; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYOXYETHYLENE SORBITAN MONOLAURATE*(TW EEN 20), LO; POLYOXYETHYLENESORBITAN MONOLAURATE*CELL CULTURE TE; POLYOXYETHYLENESORBITAN MONOLAURATE*MOLE CULAR BIOLO; POLYOXYETHYLENE SORBITAN MONOLAURATE*(TW EEN 20), PR; Sorbitan,monodadecanoate,poly(oxy-1,2-ethanediyl)derivs.; sorbitan,monododecanoate,poly(oxy-1,2-ethanediyl)derivs.; sorbitan,monododecanote,poly(oxy-1,2-ethanediyl)derivatives; POLYOXYETHYLENE (20) SORBITAN MONOLAURATE SOLUTION, 70% WATER; POLYOXYETHYLENE (20) SORBITAN MONOLAURATE SOLUTION, 72 WT.% IN WATER; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; POLYOXYETHYLENE (20) SORBITAN MONOLAURATE SOLUTION, BIOCHEMIKA, ~10% WATER; Tween 20 (=Polyoxyethylene Sorbitan Monolaurate) [for Biochemical Research]; Polyethylene glycol sorbitan monolaurate, Polyoxyethylenesorbitan monolaurate; TWEEN 20,Polyethylene glycol sorbitan monolaurate, Polyoxyethylenesorbitan monolaurate; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20; Polyethylene glycol sorbitan monolaurate solution, Polyoxyethylenesorbitan monolaurate; TWEEN 20,Polyethylene glycol sorbitan monolaurate, Polyoxyethylenesorbitan monolaurate, Polysorbate 20; POLYSORBATE 20; Polysorbate 20; POLİSORBAT 20; polisorbat 20

POLYSORBATE 20

Polysorbate 20
From Wikipedia, the free encyclopedia
Jump to navigationJump to search
Polysorbate 20
Polysorbate 20
Names
IUPAC name
Polyoxyethylene (20) sorbitan monolaurate
Other names
Montanox 20
Polysorbate 20
PEG(20)sorbitan monolaurate
Alkest TW 20
Tween 20
Identifiers
CAS Number    
9005-64-5 check
ChemSpider    
none
ECHA InfoCard    100.105.528 Edit this at Wikidata
E number    E432 (thickeners, ...)
RTECS number    
TR7400000
CompTox Dashboard (EPA)    
DTXSID3031949 Edit this at Wikidata
Properties
Chemical formula    C58H114O26
Molar mass    1227.54 g/mol
Appearance    Clear, yellow to yellow-green viscous liquid.
Density    1.1 g/mL (approximate)
Boiling point    > 100 °C (212 °F; 373 K)
Surface tension:
CMC    8.04×10−5 M at 21 °C[1]
HLB    16.7[1]
Hazards
Main hazards    Irritant
Safety data sheet    External MSDS
NFPA 704 (fire diamond)    
NFPA 704 four-colored diamond
1
Flash point    110 °C (230 °F; 383 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒ verify (what is check☒ ?)
Infobox references
Polysorbate 20 (common commercial brand names include Scattics, Alkest TW 20 and Tween 20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid. Its stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications. As the name implies the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.[2]

Contents
1    Food applications
2    Biotechnical applications
3    Pharmaceutical applications
4    Industrial and domestic applications
5    See also
6    References
7    External links
Food applications
Polysorbate 20 is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.

The World Health Organization has suggested acceptable daily intake limits of 0–25 mg of polyoxyethylene sorbitan esters per kg body weight.[3]

Biotechnical applications
In biological techniques and sciences, polysorbate 20 has a broad range of applications. For example, it is used:

as a washing agent in immunoassays, such as Western blots and ELISAs. It helps to prevent non-specific antibody binding. In this major application, it is dissolved in Tris-buffered saline or phosphate buffered saline at dilutions of 0.05% to 0.5% v/v. These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.
to saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).
to stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosis exposure
as a solubilizing agent of membrane proteins
for lysing mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.
Pharmaceutical applications
Polysorbate 20 is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.

Industrial and domestic applications
Polysorbate 20 is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.

Polysorbate 20 is also used as wetting agent in rubber balers in the elastomer industry.

Polysorbate 20 has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies.[4]

Work by Kiese et al. in 2008 looked at comparing aggregate formation caused by stirring and shaking, with and without the presence of polysorbate 20, and the effect of fill volumes (varying headspace) on protein stability during shaking, also with and without polysorbate 20 [42]. It was found that the two different types of stress probably resulted in different mechanisms of aggregation. In the absence of polysorbate 20, stirring was shown to be a very high stress method, producing highly turbid samples with large, visible protein aggregates. Intermediate, smaller, soluble aggregates did not increase – presumably as they were short lived in solution [42]. Stirring stress could have been a result of:
The most commonly used surfactants are polysorbate 20 and 80. These surfactants may contain peroxides, which can oxidize amino acid residues that are prone to oxidation (Kishore, Kiese, et al., 2011; Kishore, Pappenberger, et al., 2011). Commercial sources of peroxide-free polysorbates are available, but need to be handled and stored properly (Ha, Wang, & Wang, 2002). In particular, incubation of polysorbate 80 in air at high temperatures promotes peroxide formation, and removal of oxygen is recommended for long-term storage. The oxidation induced by peroxides as a result of polysorbate 20 degradation can be inhibited by antioxidants as shown in a study using an IgG1 mAb Fab (Lam, Lai, Chan, Ling, & Hsu, 2011). In this study, it was shown that a Trp residue was oxidized as a result of the presence of increased levels of peroxide in polysorbate 20, and the decomposition of the polysorbate-involved free radicals.
whereas polysorbate 20 contained fewer degradation products than found in polysorbate 80 (Gilardi-Lorenz, 2006). Many of these impurities found in polysorbate 80 were not found in polysorbate 20, and thus polysorbate 20 may be the preferred surfactant for protein formulations.

Polysorbate 20
Polysorbate 20 is a surfactant and emulsifier used in cleaning and personal care products. It is an excellent solvent for essential oils, but also used as a wetting agent, viscosity stabilizer and dispersant.

INCI Name: Polysorbate 20
Other name: POE (20) Sorbitan laurate
Appearance: Light golden liquid
Applications: Creams, ointments or pomades, balms, lipsticks, mascaras, air freshener, body spray ..
HLB: 16.7

Polisorbat 20 / Polysorbate in Turkish
Medicine Polisorbat 20 / Polysorbate in Turkish
Overview Uses Side effects Precautions Interactions Contraindications
Overview
Polysorbate 20 / Polysorbate in Turkish is used for Emulsifier, Dispersing agent and other conditions.
Detailed information regarding the use of Polysorbate 20 / Polysorbate in Turkish, side effects, product comments, questions, interactions and precautions are as follows:
uses
Polysorbate 20 / Polysorbate in Turkish is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
Emulsifier
Dispersant
Further information: Uses
Side effects
The following is a list of possible side-effects that may occur in medicines that contain Polysorbate 20 / Polysorbate in Turkish. This is not an exhaustive list. These side effects are likely to occur, but do not always occur. Some of the side effects are rare but can be very serious. Be sure to consult your doctor if you observe any of the following side effects, especially those that do not go away even if you expect them to.
Eye irritation
If you notice any side effects other than those listed below, consult your doctor for medical advice. You can also report side effects to your nearest health ministry official.
Measures
Please consult your doctor or pharmacist or refer to the package insert for this information.
Please consult your doctor or pharmacist or refer to the package insert for this information.
Please consult your doctor or pharmacist or refer to the package insert for this information.
Frequently Asked Questions
Is it safe to drive or use heavy machinery while using this product?
If you experience drowsiness, dizziness, hypotension (low blood pressure) or headache while using Polysorbate 20, it may not be safe to drive and / or use a construction machine. If the medication used causes drowsiness, dizziness or lowers your blood pressure, you should not drive. In addition, pharmacists advise patients not to drink alcohol with the drug, as alcohol intensifies side effects such as drowsiness. Please check for these effects on your body when using Polysorbate 20 / Polysorbate in Turkish. Always consult your doctor for advice specific to your body and health condition.
Is this drug or product addictive or addictive?
Many drugs are not marketed as addictive or abusive. Often, ministries categorize drugs as controlled addicts and non-addictive. For example, this classification is H and X in India and II and V in the USA. Please check the box to make sure the drug belongs to such a special classification. Finally, do not try to self-medicate and increase your body's dependence without the advice of a doctor.
Can I stop using this product right away or do I get rid of it gradually?
Some drugs should be tapered or their use should not be stopped suddenly to avoid withdrawal effects. Consult your doctor for advice specific to your body and health condition and other medications you can use.
Other important information about Polisorbat 20 / Polysorbate in Turkish
Forgetting to take a dose
If you forget to take a dose, use it immediately. If your next dose is too close to your time, stop taking the missed dose and stick to your dosing schedule. Do not take extra doses to treat the missed dose. If you regularly forget your doses, set an alarm or ask a family member to remind you. Please consult your doctor to make changes to your dosing schedule or to make up for missed doses if you have recently forgotten too many doses.
Polisorbat 20 / Polysorbate in Turkish
Do not use more than prescribed dose. Consuming more of the drug will not improve your symptoms; on the contrary, it can cause poisoning or serious side effects. If you suspect that you or a relative has used an overdose of Polysorbate 20 / Polysorbate in Turkish, please visit the emergency department of the nearest hospital. To help doctors, bring necessary information such as a medicine box, bottle, or label.
Do not give your medication to someone else, even if you know they have the same condition or they appear to be in similar situations. This can cause an overdoselyre.
For more information, consult your pharmacist or check the package insert.
Storage of Polysorbate 20 / Polysorbate in Turkish
Store medicines at room temperature, away from heat and light. Do not freeze medicines unless it is written on the package insert. Keep medicines out of the reach of children and pets.
Do not pour medicines into the toilet or sink unless you are told to do so in the package insert. Drugs disposed in this way can pollute the nature. Please consult your pharmacist or doctor for more details on how to safely discard Polisorbate 20 / Polysorbate in Turkish.
Expired Polysorbate 20 / Polysorbate in Turkish
Using a single dose of expired Polysorbate 20 / Polysorbate in Turkish is likely to cause an adverse event. Consult your family doctor or pharmacist for appropriate advice or if you feel unwell. Expired drugs will not be effective in treating the conditions on your prescription. In order to stay safe, it is very important not to use expired medications. If you have a chronic illness that requires constant medication, such as heart disease, seizures, and life-threatening allergies, it is even more important to stay in touch with your GP so that you can replace expired medications immediately.

Polysorbate 20
From Wikipedia, the free encyclopedia
Jump to navigationJump to search
Polysorbate 20
Polysorbate 20
Names
IUPAC name
Polyoxyethylene (20) sorbitan monolaurate
Other names
Montanox 20
Polysorbate 20
PEG(20)sorbitan monolaurate
Alkest TW 20
Tween 20
Identifiers
CAS Number    
9005-64-5 check
ChemSpider    
none
ECHA InfoCard    100.105.528 Edit this at Wikidata
E number    E432 (thickeners, ...)
RTECS number    
TR7400000
CompTox Dashboard (EPA)    
DTXSID3031949 Edit this at Wikidata
Properties
Chemical formula    C58H114O26
Molar mass    1227.54 g/mol
Appearance    Clear, yellow to yellow-green viscous liquid.
Density    1.1 g/mL (approximate)
Boiling point    > 100 °C (212 °F; 373 K)
Surface tension:
CMC    8.04×10−5 M at 21 °C[1]
HLB    16.7[1]
Hazards
Main hazards    Irritant
Safety data sheet    External MSDS
NFPA 704 (fire diamond)    
NFPA 704 four-colored diamond
1
Flash point    110 °C (230 °F; 383 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
☒ verify (what is check☒ ?)
Infobox references
Polysorbate 20 (common commercial brand names include Scattics, Alkest TW 20 and Tween 20) is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan before the addition of lauric acid. Its stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications. As the name implies the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.[2]

Contents
1    Food applications
2    Biotechnical applications
3    Pharmaceutical applications
4    Industrial and domestic applications
5    See also
6    References
7    External links
Food applications
Polysorbate 20 is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.

The World Health Organization has suggested acceptable daily intake limits of 0–25 mg of polyoxyethylene sorbitan esters per kg body weight.[3]

Biotechnical applications
In biological techniques and sciences, polysorbate 20 has a broad range of applications. For example, it is used:

as a washing agent in immunoassays, such as Western blots and ELISAs. It helps to prevent non-specific antibody binding. In this major application, it is dissolved in Tris-buffered saline or phosphate buffered saline at dilutions of 0.05% to 0.5% v/v. These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.
to saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).
to stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosis exposure
as a solubilizing agent of membrane proteins
for lysing mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.
Pharmaceutical applications
Polysorbate 20 is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.

Industrial and domestic applications
Polysorbate 20 is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.

Polysorbate 20 is also used as wetting agent in rubber balers in the elastomer industry.

Polysorbate 20 has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies.[4]

Work by Kiese et al. in 2008 looked at comparing aggregate formation caused by stirring and shaking, with and without the presence of polysorbate 20, and the effect of fill volumes (varying headspace) on protein stability during shaking, also with and without polysorbate 20 [42]. It was found that the two different types of stress probably resulted in different mechanisms of aggregation. In the absence of polysorbate 20, stirring was shown to be a very high stress method, producing highly turbid samples with large, visible protein aggregates. Intermediate, smaller, soluble aggregates did not increase – presumably as they were short lived in solution [42]. Stirring stress could have been a result of:
The most commonly used surfactants are polysorbate 20 and 80. These surfactants may contain peroxides, which can oxidize amino acid residues that are prone to oxidation (Kishore, Kiese, et al., 2011; Kishore, Pappenberger, et al., 2011). Commercial sources of peroxide-free polysorbates are available, but need to be handled and stored properly (Ha, Wang, & Wang, 2002). In particular, incubation of polysorbate 80 in air at high temperatures promotes peroxide formation, and removal of oxygen is recommended for long-term storage. The oxidation induced by peroxides as a result of polysorbate 20 degradation can be inhibited by antioxidants as shown in a study using an IgG1 mAb Fab (Lam, Lai, Chan, Ling, & Hsu, 2011). In this study, it was shown that a Trp residue was oxidized as a result of the presence of increased levels of peroxide in polysorbate 20, and the decomposition of the polysorbate-involved free radicals.
whereas polysorbate 20 contained fewer degradation products than found in polysorbate 80 (Gilardi-Lorenz, 2006). Many of these impurities found in polysorbate 80 were not found in polysorbate 20, and thus polysorbate 20 may be the preferred surfactant for protein formulations.

Polysorbate 20
Polysorbate 20 is a surfactant and emulsifier used in cleaning and personal care products. It is an excellent solvent for essential oils, but also used as a wetting agent, viscosity stabilizer and dispersant.

INCI Name: Polysorbate 20
Other name: POE (20) Sorbitan laurate
Appearance: Light golden liquid
Applications: Creams, ointments or pomades, balms, lipsticks, mascaras, air freshener, body spray ..
HLB: 16.7

Polisorbat 20 / Polysorbate in Turkish
Medicine Polisorbat 20 / Polysorbate in Turkish
Overview Uses Side effects Precautions Interactions Contraindications
Overview
Polysorbate 20 / Polysorbate in Turkish is used for Emulsifier, Dispersing agent and other conditions.
Detailed information regarding the use of Polysorbate 20 / Polysorbate in Turkish, side effects, product comments, questions, interactions and precautions are as follows:
uses
Polysorbate 20 / Polysorbate in Turkish is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
Emulsifier
Dispersant
Further information: Uses
Side effects
The following is a list of possible side-effects that may occur in medicines that contain Polysorbate 20 / Polysorbate in Turkish. This is not an exhaustive list. These side effects are likely to occur, but do not always occur. Some of the side effects are rare but can be very serious. Be sure to consult your doctor if you observe any of the following side effects, especially those that do not go away even if you expect them to.
Eye irritation
If you notice any side effects other than those listed below, consult your doctor for medical advice. You can also report side effects to your nearest health ministry official.
Measures
Please consult your doctor or pharmacist or refer to the package insert for this information.
Please consult your doctor or pharmacist or refer to the package insert for this information.
Please consult your doctor or pharmacist or refer to the package insert for this information.
Frequently Asked Questions
Is it safe to drive or use heavy machinery while using this product?
If you experience drowsiness, dizziness, hypotension (low blood pressure) or headache while using Polysorbate 20, it may not be safe to drive and / or use a construction machine. If the medication used causes drowsiness, dizziness or lowers your blood pressure, you should not drive. In addition, pharmacists advise patients not to drink alcohol with the drug, as alcohol intensifies side effects such as drowsiness. Please check for these effects on your body when using Polysorbate 20 / Polysorbate in Turkish. Always consult your doctor for advice specific to your body and health condition.
Is this drug or product addictive or addictive?
Many drugs are not marketed as addictive or abusive. Often, ministries categorize drugs as controlled addicts and non-addictive. For example, this classification is H and X in India and II and V in the USA. Please check the box to make sure the drug belongs to such a special classification. Finally, do not try to self-medicate and increase your body's dependence without the advice of a doctor.
Can I stop using this product right away or do I get rid of it gradually?
Some drugs should be tapered or their use should not be stopped suddenly to avoid withdrawal effects. Consult your doctor for advice specific to your body and health condition and other medications you can use.
Other important information about Polisorbat 20 / Polysorbate in Turkish
Forgetting to take a dose
If you forget to take a dose, use it immediately. If your next dose is too close to your time, stop taking the missed dose and stick to your dosing schedule. Do not take extra doses to treat the missed dose. If you regularly forget your doses, set an alarm or ask a family member to remind you. Please consult your doctor to make changes to your dosing schedule or to make up for missed doses if you have recently forgotten too many doses.
Polisorbat 20 / Polysorbate in Turkish
Do not use more than prescribed dose. Consuming more of the drug will not improve your symptoms; on the contrary, it can cause poisoning or serious side effects. If you suspect that you or a relative has used an overdose of Polysorbate 20 / Polysorbate in Turkish, please visit the emergency department of the nearest hospital. To help doctors, bring necessary information such as a medicine box, bottle, or label.
Do not give your medication to someone else, even if you know they have the same condition or they appear to be in similar situations. This can cause an overdoselyre.
For more information, consult your pharmacist or check the package insert.
Storage of Polysorbate 20 / Polysorbate in Turkish
Store medicines at room temperature, away from heat and light. Do not freeze medicines unless it is written on the package insert. Keep medicines out of the reach of children and pets.
Do not pour medicines into the toilet or sink unless you are told to do so in the package insert. Drugs disposed in this way can pollute the nature. Please consult your pharmacist or doctor for more details on how to safely discard Polisorbate 20 / Polysorbate in Turkish.
Expired Polysorbate 20 / Polysorbate in Turkish
Using a single dose of expired Polysorbate 20 / Polysorbate in Turkish is likely to cause an adverse event. Consult your family doctor or pharmacist for appropriate advice or if you feel unwell. Expired drugs will not be effective in treating the conditions on your prescription. In order to stay safe, it is very important not to use expired medications. If you have a chronic illness that requires constant medication, such as heart disease, seizures, and life-threatening allergies, it is even more important to stay in touch with your GP so that you can replace expired medications immediately.