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Polyvinylpyrrolidone PVP K 90, also commonly called polyvidone or povidone, is a water-soluble polymer compound made from the monomer N-vinylpyrrolidone.
Polyvinylpyrrolidone PVP K 90 is available in a range of molecular weights and related viscosities, and can be selected according to the desired application properties.
A vinyl polymer composed of repeating -CH2-CR- units where R is a 2-oxopyrrolidin-1-yl group.
CAS: 9003-39-8
MF: CH4
MW: 16.04246
EINECS: 1312995-182-4
Synonyms
toxobin;vinisil;vinylpyrrolidinonepolymer;vinylpyrrolidonepolymer;PVP K30 USP24;PVP K120;K30 PVP K30;K 30 POVIDONE K 30 BP/USP
Polyvinylpyrrolidone PVP K 90 is abbreviated as PVP, and is the polymer of vinylpyrrolidone.
According to the different degree of polymerization, it is further classified into soluble PVP and insoluble Polyvinylpyrrolidone PVP K 90.
Molecular weight of the soluble Polyvinylpyrrolidone PVP K 90 is 8,000 to 10,000.
The soluble Polyvinylpyrrolidone PVP K 90 can be used as a precipitating agent which can be settle down through its action with polyphenols.
Using this method, it is easily to have residual Polyvinylpyrrolidone PVP K 90 in the alcohol.
Due to the savings effect of Polyvinylpyrrolidone PVP K 90 inside the human body, the World Health Organization doesn’t recommend to apply this substance.
In recent years, the use of soluble Polyvinylpyrrolidone PVP K 90 has been rare.
Insoluble Polyvinylpyrrolidone PVP K 90 system had began to be used in the beer industry since the early 1960s.
Polyvinylpyrrolidone PVP K 90 has a relative molecule weight greater than the relative mass greater than 700,000.
Polyvinylpyrrolidone PVP K 90 is a insoluble polymer derived from the further cross-linking and polymerization of PVP and can be used as an adsorbent of polyphenols with a good efficacy.
Polyvinylpyrrolidone PVP K 90 is one of the three major pharmaceutical new excipients and can be used as the co-solvent of tablets, granules, and injection, as the glidant of capsules, as the dispersant agent of liquid preparations and the colorant, as the stabilizer of enzyme and heat sensitive drug, as the co-precipitating agent of poorly soluble drugs, and as the detoxicant of ophthalmic drugs and lubricants.
Polyvinylpyrrolidone PVP K 90 is industrially used as expanded polystyrene additive, as the gelling agents for suspension polymerization, stabilizer, and fiber treating agents, paper processing aids, adhesives, and thickening agents.
Polyvinylpyrrolidone PVP K 90 and its copolymers CAP is an important raw material of cosmetics, mainly used for hair retaining agent.
The film Polyvinylpyrrolidone PVP K 90 formed in the hair is elastic and shiny, and has excellent carding property as well as being free of dust.
Adopting different category of resin can meet various kinds of relative humidity climatic conditions.
Therefore, Polyvinylpyrrolidone PVP K 90 is an indispensable raw material in styling hair cream, hair gel, and mousse.
Polyvinylpyrrolidone PVP K 90 can also be used for the cosmetics of skin moisturizing agents and the dispersants for grease based hair dying, also as foam stabilizers, and can improve the consistency of the shampoo.
Insoluble Polyvinylpyrrolidone PVP K 90 is the stabilizer of beer and juice which can improve its transparency, color, and flavor.
Polyvinylpyrrolidone PVP K 90 is a polymer that has been shown to be a potential biomarker. Polyvinylpyrrolidone PVP K 90 can be used as a marker for propranolol hydrochloride and transfer reactions.
Polyvinylpyrrolidone PVP K 90 is insoluble in water and hydrochloric acid, but soluble in organic solvents.
Polyvinylpyrrolidone PVP K 90 can be analyzed using FT-IR spectroscopy and surface methodology.
The chemical stability of Polyvinylpyrrolidone PVP K 90 is stable at pH values between 2 and 5.
History
Polyvinylpyrrolidone PVP K 90 was first synthesized by BASF chemist Walter Reppe, and a patent was filed in 1939 for one of the derivatives of acetylene chemistry.
Polyvinylpyrrolidone PVP K 90 was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.
BASF continues to make Polyvinylpyrrolidone PVP K 90, including a pharmaceutical portfolio under the brand name of Kollidon.
Polyvinylpyrrolidone PVP K 90 Chemical Properties
Melting point: >300 °C
Boiling point: 90-93 °C
Density: 1,69 g/cm3
Tg: 175
Refractive index: (25) 1.5300
Refractive index: 1.5300
Storage temp.: 2-8°C
Solubility: H2O: soluble100mg/mL
Form: powder
Color: White to yellow-white
PH: 3.0-5.0
Water Solubility: Soluble in water.
Sensitive: Hygroscopic
Merck: 14,7697
Stability: Stable. Incompatible with strong oxidizing agents. Light sensitive. Hygroscopic.
InChI: InChI=1S/C8H15NO/c1-3-7(2)9-6-4-5-8(9)10/h7H,3-6H2,1-2H3
InChIKey: FAAHNQAYWKTLFD-UHFFFAOYSA-N
IARC: 3 (Vol. 19, Sup 7, 71) 1987
EPA Substance Registry System: Polyvinylpyrrolidone PVP K 90 (9003-39-8)
Polyvinylpyrrolidone PVP K 90 is soluble in water and other polar solvents.
For example, Polyvinylpyrrolidone PVP K 90 is soluble in various alcohols, such as methanol and ethanol, as well as in more exotic solvents like the deep eutectic solvent formed by choline chloride and urea (Relin).
When dry Polyvinylpyrrolidone PVP K 90 is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water.
In solution, Polyvinylpyrrolidone PVP K 90 has excellent wetting properties and readily forms films.
This makes Polyvinylpyrrolidone PVP K 90 good as a coating or an additive to coatings.
A 2014 study found fluorescent properties of Polyvinylpyrrolidone PVP K 90 and its oxidized hydrolyzate.
Uses
Medical
Structure of povidone-iodine complex, a common antiseptic.
There are high-purity injectable grades of Polyvinylpyrrolidone PVP K 90 available on the market, for specific use in intravenous, intramuscular, and subcutaneous applications.
Polyvinylpyrrolidone PVP K 90 is used as a binder in many pharmaceutical tablets; it simply passes through the body when taken orally.
Polyvinylpyrrolidone PVP K 90 added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.
This complex is used in various products such as solutions, ointment, pessaries, liquid soaps, and surgical scrubs.
Polyvinylpyrrolidone PVP K 90 is sold under the trade names Pyodine and Betadine, among others.
Polyvinylpyrrolidone PVP K 90 is used in pleurodesis (fusion of the pleura because of incessant pleural effusions).
For this purpose, Polyvinylpyrrolidone PVP K 90 is as effective and safe as talc, and may be preferred because of its easy availability and low cost.
Polyvinylpyrrolidone PVP K 90 is used in some contact lenses and their packaging solutions.
Polyvinylpyrrolidone PVP K 90 reduces friction, thus acting as a lubricant, or wetting agent, built into the lens.
Examples of this use include Bausch & Lomb's Ultra contact lenses with MoistureSeal Technology, Air Optix contact lens packaging solution (as an ingredient called "copolymer 845"), and Johnson & Johnson's Acuvue contact lenses.
Polyvinylpyrrolidone PVP K 90 is used as a lubricant in some eye drops, e.g. Bausch & Lomb's Soothe.
Polyvinylpyrrolidone PVP K 90 was used as a plasma volume expander for trauma victims after the 1950s.
Polyvinylpyrrolidone PVP K 90 is not preferred as a volume expander due to its ability to provoke within the lung are unknown.
Technical
Polyvinylpyrrolidone PVP K 90 is also used in many technical applications:
as a special additive for batteries, ceramics, fiberglass, inks, and inkjet paper, and in the chemical-mechanical planarization process
as an emulsifier and disintegrant for solution polymerization
to increase resolution in photoresists for cathode-ray tubes (CRT)
in aqueous metal quenching
for production of membranes, such as dialysis and water purification filters
as a binder and complexation agent in agricultural applications such as crop protection, seed treatment and coating
as a thickening agent in tooth whitening gels
as an aid for increasing the solubility of drugs in liquid and semi-liquid dosage forms (syrups, soft gelatine capsules) and as an inhibitor of recrystallisation
as an additive to Doro's RNA extraction buffer
as a liquid-phase dispersion enhancing agent in DOSY NMR
as a surfactant, reducing agent, shape controlling agent and dispersant in nanoparticle synthesis and their self-assembly
as a stabilizing agent in all inorganic solar cells
