PRODUCTS

POLYSORBATE 65

CAS NUMBER: 9005-71-4

EC NUMBER: 500-020-4

MOLECULAR FORMULA: C32H62O10

MOLECULAR WEIGHT: 606.8

IUPAC NAME: 2-{2-[(2R,3R)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate

Like other polysorbates, the number 65 after polysorbate means the type of fatty acid, here is monostearate; the number 20 following polyoxyethylene indicates the total number of oxyethylene groups in the molecule structure.
Polysorbate 65 is Soluble in water

Polysorbate 65 is insoluble in mineral oil and vegetable oils.
Polysorbate 65 is Soluble in ethyl acetate and toluene.

Polysorbate 65 or tween 65, the full name polyoxyethylene (20) sorbitan monostearate, is an ingredient made from sorbitol, stearic acid (C18) and ethylene oxide.
Polysorbate 65 is primarily used as an emulsifier in food (the European food additive number E435) and a solubilizer & surfactant in cosmetics.
Like other polysorbates, the number 60 after polysorbate means the type of fatty acid, here is monostearate; the number 20 following polyoxyethylene indicates the total number of oxyethylene groups in the molecule structure.

Alternative Classes:
-Tetrahydrofurans
-Carboxylic acid esters
-Carboxylic acid derivatives in which the carbon atom from the carbonyl group is attached to an alkyl or an aryl moiety through an oxygen atom (forming an ester group).
-Oxacyclic compounds
-Monocarboxylic acids and derivatives
-Dialkyl ethers
-Primary alcohols
-Organic oxides
-Hydrocarbon derivatives
-Carbonyl compounds

How is Polysorbate 65 made?
According to the FDA, Polysorbate 65 is manufactured by reacting stearic acid with sorbitol to obtain sorbitan monostearate first and then condensed with ethylene oxide. (1)

What is Polysorbate 65 made of?
As the commercial food grade stearic acid usually contains palmitic acid, so Polysorbate 65 is a mixture of ethoxylated ethers of stearic and palmitic acid esters of sorbitol and its mono- and dianhydrides and other related compounds.

Specification:
Other Names: Tween 65
CAS Number: 9005-71-4
Chemical formula: C64H126O26
Molecular Weight: 1312
Properties:
Appearance:
A lemon to orange-coloured oily liquid or semi-gel at 25°C. (2)

Structure:
Polysorbate 65 chemical structure

Hydrophilic groups: long polyoxyethylene groups
Lipophilic group: stearic acid

Polysorbate 65 is more lipophilic than polysorbate 20 and 40 due to the long length of the fatty acids – stearic acid, compared with other fatty acids, lauric acid (C14) and palmitic acid (C16) that linked to the polyoxyethylene sorbitan part of the molecule, respectively.

Solubility:
Soluble in water, insoluble in mineral oil and vegetable oils.
Soluble in ethyl acetate and toluene.

What’re the Uses of Polysorbate 65?
Polysorbate 65 is a synthetic multi-ingredient that can be used as:
-a surfactant
-emulsifier
-solubilizer
-stabilizer in food
-cosmetics
-personal care products

Food:
Polysorbate 65 helps water-based and oil-based ingredients blend easily and prevent their separation in food.
Polysorbate 65 and 80 are mostly used in food among the category of polysorbates, but the latter is used more than 60 in food.

Cosmetics:
Polysorbate 65's general purpose in cosmetics is to mix water and oil together.
Polysorbate 65 functions as a surfactant, emulsifier, solubilizer and dispersing agent.

Some of Polysorbate 65's applications as follows:
Polysorbate 65 Helps wash away body dirties by lowering the surface tension on the skin when used in shampoos and body washes.

Distribute essential oils, fragrances and colorants evenly in water.
Following cosmetic products may with it:
-Lotions

-Creams

-Hair products

-Skin care products

-Makeup products

Polysorbate 65 is a mixture of stearate esters of sorbitol and sorbitol anhydrides
Polysorbate 65 or Tween 65 is the abbreviation of “polyoxyethylene (20) sorbitan”.

Polysorbate 65 is a surfactant type polysorbate whose stability and relative non-toxicity allow it to be used as a detergent and emulsifier in the food, industrial, cosmetic, and pharmaceutical industries.
Uses:
-Food Additive

-Ice Cream

-Soft Drinks

-Cakes

-Puddings

-Desserts

-Confectionery

-Detergent

-Emulsifier

-Wetting Agent

-Pharmaceutical

Polysorbate 65, also known as polyoxyethylene (20) sorbitan tristearate, consists of sorbitol, ethylene oxide, and stearic acid.
Polysorbate 65 is used in a variety of products including skin fresheners, skin care products, skin cleansing products, makeup bases and foundations, shampoos, permanent waves and fragrance powders.

The Polysorbate ingredients help other ingredients to dissolve in a solvent in which they would not normally dissolve.
They also help to form emulsions by reducing the surface tension of the substances to be emulsified.

Substituents:
-Fatty acid ester
-Tetrahydrofuran
-Carboxylic acid ester
-Carboxylic acid derivative
-Dialkyl ether
-Ether
-Monocarboxylic acid or derivatives
-Organoheterocyclic compound
-Oxacycle
-Organic oxide
-Carbonyl group
-Alcohol
-Organooxygen compound
-Primary alcohol
-Hydrocarbon derivative
-Organic oxygen compound
-Aliphatic heteromonocyclic compound

Polysorbate 65 is surfactants that are produced by reacting the polyol, sorbitol, with ethylene oxide.
The number in the name of the Polysorbate indicates the average number of moles of ethylene oxide that has been reacted per mole of sorbitol.

The polyoxyethylenated sorbitan is then reacted with fatty acids obtained from vegetable fats and oils such as lauric acid, palmitic acid, stearic acid and oleic acid.
Polysorbate 65 is function to disperse oil in water as opposed to water in oil

Polysorbate 65 is a synthetically produced emulsifier and dispersing agent used to carry flavors and colors in foods.
Polysorbate 65 is considered safe and has no adverse effects reported at the levels present in food.

Polysorbate 65 may aggravate propylene glycol sensitivity.

Applications:
-Emulsifier for pharmaceuticals and cosmetics

-Stabilizer for color materials

-Stabilizer for emulsion polymerizations

-Emulsifier for adjuvant of agrochemicals

-Emulsifier for water based metal process cutting oils

-Surface coating type antistatic agents

Polysorbate 65 is a class of emulsifiers used in some pharmaceuticals and food preparation.
Polysorbate 65 is often used in cosmetics to solubilize essential oils into water-based products.
Polysorbate 65 is oily liquids derived from ethoxylated sorbitan

Chemical Properties:
-waxy solid
-faint odor
-bitter taste
-Soluble in mineral oil, vegetable oil, mineral spirits, acetone, ether, dioxane, alc, methanol; dispersible in water, carbon tetrachloride.

Polysorbate 65 is a mid-range HLB, nonionic surfactant suggested for use in textile chemicals (lubricant, emulsifier), household products (o/w emulsifier) and cosmetic formulations (o/w emulsifier).
Polysorbate 65 is used as an emulsifier. Suggested applications: ice cream, cakes and cake icings

Polysorbate 65 is an emulsifier manufactured by reacting stearic acid with sorbitol to yield a product which is then reacted with ethylene oxide.
Polysorbate 65 is a nonionic surfaceactive agent which is dispersible in fat, oil, and water.

Polysorbate 65 is also termed polysorbate 65.
Polysorbate 65 is used in frozen desserts, cakes, and coffee whiteners.
Polysorbate 65 is frequently used with sorbitan monostearates or monoand diglycerides

PHYSICAL PROPERTIES:

-Molecular Weight: 606.8

-XLogP3-AA: 5.8

-Exact Mass: 606.43429817

-Monoisotopic Mass: 606.43429817

-Topological Polar Surface Area: 133 Å²

-Water Solubility: 0.018 g/L

-logP: 2.75

-logP: 2.39

-logS: -4.5

-pKa (Strongest Acidic): 14.64

-pKa (Strongest Basic): -2.7

-Physiological Charge: 0

-Hydrogen Acceptor Count: 9

-Hydrogen Donor Count: 3

-Polar Surface Area: 133.14 Å²

Polysorbate 65 is Soluble in water
Polysorbate 65 is insoluble in mineral oil and vegetable oils.
Polysorbate 65 is Soluble in ethyl acetate and toluene.

CHEMICAL PROPERTIES:

-Hydrogen Bond Donor Count: 3

-Hydrogen Bond Acceptor Count: 10

-Rotatable Bond Count: 32

-Heavy Atom Count: 42

-Formal Charge: 0

-Complexity: 594

-Isotope Atom Count: 0

-Defined Atom Stereocenter Count: 4

-Undefined Atom Stereocenter Count: 0

-Defined Bond Stereocenter Count: 0

-Undefined Bond Stereocenter Count: 0

-Covalently-Bonded Unit Count: 1

-Compound Is Canonicalized: Yes

-Rotatable Bond Count: 26

-Refractivity: 134.25 m³·mol⁻¹

-Polarizability: 60.16 Å³

Polysorbate 65 is a class of emulsifiers used in some pharmaceuticals and food preparation.
Polysorbate 65 is often used in cosmetics to solubilize essential oils into water-based products.

Polysorbate 65 is oily liquids derived from ethoxylated sorbitan
Polysorbate 65 is an emulsifier manufactured by reacting stearic acid with sorbitol to yield a product which is then reacted with ethylene oxide.

Polysorbate 65 is a nonionic surfaceactive agent which is dispersible in fat, oil, and water.
Polysorbate 65 is also termed polysorbate 65.

Polysorbate 65 is used in frozen desserts, cakes, and coffee whiteners.
Polysorbate 65 is frequently used with sorbitan monostearates or monoand diglycerides

SYNONYMS:

glycosperse TS-20 KFG
hetsorb TS-20
liposorb TS-20
lonzest STS-20
nikkol TS-30V
poe-20 sorbitan tristearate
polyethyleneglycol sorbitan tristearate
polyoxyethylene (20) sorbitan tristearate
rheodol TW-S320V
tween 65
emsorb6907
POLYETHYLENEGLYCOLSORBITANTRISTEARATE
EmulsifierT-65
sorbimacrogoltristearate300
sorbitan,tristearate,polyoxyethylenederivs.
glycospersets20
POE20
polyoxyethylenesorbitan tristearate*(tween 65)
POLYOXYETHYLENE SORBITANTRISTEARATE
TWEEN(TM) 65
sorbitan,trioctadecanoate,poly(oxy-1,2-ethanediyl)derivs.
POLYOXYETHYLENE GLYCOL SORBITAN TRISTEARATE
POLYOXYETHYLENE-1,4-SORBITAN-TRISTEARATE
MFCD00165348
POLYSORBATE 65
TWEEN 65
T-65
POLYOXYETHYLENE(20) SORBITAN TRISTEARATE