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Polyvinylpyrrolidone K 17, also commonly called polyvidone or povidone, is a water-soluble polymer compound made from the monomer N-vinylpyrrolidone.
Polyvinylpyrrolidone K 17 is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties.
Polyvinylpyrrolidone K 17 is a low-molecular-weight grade of polyvinylpyrrolidone, a water-soluble synthetic polymer widely used in pharmaceuticals, cosmetics, and industrial applications.
CAS Number: 9003-39-8
Molecular Formula: CH4
Molecular Weight: 16.04246
EINECS Number: 1312995-182-4
Synonyms: Povidone, Polyvinylpyrrolidone, PVP, Kollidon, Poly(1-vinyl-2-pyrrolidinone), Poly(vinylpyrrolidone), 1-Ethenyl-2-pyrrolidinone homopolymer, 1-Vinyl-2-pyrrolidinone polymer, Bolinan, FZ989GH94E, Kollidon 30, N-Vinylbutyrolactam polymer, Periston, Plasdone, Polividone, Poly(1-vinyl-2-pyrrolidone), Poly(N-vinylbutyrolactam), Povidone, Unspecified, Protagent, Vinisil, Vinylpyrrolidinone polymer, Vinylpyrrolidone polymer, poly(N-vinylpyrrolidone), 1-Vinyl-2-pyrrolidone polymer, 2-Pyrrolidinone, 1-vinyl-, polymers, Albigen A, Crospovidonum, Hemodesis, Hemodez, Kollidon 17, Kollidon 25, N-Vinyl-2-pyrrolidone polymer, N-Vinylpyrrolidinone polymer, N-Vinylpyrrolidone polymer, Neocompensan, PVP 40, PVP-K 90, Peregal ST, Peviston, Plasdone 4, Plasdone K 29-32, Plasmosan, Polividona, Poly(1-vinylpyrrolidinone), Poly(N-vinyl-2-pyrrolidinone), Poly(N-vinyl-2-pyrrolidone), Poly(N-vinylpyrrolidinone), Polyclar AT, Polyclar H, Polyvidone, Polyvidonum, Povidonum, Subtosan, (C6H9NO)n, 1-Ethenyl-2-pyrrolidinone polymers, AT 717, Agent AT 717, Aldacol Q, Antaron P 804, Ganex P 804, Ganex p-804, K 115, K 15, K 25, K 25 (polymer), K 30, K 30 (polymer), K 60, K 60 (polymer), K 90, LUVISKOL K 30, LUVISKOL K 90, Luviskol, MPK 90, PVP 5, PVP-K 15, PVP-K 60, Peragal ST, Periston-N, Plasdone XL, Poly(1-ethenyl-2-pyrrolidinone), Poly(1-vinyl-2-pyrrolidinone) homopolymer, Poly(vinylpyrrolidinone), Poly-N-vinyl pyrrolidone, Polyclar L, Polyvidon, Povidona, Povidone K 30, Toxobin, 1-VINYL-2-PYRROLIDINONE, POLYMERS, 143 RP, 143RP, 2-Pyrrolidinone, 1-ethenyl, homopolymer, 2-Pyrrolidinone, 1-vinyl-, polymers, compd. with aluminum acetate, AGRIMER 30, AGRIMER K 30, ANTITOX VANA, Agrimer, B 7509, CCRIS 3611, CEVIAN A 88036, Caswell No. 681, D08AG02, D09AA09, D11AC06, DIVERGAN RS, DTXSID0025941, E-1201, EPA Pesticide Chemical Code 079033, G01AX11, GAFTEX AE-K 15, HSDB 205, HUEPER'S POLYMER NO.5, INS NO.1201, INS-1201, K 115 (VINYL POLYMER), K 115 (polyamide), K 120, K 120 (POLYMER), K 15 (POLYMER), K 25 (SURFACTANT), K115, K115 (polyamide), K15, K60, K60 (polymer), KOLLIDON 17PF, KOLLIDON 90, KOLLIDON CE 50/50, KOLLIDON K 25, KOLLIDON K 30, KOLLIDON K 90, LFC, LUMITEN PR 8450, LUVISKOL K 12, LUVISKOL K 17, LUVISKOL K 25, LUVISKOL K 60, LUVISKOL K 80, LUVISKOL KPO, N-VINYL-2-PYRROLIDONE HOMOPOLYMER, N-VINYLPYRROLIDONE HOMOPOLYMER, NCI-C60582, NP-K 30, NPK 15, NPK 90, NSC 114022, NSC 142693, NSC-114022, NSC-142693, P 0696, PAK-K 15, PERISTON N, PLASDONE C, PLASDONE C 15, PLASDONE K 15, PLASDONE K 30, PLASDONE K 90, POLY(N-VINYL-GAMMA-BUTYROLACTAM), POLY-(1-VINYL-2-PYRROLIDONE), POLYPLASDONE, POLYPLASDONE INF 10, POLYPLASDONE XL 10, POLYVINYLPYRROLIDON XL, POLYVINYLPYRROLIDONE-(1201), POVIDONE (EP MONOGRAPH), POVIDONE (MART.), POVIDONE (USP MONOGRAPH), POVIDONE (USP-RS), POVIDONE K 25, POVIDONE K 29-32, POVIDONE K 2932, POVIDONE K 90, POVIDONES, PVP 1, PVP 1230, PVP 2, PVP 25, PVP 3, PVP 4, PVP 50, PVP 6, PVP 7, PVP K 3, PVP-K 120, PVP-K 17, PVP-K 25, PVP-K 3, PVP-K 40, PVP-K 80, PVPON, Plasdone No. 4, Polvidone, Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.1, Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.2, Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.3, Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.4, Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.5, Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.6, Poly(1-vinyl-2-pyrrolidinone) Hueper's Polymer No.7, Polyclar A. T., Polyclar-AT, Polygyl, Polyvidons, R02AA15, S01AX18, SD 13, SD 13 (POLYMER), SOKALAN HP 50, SOKALAN HP 53, Sauflon, UNII-2S7830E561, UNII-333AG72FWJ, UNII-40UAA97IT9, UNII-68401960MK, UNII-6B46OH7T95, UNII-C67P1734QJ, UNII-E54VE15114, UNII-FZ989GH94E, UNII-H7AGY1OJO8, UNII-K0KQV10C35, UNII-RDH86HJV5Z, UNII-SZR7Z3Q2YH, UNII-U725QWY32X, Unspecified Povidone, poly(1-(2-oxopyrrolidin-1-yl)ethylene), poly(N-vinyl pyrrolidone), toxobin;vinisil;vinylpyrrolidinonepolymer;vinylpyrrolidonepolymer;PVP K30 USP24;PVP K120;K30 PVP K30;K 30 POVIDONE K 30 BP/USP
Polyvinylpyrrolidone K 17 acts as a binder in tablet formulations, a film-forming agent in personal care products, and a stabilizer in suspensions and emulsions.
Due to its lower molecular weight, PVP K 17 has relatively low viscosity in solution, making it suitable for applications requiring good solubility and rapid dissolution.
Polyvinylpyrrolidone K 17 is commonly used in oral, topical, and ophthalmic formulations, as well as in adhesives, coatings, and food processing.
Polyvinylpyrrolidone K 17, also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone
Polyvinylpyrrolidone K 17, PVP K25, PVP K30, PVP K90 exists in white powder or aqueous solution.
Polyvinylpyrrolidone K 17 readily dissolves in water, alcohol, amine and halohydrocarbon, but is not dissolved in acetone and aether etc..
It has good solubility, biocompatibility, and physiologically inert, film-forming character, colloid protect ability and compound ability to many organic or inorganic compounds.
Polyvinylpyrrolidone K 17 is also steady to acid, salt and heat, so it is widely used.
Polyvinylpyrrolidone K 17 is abbreviated as PVP, and is the polymer of vinylpyrrolidone.
According to the different degree of polymerization, it is further classified into soluble PVP and insoluble PVPP (polyvinyl polypyrrolidone).
Molecular weight of the soluble PVP is 8,000 to 10,000.
The soluble PVP can be used as a precipitating agent which can be settle down through its action with polyphenols.
Using this method, it is easily to have residual PVP in the alcohol.
Due to the savings effect of PVP inside the human body, the World Health Organization doesn’t recommend to apply this substance.
In recent years, the use of soluble PVP has been rare.
Insoluble PVPP system had began to be used in the beer industry since the early 1960s.
Polyvinylpyrrolidone K 17 has a relative molecule weight greater than the relative mass greater than 700,000.
Polyvinylpyrrolidone K 17 is a insoluble polymer derived from the further cross-linking and polymerization of PVP and can be used as an adsorbent of polyphenols with a good efficacy.
Polyvinylpyrrolidone K 17 Technical Grade is a Homopolymer of vinylpyrrolidone (Polyvinylpyrrolidone) in a powder form.
Polyvinylpyrrolidone K 17 is a homopolymer of vinylpyrrolidone in a colorless to slight yellow-colored, transparent liquid form.
Polyvinylpyrrolidone K 17 has a K value of 15-19 and a total solids content of 39-41%.
Polyvinylpyrrolidone K 17 is most commonly used as a suspending, dispersing, and emulsifying agent in paint, coating, adhesive, ink, and textile dyeing and printing applications.
Polyvinylpyrrolidone K 17 is one of the three major pharmaceutical new excipients and can be used as the co-solvent of tablets, granules, and injection, as the glidant of capsules, as the dispersant agent of liquid preparations and the colorant, as the stabilizer of enzyme and heat sensitive drug, as the co-precipitating agent of poorly soluble drugs, and as the detoxicant of ophthalmic drugs and lubricants.
It is industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents.
Polyvinylpyrrolidone K 17 and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent.
The film it formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust.
Adopting different category of resin can meet various kinds of relative humidity climatic conditions.
Therefore, it is an indispensable raw material in styling hair cream, hair gel, and mousse.
It can also be used for the cosmetics of skin moisturizing agents and the dispersants for grease based hair dying, also as foam stabilizers, and can improve the consistency of the shampoo.
Insoluble Polyvinylpyrrolidone K 17 is the stabilizer of beer and juice which can improve its transparency, color, and flavor.
Polyvinylpyrrolidone K 17 is a water soluble polyamide. Commercially available PVP is divided into four viscosity grades according to its press K value (Fikentscher K value): K-15, K-30, K-60, K-90, with the average molecular weight being 10,000, 40000,160000, and 360000, respectively.
K value or molecular weight is an important factor which decides the various properties of PVP.
Polyvinylpyrrolidone K 17 is dissolved in water, chlorinated solvents, alcohol, amine, nitro-paraffin and low molecular weight fatty acids, and is mutually soluble with most inorganic salts and a variety of resin; insoluble in acetone and ether.
Polyvinylpyrrolidone K 17 used for the matrix of dropping pill matrix is odorless, tasteless, white to pale yellow waxy solid with the relative density being 1.062, and its 5% aqueous solution pH being 3 to 7.
Polyvinylpyrrolidone K 17 is hygroscopic and of good thermal stability, and can be dissolved in various kinds of organic solvents, and has high melting point.
Adding certain natural or synthetic polymers or organic compounds can effectively adjust the PVP’s hygroscopicity and softness.
Polyvinylpyrrolidone K 17 is not prone to have chemical reaction.
Under normal storage conditions, dry PVP is quite stable.
Polyvinylpyrrolidone K 17 has excellent physical inertia and biocompatibility and has not stimulation to skin, eyes no stimulation with no allergic reactions and being non-toxic.
Because of the hydrogen bonding or complexation effect, Polyvinylpyrrolidone K 17’s viscosity is increased and this further inhibits the formation and growth of crystallized nuclei of drugs, making the drug being in the amorphous state.
The dropping pill whose matrix is PVP can enhance the dissolution and bioavailability of poorly soluble drugs.
In general, the greater the PVP amount, the higher dissolution and solubility of drug in the medium. Susana et al have studied the dissolution of the PVP solid dispersant of the slightly soluble drug albendazole.
The increased amount of Polyvinylpyrrolidone K 17 can increase the dissolution rate and efficiency of drug inside the solid dispersant.
Teresa et al have studied the dissolution of the poorly soluble drugs, flunarizine in PVP solid dispersant and obtained similar conclusion.
Polyvinylpyrrolidone K 17 also found that the higher the content, the more significant increase in dissolution.
IR has showed that flunarizine and Polyvinylpyrrolidone K 17 has no chemical reaction except in some cases that a best dissolution efficacy is obtained only in certain ratio between some drugs with the PVP.
Tantishaiyakul et al has found that: when the ratio of piroxicam: Polyvinylpyrrolidone K 17 is 1:5 and 1:6, the dissolution of the solid dispersant is the largest with a 40 times as high as that of single drug within 5min.
Polyvinylpyrrolidone K 17 can also be dissolved in another molten dropping pill matrix, such as polyethylene glycol (PEG), polyoxyethylene monostearate (S-40), poloxamer and stearyl acid, glyceryl monostearate, etc for making complex matrix.
Polyvinylpyrrolidone K 17 powder is polyvinylpyrrolidone (PVP) by BASF.
It can be used as a protective colloid and thickening agent in adhesive dispersions.
Polyvinylpyrrolidone K 17 powder is used in adhesive sticks, wettable gums for postage stamps, envelopes and in pick-up adhesives for bonds that can be broken and remade several times.
Ashland offers a comprehensive range of Plasdone povidone (PVP).
Plasdone povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms.
Polyvinylpyrrolidone K 17 is a synthetic, water-soluble polymer that belongs to the polyvinylpyrrolidone family, which is widely used in pharmaceuticals, cosmetics, food, and industrial applications.
The "K 17" designation refers to its specific molecular weight range, with a relatively low viscosity compared to higher K-value grades like K 30 or K 90.
This property makes it particularly suitable for applications that require a fast-dissolving polymer with excellent solubility and stability.
In the pharmaceutical industry, Polyvinylpyrrolidone K 17 is frequently used as a binder in tablet formulations, helping to improve tablet cohesion and mechanical strength.
Polyvinylpyrrolidone K 17 enhances drug solubility and bioavailability, making it valuable in the formulation of poorly water-soluble drugs.
Additionally, Polyvinylpyrrolidone K 17 serves as a film-forming agent in coatings, helping to create smooth, protective layers on tablets or capsules.
Melting point: >300 °C
Boiling point: 90-93 °C
Density: 1,69 g/cm3
bulk density: 330kg/m3
Tg: 175
refractive index: (25) 1.5300
refractive index: 1.5300
storage temp.: 2-8°C
solubility: H2O: soluble100mg/mL
form: powder
color: White to yellow-white
PH: 3.0-5.0
Viscosity: 0.06(Intrinsic viscosity)
Viscosity:1.61(Intrinsic viscosity)
biological source: synthetic (oragnic)
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
Merck: 14,7697
Stability: Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
InChI: InChI=1S/C8H15NO/c1-3-7(2)9-6-4-5-8(9)10/h7H,3-6H2,1-2H3
InChIKey: FAAHNQAYWKTLFD-UHFFFAOYSA-N
SMILES: N1(C(C)CC)C(=O)CCC1
Polyvinylpyrrolidone K 17 is the cross-linked homopolymer of pure vinylpyrrolidone.
It is hygroscopic and free-flowing white or off-white powder.
Polyvinylpyrrolidone K 17 has a slight foul smell.
Polyvinylpyrrolidone K 17 is insoluble in common solvents such as water, ethanol and ether.
So its molecule weight range can’t be measured.
However, PVP has ability to form complex with various kinds of substances (such as “Hu” class substance which can lead to the discoloration of a variety of wines and beverages discoloration).
Also Polyvinylpyrrolidone K 17 is easily to be removed after filtration because of its insolubility.
Polyvinylpyrrolidone K 17 is manufactured by the Reppe process.
Acetylene and formaldehyde are reacted in the presence of a highly active copper acetylide catalyst to form butynediol, which is hydrogenated to butanediol and then cyclodehydrogenated to form butyrolactone.
Polyvinylpyrrolidone K 17 is produced by reacting butyrolactone with ammonia. This is followed by a vinylation reaction in which pyrrolidone and acetylene are reacted under pressure.
The monomer, vinylpyrrolidone, is then polymerized in the presence of a combination of catalysts to produce povidone.
Polyvinylpyrrolidone K 17, a polymer of vinylpyrrolidinone, is an excipient used as a suspending and dispersing agent.
Injectable preparations containing polymers with a molecular weight in the order of 12,000 have caused painful local granulomatous lesions.
This has led to the withdrawal of polyvidone from such preparations in some countries.
Polyvinylpyrrolidone K 17 was formerly also used as a plasma expander but, because it was sequestered within the liver and spleen, this use has been discontinued.
However, Polyvinylpyrrolidone K 17 remains widely used as a vehicle for ophthalmic preparations, and as the major component of artificial tears.
Polyvinylpyrrolidone K 17 is commonly found in hair styling products, skin care formulations, and oral care products.
It acts as a film former, giving hair gels and sprays their holding properties while providing flexibility and non-tackiness.
In skin care products, it helps improve texture, enhance moisture retention, and stabilize emulsions.
Beyond pharmaceuticals and cosmetics, Polyvinylpyrrolidone K 17 is also used in food applications as a stabilizer, dispersing agent, or thickener.
In the beverage industry, for example, it can be used as a clarifying agent to remove unwanted polyphenols and tannins from beer and wine, improving their stability and appearance.
Additionally, Polyvinylpyrrolidone K 17 has industrial applications in adhesives, coatings, and printing inks, where its film-forming, binding, and stabilizing properties contribute to improved performance.
Its non-toxic and biocompatible nature makes it a preferred choice in many formulations where safety and effectiveness are essential.
Polyvinylpyrrolidone K 17 is a versatile polymer with a wide range of applications across multiple industries, valued for its excellent solubility, binding capacity, and film-forming properties.
Polyvinylpyrrolidone K 17 is not easy to have chemical reaction.
When stored at normal conditions, dry Polyvinylpyrrolidone K 17 is quite stable.
Solution undergone mildew treatment is also stable.
When heated in air to 150 °C or mixed with ammonium persulfate to heat at 90 °C for 30min, Polyvinylpyrrolidone K 17 will be exchanged to become a water-insoluble compound.
In the presence of azo compound or a dichromate oxidizing agent, light will cause PVP solution to become gel.
The co-heating of PVP solution with strong base (such as sodium silicate or trisodium phosphate) will generate precipitation.
Many different compounds can generate complexes with Polyvinylpyrrolidone K 17.
For example, the complexes of PVP and iodine is very stable and have a good bactericidal effect and can reduce its toxicity; Adding the copolymers of the polyacrylic acid, tannic acid or methyl vinyl ether and maleic acid to the aqueous solution of PVP will generate insoluble complexes which are insoluble in water, alcohols and ketones.
But when being treated with base for neutralize the poly-acid can reverse the reaction; complexation between PVP and toxins, drugs and toxic chemicals can reduce their toxicity; some kinds of dyes can also form a strong complex with PVP, which is the basis for using PVP as a dye bleaching agent.
In the early 1950s, older, with shellac and oil-based hairspray had been rapidly replaced by PVP sprays which are still widely used until now.
Polyvinylpyrrolidone K 17 can form wet, transparent film on the hair which is shiny and has good lubrication effect.
Polyvinylpyrrolidone K 17 has good compatibility with a variety of good propellant and also has corrosion resistance.
Polyvinylpyrrolidone K 17 is widely used in hair styling, as the film former in combing products, as the creatinine and stabilizer of skin care lotions and creams, as the base stock material for eye and facial cosmetics and lipstick base, and also as hair dye dispersants and shampoo foam stabilizer.
Polyvinylpyrrolidone K 17 has detoxification effect and can reduce the irritation effects of other preparation on the skin and eyes.
It is also used as toothpaste detergents, gelling agents and antidotes.
The main drawback of PVP is its sensitivity to moisture.
However, this issue can be tackled by using its vinyl acetate copolymer in order to mitigate the effects of moisture and humidity.
In addition, Polyvinylpyrrolidone K 17 also has wide application in the pharmaceutical, beverage and textile industries.
Water and methanol is the preferred solvent of Polyvinylpyrrolidone K 17 pH value has little effect on the viscosity of the aqueous solution of PVP, for example, at 25 °C, pH range: 0.1~10, aqueous solution of PVP K-30 with a mass fraction of 5% concentration has a viscosity of 2.3~2.4mPa • s; in concentrated hydrochloric acid, this is 4.96mPa • s.
Effect of temperature on the viscosity of the PVP aqueous solution is also relatively not obvious.
Un-cross-linked PVP solution is not particularly thixotropic unless under very high concentration and display a short relaxation time.
The chart 3 below lists the viscosity of PVP K-30 in a variety of solvents.
Polyvinylpyrrolidone K 17 is mainly used as pharmaceutical excipient, blood compatibilizer, cosmetics thickening agents, latex stabilizers, and clarifying agent of beer brewing.
Not matter whether in solution or in the form of film, Polyvinylpyrrolidone K 17 always has a high degree of compatibility.
Polyvinylpyrrolidone K 17 has good compatibility with various kinds of inorganic salt solution, many natural and synthetic resins and other chemical compatibility.
Examples of their compatibility are seen at chart 4 and Figure 5.
Its crude product comes from the polymerization of vinylpyrrolidone under basic catalyst or the existence of N, N'-divinyl amidine and further cross-inking reaction.
Then use water, 5% acetic acid and 50% ethanol for reflux to until extract ≤50mg/kg (for over 3h).
Polyvinylpyrrolidone K 17 occurs as a fine, white to creamy-white colored, odorless or almost odorless, hygroscopic powder.
Polyvinylpyrrolidone K 17 with K-values equal to or lower than 30 are manufactured by spray-drying and occur as spheres.
Polyvinylpyrrolidone K 17 and higher K-value povidones are manufactured by drum drying and occur as plates.
Polyvinylpyrrolidone K 17 is compatible in solution with a wide range of inorganic salts, natural and synthetic resins, and other chemicals.
It forms molecular adducts in solution with sulfathiazole, sodium salicylate, salicylic acid, phenobarbital, tannin, and other compounds; see Section 18.
The efficacy of some preservatives, e.g. thimerosal, may be adversely affected by the formation of complexes with povidone.
Polyvinylpyrrolidone K 17 is soluble in water and other polar solvents.
For example, it is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).
When dry Polyvinylpyrrolidone K 17 is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water.
In solution, it has excellent wetting properties and readily forms films.
This makes it good as a coating or an additive to coatings.
Polyvinylpyrrolidone K 17 was first synthesized by BASF chemist Walter Reppe, and a patent was filed in 1939 for one of the derivatives of acetylene chemistry.
Polyvinylpyrrolidone K 17 was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.
BASF continues to make PVP, including a pharmaceutical portfolio under the brand name of Kollidon.
Uses:
Clarifying agent; pigment stabilizer; colloidal stabilizer; Polyvinylpyrrolidone K 17 is mainly used for beer clarifying and quality stabilizing (reference amount 8~20g/100L, maintained for 24h and remove it by filtration), and can also be applied in combination with enzymes (protease) and protein adsorbents.
Polyvinylpyrrolidone K 17 is also used to clarify the wine and as a stabilizer to prevent discoloration (reference amount 24~72g/100L).
Clarifying agents; stabilizers; thickeners agent; tablet fillers; dispersants; Polyvinylpyrrolidone K 17 of molecular weight 360,000 are often used as the clarifying agent of beer, vinegar, and grape wine.
Polyvinylpyrrolidone K 17 is used as the fixing liquid for gas chromatography.
It is used as a colloidal stabilizer and clarifying agent for beer clarification.
Apply proper amount according the demands of production.
Polyvinylpyrrolidone K 17 can be used for pharmacy, aquaculture, and livestock disinfectant for the sterilization of the skin and mucous.
PolyFilterTM molecule has an amide bond for absorbing the hydroxyl groups located in polyphenol molecule to form hydrogen bonds, and therefore, can be used as the stabilizer of beer, fruit wine/grape wine, and drinking wine to extend their shelf life and improve the transparency, color and taste.
Polyvinylpyrrolidone K 17s have two specifications: disposable type and regeneration type.
Disposable products are suitable for application by SMEs; renewable products demand the purchase of special filtration equipment; but since it is recyclable, it is suitable for large breweries for recycle application.
In daily cosmetics, Polyvinylpyrrolidone K 17 and its copolymer has good dispersion property and filming property, and thus being able to be used as a setting lotion, hair spray and styling mousse, as opacifiers for hair care agents, as the stabilizer of shampoo foam, as wave styling agent and as the dispersants and affinity agents in hair dye.
Adding PVP to cream, sunscreen, and hair removal agent can enhance wetting and lubricating effect.
Taking advantage of the excellent properties of PVP such as surface activity, film-forming and non-irritating to the skin, no allergic reactions, etc., has broad prospects in its application in hair care and skin care products.
Polyvinylpyrrolidone K 17 is used as an adhesive in glue sticks; an emulsifier and a disintegrant for solution polymerization; an additive to Doro's RNA extraction buffer; as a liquid-phase dispersion enhancing agent in diffusion-ordered spectroscopy (DOSY) NMR and as a thickening agent in tooth whitening gels.
Polyvinylpyrrolidone K 17 finds use in personal care products like shampoos and toothpastes, in ink for inkjet printers as well as in contact lens solutions.
It is used as a food additive and in the wine industry as a fining agent for white wine.
Polyvinylpyrrolidone K 17 is used as a capping agent to synthesize silver nanowires through a polyol process.
Polyvinylpyrrolidone K 17 is water-soluble and is usually polymerized in aqueous solution at about 50??C with ammonia and hydrogen peroxide.
The polymer is also water-soluble and is isolated by spray-drying.
Commercial grades of Polyvinylpyrrolidone K 17 have average molecular weights (Mv) ranging from about 10000 up to 360000.
The largest use of Polyvinylpyrrolidone K 17 is in cosmetic formulations, especially hair lacquers.
In the latter applications, Polyvinylpyrrolidone K 17 is the preferred film-former on account of good adhesion to hair, lustre of the film and ease of removal on washing.
The polymer is also used as a binder in pharmaceutical tablets.
Polyvinylpyrrolidone K 17 also finds use in the textile industry, particularly in colour stripping operations, where the great affinity of the polymer for dyestuffs is utilized.
An interesting application of Polyvinylpyrrolidone K 17 is in aqueous solution as a blood plasma substitute; such material was extensively used in Germany during the Second World War.
Although povidone is used in a variety of pharmaceutical formulations, it is primarily used in solid-dosage forms.
In tableting, Polyvinylpyrrolidone K 17 solutions are used as binders in wet-granulation processes.
Polyvinylpyrrolidone K 17 is also added to powder blends in the dry form and granulated in situ by the addition of water, alcohol, or hydroalcoholic solutions.
Polyvinylpyrrolidone K 17 is used as a solubilizer in oral and parenteral formulations, and has been shown to enhance dissolution of poorly soluble drugs from solid-dosage forms.
Polyvinylpyrrolidone K 17 solutions may also be used as coating agents or as binders when coating active pharmaceutical ingredients on a support such as sugar beads.
Polyvinylpyrrolidone K 17 is additionally used as a suspending, stabilizing, or viscosity-increasing agent in a number of topical and oral suspensions and solutions.
The solubility of a number of poorly soluble active drugs may be increased by mixing with povidone.
Special grades of pyrogen-free povidone are available and have been used in parenteral formulations.
Polyvinylpyrrolidone K 17 binds to polar molecules exceptionally well, owing to its polarity.
This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.
Polyvinylpyrrolidone K 17 is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes.
It has also been used in contact lens solutions and in steel-quenching solutions.
Polyvinylpyrrolidone K 17 is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.
As a food additive, Polyvinylpyrrolidone K 17 is a stabilizer and has E number E1201.
It is also used in the wine industry as a fining agent for white wine and some beers.
In in-vitro fertilisation laboratories, polyvinylpyrrolidone is used to slow down spermatozoa in order to capture them for e.g. ICSI.
In molecular biology, Polyvinylpyrrolidone K 17 can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer.
It is also exceptionally good at absorbing polyphenols during DNA purification.
Polyvinylpyrrolidone K 17s are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.
In microscopy, Polyvinylpyrrolidone K 17 is useful for making an aqueous mounting medium.
Polyvinylpyrrolidone K 17 can be used to screen for phenolic properties, as referenced in a 2000 study on the effect of plant extracts on insulin production.
Polyvinylpyrrolidone K 17, PVP K 17 Cas 9003-39-8 - used as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly.
There are high-purity injectable grades of PVP available on the market, for specific use in intravenous, intramuscular, and subcutaneous applications.
Polyvinylpyrrolidone K 17 is used as a binding agent in glues, adhesives, and coatings for improved adhesion and durability.
Helps stabilize ink formulations and improve print quality.
Polyvinylpyrrolidone K 17 is used in lithium-ion battery formulations as a binder for electrodes.
Functions as a sizing agent, improving fiber cohesion and fabric quality.
Polyvinylpyrrolidone K 17 is a frequently used binder in pharmaceutical tablet formulations.
Pharmacokinetic studies in humans and various laboratory animal models indicate no to very little systemic absorption of PVP following oral administration.
Polyvinylpyrrolidone K 17 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.
This complex is used in various products such as solutions, ointment, pessaries, liquid soaps, and surgical scrubs.
Polyvinylpyrrolidone K 17 is sold under the trade names Pyodine and Betadine, among others.
It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions).
For this purpose, povidone-iodine is as effective and safe as talc, and may be preferred because of its easy availability and low cost.
Polyvinylpyrrolidone K 17 is used in some contact lenses and their packaging solutions.
It reduces friction, thus acting as a lubricant, or wetting agent, built into the lens. Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology, Air Optix contact lens packaging solution (as an ingredient called "copolymer 845"), and Johnson & Johnson's Acuvue contact lenses.
Polyvinylpyrrolidone K 17 is used as a lubricant in some eye drops, e.g. Bausch & Lomb's Soothe.
Polyvinylpyrrolidone K 17 was used as a plasma volume expander for trauma victims after the 1950s.
It is not preferred as a volume expander due to its ability to provoke histamine release and also interfere with blood grouping.
Polyvinylpyrrolidone K 17 has a wide range of applications due to its excellent solubility, binding capacity, film-forming properties, and stabilizing effects.
Used in solid dosage forms like tablets and capsules to improve cohesion and mechanical strength.
Enhances the solubility and bioavailability of poorly water-soluble drugs.
Polyvinylpyrrolidone K 17 helps form protective coatings on tablets and capsules, improving stability and appearance.
Prevents sedimentation in liquid formulations, ensuring even distribution of active ingredients.
Aids in uniform distribution of drug particles in formulations.
Polyvinylpyrrolidone K 17 acts as a film-forming agent in hair gels, sprays, and mousses, providing hold without excessive stiffness.
Helps stabilize emulsions and enhance the texture of creams, lotions, and serums.
Polyvinylpyrrolidone K 17 is used in mouthwashes and toothpaste as a thickener and stabilizer.
Contributes to film formation in foundations, mascaras, and sun protection products.
Polyvinylpyrrolidone K 17 is also used in many technical applications: as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process, as an emulsifier and disintegrant for solution polymerization to increase resolution in photoresists for cathode-ray tubes (CRT).
Polyvinylpyrrolidone K 17 for production of membranes, such as dialysis and water purification filters, as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating, as a thickening agent in tooth whitening gels, as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation, as an additive to Doro's RNA extraction buffer.
Storage:
Polyvinylpyrrolidone K 17 darkens to some extent on heating at 150°C, with a reduction in aqueous solubility.
It is stable to a short cycle of heat exposure around 110–130°C; steam sterilization of an aqueous solution does not alter its properties.
Aqueous solutions are susceptible to mold growth and consequently require the addition of suitable preservatives.
Polyvinylpyrrolidone K 17 may be stored under ordinary conditions without undergoing decomposition or degradation.
However, since the powder is hygroscopic, it should be stored in an airtight container in a cool, dry place.
Safety Profile:
The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses, and it is generally recognized as safe (GRAS).
Polyvinylpyrrolidone K 17 is included in the Inactive Ingredient Database for use in oral, topical, and injectable formulations.
However, there have been documented cases of allergic reactions to Polyvinylpyrrolidone K 17, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP has come in contact with autologous serum (internal blood fluids) and mucous membranes.
Polyvinylpyrrolidone K 17 a boy had an anaphylactic response after application of PVP-Iodine for treatment of impetigo.
He was found to be allergic to the PVP component of the solution.
A woman had experienced urticaria (hives) from various hair products, later found to contain PVP.
The woman had an anaphylactic response after povidone-iodine solution was applied internally during a surgery. She was found to be allergic to PVP.
A man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.
Additionally, Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses.
Yet subsequent testing results in some patients show no signs of allergy to the suspect chemical.
Allergies attributed to these other chemicals may possibly be caused by the PVP instead.
Mtldly toxic by intraperitoneal and intravenous routes. Questionable carcinogen.
When heated to decomposition it emits toxic fumes of NOx.
Polyvinylpyrrolidone K 17 is physiologically inert.
Acute oral toxicity of Polyvinylpyrrolidone K 17: LD50 > 100g/kg.
It does not irritate the skin or eyes, do not cause skin allergies.
A large number of long-term toxicology studies have confirmed that Polyvinylpyrrolidone K 17 can tolerate intraperitoneal, intramuscular, intravenous administration and parenteral applications. Subacute and chronic toxicity result was negative.
Polyvinylpyrrolidone K 17 has been used in pharmaceutical formulations for many years, being first used in the 1940s as a plasma expander, although it has now been superseded for this purpose by dextran.
Polyvinylpyrrolidone K 17 is widely used as an excipient, particularly in oral tablets and solutions.
When consumed orally, povidone may be regarded as essentially nontoxic since it is not absorbed from the gastrointestinal tract or mucous membranes.
Polyvinylpyrrolidone K 17 additionally has no irritant effect on the skin and causes no sensitization.
Polyvinylpyrrolidone K 17 exists that povidone may accumulate in the organs of the body following intramuscular injection.
A temporary acceptable daily intake for povidone has been set by the WHO at up to 25 mg/kg body-weight.
