PRODUCTS

POLYVINYLPYROLIDONE K 12

Polyvinylpyrolidone K 12 is used as a binder in many pharmaceutical tablets and used in many technical applications with various roles such as an adhesive, additive, and emulsifier.
Polyvinylpyrolidone K 12 is also used in some eye drops as a lubricant.
Polyvinylpyrolidone K 12 is used stabilizer, co-precipitation agent for poorly soluble drugs, detoxifier and lubricant for eye drops, etc.

CAS Number: 9003-39-8
EC Number: 500-004-3
MDL Number: MFCD01076626
Molecular Formula: (C6H9NO)n (as it is a polymer, the value of n varies)
Molecular Weight: Approximately 2,000 – 3,000 g/mol (varies based on polymerization degree for K-12)

SYNONYMS:
PVP K-12, Povidone K-12, Polyvinylpyrrolidone K-12, Polyvidone K-12, Kollidon K-12, PVP K-12, Polyvidone K-12, Povidone K-12, n-vinyl-2-pyrrolidone, n-vinylpyrrolidone, 1-vinyl-2-pyrrolidone, 1-vinylpyrrolidin-2-one, n-vinyl-2-pyrrolidinone, vinylpyrrolidone, 2-pyrrolidinone, 1-ethenyl, 1-vinyl-2-pyrrolidinone, n-vinylpyrrolidinone, 1-vinylpyrrolidone

Polyvinylpyrolidone K 12 has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder.
Polyvinylpyrolidone K 12 formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents.

The k number refers to the mean molecular weight of the povidone.
Polyvinylpyrolidone with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights.
The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body.

The best-known example of povidone formulations is povidone-iodine, an important disinfectant
Polyvinylpyrolidone K 12 is also known as polyvinylpyrrolidone (PVP) or polyvidone which is a synthetic water-soluble polymer made from the monomer N-vinylpyrrolidone.

Polyvinylpyrolidone K 12 is a homopolymer of vinylpyrrolidone in a colorless to slight yellow-colored, transparent liquid form.
Polyvinylpyrolidone K 12 has a K value of 10-13 and a total solids content of 39-41%.
Polyvinylpyrolidone K 12 is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution.

Available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications.
Polyvinylpyrolidone K 12 is considered to be physiologically inert:
Applications of Polyvinylpyrolidone K 12 take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.

Polyvinylpyrolidone K 12 has high polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.
Polyvinylpyrolidone K 12 is hygroscopic and amorphous.

Dispersancy, where components in a mixture are uniformly distributed through the use of Polyvinylpyrolidone K 12.
Hydrophilicity, where the substantial water solubility of Polyvinylpyrolidone K 12 is its dominant feature and frequently a factor along with other properties valuable to numerous applications.

Adhesion, taking advantage of the higher molecular weight Polyvinylpyrolidone K 12 formulating in aqueous media, then evaporating sufficient water to generate a solid product for the desired application.
Cohesivity, where cohesive strength is achieved through a variety of dry blending and granulation techniques.

Polyvinylpyrolidone K 12 is cross-linkable to a water insoluble, swellable material either in the course of vinylpyrrolidone polymerization, by addition of an appropriate multifunctional comonomer or by post-reaction, typically through hydrogen abstraction chemistry.
Polyvinylpyrolidone K 12 is linear, random and is produced by the free-radical polymerization.

Polyvinylpyrolidone K 12 has high polarity, dispersany, adhesion and cohesion.
Polyvinylpyrolidone K 12 forms hard, glossy and oxygen permeable film.
Polyvinylpyrolidone K 12 is soluble in water and polar solvents. Insoluble in esters, ethers, ketones and hydrocarbons.

Polyvinylpyrolidone K 12 is suitable for digital ink-jet printing.
Polyvinylpyrolidone K 12 is a water-soluble polymer made from the monomer N-vinylpyrrolidone.

Polyvinylpyrolidone K 12, also known as Povidone K-12, is a water-soluble polymer synthesized from the monomer N-vinylpyrrolidone.
The 'K' value denotes the average molecular weight of the polymer; for Polyvinylpyrolidone K 12, this corresponds to a molecular weight of approximately 2,000 to 3,000 g/mol

USES and APPLICATIONS of POLYVINYLPYROLIDONE K 12:
Polyvinylpyrolidone K 12 is used as a binder in many pharmaceutical tablets and used in many technical applications with various roles such as an adhesive, additive, and emulsifier.
Polyvinylpyrolidone K 12 is also used in some eye drops as a lubricant.

Polyvinylpyrolidone K 12 added to iodine forms a complex called povidone-iodinethat possesses disinfectant properties due to the presence of iodine, a bactericidal component.
Polyvinylpyrolidone K 12 is one of the three new pharmaceutical excipients.

Polyvinylpyrolidone K 12 can be used as a cosolvent for tablets, granules, injections, glidants for capsules, dispersants for liquid preparations and colorants, enzymes and heat-sensitive drugs.
Polyvinylpyrolidone K 12 is used stabilizer, co-precipitation agent for poorly soluble drugs, detoxifier and lubricant for eye drops, etc.

Industrially, Polyvinylpyrolidone K 12 is used as foamed polystyrene additives, gelling agents, stabilizers, fiber treatment agents, paper processing aids, adhesives, and thickeners for suspension polymerization.
Polyvinylpyrolidone K 12 is mainly used as hair maintenance agents.

Polyvinylpyrolidone K 12 adopts different specifications of resins.
Polyvinylpyrolidone K 12 satisfies various relative humidity and climatic conditions, so it is an indispensable raw material for styling hair cream, hair gel, and mousse.

Polyvinylpyrolidone K 12 can also be used as a skin care moisturizer in cosmetics, a grease base material, a hair dye dispersant, and a foam stabilizer to improve the consistency of shampoos.
Insoluble Polyvinylpyrolidone K 12 is a stabilizer for beer and fruit juice, which can improve its transparency, color and taste.

Polyvinylpyrolidone K 12 is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs.
Polyvinylpyrolidone K 12 has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.

Polyvinylpyrolidone K 12 is most commonly used as a suspending, dispersing, and emulsifying agent in paint, coating, adhesive, ink, and textile dyeing and printing applications.
Medical Applications of Polyvinylpyrolidone K 12: Historically used as a plasma volume expander for trauma victims.

Industrial Applications: Polyvinylpyrolidone K 12 acts as a dispersant in inks and coatings, and as a binder in ceramics and batteries.
Polyvinylpyrolidone K 12's versatility stems from its excellent solubility, adhesive properties, film-forming ability, and chemical stability, making it valuable across various industries.

Home care applications of Polyvinylpyrolidone K 12: dishwashing liquids, dishwashing and laundry tablets, laundry detergents, and hard surface cleaners.
Polyvinylpyrolidone K 12 is used for production of membranes, such as dialysis and water purification filters.

Polyvinylpyrolidone K 12 is used as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating.
Polyvinylpyrolidone K 12 can be plasticized with water and most common organic plasticizers.

Applications of Polyvinylpyrolidone K 12 take advantage of one or more properties inherent in the polymer, typically due to the lactam ring.
Polyvinylpyrolidone K 12 has high polarity and the resultant propensity to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.

-Pharmaceutical Industry uses of Polyvinylpyrolidone K 12:
Polyvinylpyrolidone K 12 serves as a binder in tablet formulations, enhancing the cohesion of tablet ingredients.
Polyvinylpyrolidone K 12 also acts as a stabilizer for oral suspensions and as a solubilizing agent for active pharmaceutical ingredients.

-Cosmetics and Personal Care uses of Polyvinylpyrolidone K 12:
Polyvinylpyrolidone K 12 functions as a film-forming agent in hair styling products, providing flexibility and hold.
Additionally, Polyvinylpyrolidone K 12 is used as a thickener and stabilizer in creams, lotions, and toothpaste.

HOME CARE FEATURES AND BENEFITS OF POLYVINYLPYROLIDONE K 12:
*Polyvinylpyrolidone K 12 acts as rheology modifier
*Polyvinylpyrolidone K 12 is a highly adhesive tablet binder
*Polyvinylpyrolidone K 12 stabilizes emulsion and structures liquid products
*Polyvinylpyrolidone K 12 provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition
*Polyvinylpyrolidone K 12 functions as binder and protective coating for enzymes
*Polyvinylpyrolidone K 12 provides surface shine enhancement
*Polyvinylpyrolidone K 12 forms hard, transparent, glossy films

PHYSICAL and CHEMICAL PROPERTIES of POLYVINYLPYROLIDONE K 12:
Physical state: Powder
Color: Beige
Odor: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available

Decomposition temperature: No data available
pH: 5.0 - 8 at 10 g/l at 20 °C
Viscosity:
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available

Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
CAS Number: 9003-39-8
EC Number: Not specifically assigned; PVP is listed under EC Number 618-363-4.
Appearance: White to off-white solid.
Odor: Odorless.
Solubility: Soluble in water and various organic solvents,
including alcohols and chloroform.
Hygroscopicity: Hygroscopic; readily absorbs moisture from the atmosphere.
Density: Approximately 1.2 g/cm³.

Glass Transition Temperature: 150–180°C.
Appearance (Form): Powder to flakes
Appearance (Colour): White to off-white
Identification: Passes test
Assay of nitrogen (on dried substance): 11.5 - 12.8%
Water: ≤ 5%
pH: 3.0 - 5.0 (5% aq. soln.)
CAS Number: 9003-39-8
EC Number: 500-004-3
MDL Number: MFCD01076626

Appearance of solution (5 % in water at 25°C): Free of haze
Appearance of solution (Ph. Eur.): Clear and not more intensely colored than ref. B6
Appearance of solution (Ph. Eur.): Clear and not more intensely colored than ref. BY6
Appearance of solution (Ph. Eur.): Clear and not more intensely colored than ref. R6
K-value: 10.2 to 13.8 (5 % solids w/v aq. soln.)
Appearance of solution (5 % in water at 25°C): Free of haze
Appearance of solution (Ph. Eur.): Clear and not more intensely colored than ref. B6
Appearance of solution (Ph. Eur.): Clear and not more intensely colored than ref. BY6

Molecular Formula: (C6H9NO)n
SMILES: -CC(-)N1CCCC1=O
MDL Number: MFCD01076626
CAS: 9003-39-8
Categories: Polymer science compounds, Hydrophobic polymers
Appearance (Form): Powder to flakes
Appearance (Colour): White to off-white
Identification: Passes test
Molecular Formula: (C6H9NO)n (as it is a polymer, the value of n varies)
Molecular Weight: Approximately 2,000 – 3,000 g/mol
(varies based on polymerization degree for K-12)

Molecular Formula: (C6H9NO)n
Assay of nitrogen (on dried substance): 11.5 - 12.8%
Water: ≤ 5%
pH: 3.0 - 5.0 (5% aq. soln.)
Appearance: White to yellowish-white Powder or flakes
Infrared spectrum: Conforms
Water: ≤5.0 % (K.F.)
Sulfated ash: ≤0.1 %
Additional info: European color test - R color: R6

HPLC: ≤3.0 % 2-Pyrrolidone
Identification: Passes test
pH: 3.0 to 5.0 (5 % in water)
Nitrogen (N): 11.5 to 12.8 % (on anhydrous substance)
MDL Number: MFCD01076626
InChI Key: WHNWPMSKXPGLAX-UHFFFAOYSA-N
PubChem CID: 6917
ChEBI: CHEBI:82551
IUPAC Name: 1-ethenylpyrrolidin-2-one
SMILES: -CC(-)N1CCCC1=O

FIRST AID MEASURES of POLYVINYLPYROLIDONE K 12:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of POLYVINYLPYROLIDONE K 12:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of POLYVINYLPYROLIDONE K 12:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of POLYVINYLPYROLIDONE K 12:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of POLYVINYLPYROLIDONE K 12:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of POLYVINYLPYROLIDONE K 12:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available