PRODUCTS

POLYSORBATE 65 (E 436)

Pharmaceuticals: Polysorbate 65 (E 436) is used as a solubilizer and stabilizer in certain drug formulations.
Polysorbate 65 (E 436) is used ice cream, frozen custard, cake icings and fillings.
Food Additive (E 436) uses of Polysorbate 65 (E 436): Emulsifier and stabilizer in margarine, baked goods, and confectioneries.

CAS Number: 9005-71-4
EC Number: 500-020-4
MDL number: MFCD00165348
Chemical name: Polyoxyethylene (20) sorbitan tristearate
Molecular Formula: C100H194O28

SYNONYMS:
Polysorbate 65, E 436, Sorbitan Tristearate Polyoxyethylene, Polyoxyethylene (20) Sorbitan Tristearate, PEG-20 Sorbitan Tristearate, Tween 65, Ethoxylated Sorbitan Tristearate, POE Sorbitan Tristearate, Polyethylene Glycol Sorbitan Tristearate, Ahco 7166T, E 436, Emsorb 6907, Ethoxylated sorbitan tristearate, Glycosperse TS 20, Komul NP 4, Liposorb TS 20, Montanox 65, Nikkol TS 30, POE sorbitan tristearate, Poly(oxyethylene) sorbitan tristearate, Polyethylene glycol sorbitan ether tristearate, Polyethylene glycol sorbitan tristearate, Polyethylene glycol sorbitan tristearate ether, Polyoxyethylene 20 sorbitan tristearate, Polysorbate 65, Rheodol TW-S 320, Rheodol TW-S 320V, Sorbimacrogol tristearate 300, Sorgen TW 65, T 65, T-MAZ 65K, TS 30V, Tween 65 (trade name), Polyoxyethylene (20) sorbitan tristearate (IUPAC), E 436, 9005-71-4, E-436, INS NO.436, INS-436, JEESORB STS-20, LIPOSORB TS-20, NIKKOL TS-30, PEG-20 SORBITAN TRISTEARATE, POLYOXYETHYLENE (20) SORBITAN TRISTEARATE, POLYSORBATE 65 [FCC], POLYSORBATE 65 [II], POLYSORBATE 65 [USAN], SORBAX PTS-20, TWEEN 65, Polysorbate 65, Tween 65, 14BGY2Y3MJ, Peg-20 sorbitan tristearate, Polyoxyethylene (20) sorbitan tristearate, DTXSID30891988, E-436, Emsorb 6907, Glycosperse TS 20, INS NO.436, INS-436, JEESORB STS-20, LIPOSORB TS-20, NIKKOL TS-30, POLYSORBATE 65 (II), Peg sorbitan tristearate, SORBAX PTS-20, Sorbimacrogol tristearate 300, Sorbitan, tristearate, polyoxyethylene derivs., UNII-14BGY2Y3MJ, glycosperse TS-20 KFG, hetsorb TS-20, liposorb TS-20, lonzest STS-20, nikkol TS-30V, poe-20 sorbitan tristearate, polyethyleneglycol sorbitan tristearate, polyoxyethylene (20) sorbitan tristearate, rheodol TW-S320V, tween 65, POLYSORBATE 65, PEG-20 SORBITAN TRISTEARATE, PEG SORBITAN TRISTEARATE, SORBITAN, TRIOCTADECANOATE, POLY(OXY-1,2-ETHANEDIYL) DERIVS., SORBITAN, TRISTEARATE, POLYOXYETHYLENE DERIVS., POLYOXYETHYLENE SORBITAN TRISTEARATE, POLYOXYETHYLENE (20) SORBITAN TRISTEARATE, Polysorbate 65, Sorbimacrogol tristearate 300, Sorbitan, trioctadecanoate, poly (oxy-1,2-ethanediyl) derivs., PEG-20 sorbitan tristearate, POE (20) sorbitan tristearate

Polysorbate 65 (E 436) is an emulsifier used in food applications to stabilize emulsions and improve texture.
Polysorbate 65 (E 436) is created from sorbitan and ethylene oxide, allowing it to effectively blend oil and water.
Polysorbate 65 (E 436) is a light yellow and viscous paste emulsifier known with the food code E 436.

Polysorbate 65 (E 436)'s emulsifying properties also make it useful in cosmetics and pharmaceutical formulations.
Polysorbate 65 (E 436) is often used in baked goods, dairy products, and confections, where it helps prevent ingredient separation and contributes to a consistent texture.

Polysorbate 65 (E 436) is a surfactant that is used as an emulsifier and wetting agent , for example in food.
Polysorbate 65 (E 436), also known as designated as E 436 in the European Union, is a non-ionic surfactant derived from sorbitol, stearic acid, and ethylene oxide.

Polysorbate 65 (E 436) appears as a creamy-white to tan waxy solid or viscous liquid.
Polysorbate 65 (E 436)'s hydrophilic (water-loving) nature comes from the polyoxyethylene groups, while the lipophilic (fat-loving) nature comes from the stearate portion.

This amphiphilic property allows Polysorbate 65 (E 436) to act as an emulsifier, stabilizer, and dispersing agent in various food and industrial applications.
Polysorbate 65 (E 436), also known as PEG 65 and Polyoxyethylene Sorbitan Tristearate, is a polyoxyethylene derivative of sorbitol, ethylene oxide as a petroleum derivative and stearic acid.

Polysorbate 65 (E 436) is a synthetic compound produced from ethylene oxide (a synthetic compound), sorbitol (420) and stearic acid (a natural fatty acid).
Polysorbate 65 (E 436) is an emulsifier derived from animal fatty acids, and natural oils and used as synthetic flavourings, surfactants, de foaming agents, and dough conditioners.

Polysorbate 65 (E 436) may increase the absorption of fat-soluble substances.
Polysorbate 65 (E 436) is a light yellow and viscous paste emulsifier known with the food code E 436.
Polysorbate 65 (E 436) is also regarded as a detergent.

Polysorbate 65 (E 436) is also used as a stabilizer and wetting agent etc.
Polysorbate 65 (E 436) is a surfactant that is used as an emulsifier and wetting agent , for example in food.
Polysorbate 65 (E 436) is an emulsifier used in food applications to stabilize emulsions and improve texture.

Polysorbate 65 (E 436) is a surfactant that is used as an emulsifier and wetting agent , for example in food.
Polysorbate 65 (E 436) is approved in the EU as a food additive with the number E 436 for certain foods in quantities of up to five grams per kilogram or in baking fats up to ten grams per kilogram.

The permitted daily dose is 10 milligrams per kilogram of body weight for all polysorbates combined.
Polysorbate 65 (E 436) is a mixture of stearate esters of sorbitol and sorbitol anhydrides, with 20 moles EO.
The Tween-65 emulsifier is also known as Polysorbate 65 (E 436).

Polysorbate 65 (E 436), the full name polyoxyethylene (20) sorbitan tristearate.
Three stearic acids are in its molecule structure, while polysorbate-60 only has one.
Polysorbate 65 (E 436) is unnatural as it is made from the chemical synthesis of sorbitan fatty acid and ethylene oxide.

USES and APPLICATIONS of POLYSORBATE 65 (E 436):
Polysorbate 65 (E 436) is approved in the EU as a food additive with the number E 436 for certain foods in quantities of up to five grams per kilogram or in baking fats up to ten grams per kilogram.
The permitted daily dose is 10 milligrams per kilogram of body weight for all polysorbates combined.

Polysorbate 65 (E 436)'s usage levels are regulated and must adhere to specific limits defined by EFSA regulations.
Industrial Uses of Polysorbate 65 (E 436): Beyond food applications, Polysorbate 65 (E 436) finds use in various industrial settings, including:
Cosmetics and Personal Care Products: Polysorbate 65 (E 436) acts as an emulsifier, solubilizer, and dispersing agent in creams, lotions, and shampoos.

Pharmaceuticals: Polysorbate 65 (E 436) is used as a solubilizer and stabilizer in certain drug formulations.
Textile Industry: Polysorbate 65 (E 436) is employed as a wetting agent and emulsifier in textile processing.
Polysorbate 65 (E 436) is used ice cream, frozen custard, cake icings and fillings.

Food Additive (E 436) uses of Polysorbate 65 (E 436): Emulsifier and stabilizer in margarine, baked goods, and confectioneries.
Cosmetic Applications: Polysorbate 65 (E 436) is used in lotions, creams, and hair care products for emulsifying and stabilizing.
Pharmaceuticals: Polysorbate 65 (E 436) helps in drug solubilization and emulsion stabilization.

Industrial Applications: Polysorbate 65 (E 436) enhances emulsification in oil and water systems.
Polysorbate 65 (E 436) has synthetic food additive with emulsifying and flavoring role.
Polysorbate 65 (E 436) is also used as a solvent for other food additives.

Polysorbate 65 (E 436) is used in fine bakery products, sauces, desserts, confectioneries, fat emulsions for pastry, instant soups, ice, dietetic foods for body weight control.
Polysorbate 65 (E 436) is not recommended for vegetarians, because it can come from animal fats.

Polysorbate 65 (E 436) is used in many different products.
Polysorbate 65 (E 436) is used as an emulsifier in cosmetics, detergents and many other industrial areas, especially in the food sector.
Polysorbate 65 (E 436), as in all emulsifiers, is an additive that creates oil-water phases or water-oil phases and provides emulsion in these products.

Polysorbate 65 (E 436) can be used in different proportions in the production of products such as food mayonnaise, sauces, cream oils, beer, malt.
Polysorbate 65 (E 436) is used as an emulsifier, stabiliser in a large range of foods including chewing gum, ice cream, soft drinks, bakery products, frozen desserts, imitation dairy products, emulsified sauces and soups.

Polysorbate 65 (E 436) is also used in a wide range of detergents, pharmaceuticals and beauty and skin products.
These compounds (E430-E436) contain fatty acids, which are nearly always from vegetable oils; however, use of animal fat (including pork) cannot be fully ruled out.

Polysorbate 65 (E 436) is used as an emulsifier in medicine, food, textiles, and cosmetics.
Polysorbate 65 (E 436) is also used as a stabilizer and wetting agent etc.
Polysorbate 65 (E 436) is a surfactant that is used as an emulsifier and wetting agent , for example in food.

Polysorbate 65 (E 436) is often used in baked goods, dairy products, and confections, where it helps prevent ingredient separation and contributes to a consistent texture.
Its emulsifying properties also make Polysorbate 65 (E 436) useful in cosmetics and pharmaceutical formulations.

Polysorbate 65 (E 436) uses and applications include: Surfactant, ow emulsifier, solubilizer, wetting agent in agriculture, cosmetics, pharmaceuticals, leather, metalworking, textiles, polymerization, paints, pulppaper; emulsifier, dispersant for foods; emulsifier for food processing, food packaging; softener, lubricant, antistat for textiles; thickener, lubricant for cosmetics; corrosion inhibitor ; diluent in pharmaceutical colorants

The World Health Organization has evaluated the acceptable daily intake of polysorbate 20, 40, 60, 65, and 80.
Calculated on the basis of total polysorbate, the daily intake can be as high as 25mg per kilogram of body weight.
The marketed topical emulsion, the maximum dosage in the cream is 6.00%.

Polysorbate 65 (E 436) is hydrophilic nonionic surfactants widely used as emulsifiers for stable oil-in-water pharmaceutical emulsions.
Polysorbate 65 (E 436) is also used as a stabilizer and wetting agent etc.

Polysorbate 65 (E 436) is also used as solubilizers for various substances, including essential oils and oil-soluble vitamins, and as wetting agents for oral or parenteral suspensions.
Polysorbate 65 (E 436) has been found to help increase the oral bioavailability of drug molecules that are substrates of p-glycoprotein.

FOOD USES OF POLYSORBATE 65 (E 436):
According to EFSA, Polysorbate 65 (E 436) is permitted as a food additive in certain categories and levels within the EU.
Polysorbate 65 (E 436) is primarily used as an emulsifier to blend oil and water phases, preventing separation and creating a stable, homogenous mixture.

This is particularly important in products like:
*Baked Goods:
Polysorbate 65 (E 436) improves texture and volume.

*Sauces and Dressings:
Polysorbate 65 (E 436) creates a smooth, creamy consistency.

*Ice Cream and Frozen Desserts:
Polysorbate 65 (E 436) enhances texture and prevents ice crystal formation.

*Fat-Based Spreads:
Polysorbate 65 (E 436) stabilizes emulsions.

*Certain Flavourings:
Polysorbate 65 (E 436) acts as a solubilizer and carrier.

BENEFICIAL PROPERTIES OF POLYSORBATE 65 (E 436) IN FOOD APPLICATIONS:
In food, polysorbate 65 contributes to several desirable qualities:

*Improved texture and mouthfeel:
Polysorbate 65 (E 436) creates smoother, creamier consistencies.

*Enhanced stability:
Polysorbate 65 (E 436) prevents separation of oil and water phases, extending shelf life.

*Increased volume and aeration:
In baked goods, contributes to a lighter, airier texture.

*Improved dispersion of ingredients:
Polysorbate 65 (E 436) helps distribute ingredients evenly throughout the product.

These benefits contribute to the overall quality and acceptability of food products.

PRODUCTION PROCESS OF POLYSORBATE 65 (E 436):
Polysorbate 65 (E 436) is produced by the esterification of sorbitol with stearic acid, followed by ethoxylation with ethylene oxide.
The degree of ethoxylation determines the specific properties of the final product.

The process is carefully controlled to achieve the desired hydrophilic-lipophilic balance (HLB) value, which influences Polysorbate 65 (E 436)'s functionality.
Manufacturers must adhere to strict quality control measures to ensure the final product meets required purity and safety standards.

CLASS OF POLYSORBATE 65 (E 436):
*Emulsifiers,
*Stabilisers,
*Thickeners
*Gelling Agents

PRODUCTION OF POLYSORBATE 65 (E 436):
Polysorbate 65 (E 436) is produced by reacting an anhydride of sorbitol (a so-called sorbitan – 1,4-sorbitan anhydride; for the structural formula see sorbitan fatty acid ester ) with ethylene oxide and subsequent esterification with stearic acid

CHARACTERISTICS OF POLYSORBATE 65 (E 436):
Polysorbate 65 (E 436) is a synthetic surfactant that has an HLB value of 10.5 and is therefore suitable for the production of water-in-oil emulsions .
Polysorbate 65 (E 436) is biodegradable.

ORIGIN OF POLYSORBATE 65 (E 436):
Polysorbate 65 (E 436) is a synthetic compound, produced from ethylene oxide (a synthetic compound), sorbitol (see E420) and stearic acid (a natural fatty acid).

FUNCTION OF POLYSORBATE 65 (E 436):
*Emulsifier,
*anti-foaming agent, etc.

BENEFITS OF POLYSORBATE 65 (E 436):
*Polysorbate 65 (E 436) improves texture and consistency in food, cosmetics, and pharmaceutical formulations.
*Polysorbate 65 (E 436) extends the shelf life of emulsions.
*Polysorbate 65 (E 436) erovides smooth and homogenous mixtures.
*Safe for consumption and topical use in regulated amounts.

PROPERTIES OF POLYSORBATE 65 (E 436):
*Non-ionic surfactant with excellent emulsifying and dispersing properties.
*Polysorbate 65 (E 436) provides stability to emulsions and suspensions under various pH and temperature conditions.
*Compatible with other surfactants and additives.

FUNCTION AND PROPERTIES OF POLYSORBATE 65 (E 436):
*Emulsifier,
*anti-foaming, etc.

PROPERTIES OF POLYSORBATE 65 (E 436):
Polysorbate 65 (E 436) is a yellow-waxy solid.
Polysorbate 65 (E 436) is an oily liquid derived from PEG-ylated sorbitan (a derivative of sorbitol) esterified with fatty acids.
Polysorbate 65 (E 436) is soluble in ethanol, isopropanol, and mineral oil.
HLB value of Polysorbate 65 (E 436) is 10.5.

INDUSTRY OF POLYSORBATE 65 (E 436):
*Cosmetic ,
*Pharmaceutical ,
*Textiles

FUNCTIONS OF POLYSORBATE 65 (E 436):
*Surfactant ,
*Emulsifier ,
*Dispersant ,
*Lubricant

STABILITY AND STORAGE CONDITIONS OF POLYSORBATE 65 (E 436):
Polysorbate 65 (E 436) is stable to electrolytes, weak acids and weak bases; it will gradually saponify in case of strong acids and strong bases.
Polysorbate 65 (E 436)'s oleate is susceptible to oxidation.

Polysorbate 65 (E 436) is hygroscopic, check its moisture content before use, and dry if necessary.
Polysorbate 65 (E 436), like other polyoxyethylene surfactants, will produce peroxides when stored for too long.
Polysorbate 65 (E 436) should be stored in a sealed container, away from light, in a cool and dry place.

SOURCE AND PREPARATION OF POLYSORBATE 65 (E 436):
Polysorbate 65 (E 436) is a polyoxyethylene ether of tristearate produced by esterifying the hydroxyl group of dehydrated sorbitol with stearic acid.

Polysorbate 65 (E 436) is prepared from pear (sugar) alcohol through a three-step reaction.
First, sorbitol is dehydrated to form sorbitan (cyclic sorbitan); sorbitan is esterified with fatty acids, such as oleic acid or stearic acid, to form hexose esters; finally, Polysorbate 65 (E 436) reacts with ethylene oxide under the action of a catalyst Generate polysorbate.

PHYSICAL and CHEMICAL PROPERTIES of POLYSORBATE 65 (E 436):
EC Number: 500-022-1
CAS Number: 9005-71-4
Molecular Formula: C100H194O28
Molecular Weight: Approximately 1475 g/mol
Appearance: Yellowish, viscous liquid or soft paste
Density: ~1.1 g/cm³ at 25°C
Solubility: Soluble in water and ethanol; forms stable emulsions
Melting Point: Semi-solid at room temperature
Boiling Point: Decomposes before boiling
Flash Point: >149°C (300°F)
Hydrophilic-Lipophilic Balance (HLB): 10.5
CAS Number: 9005-71-4
Other(deleted CASRN): 9015-61-6

FDA UNII: 14BGY2Y3MJ
MDL: MFCD00165348
Molecular Weight: 1844.62378000
Formula: C100 H194 O28
Molecular Formula: C100H194O28
Molecular Weight: 1844.55
Grade: Pharmaceutical Excipients
Description: The product is an amber oily viscous liquid.
Chemical Name: Polyoxyethylene 20 sorbitan monolaurate
CAS Number: 9005-71-4
Appearance: Amber to light yellow oily liquid
Acid value: 2 mg KOH/g Max.
Saponification value: 45-55 mg KOH/g
Hydroxyl value: 65-80 mg KOH/g
Water: 3.0% Max.

FIRST AID MEASURES of POLYSORBATE 65 (E 436):
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of POLYSORBATE 65 (E 436):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of POLYSORBATE 65 (E 436):
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of POLYSORBATE 65 (E 436):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of POLYSORBATE 65 (E 436):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of POLYSORBATE 65 (E 436):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available