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Polyvinyl alcohol-polyethylene glycol-graft-copolymer is a synthetic polymer comprised of approximately 75% polyvinyl alcohol and 25% polyethylene glycol.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer is primarily used in the pharmaceutical and dietary supplement industries as a film-coating agent and tablet binder.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer is a synthetic polymer consisting of a polyvinyl alcohol (PVA) backbone onto which polyethylene glycol (PEG) side chains are chemically attached (grafted).
CAS Number: 96734-39-3
Molecular Formula: ((C2H4O)nH2O.C2H4O)x
Synonyms:Ethenol, polymer with alpha-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl), RefChem:592667, DTXSID901011560, Graft polymer from polyvinyl alcohol, polyethyleneglycol, Ethenol, polymer with alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl), Ethenol, polymer with alpha.-hydro-omega-hydroxypoly(oxy-1,2-ethanediyl), Ethane-1,2-diol;ethenol, 50856-26-3, SCHEMBL634056, KMIMOJVUFBBNHO-UHFFFAOYSA-N, Ethenol, polymer with |A-hydro-|O-hydroxypoly(oxy-1,2-ethanediyl), Macrogol-poly(vinyl alcohol) graft-copolymer;Kollicoat? IR;Polyvinyl alcohol-polyethylene glycol graft-copolymer;Macrogol polyvinyl alcohol grafted copolymer CRS;Macrogol polyvinyl alcohol grafted copolymer CR;Macrogol polyvinyl alcohol grafted copolymer/A1A;Ethenol, polymer with α-hydro-ω-hydroxypoly(oxy-1,2-ethanediyl)
Polyvinyl alcohol-polyethylene glycol-graft-copolymer is widely used in pharmaceutical, biomedical, cosmetic, and industrial formulations because it combines the film-forming properties of PVA with the water solubility and flexibility of PEG.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer is designed to improve the performance of formulations compared with either polymer alone.
This improves solubility, stability, and functional versatility.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer is a graft copolymer, meaning one polymer chain (PEG) is attached as branches to another polymer chain (PVA).
This architecture provides a combination of hydrophilic behavior, film formation, and controlled interaction with water.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves formulation performance and processing characteristics.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer is typically supplied as a white to off-white powder or granules that readily dissolve or disperse in water.
It can form clear films and stable aqueous solutions.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves handling and formulation flexibility.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer acts as a solubilizer, film-forming agent, binder, stabilizer, and dispersing agent in many applications.
Its hydrophilic nature helps improve the dissolution and distribution of active ingredients.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves product performance and consistency.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer is best described as a water-soluble synthetic copolymer used to enhance solubility, film formation, stability, and delivery of ingredients in pharmaceutical and industrial products.
Polyvinyl alcohol–polyethylene glycol–graft copolymer is a member of the broader class of amphiphilic polymers, meaning it can interact effectively with both water and certain less water-soluble substances.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer characteristic makes it especially useful in formulations where ingredients must remain uniformly distributed.
This improves solubilization and formulation stability.
The PVA backbone provides mechanical strength and film-forming capability, while the PEG side chains increase water affinity and flexibility.
The balance between these two components can be adjusted during manufacturing to achieve specific performance characteristics.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves formulation customization and application versatility.
In solid dispersion technology, the copolymer is commonly used to help convert poorly soluble active ingredients into more readily dissolving forms.
By keeping ingredients dispersed at the molecular level, it can prevent crystallization and improve dissolution behavior.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves bioavailability and formulation effectiveness.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer can function as a carrier matrix for active ingredients because it remains processable under controlled manufacturing conditions while maintaining good water compatibility.
This makes it valuable in advanced pharmaceutical manufacturing.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves production efficiency and product performance.
In film technology, the polymer forms transparent, flexible films that resist cracking better than some traditional film-forming materials.
These films can be used for coatings, delivery systems, and specialty formulations.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves durability and appearance.
In hydrogel development, the copolymer contributes to water absorption and retention while maintaining structural integrity.
This makes it useful in biomedical and controlled-release research.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves hydrogel performance and stability.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer may be used as a stabilizing polymer that helps prevent particles from aggregating during storage.
This supports long-term formulation stability.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves particle distribution and shelf life.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer segments help reduce unwanted protein adsorption and improve surface compatibility with biological environments.
This is important in certain medical-device and biomaterial applications.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves biocompatibility and surface performance.
In nanomedicine research, PVA–PEG graft copolymers are investigated as carriers for nanoparticles, helping stabilize particles and improve distribution in aqueous media.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves nanoparticle stability and delivery efficiency.
In advanced hydrogel systems, the polymer can contribute to networks that absorb large amounts of water while maintaining mechanical integrity.
These materials are being explored for wound dressings, tissue engineering, and drug delivery applications.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves hydration capacity and material functionality.
In polymer science, graft copolymers are important because they allow scientists to combine different molecular properties within a single material architecture.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer graft copolymers are a well-known example of how structural design can be used to tailor performance.
storage temp.: 2-8°C
PH: 5.0-8.0 (20% in H2O)
Viscosity: 50-250 mPa.s, 20 %(23 °C, Brookfield RVT) (SP.2, 100RPM)
EPA Substance Registry System: Ethenol, polymer with .alpha.-hydro-.omega.-hydroxypoly(oxy-1,2-ethanediyl) (96734-39-3)
UNSPSC Code: 41116107
NACRES: NA.24
The combination of PVA and PEG allows the copolymer to exhibit properties that neither polymer alone can fully provide.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer contributes strength and film formation, while PEG contributes flexibility, water compatibility, and reduced brittleness.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves mechanical and functional balance.
In pharmaceutical technology, it is often used to improve the dissolution of poorly water-soluble drugs by helping disperse and stabilize active ingredients in aqueous environments.
This can enhance drug availability and formulation performance.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves drug delivery efficiency.
In tablet and capsule formulations, it may be used as a binder or carrier material that helps maintain product integrity while supporting dissolution after administration.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves dosage form reliability.
In coating systems, it forms clear, uniform films that protect active ingredients and control surface properties.
These films can also improve product appearance and stability.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves coating quality and durability.
In cosmetic formulations, it is used to stabilize emulsions and improve texture in products such as creams, gels, and personal care formulations.
Its hydrophilic nature contributes to smooth application characteristics.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves sensory performance and stability.
In biomedical research, PVA–PEG copolymers are studied for use in hydrogels, drug delivery systems, and tissue-engineering materials because they are highly water compatible.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves material design flexibility and biocompatibility.
In dispersion technology, it helps keep particles evenly distributed in liquids, reducing aggregation and sedimentation.
This improves formulation uniformity and storage stability.
In controlled-release systems, it may be used to influence how active ingredients are released from a formulation over time.
This improves release control and product effectiveness.
In water-based industrial formulations, it acts as a stabilizer and processing aid where film formation and water compatibility are required.
This improves manufacturing performance and product quality.
In polymer science, it is an example of how graft copolymerization can combine multiple desirable properties into a single material.
This improves polymer design versatility and application range.
In drug delivery research, the polymer is studied for its ability to influence release rates and improve compatibility between active ingredients and aqueous environments.
This improves controlled-release performance and therapeutic effectiveness.
In coating science, it can create smooth, uniform surface layers that protect active ingredients from environmental influences such as moisture or mechanical stress.
This improves product stability and shelf life.
In polymer engineering, graft copolymers like Polyvinyl alcohol-polyethylene glycol-graft-copolymer are valued because they combine multiple functional properties into a single material without requiring separate additives.
This improves formulation simplicity and performance optimization.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer brand name Kollicoat IR (BASF) is a multifunctional excipient used as a pill binder as well as a wet binder.
A typical formulation is composed of 25% polyethylene glycol (PEG) and 75% polyvinyl alcohol (PVA); where the vinyl alcohol moieties are grafted on a polyethylene glycol backbone.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer is particularly valuable because it combines the advantages of two of the most widely used pharmaceutical polymers: polyvinyl alcohol (PVA) and polyethylene glycol (PEG).
The resulting graft structure often performs better than a simple physical mixture of the two polymers.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves functional efficiency and formulation performance.
One of its most important properties is its ability to act as a solubility enhancer for poorly water-soluble active ingredients.
Many modern pharmaceutical compounds have low water solubility, and this polymer helps keep them dispersed in a more readily dissolving form.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves drug absorption and therapeutic effectiveness.
In amorphous solid dispersions (ASDs), the polymer helps prevent active ingredients from recrystallizing during storage.
Maintaining an amorphous state often improves dissolution rates and bioavailability.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves long-term formulation stability and performance.
In spray-drying processes, it is used as a carrier polymer that surrounds active ingredients and forms stable particles with controlled properties.
Its water compatibility makes it suitable for large-scale pharmaceutical manufacturing.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves particle quality and production efficiency.
In controlled-release technologies, the polymer matrix can influence how quickly water penetrates a formulation and how active compounds are released.
Researchers can modify the polymer composition to achieve different release profiles.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves dosage control and therapeutic consistency.
Uses:
Polyvinyl alcohol-polyethylene glycol-graft-copolymer graft-copolymer EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer is mainly used as a solubilizer, binder, film-forming agent, stabilizer, dispersing agent, and carrier polymer because it combines water solubility with strong film-forming properties.
In pharmaceutical formulations, it is used to improve the solubility and dispersion of active ingredients.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves drug dissolution and formulation performance.
In tablet and capsule products, it is used as a binder and carrier material.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves dosage form stability and reliability.
In pharmaceutical coatings, it is used to form protective and functional films.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves appearance, protection, and performance.
In cosmetics and personal care products, it is used as a stabilizer and texture modifier.
This improves consistency and application characteristics.
In hydrogels and biomedical materials, it is used as a water-compatible polymer matrix.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves material functionality and biocompatibility.
Polyvinyl alcohol–polyethylene glycol–graft copolymer is mainly used as a solubilizer, carrier polymer, film former, stabilizer, dispersant, and matrix material because it combines strong water compatibility with excellent film-forming properties.
In solid dispersion pharmaceutical products, it is used to improve the dissolution of poorly water-soluble active ingredients.
This improves bioavailability and therapeutic performance.
In tablet and capsule formulations, it is used as a carrier and binder.
This improves formulation stability and manufacturing consistency.
In pharmaceutical coating systems, it is used to form flexible protective films.
This improves appearance, protection, and product performance.
In hydrogels and biomedical materials, it is used as a water-compatible polymer matrix.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves hydration properties and material functionality.
In cosmetic formulations, it is used as a stabilizer and texture-enhancing polymer.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves consistency and application quality.
In particle dispersions and suspension systems, it is used to maintain uniform distribution of ingredients.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves storage stability and formulation homogeneity.
Polyvinyl alcohol–polyethylene glycol–graft copolymer is mainly used as a solubility enhancer, carrier polymer, film-forming agent, stabilizer, dispersant, binder, and controlled-release matrix because it combines the strength and film-forming ability of PVA with the water solubility and flexibility of PEG.
In pharmaceutical solid dispersions, it is used to increase the solubility of poorly water-soluble active pharmaceutical ingredients (APIs).
This improves dissolution rate, bioavailability, and therapeutic effectiveness.
In tablet formulations, it is used as a binder and matrix-forming agent that helps maintain tablet integrity during manufacturing and storage.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves tablet strength and consistency.
In capsule formulations, it is used as a carrier polymer for active ingredients.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves ingredient distribution and formulation stability.
In film coating systems, it is used to form clear, flexible, and durable coatings on tablets and other dosage forms.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves appearance, moisture protection, and mechanical resistance.
In controlled-release drug delivery systems, it is used as a matrix material that influences how quickly active ingredients are released.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves dosage control and treatment consistency.
In spray-dried pharmaceutical products, it is used as a carrier and stabilizing polymer during particle formation.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves powder quality and manufacturing efficiency.
In nanoparticle formulations, it is used as a stabilizer and dispersing agent to prevent particle aggregation.
This improves particle stability and uniformity.
In hydrogels and biomedical materials, it is used as a water-compatible structural polymer that can absorb and retain significant amounts of water.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves hydration capacity and material performance.
In cosmetics and personal care products, it is used as a stabilizer, film former, and texture modifier in creams, gels, and lotions.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves consistency, spreadability, and product stability.
In research and advanced drug delivery systems, it is used as a multifunctional polymer platform for developing new pharmaceutical formulations and biomaterials.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves formulation flexibility and technological innovation.
Safety Profile:
Polyvinyl alcohol–polyethylene glycol–graft copolymer is generally considered a low-toxicity and low-hazard polymer, particularly in pharmaceutical and cosmetic grades intended for regulated applications.
The primary hazard is dust-related irritation when handled as a dry powder.
Fine particles may cause temporary irritation of the eyes, skin, or respiratory tract.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves workplace safety awareness.
Inhalation of airborne powder may cause temporary respiratory discomfort, such as coughing or throat irritation in poorly ventilated environments.
Proper dust control is recommended.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves occupational safety.
Eye contact may cause mild mechanical irritation due to particulate matter.
Rinsing with water is usually sufficient.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves handling safety.
Skin contact is generally considered low risk, and the polymer is not normally associated with significant skin irritation under standard conditions.
Polyvinyl alcohol-polyethylene glycol-graft-copolymer improves user safety confidence.
From a toxicological perspective, the polymer components (PVA and PEG) are generally regarded as having low acute toxicity, and related materials are widely used in pharmaceutical and biomedical applications.
