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POLYVINYLPYRROLIDONE K 15 = PVP = POVIDONE = POLYVIDONE
CAS Number: 9003-39-8
EC Number: 201-800-4
MDL number: MFCD00149016
Linear Formula: C29H43N5O5
Polyvinylpyrrolidone K 15 is a homopolymer of vinylpyrrolidone in a white to milky white-colored powder form.
Polyvinylpyrrolidone K 15, also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.
Polyvinylpyrrolidone K 15 has a low molecular weight.
Polyvinylpyrrolidone K-15 is also known as polyvidone or povidone.
Polyvinylpyrrolidone K 15 is a hygroscopic, amorphous polymer supplied as a white, free-flowing powder or a clear aqueous solution.
Polyvinylpyrrolidone K 15 is a non-ionic high molecular polymer.
PVP is classified according to its average molecular weight.
It is customarily used to indicate the K value.
Different K values represent different PVP average molecular weight ranges.
The K value is actually a characteristic value related to the relative viscosity of the PVP aqueous solution, and the viscosity is a physical value related to the molecular weight of the high molecular polymer.
Therefore, the K value can be used to characterize the average molecular weight of PVP.
Generally, the K value is more Large, the greater the viscosity.
Polyvinylpyrrolidone K 15, also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone.
White or creamy white powder,odourless,nontoxic,non-irritant,dissolves readily in water,alcohol,amine and many other organic solvents.
Polyvinylpyrrolidone K 15 exists as white or milk white powder or colorless or slight yellow transparent liquid.
Polyvinylpyrrolidone K 15 can dissolve in water and a variety of organic solvents.
Polyvinylpyrrolidone K 15 has good hygroscopicity, film-forming capability, complexing ability and physiological compatibility.
Polyvinylpyrrolidone PVP-K CAS 9003-39-8 is a hygroscopic polymer with a molecular weight ranging from 45000 to 58000, available as a white or creamy white powder.
Excellent hygroscopic, film-forming, adhesive, chemical stability and toxicological safety characters in water and many other organic solvents.
PVP are available in several molecular weight grades, they are characterized by K-value, and used in a great variety of applications.
What the different is we use K value to distinguish different PVP.
The K value of PVP is actually the characteristic value associated with the relative viscosity of the PVP aqueous solution, and the viscosity is the physical quantity associated with the molecular weight of the polymer.
Therefore, the average molecular weight of the PVP can be characterized by the K value. Usually the greater the K value, the greater the viscosity, the stronger the adhesion.
Molecular weight of polymer is generally expressed as weight average(Mw), number average and viscosity average.
The most commonly used expression is weight average molecular weight, which is measured by light scattering method.
Mw Values of PVP-K series products are shown as following:
PVP-K12 2,000-------------------3,000
PVP-K17 7,000--------------1,1000
PVP-K25 28,000-----------------34,000
PVP-K30 44,000-----------------54,000
PVP-K60 320,000---------------380,000
PVP-K90 1,000,000-----------1,500,000
PVP-K120 1,600,000-----------2,000,000
Besides, different K value of PVP have different characteristics and applications.
Polyvinylpyrrolidone K 15 exists as white or milk white powder or colorless or slight yellow transparent liquid.
Polyvinylpyrrolidone K 15 can dissolve in water and a variety of organic solvents.
Polyvinylpyrrolidone K 15 has good hygroscopicity, film-forming capability, complexing ability and physiological compatibility.
USES and APPLICATIONS of POLYVINYLPYRROLIDONE K 15:
-Plastics & Rubber
-Polyvinylpyrrolidone K 15 is most commonly used as a suspending, dispersing, and emulsifying agent in paint, coating, adhesive, ink, and textile dyeing and printing applications.
-Polyvinylpyrrolidone K 15 is a water-soluble polymer used in tissue and biomedical engineering, pharmaceutical applications and cosmetics.
-Broad-spectrum germicidal action.
-Skin and equipment disinfectant before injection or surgery.
-Anti-infection treatment for oral, gynecological, surgical, skin, etc.
-Disinfects family tableware and apparatus.
-Sterilizes, disinfects in the food stuff industry,breeding aquatics,animal diseases.
-Polyvinylpyrrolidone K-15 acts as a film former and stabilizer.
-Polyvinylpyrrolidone K 15 was used as a plasma volume expander for trauma victims after the 1950s.
-Polyvinylpyrrolidone K 15 is a hygroscopic and amorphous polyvinylpyrrolidone polymer powder.
-Polyvinylpyrrolidone K 15 forms clear, hard, shiny and glossy films.
-Polyvinylpyrrolidone K 15 provides strong and stiff hold.
-Shows excellent compatibility with acrylate thickeners.
-Polyvinylpyrrolidone K 15 stabilizes foam, emulsions, dispersions and suspensions.
-Polyvinylpyrrolidone K 15 finds application in formulating hair care products like sprays, mousses, gels, styling lotions/creams, colorants and novelty stylers.
-Polyvinylpyrrolidone K 15 is used for styling formulas or a face mask (peel-off) to harden the texture.
-Thickeners & Stabilizers
-Film Formers
-Shine / radiance
-Glossy/ultra-glossy
-Foam quality
-Hardening
-Hold
-Polyvinylpyrrolidone K 15 is a kind of new excellent pharmaceutical excipient.
-Polyvinylpyrrolidone K 15 is mainly used as binder for tablet and granule, dissolving assistant for injection, flow assistant for capsule, dispersant for liquid medicine and pigment, stabilizer for enzyme and heat-sensitive drug, coprecipitant for poorly soluble drugs, lubricator and antitoxic assistant for eye drug.
-Polyvinylpyrrolidone K 15 has been used as excipient in more than one hundred drugs.
-Low molecular weight PVP K15 ,for use as a solubilizing agent,crystallization inhibitor and suspension stabilizer in injectables and ophthalmic formulations
-Polyvinylpyrrolidone K 15 is used as a binder in many pharmaceutical tablets; Polyvinylpyrrolidone K 15 simply passes through the body when taken orally.
-Industrial applications of Polyvinylpyrrolidone K 15 include use as an adhesive to improve strength and thickness; increase strength in paper production; use as a resin coating; improve dye coloration in synthetic fibers; also commonly used in inks, imaging, lithography, detergents and soaps , textiles, pottery, electricity, metallurgy, and as a polymerization additive.
-Polyvinylpyrrolidone K 15 is also widely used in the pharmaceutical industry due to its excellent adhesion, film formation, dispersion and thickening properties.
-Polyvinylpyrrolidone K 15 is a polymer used as a pharmaceutical aid, complexing agent, and solubilizer.
-Polyvinylpyrrolidone K 15 was used as a plasma volume expander for trauma victims.
-Polyvinylpyrrolidone K 15 acts as diluent, solvent and cleaning agent in various kinds of industries.
-Polyvinylpyrrolidone K 15 also acts as an adjuvant, emulsifier, filtering aid, tableting aid, thickener.
-Application in Cosmetics:
Polyvinylpyrrolidone K 15 is widely used in a wide range of hair care, skin care and oral care products.
Polyvinylpyrrolidone K 15 are particularly suitable for formulations where viscosity modification and film forming properties are required.
Polyvinylpyrrolidone K 15 products are especially suitable for hair styling products.
Polyvinylpyrrolidone K 15 is widely used in cosmetics as below:
* Hair Gels
* Hair foam
* Liquid hair fixing preparations
* Pump Sprays
-Both hair styling products And mask products should use different levels of Polyvinylpyrrolidone K 15 together in order to obtain a suitable formula.
-Polyvinylpyrrolidone K 15 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.
-Polyvinylpyrrolidone K 15 is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs.
-Low molecular weight Polyvinylpyrrolidone K 15 is often used as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injection, and ophthalmic formulations.
-Suitable for use in styling formulas in liquid form, such as in spray form by giving natural styling (natural-hold) not stiff, used to catch curls
-Polyvinylpyrrolidone K 15 possess excellent adhesive,film-forming, dispersing and thickening properties, which are widely used in the pharmaceutical industry.
-Polyvinylpyrrolidone K 15 is used in pleurodesis (fusion of the pleura because of incessant pleural effusions).
-Pharmaceuticals & Nutraceuticals— Excipients
-Base Fluids, Glidants & Lubricants
-Binders & Disintegrants
-Bioexcipients
-Formulation & Processing Aids
-Pharmaceutical Coatings
-Solvents & Solubilizers
-Polyvinylpyrrolidone K 15 has excellent adhesive, film-forming, dispersion and thickening properties and is widely used in the pharmaceutical industry.
-In pill crushing, Polyvinylpyrrolidone K 15 is commonly used as a tablet binder to make the pills strong and not easy to break.
-Use in styling formulas by acting as a hair fixative.
-Application in industrial fields:
*Suspension, dispersion and emulsifier
*Glass fiber
*detergent
*Plastics and resin
*Ink, paint and coating
*Textile dyeing and printing
*Film and adhesive
*TV tube
-Polyvinylpyrrolidone K 15 is used in some contact lenses and their packaging solutions.
-Polyvinylpyrrolidone K 15 reduces friction, thus acting as a lubricant, or wetting agent, built into the lens.
-Suitable for use in styling formulas in liquid form, such as in spray form by giving natural styling (natural-hold) not stiff, used to catch curls
-Polyvinylpyrrolidone K 15 is used as a lubricant in some eye drops.
-Healthcare & Pharma — Drug Delivery & Care Solutions
-Oral
-Parenteral
-Healthcare & Pharma — Pharmaceutical Manufacturing
-API Manufacturing
-Excipients & Coatings
-Pharmaceutical Processing
-Low molecular weight Polyvinylpyrrolidone K 15, often used as a solubilizing agent, crystallization inhibitor and suspension stabilizer in injection.
-Polyvinylpyrrolidone K 15 have excellent solubility in water and a range of organic solvents and are supplied as a free-flowing powder with spherical particle morphology.
-Polyvinylpyrrolidone K 15 ensures rapid dispersibility and ultimate flexibility in the solvent of choice.
-Due to Polyvinylpyrrolidone K 15's non-ionic property, Polyvinylpyrrolidone K 15 do not bear any risk of interaction with ionic APIs.
-Polyvinylpyrrolidone K 15 is widely used in pharmaceutical fields, thanks to Polyvinylpyrrolidone K 15’s excellent solubility,film-formingcapability, chemical stability,physiologicalinertia and cementability.
-Polyvinylpyrrolidone K 15 in solid drugs can be used not only as a binder, solubilizer, disintegrating agent, extend agent, but also as a film coat and capsules and controlled release film.
-Binders for tablets, granules and capsules (the most widely used)
-Enhance bioavailability, filmforming coating agents, cosolvents, glidants for capsules, extenders and lubricants for ophthalmic drugs.
-Cosolvent for injection, suspension stabilizer, dispersant and solubilizer for liquid preparations.
-Filmforming agent and thickener for hair styling products, emulsion stabilizer for cream emulsion, dispersant for hair dye.
-Polyvinylpyrrolidone K 15 possess excellent adhesive,film-forming,dispersing and thickening properties,and are widely used in the pharmaceutical industry.
- Polyvinylpyrrolidone K 15 has been used for trauma victims as a plasma volume expander, as well as a binder in some pharmaceutical tablets.
-Adhesion, taking advantage of higher molecular weight Polyvinylpyrrolidone K 15 forms in aqueous medium, then evaporates enough water to produce a solid product for application.
-Cohesiveness, where the adhesive strength is achieved through a variety of dry mixing and granulation techniques.
-High polarity and tendency to form complexes with hydrogen donors, such as phenols and carboxylic acids, as well as anionic dyes and inorganic salts.
-Dispersion, in which the ingredients in the mixture are evenly distributed through the use of Polyvinylpyrrolidone K 15.
-Hydrophobicity, where the remarkable water solubility of Polyvinylpyrrolidone K 15 is Polyvinylpyrrolidone K 15's dominant property and is often a factor, along with other properties, of great value for many applications.
-Polyvinylpyrrolidone K 15 is widely used in pharmaceutical fields, because of its excellent solubility, film forming ability, chemical stability, physiological ability and cement capacity.
-Polyvinylpyrrolidone K 15 is mainly applied as adhesive for tablets
-Polyvinylpyrrolidone K 15 can also be a dissolving assistant for injection
-Polyvinylpyrrolidone K 15 is also used as a flow assistant for capsules
-Polyvinylpyrrolidone K 15 can also be dispersed for liquid medicine and pigment
-Stabilizers for enzymes and heat-sensitive drugs is another use for this product.
-Polyvinylpyrrolidone K 15 found its application as coprecipitant for poorly soluble drug lubricants, etc.
-Polyvinylpyrrolidone K 15 can be plasticized with water and the most common organic plasticizers.
-Applications take advantage of one or more properties inherent in polymers, usually due to a lactam ring.
-Polyvinylpyrrolidone K 15 can dissolve in water and most organic solvents.
-Polyvinylpyrrolidone K 15 has been widely used in drug tablets, the use of PVP for tablet adhesive, for example: compound sulfamethoxazole, aspirin, compound aspirin, acetaminophen, vitamin c, dipyridamole, dimethyl tetracycline, clonidine, benzenesulfonamide, compound analgesic, chewable tablets.
-Dishwashing liquids
-Dishwashing and laundry tablets
-Laundry detergents
-Hard surface cleaners
-Home care features and benefits:
*Acts as rheology modifier
*Is a highly adhesive tablet binder
*Stabilizes emulsion and structures liquid products
*Provides anti-soil redeposition, enzyme stabilization and dye transfer inhibition
*Functions as binder and protective coating for enzymes
*Provides surface shine enhancement
*Forms hard, transparent, glossy films
*Home care applications
PHYSICAL and CHEMICAL PROPERTIES of POLYVINYLPYRROLIDONE K 15:
Average Molecular Wt.: 10000
Physical state: white powder
Color: beige
Odor: No data available
Melting point/freezing point:
Melting point/range: 165 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: 5,0 - 8 at 10 g/l at 20 °C
Viscosity
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapor density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Assay (from N): 12.0 - 12.8 %
pH (5 %; H2O): 3.0 - 5.0
Heavy metals (as Pb): max. 0.001 %
Water (K.F.): max. 5 %
Solubility (10 %; H2O): clear, colorless to yellowish
Solubility: greater than or equal to 100 mg/mL at 68° F (NTP, 1992)
-Soluble in water and in ethanol.
-Insoluble in ether
-Sol in water giving a colloidal soln
-Practically insol in ether
-Sol in alcohol, chloroform
-Sol in chlorinated hydrocarbons, amines, nitro paraffins, lower wt fatty acids
-Soluble in water
-Soluble in alcohol
-Practically insoluble in chloroform, carbon tetrachloride, ether, solvent hexane, acetone.
-Practically insoluble in acetone, and light petroleum.
-Soluble in water and many organic solvents
-In water, 5.2X10+4 mg/L @ 25 °C /Estimated/
-Solubility in water: good
-Solubility in water: very good
FIRST AID MEASURES of POLYVINYLPYRROLIDONE K 15:
-Description of first-aid measures:
*If inhaled:
If breathed in, move person into fresh air.
*In case of skin contact:
Wash off with soap and plenty of water.
*In case of eye contact:
Flush eyes with water as a precaution.
*If swallowed:
Rinse mouth with water.
-Indication of any immediate medical attention and special treatment needed:
No data available
ACCIDENTAL RELEASE MEASURES of POLYVINYLPYRROLIDONE K 15:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Sweep up and shovel.
Keep in suitable, closed containers for disposal.
FIRE FIGHTING MEASURES of POLYVINYLPYRROLIDONE K 15:
-Extinguishing media:
--Suitable extinguishing media:
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
-Advice for firefighters:
Wear self-contained breathing apparatus for firefighting if necessary.
-Further information:
No data available
EXPOSURE CONTROLS/PERSONAL PROTECTION of POLYVINYLPYRROLIDONE K 15:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
*Skin protection
Handle with gloves.
Wash and dry hands.
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Respiratory protection
Respiratory protection is not required.
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of POLYVINYLPYRROLIDONE K 15:
-Precautions for safe handling:
--Hygiene measures:
General industrial hygiene practice.
-Conditions for safe storage, including any incompatibilities:
Storage conditions
Store in cool place.
Keep container tightly closed in a dry and well-ventilated place.
Storage class:
Storage class (TRGS 510): 13: Non Combustible Solids
STABILITY and REACTIVITY of POLYVINYLPYRROLIDONE K 15:
-Reactivity: No data available
-Chemical stability: Stable under recommended storage conditions.
-Possibility of hazardous reactions: No data available
-Conditions to avoid: No data available
SYNONYMS:
PVP
Povidone
Polyvidone
Poly(1-vinyl-2-pyrrolidinone)homopolymer
1-[(3R,5S,7R)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-1,3-dihydro-2H-pyrrol-2-one
Polyvinylpyrrolidone K15
1-[(3R,5S,7R)-1,5,7,9-tetrakis(2-oxopyrrolidin-1-yl)nonan-3-yl]-3H-pyrrol-2-one
Poly[1-(2-oxo-1-pyrrolidinyl)ethylene]
1-ethenylpyrrolidin-2-one
