POLYTETRAMETHYLENE ETHER GLYCOL (POLYTETRAHYDROFURAN)

Polytetramethylene ether glycol (Polytetrahydrofuran) is a linear polyether diol synthesized by the cationic ring-opening polymerization of tetrahydrofuran (THF), consisting of repeating –(CH₂–CH₂–CH₂–CH₂–O)– units terminated with hydroxyl groups that provide high reactivity toward isocyanates, acids, and epoxides.
Polytetramethylene ether glycol (Polytetrahydrofuran) is one of the most important soft-segment precursors in polyurethane chemistry and is widely used in thermoplastic polyurethanes, elastomers, spandex fibers, coatings, adhesives, and sealants due to its excellent elasticity, low glass-transition temperature, superior hydrolysis resistance, and outstanding low-temperature flexibility.
Polytetramethylene ether glycol (Polytetrahydrofuran)-based materials are indispensable in automotive components, industrial belts, footwear, medical elastomers, and high-performance polymer systems because of their exceptional abrasion resistance, weatherability, oil resistance, long-term mechanical durability, and precise molecular-weight control.

CAS Number: 25190-06-1
EC Number: 607-138-00-X
Molecular Formula: (C4H8O)nH2O
Molecular Weight: 305.43

Synonyms: Polytetrahydrofuran, PTMEG, Poly(tetramethylene ether) glycol, Poly(tetramethylene oxide) glycol, PolyTHF, Poly(tetramethylene) ether diol, Polyoxybutylene glycol, Poly(oxy-1,4-butanediyl) diol, Poly(THF) diol, Polybutylene ether glycol, Polybutylene glycol ether, Polyether tetramethylene glycol, Tetramethylene ether glycol polymer, Oxybutylene polymer diol, Tetrahydrofuran polymer diol, Poly(tetrahydrofuran) glycol, PTMO glycol, Poly(tetramethylene oxide) diol, Polyether diol (PTMO type), Polybutanediol ether, Poly(butylene oxide) glycol, Polybutylene oxide diol, Polytetramethylene glycol, Polyether tetramethylene diol, Poly(oxybutylene) diol, Tetramethylene oxide polymer, Polyether glycol (tetramethylene based), Poly(tetrahydrofuran) diol, Oxybutylene polyether diol, Polybutylene ether diol, THF polymer glycol, Polymerized tetrahydrofuran diol, Polyether polyurethane precursor (PTMEG), Tetramethylene polyether diol, Polyether soft segment diol, PTMEG polyol, Polyether elastomer precursor, Poly(THF) polyol, Polyether glycol PTMO, Tetramethylene-based polyether glycol

Polytetramethylene ether glycol (Polytetrahydrofuran), is a linear polyether diol produced by the cationic ring-opening polymerization of tetrahydrofuran (THF).
Polytetramethylene ether glycol (Polytetrahydrofuran) consists of repeating –(CH₂–CH₂–CH₂–CH₂–O)– units and is terminated with hydroxyl groups at both chain ends, which provide high reactivity toward isocyanates, acids, and epoxides.

Polytetramethylene ether glycol (Polytetrahydrofuran) is a key soft-segment precursor in polyurethane chemistry, where it is used to manufacture thermoplastic polyurethanes (TPU), elastomers, spandex fibers, coatings, adhesives, and sealants.
The ether backbone gives excellent elasticity, low glass-transition temperature, superior hydrolysis resistance, and outstanding low-temperature flexibility compared with polyester-based polyols.

Polytetramethylene ether glycol (Polytetrahydrofuran) exhibits low viscosity for its molecular weight, narrow molecular-weight distribution, high purity, and excellent compatibility with both polyurethane and epoxy systems.
Its molecular weight can be precisely controlled over a broad range (typically 250–3000 g/mol), enabling fine tuning of hardness, tensile strength, elongation, resilience, and dynamic mechanical behavior of final polymer products.

Because of its excellent abrasion resistance, weatherability, oil resistance, and long-term mechanical durability, Polytetramethylene ether glycol (Polytetrahydrofuran)-based materials are widely used in automotive components, industrial belts, footwear soles, medical elastomers, textile fibers, and high-performance coatings.
The balance of processability, chemical stability, and exceptional elastic performance makes Polytetramethylene ether glycol (Polytetrahydrofuran) one of the most important polyether polyols in advanced polymer engineering.

Polytetramethylene ether glycol (Polytetrahydrofuran) is a linear polymer with a repeating unit of tetramethylene oxide.
Polytetramethylene ether glycol (Polytetrahydrofuran) is mainly used in the production of polyurethane elastomers, spandex fibers, and thermoplastic polyurethanes.

Due to its excellent mechanical properties, chemical resistance, and low-temperature flexibility, Polytetramethylene ether glycol (Polytetrahydrofuran) has become an essential material in many fields.

Polytetramethylene ether glycol (Polytetrahydrofuran) is a collection of chemical compounds with formula HO(CH2)4O(CH2)4)nOH or HO((CH2)4O-)n-H.
Polytetramethylene ether glycol (Polytetrahydrofuran) is a mixture of polyether diols terminated with alcohol groups.
Polytetramethylene ether glycol (Polytetrahydrofuran) is produced by polymerization of tetrahydrofuran as well as 1,4-butanediol.

Polytetramethylene ether glycol (Polytetrahydrofuran) is commercially available as polymers of low average molecular weights, between 250 and 3000 daltons.
In this form Polytetramethylene ether glycol (Polytetrahydrofuran) is a white waxy solid that melts between 20 and 30 °C.
The commercial product can be processed further into polymers with molecular weights of 40,000 and higher.

Polytetramethylene ether glycol (Polytetrahydrofuran) is sold under various trade names including Terathane from Invista and PolyTHF from BASF.
The BASF plant in Ludwigshafen at one point was producing 250,000 metric tons per year.

Polytetramethylene ether glycol (Polytetrahydrofuran) is a colourless, clear liquid (lower molecular weights) or white, waxy solid at room temperature.
Polytetramethylene ether glycol (Polytetrahydrofuran) will melt to yield a co lourless, clear liquid.

Polytetramethylene ether glycol (Polytetrahydrofuran) is soluble in many conventional organic solvents, partly infinitely mixable.
Polytetramethylene ether glycol (Polytetrahydrofuran) is practically insoluble in water.

Polytetramethylene ether glycol (Polytetrahydrofuran) is also an important intermediate in manufacturing thermoplastic polyurethane elastomers (TPU).
These products are used for highly abrasion-resistant and flexible hoses, films and cable sheathing.
Other applications include thermo-plastic polyetheresters, polyetheramide and cast polyurethane elastomers, provenin their use for skateboard wheels and inline skates.

Polytetramethylene ether glycol (Polytetrahydrofuran) is a polymer composed of repeating units of -CH2CH2CH2CH2O- and is also known as poly(tetramethylene ether) glycol (PTMEG).
Polytetramethylene ether glycol (Polytetrahydrofuran) is obtained through the CROP (cyclic oligomerization and polymerization) of tetrahydrofuran (THF).
Polytetramethylene ether glycol (Polytetrahydrofuran) has a melting range of 23-28°C and can be azeotropically dehydrated by toluene using a Dean-Stark trap.

Polytetramethylene ether glycol (Polytetrahydrofuran) is a linear polyether diol synthesized through the cationic ring-opening polymerization of tetrahydrofuran (THF) using acidic catalysts such as boron trifluoride or heteropoly acids.
Polytetramethylene ether glycol (Polytetrahydrofuran)'s molecular structure consists of repeating –(CH₂–CH₂–CH₂–CH₂–O)– ether units with hydroxyl (–OH) groups at both chain termini, which render PTMEG highly reactive toward isocyanates, carboxylic acids, epoxides, and anhydrides.
The terminal hydroxyl functionality enables Polytetramethylene ether glycol (Polytetrahydrofuran) to act as an essential soft-segment polyol in step-growth polymerizations, particularly in polyurethane and polyester synthesis.

The ether-based backbone of Polytetramethylene ether glycol (Polytetrahydrofuran) provides a combination of low glass-transition temperature, high segmental mobility, superior elasticity, excellent low-temperature performance, and outstanding resilience, distinguishing it from polyester-based polyols.
Due to the absence of ester linkages in the backbone, Polytetramethylene ether glycol (Polytetrahydrofuran) also exhibits exceptional hydrolytic stability, strong resistance to moisture-induced degradation, and high chemical durability, even under demanding service conditions.
These properties make Polytetramethylene ether glycol (Polytetrahydrofuran) especially suitable for dynamic and fatigue-resistant polymer systems.

Industrially, Polytetramethylene ether glycol (Polytetrahydrofuran) is one of the most important soft-segment building blocks in thermoplastic polyurethane (TPU), spandex (elastane) fibers, elastomers, reaction-injection-molded (RIM) polyurethanes, coatings, adhesives, and sealants.
In TPU and elastomer production, Polytetramethylene ether glycol (Polytetrahydrofuran) imparts high tensile strength, excellent elongation at break, superior abrasion resistance, and long-term mechanical performance.
In spandex fibers, Polytetramethylene ether glycol (Polytetrahydrofuran) provides the essential combination of high elasticity, rapid recovery, and permanent shape retention, which defines the performance of stretch textiles.

Polytetramethylene ether glycol (Polytetrahydrofuran) is characterized by low viscosity relative to its molecular weight, narrow molecular-weight distribution, high purity, and excellent miscibility with isocyanates, epoxy resins, and many reactive diluents.
Commercial grades are available across a wide molecular-weight range, typically from 250 to 3000 g/mol, allowing precise control over polymer hardness, flexibility, tensile behavior, tear resistance, and viscoelastic properties.
Lower-molecular-weight Polytetramethylene ether glycol (Polytetrahydrofuran) grades are used where higher rigidity and solvent compatibility are required, while higher-molecular-weight grades are selected for maximum elasticity and softness.

From a performance standpoint, Polytetramethylene ether glycol (Polytetrahydrofuran)-based polyurethane systems exhibit excellent resistance to oils, fuels, greases, fuels, weathering, ozone exposure, and repeated cyclic loading.
This makes them ideal for automotive components, industrial belts, hoses, rollers, shock-absorbing elements, footwear soles, medical elastomers, and vibration-damping materials.
In coatings and adhesives, Polytetramethylene ether glycol (Polytetrahydrofuran) contributes to flexibility, crack resistance, low-temperature toughness, and long-term adhesion durability.

In terms of thermal behavior, Polytetramethylene ether glycol (Polytetrahydrofuran) typically shows high thermal stability, low volatility, and controlled crystallization behavior, depending on molecular weight.
Polytetramethylene ether glycol (Polytetrahydrofuran)'s ether-based structure provides superior performance under repeated thermal cycling compared to polyester polyols, which are more susceptible to hydrolysis and thermal scission.
The crystallinity of Polytetramethylene ether glycol (Polytetrahydrofuran) increases with molecular weight, influencing phase separation and mechanical reinforcement in segmented polyurethane systems.

From a processing perspective, Polytetramethylene ether glycol (Polytetrahydrofuran) offers excellent flow behavior, ease of metering, and high reactivity control, allowing precise formulation of one-component and two-component reactive systems.
Polytetramethylene ether glycol (Polytetrahydrofuran)'s compatibility with epoxy resins also allows its use in flexible epoxy networks, impact-modified thermosets, and hybrid polymer systems requiring both toughness and chemical resistance.

Due to Polytetramethylene ether glycol (Polytetrahydrofuran)'s excellent balance of chemical stability, mechanical strength, elasticity, low-temperature flexibility, abrasion resistance, and processability, Polytetramethylene ether glycol (Polytetrahydrofuran) has become one of the most strategically important polyether polyols in modern polymer science and industrial materials engineering.
Polytetramethylene ether glycol (Polytetrahydrofuran)'s ability to deliver long-term durability under mechanical, thermal, and chemical stress places PTMEG at the core of high-performance elastomer, polyurethane, fiber, coating, and adhesive technologies.

Polytetramethylene ether glycol (Polytetrahydrofuran) offers several key benefits that make it a preferred material for manufacturers and engineers across industries:

Exceptional Flexibility:
Polytetramethylene ether glycol (Polytetrahydrofuran) exhibits exceptional elasticity and flexibility, making it ideal for applications that require materials with excellent stretchability and resilience.

Superior Chemical Resistance:
Polytetramethylene ether glycol (Polytetrahydrofuran) is renowned for its excellent resistance to solvents, oils, and grease.
This property makes Polytetramethylene ether glycol (Polytetrahydrofuran) an ideal material for producing coatings, adhesives, and sealants that can withstand harsh environments and provide long-lasting protection.

Outstanding Thermal Stability:
With its ability to withstand high temperatures without significant degradation, Polytetramethylene ether glycol (Polytetrahydrofuran) is the perfect choice for applications that require exposure to heat.

Customizable Properties:
Polytetramethylene ether glycol (Polytetrahydrofuran) can be synthesized to achieve a wide range of molecular weights, allowing for the production of tailored materials with varying degrees of flexibility and strength.

Versatility:
Polytetramethylene ether glycol (Polytetrahydrofuran) is used in various industries, including automotive, textiles, coatings, adhesives, and more, due to its unique properties and exceptional performance.

Durability:
Polytetramethylene ether glycol (Polytetrahydrofuran) is known for its exceptional durability, making it a reliable choice for products that require long-lasting performance and protection.

Applications of Polytetramethylene Ether Glycol (Polytetrahydrofuran):
The main use of polytetrahydrofuran is to make elastic fibres such as spandex (elastane) for stretchable fabrics and for polyurethane resins.
The latter are polyurethane prepolymers dissolved in solvent.

They are used in the manufacture of artificial leather.
These elastomers are either polyurethanes made by reacting Polytetramethylene ether glycol (Polytetrahydrofuran) with diisocyanates, or polyesters made by reacting PTMEG with diacids or their derivatives.
The polymer is also a starting material for thermoplastic polyurethane, thermoplastic polyesters, polyetheramide and cast polyurethane elastomers, used for instance in the wheels of roller skates and skateboards.

Polytetramethylene ether glycol (Polytetrahydrofuran) can be used in the preparation of soft segment polyurethane for a variety of applications.
Polytetramethylene ether glycol (Polytetrahydrofuran) can also be used in the surface modification of cellulose fibers which can further be used as reinforcing polymerix materials.

Polytetramethylene ether glycol (Polytetrahydrofuran) is a strategically important polyether polyol used primarily as a soft-segment precursor in high-performance polymer systems.
Polytetramethylene ether glycol (Polytetrahydrofuran)'s unique ether-based structure, terminal hydroxyl functionality, and excellent mechanical durability enable wide industrial utilization across elastomers, fibers, coatings, adhesives, and advanced engineering materials.

Thermoplastic Polyurethanes (TPU):
Polytetramethylene ether glycol (Polytetrahydrofuran) is one of the most widely used soft segments in TPU production.

Polytetramethylene ether glycol (Polytetrahydrofuran) provides:
High elasticity and resilience
Excellent abrasion and tear resistance
Superior low-temperature flexibility
Long-term fatigue resistance

TPU materials based on Polytetramethylene ether glycol (Polytetrahydrofuran) are used in:
Automotive interior and exterior parts
Cable jacketing
Hoses and tubing
Footwear components (soles, midsoles)
Protective films and sheets

Spandex (Elastane) Fibers:
Polytetramethylene ether glycol (Polytetrahydrofuran) is the primary polyol used in spandex fiber manufacturing.

Polytetramethylene ether glycol (Polytetrahydrofuran) delivers:
Extremely high elongation (>500%)
Rapid elastic recovery
Permanent shape retention
Resistance to sweat, oils, and detergents

Applications include:
Sportswear and activewear
Medical compression garments
Hosiery
Stretch denim and textile blends

Cast and RIM Polyurethane Elastomers:

Polytetramethylene ether glycol (Polytetrahydrofuran)-based elastomers are used in:
Industrial rollers and wheels
Conveyor belts
Gaskets and seals
Vibration-damping components
Shock-absorbing elements

These materials show:
High load-bearing capacity
Excellent dynamic fatigue resistance
Strong resistance to oil, grease, and fuels

Coatings:

Polytetramethylene ether glycol (Polytetrahydrofuran) is used in:
Polyurethane coatings
Flexible epoxy–urethane hybrid coatings
Low-temperature crack-resistant coatings

Key benefits:
Flexibility at sub-zero temperatures
Weather and UV resistance
Impact and abrasion resistance
Long-term adhesion durability

Applications:
Automotive coatings
Industrial floor coatings
Protective metal coatings
Textile and leather finishes

Adhesives and Sealants:

In reactive PU and hybrid systems, Polytetramethylene ether glycol (Polytetrahydrofuran) provides:
High flexibility with strong adhesion
Resistance to moisture and hydrolysis
Long service life under cyclic loading

Polytetramethylene ether glycol (Polytetrahydrofuran) is used in:
Construction sealants
Automotive bonding
Electronics encapsulation
Flexible packaging adhesives

Epoxy Modification and Toughening Agents:

Polytetramethylene ether glycol (Polytetrahydrofuran) is used as:
Flexible epoxy toughener
Impact-modifying reactive diluent

Polytetramethylene ether glycol (Polytetrahydrofuran) improves:
Fracture toughness
Impact strength
Crack resistance
Flexural durability

Applications include:
Structural composites
Electronic potting compounds
Aerospace adhesives

Medical and Biomedical Elastomers:

Due to its biostability and hydrolysis resistance, Polytetramethylene ether glycol (Polytetrahydrofuran) is used in:
Catheters
Tubing
Implantable elastomers
Blood-contacting devices (after formulation approval)

Key advantages:
Low extractables
Long-term flexibility
Resistance to body fluids

Footwear Industry:

Polytetramethylene ether glycol (Polytetrahydrofuran)-based PU systems are dominant in:
High-performance footwear soles
Sports shoes
Safety shoes

They provide:
Energy return
Shock absorption
Long wear resistance
Comfort and durability

Industrial Belts and Mechanical Components:

Polytetramethylene ether glycol (Polytetrahydrofuran) is used in:
Timing belts
Drive belts
Power transmission components

Because of:
High abrasion resistance
Fatigue endurance
Oil and chemical resistance

Specialty Polymer and Hybrid Systems:

Polytetramethylene ether glycol (Polytetrahydrofuran) is used in:
Polyurethane–polyester blends
PU–epoxy hybrids
Shape-memory polymers
Soft thermoset networks

Supporting:
Impact-resistant composites
Flexible structural materials
Advanced damping systems

Production Methods of Polytetramethylene Ether Glycol (Polytetrahydrofuran):
The main production methods of Polytetramethylene ether glycol (Polytetrahydrofuran) are the acid-catalyzed polymerization of tetrahydrofuran (THF) and the use of ring-opening polymerization catalysts.

Acid-Catalyzed Polymerization method:
THF is polymerized in the presence of an acid catalyst such as sulfuric acid or phosphoric acid.
The reaction is carried out at a certain temperature and pressure.

The acid catalyst initiates the polymerization by protonating the oxygen atom of THF, forming a reactive intermediate.
The reactive intermediate then reacts with another THF molecule, leading to the growth of the polymer chain.

However, acid-catalyzed polymerization has some disadvantages.
For example, the reaction is difficult to control, and Polytetramethylene ether glycol (Polytetrahydrofuran) may contain impurities such as oligomers and by-products.
In addition, the acid catalyst needs to be removed after the reaction, which increases the complexity of the production process.

Ring-Opening Polymerization Catalysts:
To overcome the limitations of acid-catalyzed polymerization, various ring-opening polymerization catalysts have been developed.
These catalysts can initiate the polymerization of THF under milder conditions and with better control over the reaction.
Some common ring-opening polymerization catalysts include metal alkoxides, metal halides, and organometallic compounds.

For example, boron trifluoride etherate is a widely used catalyst for the polymerization of THF.
Polytetramethylene ether glycol (Polytetrahydrofuran) can initiate the polymerization at a relatively low temperature and pressure, and the reaction rate is fast.
Polytetramethylene ether glycol (Polytetrahydrofuran) obtained by using this catalyst has a narrow molecular weight distribution and high purity.

Production Process of Polytetramethylene Ether Glycol (Polytetrahydrofuran):

The production process of Polytetramethylene ether glycol (Polytetrahydrofuran) generally includes the following steps:

Raw Material Preparation:
THF is the main raw material for the production of Polytetramethylene ether glycol (Polytetrahydrofuran). 
Polytetramethylene ether glycol (Polytetrahydrofuran) is usually obtained by the catalytic hydrogenation of furan or by the oxidation of butadiene.
The THF obtained needs to be purified to remove impurities such as water, peroxides, and aldehydes.

Polymerization:
The purified THF is then polymerized using an appropriate catalyst.
The polymerization reaction is carried out in a reactor under controlled conditions of temperature, pressure, and catalyst concentration.
The reaction time and temperature depend on the type of catalyst used and the desired molecular weight of Polytetramethylene ether glycol (Polytetrahydrofuran).

Product Purification :
After the polymerization reaction is completed, Polytetramethylene ether glycol (Polytetrahydrofuran) needs to be purified to remove unreacted THF, catalyst residues, and other impurities.
This can be done by distillation, extraction, or other purification methods.
The purified Polytetramethylene ether glycol (Polytetrahydrofuran) is then dried and packaged for shipment.

Synthesis of Polytetramethylene Ether Glycol (Polytetrahydrofuran):

Polytetrahydrofuran is commonly prepared by acid-catalyzed polymerization of tetrahydrofuran:
nC4H8O + H2O → HO(CH2)4[O(CH2)4]n−1OH

Regulation
Polytetrahyrofuran polyethylene glycol can be controlled for export from the U.S. under the Export Administration Regulations on the Commerce Control List and/or on export control regulations based on the Wassenaar Arrangement (ECCN: 1C111.b.5).-
Under these regulations export/transfer of Polytetramethylene ether glycol (Polytetrahydrofuran) may require a license or export authorization.

Stability and Reactivity of Polytetramethylene Ether Glycol (Polytetrahydrofuran):

Chemical Stability:
Polytetramethylene ether glycol (Polytetrahydrofuran) is chemically stable under normal ambient temperatures and recommended storage conditions.
Polytetramethylene ether glycol (Polytetrahydrofuran) does not undergo hazardous decomposition during routine handling, processing, or storage when kept in sealed containers away from incompatible materials.

Reactivity:
Polytetramethylene ether glycol (Polytetrahydrofuran) is generally low-reactivity and chemically inert under normal industrial conditions.
However, Polytetramethylene ether glycol (Polytetrahydrofuran) can react with strong oxidizing agents, strong acids, or strong bases under elevated temperatures.
Hydroxyl end groups may participate in esterification, urethane formation, and oxidation reactions under aggressive chemical environments.

Conditions to Avoid:
Avoid excessive heat, open flames, prolonged exposure to air at elevated temperatures, and contact with strong oxidizers.
Prevent prolonged moisture exposure at high temperatures, which may promote oxidative degradation.

Incompatible Materials:
Avoid contact with strong oxidizing agents (peroxides, nitric acid), strong acids, strong bases, and halogenated oxidizers.
These substances may cause degradation or uncontrolled reactions.

Hazardous Decomposition Products:
Under normal use, no hazardous decomposition products are expected.
At extreme temperatures or during combustion, decomposition may generate carbon monoxide (CO), carbon dioxide (CO₂), aldehydes, and ether fragments.

Handling and Storage of Polytetramethylene Ether Glycol (Polytetrahydrofuran):

Safe Handling:
Handle Polytetramethylene ether glycol (Polytetrahydrofuran) using standard industrial hygiene practices.
Avoid inhalation of any vapors or mists that may be generated at elevated temperatures.

Prevent skin and eye contact during transfer and processing.
Use closed or semi-closed systems where possible.

Hygiene Measures:
Wash hands and exposed skin thoroughly after handling.
Avoid eating, drinking, or smoking in processing areas.
Remove contaminated clothing before entering clean areas and launder before reuse.

Storage Requirements:
Store in tightly closed containers in a cool, dry, well-ventilated location.
Keep away from direct sunlight, ignition sources, and incompatible materials.
Protect containers from physical damage.

Packaging Integrity:
Keep containers sealed when not in use to prevent moisture contamination and oxidation.
Avoid excessive stacking that may deform containers.

Shelf Stability:
Product maintains chemical stability for extended periods when stored under recommended dry, sealed, and temperature-controlled conditions.
Prolonged exposure to moisture and oxygen at elevated temperatures may gradually reduce molecular stability.

First Aid Measures of Polytetramethylene Ether Glycol (Polytetrahydrofuran):

Inhalation:
Move the exposed person to fresh air immediately.
If breathing difficulty, coughing, or irritation occurs, seek medical attention.
Symptoms may include mild respiratory discomfort if mist is inhaled.

Skin Contact:
Wash affected skin thoroughly with soap and water.
Remove contaminated clothing.

Polytetramethylene ether glycol (Polytetrahydrofuran) generally has low skin irritation potential, but prolonged contact may cause mild irritation.
Seek medical attention if irritation persists.

Eye Contact:
Rinse eyes cautiously with clean water for several minutes while holding eyelids open.
Remove contact lenses if present and easy to do.
Seek medical attention if redness or discomfort continues.

Ingestion:
Rinse mouth with water.
Do not induce vomiting.
If large quantities are swallowed or gastrointestinal discomfort occurs, seek medical evaluation.

Notes for Physician:
Treatment is symptomatic and supportive.
No specific antidote exists.
Polytetramethylene ether glycol (Polytetrahydrofuran) has low acute systemic toxicity.

Firefighting Measures of Polytetramethylene Ether Glycol (Polytetrahydrofuran):

Flammability:
Polytetramethylene ether glycol (Polytetrahydrofuran) is combustible at elevated temperatures but does not readily ignite under normal ambient conditions.

Suitable Extinguishing Media:
Use alcohol-resistant foam, carbon dioxide (CO₂), dry chemical powder, or water spray depending on surrounding fire conditions.

Unsuitable Extinguishing Media:
Direct high-pressure water jets should be avoided, as they may spread burning material if involved in a fire.

Hazardous Combustion Products:
Thermal decomposition may produce carbon monoxide (CO), carbon dioxide (CO₂), aldehydes, and irritating organic vapors.

Special Protective Equipment for Firefighters:
Wear self-contained breathing apparatus (SCBA) and full protective firefighting gear to prevent inhalation of toxic combustion gases.

Specific Hazards:
Containers exposed to fire may rupture due to internal pressure buildup.
Cool exposed containers with water spray.

Accidental Release Measures of Polytetramethylene Ether Glycol (Polytetrahydrofuran):

Personal Precautions:
Avoid direct contact with Polytetramethylene ether glycol (Polytetrahydrofuran). Ensure adequate ventilation.
Use appropriate personal protective equipment including gloves and safety goggles.
Prevent inhalation of any heated vapors or aerosols.

Environmental Precautions:
Prevent large quantities from entering drains, surface waters, or soil.
Polytetramethylene ether glycol (Polytetrahydrofuran) is not highly volatile but may spread over surfaces due to low surface tension.

Cleanup Methods:
Absorb spilled material with inert absorbents such as sand, vermiculite, or industrial absorbent pads.
Collect into suitable waste containers.
Wash contaminated surfaces with detergent and water.

Additional Advice:
Dispose of collected waste in accordance with local environmental regulations.
Small residual films may create slip hazards and should be fully removed.

Exposure Controls and Personal Protective Equipment of Polytetramethylene Ether Glycol (Polytetrahydrofuran):

Engineering Controls:
Provide adequate general and local exhaust ventilation, especially in heated processing operations where vapors or mists may form.
Maintain airborne concentrations below applicable workplace exposure limits.

Respiratory Protection:
Not normally required under ambient conditions.
Use organic vapor respirators if aerosols or vapors are generated at elevated temperatures.

Hand Protection:
Use chemical-resistant gloves such as nitrile, neoprene, or PVC to prevent prolonged skin contact.

Eye Protection:
Wear safety glasses or chemical splash goggles to prevent eye exposure.

Skin and Body Protection:
Wear protective work clothing to minimize skin contact, especially during bulk handling.

Environmental Exposure Controls:
No special environmental controls are required under normal use; however, process containment and proper waste management practices should be implemented to minimize environmental release.

Identifiers of Polytetramethylene Ether Glycol (Polytetrahydrofuran):
Chemical Name: Poly(oxy-1,4-butanediyl) diol
CAS Number: 25190-06-1
EC Number: 607-138-00-X
REACH Registration Number: Available upon request
Molecular Formula: HO–(C₄H₈O)ₙ–H
Molecular Weight: Varies by grade (typically 250–4000 g/mol)
Product Type: Polyether diol
Recommended Use: Polyurethane elastomers, spandex fibers, coatings, adhesives, sealants, thermoplastic polyurethane (TPU), engineering plastics
Restrictions on Use: Not intended for pharmaceutical or food contact use unless specifically certified

CAS No.: 25190-06-1
Chemical Name: Poly(tetrahydrofuran)
CBNumber: CB6323066
Molecular Formula: (C4H8O)nH2O
Molecular Weight: 305.43
MDL Number: MFCD00148879

Linear Formula: H(C4H8O)nOH
CAS Number: 25190-06-1
MDL number: MFCD00148879
UNSPSC Code: 12352112
NACRES: NA.21

CAS Number: 25190-06-1
ChemSpider: none
ECHA InfoCard: 100.131.584
CompTox Dashboard (EPA): DTXSID2042307

Properties of Polytetramethylene Ether Glycol (Polytetrahydrofuran):
Chemical formula: (C4H8O)n
Molar mass: variable
Appearance: white, waxy-like
Density: 0.982 g/cm3 (30 °C)
Melting point: 23 to 28 °C (73 to 82 °F; 296 to 301 K)

apor pressure: <0.1 hPa ( 20 °C)
Quality Level: 200
form: liquid
potency: >5000 mg/kg LD50, oral (Rat)
pH: 7 (20 °C in H2O, Aqueous solution)
mp: 23-28 °C
transition temp: flash point 240 °C
solubility: <10 g/L
density: 0.982 g/cm3 at 30 °C
storage temp.: 2-30°C
SMILES string: O([C@H](CO)CC)CCCC
InChI: 1S/C8H18O2/c1-3-5-6-10-8(4-2)7-9/h8-9H,3-7H2,1-2H3/t8-/m0/s1
InChI key: BJZYYSAMLOBSDY-QMMMGPOBSA-N

Melting point: 33-36 °C
Boiling point: >204
Density: 1 g/mL at 25 °C
vapor pressure: <0.01 mm Hg ( 25 °C)
refractive index: n20/D 1.465
Flash point: >230 °F
storage temp.: Store below +30°C.
solubility: <10g/l
form: Fused mass
Specific Gravity: 0.961
PH: 7 (H2O, 20℃)Aqueous solution
Viscosity: 3,200-4,200cp (40C)
Water Solubility: <10g/L
Surface tension: 31.9mN/m at 20°C
Indirect Additives used in Food Contact Substances: POLYBUTYLENE GLYCOL
EPA Substance Registry System: Poly(oxy-1,4-butanediyl), .alpha.-hydro-.omega.-hydroxy- (25190-06-1)
UNSPSC Code: 12352112
NACRES: NA.23

Names of Polytetramethylene Ether Glycol (Polytetrahydrofuran):

Other names:
Poly(tetrahydrofuran)
PolyTHF
polytetramethylene ether glycol
PTMEG
Terathane